Advanced search
Publication Cover
Molecular and Cellular Biology Volume 28, 2008 - Issue 23
Submit an article Journal homepage
81
Views
130
CrossRef citations to date
0
Altmetric
Article

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

Mei Yee KohDepartment of Experimental Therapeutics, M. D. Anderson Cancer Center, Houston, Texas77030Correspondence[email protected]
,
Bryant G. DarnayDepartment of Experimental Therapeutics, M. D. Anderson Cancer Center, Houston, Texas77030
&
Garth PowisDepartment of Experimental Therapeutics, M. D. Anderson Cancer Center, Houston, Texas77030
Pages 7081-7095 | Received 14 May 2008, Accepted 24 Sep 2008, Published online: 27 Mar 2023

Citations (130)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Najah Albadari, Shanshan Deng & Wei Li. (2019) The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy. Expert Opinion on Drug Discovery 14:7, pages 667-682.
Read now
Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang & Wuhan Xiao. (2014) EAF2 Suppresses Hypoxia-Induced Factor 1α Transcriptional Activity by Disrupting Its Interaction with Coactivator CBP/p300. Molecular and Cellular Biology 34:6, pages 1085-1099.
Read now
Veronica L. Dengler, Matthew D. Galbraith & Joaquín M. Espinosa. (2014) Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology 49:1, pages 1-15.
Read now

Articles from other publishers (127)

Liang Chen, Jin Yang, Meng Zhang, Donglin Fu, Huan Luo & Xiaolei Yang. (2023) SPP1 exacerbates ARDS via elevating Th17/Treg and M1/M2 ratios through suppression of ubiquitination-dependent HIF-1α degradation. Cytokine 164, pages 156107.
Crossref
Sarah V Mendoza, Damian C Genetos & Clare E Yellowley. (2023) Hypoxia‐Inducible Factor‐2α Signaling in the Skeletal System. JBMR Plus 7:4.
Crossref
Xian-Miao Li, Zhen-Yu Zhao, Xiao Yu, Qi-Dong Xia, Peng Zhou, Shao-Gang Wang, Huan-Lei Wu & Jia Hu. (2023) Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy. Experimental Hematology & Oncology 12:1.
Crossref
Sonia Mazumder, Paul J. Higgins & Rohan Samarakoon. (2023) Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance. Cancers 15:4, pages 1316.
Crossref
Consuelo Arias, Paulina Sepúlveda, Rodrigo L. Castillo & Luis A. Salazar. (2023) Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells. International Journal of Molecular Sciences 24:4, pages 3073.
Crossref
Stefania Cannito, Umberto Dianzani, Maurizio Parola, Emanuele Albano & Salvatore Sutti. (2023) Inflammatory processes involved in NASH-related hepatocellular carcinoma. Bioscience Reports 43:1.
Crossref
Yanfeng Tian, Siqi Sheng, Weiwei Gao, Jianting Yao & Ye Tian. (2022) Sonodynamic therapy suppresses matrix collagen degradation in vulnerable atherosclerotic plaque by modulating caspase 3 - PEDF/HIF-1α - MMP-2/MMP-9 signaling in macrophages. PLOS ONE 17:12, pages e0279191.
Crossref
Jiayi Yang, Yuyi Ruan, Dan Wang, Jinjin Fan, Ning Luo, Huiting Chen, Xiaoyan Li, Wei Chen & Xin Wang. (2022) VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α. Cell & Bioscience 12:1.
Crossref
Saki Gotoh‐Saito, Daichi Sadato & Futoshi Shibasaki. (2022) INT6 / eIF3e represses E‐cadherin expression through HIF2α in lung carcinoma A549 cells . Genes to Cells 27:12, pages 689-705.
Crossref
Yijie Wang, Xiong Liu, Weixiao Huang, Junjie Liang & Yan Chen. (2022) The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic microenvironment. Pharmacology & Therapeutics 240, pages 108303.
Crossref
Nancy Chee, Candace Carriere, Zachary Miller, Scott Welford & Shaun Brothers. (2022) Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells. Oncology Reports 49:1.
Crossref
Yangsook Song Green, Maria C. Ferreira dos Santos, Daniel G. Fuja, Ethan C. Reichert, Alexandre R. Campos, Sophie J. Cowman, Karen Acuña Pilarte, Jessica Kohan, Sheryl R. Tripp, Elizabeth A. Leibold, Deepika Sirohi, Neeraj Agarwal, Xiaohui Liu & Mei Yee Koh. (2022) ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma. Oncogene 41:42, pages 4709-4723.
Crossref
Karolina Kozal & Anna Krześlak. (2022) The Role of Hypoxia-Inducible Factor Isoforms in Breast Cancer and Perspectives on Their Inhibition in Therapy. Cancers 14:18, pages 4518.
Crossref
Irene Garcés-Lázaro, Rebecca Kotzur, Adelheid Cerwenka & Ofer Mandelboim. (2022) NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy. Frontiers in Immunology 13.
Crossref
Balaji T. Moorthy, Chunhua Jiang, Devang M. Patel, Yuguang Ban, Corin R. O’Shea, Akhilesh Kumar, Tan Yuan, Michael D. Birnbaum, Aldrin V. Gomes, Xi Chen, Flavia Fontanesi, Theodore J. Lampidis, Antoni Barrientos & Fangliang Zhang. (2022) The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells. Developmental Cell 57:5, pages 654-669.e9.
Crossref
Corbin C. Jensen & Noel A. Warfel. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 438 468 .
Sakshi Taneja, Stefan W. Vetter & Estelle Leclerc. (2021) Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer. International Journal of Molecular Sciences 22:15, pages 8153.
Crossref
Elena G. Varlamova & Egor A. Turovsky. (2021) THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS. International Journal of Molecular Sciences 22:12, pages 6614.
Crossref
Keun-Yeong Jeong, Jae-Jun Sim, Min Hee Park & Hwan Mook Kim. (2021) Remodeling of Cancer-Specific Metabolism under Hypoxia with Lactate Calcium Salt in Human Colorectal Cancer Cells. Cancers 13:7, pages 1518.
Crossref
Qi Liu, Bayonle Aminu, Olivia Roscow & Wei Zhang. (2021) Targeting the Ubiquitin Signaling Cascade in Tumor Microenvironment for Cancer Therapy. International Journal of Molecular Sciences 22:2, pages 791.
Crossref
T. I. Baranich, A. S. Voronkova, P. L. Anufriev, A. V. Brydun, S. A. Turygina, V. V. Glinkina & V. S. Sukhorukov. (2021) Hypoxia-inducible Factors—Their Regulation and Function in Neural Tissue. Human Physiology 46:8, pages 895-899.
Crossref
Kayla J. Steinberger, Mary A. Forget, Andrey A. Bobko, Nicole E. Mihalik, Marieta Gencheva, Julie M. Roda, Sara L. Cole, Xiaokui Mo, E. Hannah Hoblitzell, Randall Evans, Amy C. Gross, Leni Moldovan, Clay B. Marsh, Valery V. Khramtsov & Timothy D. Eubank. (2020) Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer. The Journal of Immunology 205:8, pages 2301-2311.
Crossref
Sophie J. Cowman, Daniel G. Fuja, Xian-De Liu, Rebecca S. Slack Tidwell, Neelima Kandula, Deepika Sirohi, Archana M. Agarwal, Lyska L. Emerson, Sheryl R. Tripp, Jeffrey S. Mohlman, Miekan Stonhill, Guillermina Garcia, Christopher J. Conley, Adam A. Olalde, Timothy Sargis, Adela Ramirez-Torres, Jose A. Karam, Christopher G. Wood, Kanishka Sircar, Pheroze Tamboli, Kenneth Boucher, Benjamin Maughan, Benjamin T. Spike, Thai H. Ho, Neeraj Agarwal, Eric Jonasch & Mei Yee Koh. (2020) Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer. Clinical Cancer Research 26:18, pages 4970-4982.
Crossref
Yijie Wang, Yan Chen, Lei Bao, Bo Zhang, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang & Weibo Luo. (2020) CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors. Cancer Research 80:18, pages 3880-3891.
Crossref
Vincent Wai-Hin Yuen & Carmen Chak-Lui Wong. (2020) Hypoxia-inducible factors and innate immunity in liver cancer. Journal of Clinical Investigation 130:10, pages 5052-5062.
Crossref
Tineke Vanderhaeghen, Jolien Vandewalle & Claude Libert. (2020) Hypoxia‐inducible factors in metabolic reprogramming during sepsis. The FEBS Journal 287:8, pages 1478-1495.
Crossref
Anwen Shao, Yue Lang, Mengdong Wang, Chao Qin, Yu Kuang, Yide Mei, Degui Lin, Shuo Zhang & Jun Tang. (2020) Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia. Oncogene 39:13, pages 2807-2818.
Crossref
Aurélie Morin, Judith Goncalves, Sophie Moog, Luis-Jaime Castro-Vega, Sylvie Job, Alexandre Buffet, Marie-Joséphine Fontenille, Justine Woszczyk, Anne-Paule Gimenez-Roqueplo, Eric Letouzé & Judith Favier. (2020) TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition. Cell Reports 30:13, pages 4551-4566.e7.
Crossref
Verena Seifert, Josephine Liers, Torsten Kniess, Susan Richter, Nicole Bechmann, Anja Feldmann, Michael Bachmann, Graeme Eisenhofer, Jens Pietzsch & Martin Ullrich. (2019) Fluorescent mouse pheochromocytoma spheroids expressing hypoxia-inducible factor 2 alpha: Morphologic and radiopharmacologic characterization. Journal of Cellular Biotechnology 5:2, pages 135-151.
Crossref
Matthew C. Sinton, David C. Hay & Amanda J. Drake. (2019) Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome. Clinical Epigenetics 11:1.
Crossref
Md Mahbub Ullah, Connie P. C. Ow, Lucinda M. Hilliard Krause & Roger G. Evans. (2019) Renal oxygenation during the early stages of adenine-induced chronic kidney disease. American Journal of Physiology-Renal Physiology 317:5, pages F1189-F1200.
Crossref
Nirvana Sadaghianloo, Julie Contenti, Alan Dardik & Nathalie M. Mazure. (2019) Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas. International Journal of Molecular Sciences 20:21, pages 5387.
Crossref
Daniela Mennerich, Kateryna Kubaichuk & Thomas Kietzmann. (2019) DUBs, Hypoxia, and Cancer. Trends in Cancer 5:10, pages 632-653.
Crossref
Susan F. Fitzpatrick. (2019) Immunometabolism and Sepsis: A Role for HIF?. Frontiers in Molecular Biosciences 6.
Crossref
Muzammel Haque & K. G. Kousoulas. (2019) The Kaposi’s Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains. Journal of Virology 93:17.
Crossref
Rui Lei, Jian Shen, Shizhen Zhang, Aiyu Liu, Xi Chen, Yang Wang, Jiaqi Sun, Siya Dai & Jinghong Xu. (2019) Inactivating the ubiquitin ligase Parkin suppresses cell proliferation and induces apoptosis in human keloids. Journal of Cellular Physiology 234:9, pages 16601-16608.
Crossref
Saxena & Jolly. (2019) Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression. Biomolecules 9:8, pages 339.
Crossref
Jéssica Freitas Araújo Encinas, Carlos Henrique Foncesca, Matheus Moreira Perez, Diogo Pimenta Simões, Beatriz Costa Aguiar Alves, Marcelo Rodrigues Bacci, Laura Beatriz Mesiano Maifrino, Fernando Luiz Affonso Fonseca & Glaucia Luciano Veiga. (2019) Role of hypoxia‐inducible factor 1α as a potential biomarker for renal diseases—A systematic review. Cell Biochemistry and Function 37:6, pages 443-451.
Crossref
Kateryna Kubaichuk & Thomas Kietzmann. (2019) Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance. Cells 8:6, pages 598.
Crossref
Yangsook Song Green, Timothy Sargis, Ethan Conrad Reichert, Eleanor Rudasi, Daniel Fuja, Eric Jonasch & Mei Yee Koh. (2019) Hypoxia-Associated Factor (HAF) Mediates Neurofibromin Ubiquitination and Degradation Leading to Ras–ERK Pathway Activation in Hypoxia. Molecular Cancer Research 17:5, pages 1220-1232.
Crossref
Maria da Luz Sousa Fialho, Amira H. Abd Jamil, George A. Stannard & Lisa C. Heather. (2019) Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:4, pages 831-843.
Crossref
Maya Cohen, Sharon Amir, Maya Golan, Yinon Ben-Neriah & Nicola J. Mabjeesh. (2019) β-TrCP upregulates HIF-1 in prostate cancer cells. The Prostate 79:4, pages 403-413.
Crossref
Thekkuttuparambil A. Ajith. (2018) Current insights and future perspectives of hypoxia-inducible factor-targeted therapy in cancer. Journal of Basic and Clinical Physiology and Pharmacology 30:1, pages 11-18.
Crossref
Christina Befani & Panagiotis Liakos. (2018) The role of hypoxia‐inducible factor‐2 alpha in angiogenesis. Journal of Cellular Physiology 233:12, pages 9087-9098.
Crossref
Fangping Bao, Xianhui Kang, Qing Xie & Jian Wu. (2018) HIF‑α/PKM2 and PI3K‑AKT pathways involved in the protection by dexmedetomidine against isoflurane or bupivacaine‑induced apoptosis in hippocampal neuronal HT22 cells. Experimental and Therapeutic Medicine.
Crossref
Nur Mehpare Kocaturk & Devrim Gozuacik. (2018) Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System. Frontiers in Cell and Developmental Biology 6.
Crossref
Joaquín Araos, Jonathan P. Sleeman & Boyan K. Garvalov. (2018) The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies. Clinical & Experimental Metastasis 35:7, pages 563-599.
Crossref
Mark A. Perazella, Robert Dreicer & Mitchell H. Rosner. (2018) Renal cell carcinoma for the nephrologist. Kidney International 94:3, pages 471-483.
Crossref
Stephen Ohms, Jane E. Dahlstrom & Danny Rangasamy. 2018. Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics. Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics.
Damien Ambrosetti, Maeva Dufies, Bérengère Dadone, Matthieu Durand, Delphine Borchiellini, Jean Amiel, Jacques Pouyssegur, Nathalie Rioux-Leclercq, Gilles Pages, Fanny Burel-Vandenbos & Nathalie M. Mazure. (2018) The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLOS ONE 13:2, pages e0193477.
Crossref
Jihyun Song, Krishna Sundar, Radhika Gangaraju & Josef T. Prchal. (2017) Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia. Journal of Applied Physiology 123:6, pages 1671-1675.
Crossref
Juan Liu, Cen Zhang, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A. Khella, Michael L. Gatza, Dajing Xia, Jimin Gao, Eileen White, Bruce G. Haffty, Wenwei Hu & Zhaohui Feng. (2017) Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nature Communications 8:1.
Crossref
Chuck Blajszczak & Marcelo G. Bonini. (2017) Mitochondria targeting by environmental stressors: Implications for redox cellular signaling. Toxicology 391, pages 84-89.
Crossref
Suhjean Im & Dae-Won Kim. (2017) Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes. Cellular Signalling 36, pages 127-138.
Crossref
M-C Lin, J-J Lin, C-L Hsu, H-F Juan, P-J Lou & M-C Huang. (2017) GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness. Oncogene 36:30, pages 4243-4252.
Crossref
Gregg L. Semenza. (2017) A compendium of proteins that interact with HIF-1α. Experimental Cell Research 356:2, pages 128-135.
Crossref
Julia Günter, Amalia Ruiz-Serrano, Christina Pickel, Roland H. Wenger & Carsten C. Scholz. (2017) The functional interplay between the HIF pathway and the ubiquitin system – more than a one-way road. Experimental Cell Research 356:2, pages 152-159.
Crossref
Christina Befani & Panagiotis Liakos. (2017) Hypoxia upregulates integrin gene expression in microvascular endothelial cells and promotes their migration and capillary-like tube formation. Cell Biology International 41:7, pages 769-778.
Crossref
Daniel Uribe, Ángelo Torres, José Dellis Rocha, Ignacio Niechi, Carlos Oyarzún, Luis Sobrevia, Rody San Martín & Claudia Quezada. (2017) Multidrug resistance in glioblastoma stem-like cells: Role of the hypoxic microenvironment and adenosine signaling. Molecular Aspects of Medicine 55, pages 140-151.
Crossref
Krishna M. Sundar & Josef T. Prchal. (2017) The Cornerstone of the Aberrant Pathophysiology of Obstructive Sleep Apnea: Tissue Responses to Chronic Sustained Versus Intermittent Hypoxia. American Journal of Respiratory Cell and Molecular Biology 56:4, pages 419-420.
Crossref
Shinji Tanaka, Tetsuhiro Tanaka & Masaomi Nangaku. (2016) Hypoxia and hypoxia-inducible factors in chronic kidney disease. Renal Replacement Therapy 2:1.
Crossref
Antero Salminen, Kai Kaarniranta & Anu Kauppinen. (2016) AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. Biogerontology 17:4, pages 655-680.
Crossref
Mei Yee Koh, Mihai Gagea, Timothy Sargis, Robert Lemos, Geoffrey Grandjean, Adriana Charbono, Vasileos Bekiaris, John Sedy, Galina Kiriakova, Xiuping Liu, Lewis R. Roberts, Carl Ware & Garth Powis. (2016) A new HIF‐1α/RANTES‐driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology 63:5, pages 1576-1591.
Crossref
Lei Zhan, Wenyan Wang, Yu Zhang, Enxue Song, Yijun Fan & Bing Wei. (2016) Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosis. Biochimie 123, pages 130-137.
Crossref
Amelie S. Schober & Edurne Berra. (2016) DUBs, New Members in the Hypoxia Signaling clUb. Frontiers in Oncology 6.
Crossref
Sadeesh K. Ramakrishnan & Yatrik M. Shah. (2016) Role of Intestinal HIF-2α in Health and Disease. Annual Review of Physiology 78:1, pages 301-325.
Crossref
Weibo Luo, Ivan Chen, Yan Chen, Duah Alkam, Yingfei Wang & Gregg L. Semenza. (2016) PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget 7:6, pages 6379-6397.
Crossref
Á Ordóñez-Navadijo, E Fuertes-Yebra, B Acosta-Iborra, E Balsa, A Elorza, J Aragonés & M O Landazuri. (2015) Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma. Oncogene 35:5, pages 587-594.
Crossref
Mohammad Tariq, Akihiro Ito, Muhammad Ishfaq, Elliot Bradshaw & Minoru Yoshida. (2016) Eukaryotic translation initiation factor 5A (eIF5A) is essential for HIF-1α activation in hypoxia. Biochemical and Biophysical Research Communications 470:2, pages 417-424.
Crossref
Evanthia Pangou, Christina Befani, Ilias Mylonis, Martina Samiotaki, George Panayotou, George Simos & Panagiotis Liakos. (2016) HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia. Journal of Cell Science.
Crossref
Yong Li, Qingyi Ma, Shina Halavi, Katherine Concepcion, Richard E. Hartman, Andre Obenaus, Daliao Xiao & Lubo Zhang. (2016) Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic–ischemic injury in neonatal rats. Experimental Neurology 275, pages 1-10.
Crossref
Ronghai Wang, Ping Zhang, Jinhang Li, Hongzai Guan & Guangjun Shi. (2016) Ubiquitination is absolutely required for the degradation of hypoxia-inducible factor - 1 alpha protein in hypoxic conditions. Biochemical and Biophysical Research Communications 470:1, pages 117-122.
Crossref
Maimon E. Hubbi & Gregg L. Semenza. (2015) Regulation of cell proliferation by hypoxia-inducible factors. American Journal of Physiology-Cell Physiology 309:12, pages C775-C782.
Crossref
Marilene Demasi, Vanessa Simões & Diego Bonatto. (2015) Cross-talk between redox regulation and the ubiquitin–proteasome system in mammalian cell differentiation. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:8, pages 1594-1606.
Crossref
Joao Vasco Ferreira, Ana Rosa Soares, Jose Silva Ramalho, Paulo Pereira & Henrique Girao. (2015) K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy. Scientific Reports 5:1.
Crossref
IL-RAE CHO, SIRICHAT KAOWINN, JEONG MOON, JIWON SOH, HO YOUNG KANG, CHO-ROK JUNG, SANGTAEK OH, HAYNE SONG, SANG SEOK KOH & YOUNG-HWA CHUNG. (2015) Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1. International Journal of Oncology 46:5, pages 2076-2082.
Crossref
Sylwia Bartoszewska, Kinga Rochan, Arkadiusz Piotrowski, Wojciech Kamysz, Renata J. Ochocka, James F. Collawn & Rafal Bartoszewski. (2014) The hypoxia‐inducible miR‐429 regulates hypoxia‐inducible factor‐1α expression in human endothelial cells through a negative feedback loop. The FASEB Journal 29:4, pages 1467-1479.
Crossref
Anna M Czarnecka, Anna Kornakiewicz, Fei Lian & Cezary Szczylik. (2015) Future perspectives for mTOR inhibitors in renal cell cancer treatment. Future Oncology 11:5, pages 801-817.
Crossref
Ian J. FrewHolger Moch. (2015) A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma. Annual Review of Pathology: Mechanisms of Disease 10:1, pages 263-289.
Crossref
Mei Yee Koh, Vuvi Nguyen, Robert LemosJrJr, Bryant G. Darnay, Galina Kiriakova, Mena Abdelmelek, Thai H. Ho, Jose Karam, Federico A. Monzon, Eric Jonasch & Garth Powis. (2015) Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma. Cancer Research 75:2, pages 316-329.
Crossref
Ramaprasad Srinivasan, Christopher J. Ricketts, Carole Sourbier & W. Marston Linehan. (2015) New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease. Clinical Cancer Research 21:1, pages 10-17.
Crossref
Annika Jögi. 2015. Tumor Cell Metabolism. Tumor Cell Metabolism 65 98 .
Lucy Gossage. 2015. Renal Cell Carcinoma. Renal Cell Carcinoma 57 110 .
Khaled Ghattass, Sally El-Sitt, Kazem Zibara, Saide Rayes, Makhluf J Haddadin, Marwan El-Sabban & Hala Gali-Muhtasib. (2014) The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway. Molecular Cancer 13:1.
Crossref
Maimon E. HubbiDaniele M. Gilkes, Hongxia Hu Kshitiz, Ishrat Ahmed & Gregg L. Semenza. (2014) Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proceedings of the National Academy of Sciences 111:32.
Crossref
I. JOCHMANOVÁ, T. ZELINKA, J. WIDIMSKÝJr.Jr. & K. PACAK. (2014) HIF Signaling Pathway in Pheochromocytoma and Other Neuroendocrine Tumors. Physiological Research, pages S251-S262.
Crossref
Jason Brocato, Yana Chervona & Max Costa. (2014) Molecular Responses to Hypoxia-Inducible Factor 1 α and Beyond . Molecular Pharmacology 85:5, pages 651-657.
Crossref
I. Jochmanova, C. Yang, Z. Zhuang & K. Pacak. (2013) Hypoxia-Inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right Direction. JNCI Journal of the National Cancer Institute 105:17, pages 1270-1283.
Crossref
C Piccoli, F Agriesti, R Scrima, F Falzetti, M Di Ianni & N Capitanio. (2013) To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma. British Journal of Pharmacology 169:8, pages 1652-1671.
Crossref
Maimon E. Hubbi, Hongxia Hu, Kshitiz, Daniele M. Gilkes & Gregg L. Semenza. (2013) Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors. Journal of Biological Chemistry 288:29, pages 20768-20775.
Crossref
Alexander V. Zhdanov, Ruslan I. Dmitriev, Anna V. Golubeva, Svetlana A. Gavrilova & Dmitri B. Papkovsky. (2013) Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:6, pages 3553-3569.
Crossref
John S. BettAdel F. M. IbrahimAmit K. GargVan KellyPatrick PedrioliSonia RochaRonald T. Hay. (2013) The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability . Biochemical Journal 451:2, pages 185-194.
Crossref
Ji-Eun Ahn, Xin Zhou, Scot E. Dowd, Robert S. Chapkin & Keyan Zhu-Salzman. (2013) Insight into Hypoxia Tolerance in Cowpea Bruchid: Metabolic Repression and Heat Shock Protein Regulation via Hypoxia-Inducible Factor 1. PLoS ONE 8:4, pages e57267.
Crossref
Maimon E. Hubbi, Hongxia Hu, Kshitiz, Ishrat Ahmed, Andre Levchenko & Gregg L. Semenza. (2013) Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation. Journal of Biological Chemistry 288:15, pages 10703-10714.
Crossref
Chuan Shen & William G. KaelinJr.Jr.. (2013) The VHL/HIF axis in clear cell renal carcinoma. Seminars in Cancer Biology 23:1, pages 18-25.
Crossref
Lan K. Nguyen, Miguel A. S. Cavadas, Carsten C. Scholz, Susan F. Fitzpatrick, Ulrike Bruning, Eoin P. Cummins, Murtaza M. Tambuwala, Mario C. Manresa, Boris N. Kholodenko, Cormac T. Taylor & Alex Cheong. (2013) A dynamic model of the hypoxia-inducible factor 1-alpha (HIF-1α) network. Journal of Cell Science.
Crossref
Susan Richter, Nan Qin, Karel Pacak & Graeme Eisenhofer. 2013. A New Era of Catecholamines in the Laboratory and Clinic. A New Era of Catecholamines in the Laboratory and Clinic 285 317 .
Olivier Cuvillier, Isabelle Ader, Pierre Bouquerel, Leyre Brizuela, Cécile Gstalder & Bernard Malavaud. 2013. The Role of Sphingolipids in Cancer Development and Therapy. The Role of Sphingolipids in Cancer Development and Therapy 117 141 .
Hideki Hayakawa & Futoshi Shibasaki. 2013. Biochemical Basis and Therapeutic Implications of Angiogenesis. Biochemical Basis and Therapeutic Implications of Angiogenesis 93 106 .
Sreenivasulu Chintala, Tanbir Najrana, Karoly Toth, Shousong Cao, Farukh A Durrani, Roberto Pili & Youcef M Rustum. (2012) Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. BMC Cancer 12:1.
Crossref
Yan Wang, Haiquan Jia, Huiyun Lin, Xiaogang Tan, Zhiyan Du, Huihua Chen, Yuanji Xu, Xiaoxi Han, Jiakai Zhang, Siyang Zhao, Xiaodan Yu & Yinglin Lu. (2012) Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis . Journal of Cellular and Molecular Medicine 16:12, pages 3037-3051.
Crossref
Bin Bao, Asfar S. Azmi, Shadan Ali, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong & Fazlul H. Sarkar. (2012) The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826:2, pages 272-296.
Crossref
Hao Geng, Qiong Liu, Changhui Xue, Larry L. David, Tomasz M. Beer, George V. Thomas, Mu-Shui Dai & David Z. Qian. (2012) HIF1α Protein Stability Is Increased by Acetylation at Lysine 709. Journal of Biological Chemistry 287:42, pages 35496-35505.
Crossref
Mei Yee Koh & Garth Powis. (2012) Passing the baton: the HIF switch. Trends in Biochemical Sciences 37:9, pages 364-372.
Crossref
Agnieszka Loboda, Alicja Jozkowicz & Jozef Dulak. (2012) HIF-1 versus HIF-2 — Is one more important than the other?. Vascular Pharmacology 56:5-6, pages 245-251.
Crossref
Ilkka Paatero, Anne Jokilammi, Pekka T. Heikkinen, Kristiina Iljin, Olli-Pekka Kallioniemi, Frank E. Jones, Panu M. Jaakkola & Klaus Elenius. (2012) Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling. Journal of Biological Chemistry 287:13, pages 9659-9671.
Crossref
Daniela Flügel, Agnes Görlach & Thomas Kietzmann. (2012) GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α. Blood 119:5, pages 1292-1301.
Crossref
Maimon E. Hubbi, Daniele M. Gilkes, Jin H. Baek & Gregg L. Semenza. (2012) Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1. Journal of Biological Chemistry 287:9, pages 6139-6149.
Crossref
Hong Zhao, Wenyu Lin, Kattareeya Kumthip, Du Cheng, Dahlene N. Fusco, Oliver Hofmann, Nikolaus Jilg, Andrew W. Tai, Kaku Goto, Leiliang Zhang, Winston Hide, Jae Young Jang, Lee F. Peng & Raymond T. Chung. (2012) A functional genomic screen reveals novel host genes that mediate interferon-alpha’s effects against hepatitis C virus. Journal of Hepatology 56:2, pages 326-333.
Crossref
Victor A Levin, Sonali Panchabhai, Li Shen & Keith A Baggerly. (2012) Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures. Proteome Science 10:1, pages 5.
Crossref
Wendy L. Allen, Leanne Stevenson, Vicky M. Coyle, Puthen V. Jithesh, Irina Proutski, Gail Carson, Michael A. Gordon, Heinz-Josef D. Lenz, Sandra Van Schaeybroeck, Daniel B. Longley & Patrick G. Johnston. (2012) A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer. Molecular Cancer Therapeutics 11:1, pages 119-131.
Crossref
Brian Keith, Randall S. Johnson & M. Celeste Simon. (2011) HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nature Reviews Cancer 12:1, pages 9-22.
Crossref
Jessica ES Bohonowych, Shuping Peng, Udhayakumar Gopal, Michael W Hance, Shane B Wing, Kelley M Argraves, Karen Lundgren & Jennifer S Isaacs. (2011) Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer 11:1.
Crossref
S K Martin, P Diamond, S Gronthos, D J Peet & A C W Zannettino. (2011) The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma. Leukemia 25:10, pages 1533-1542.
Crossref
Yasuki Higashimura, Takashi Terai, Ryoichi Yamaji, Takakazu Mitani, Masahiro Ogawa, Naoki Harada, Hiroshi Inui & Yoshihisa Nakano. (2011) Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel–Lindau tumor suppressor protein-independent regulatory mechanisms. Biochemical and Biophysical Research Communications 413:2, pages 201-205.
Crossref
C. F. Bento & P. Pereira. (2011) Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes. Diabetologia 54:8, pages 1946-1956.
Crossref
Mei Yee Koh, Robert LemosJrJr, Xiuping Liu & Garth Powis. (2011) The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion. Cancer Research 71:11, pages 4015-4027.
Crossref
Maimon E. Hubbi, Weibo Luo, Jin H. Baek & Gregg L. Semenza. (2011) MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1. Molecular Cell 42:5, pages 700-712.
Crossref
Ji-Hye Ryu, Shan-Hua Li, Hyoung-Sook Park, Jong-Wan Park, ByungLan Lee & Yang-Sook Chun. (2011) Hypoxia-inducible Factor α Subunit Stabilization by NEDD8 Conjugation Is Reactive Oxygen Species-dependent. Journal of Biological Chemistry 286:9, pages 6963-6970.
Crossref
Xanthi Antoniou, Max Gassmann & Omolara O. Ogunshola. (2011) Cdk5 interacts with Hif-1α in neurons: A new hypoxic signalling mechanism?. Brain Research 1381, pages 1-10.
Crossref
Lisa Lukaesko & Robert Meller. 2011. Post-Translational Modifications in Health and Disease. Post-Translational Modifications in Health and Disease 281 315 .
Carla Figueira Bento, Rosa Fernandes, José Ramalho, Carla Marques, Fu Shang, Allen Taylor & Paulo Pereira. (2010) The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal. PLoS ONE 5:11, pages e15062.
Crossref
Agnieszka Loboda, Alicja Jozkowicz & Jozef Dulak. (2010) HIF-1 and HIF-2 transcription factors — Similar but not identical. Molecules and Cells 29:5, pages 435-442.
Crossref
Gregg L. Semenza. (2010) Oxygen homeostasis. WIREs Systems Biology and Medicine 2:3, pages 336-361.
Crossref
Weibo Luo, Jun Zhong, Ryan Chang, Hongxia Hu, Akhilesh Pandey & Gregg L. Semenza. (2010) Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α. Journal of Biological Chemistry 285:6, pages 3651-3663.
Crossref
Mei Yee Koh, Taly R. Spivak-Kroizman & Garth Powis. 2010. Angiogenesis Inhibition. Angiogenesis Inhibition 15 34 .
Tiffany N. Seagroves. 2009. Pharmaceutical Perspectives of Cancer Therapeutics. Pharmaceutical Perspectives of Cancer Therapeutics 521 558 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.