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Molecular and Cellular Biology Volume 28, 2008 - Issue 18
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Transforming Growth Factor β Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab

Shizhen Emily Wang1 Departments of Cancer Biology;4 Breast Cancer Research Program, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TennesseeCorrespondence[email protected] [email protected]
,
Bin Xiang2 Medicine
,
Marta Guix2 Medicine
,
Maria Graciela Olivares3 Pathology
,
Joel Parker5 Expression Analysis, Durham, North Carolina
,
Christine H. Chung1 Departments of Cancer Biology;2 Medicine
,
Atanasio Pandiella6 Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, Salamanca, Spain
&
Carlos L. Arteaga1 Departments of Cancer Biology;2 Medicine;4 Breast Cancer Research Program, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TennesseeCorrespondence[email protected] [email protected]
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Pages 5605-5620 | Received 15 May 2008, Accepted 02 Jul 2008, Published online: 27 Mar 2023

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Crossref
Qiaoni Shi & Ye-Guang Chen. (2017) Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development. Science China Life Sciences 60:10, pages 1133-1141.
Crossref
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Crossref
Michael W. Pickup, Philip Owens & Harold L. Moses. (2017) TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment. Cold Spring Harbor Perspectives in Biology 9:5, pages a022285.
Crossref
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Hongyu Shen, Liangpeng Li, Siying Zhou, Dandan Yu, Sujin Yang, Xiu Chen, Dandan Wang, Shanliang Zhong, Jianhua Zhao & Jinhai Tang. (2016) The role of ADAM17 in tumorigenesis and progression of breast cancer. Tumor Biology 37:12, pages 15359-15370.
Crossref
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Crossref
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Crossref
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Crossref
Zhan Xiao, Rosa A. Carrasco, Kevin Schifferli, Krista Kinneer, Ravinder Tammali, Hong Chen, Ray Rothstein, Leslie Wetzel, Chunning Yang, Partha Chowdhury, Ping Tsui, Philipp Steiner, Bahija Jallal, Ronald Herbst, Robert E. Hollingsworth & David A. Tice. (2016) A Potent HER3 Monoclonal Antibody That Blocks Both Ligand-Dependent and -Independent Activities: Differential Impacts of PTEN Status on Tumor Response . Molecular Cancer Therapeutics 15:4, pages 689-701.
Crossref
Joaquim Moreno-Càceres, Jèssica Mainez, Rafael Mayoral, Paloma Martín-Sanz, Gustavo Egea & Isabel Fabregat. (2016) Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1. The FEBS Journal 283:7, pages 1300-1310.
Crossref
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Crossref
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Crossref
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Crossref
JING HUANG, HONGZHONG LI & GUOSHENG REN. (2015) Epithelial-mesenchymal transition and drug resistance in breast cancer (Review). International Journal of Oncology 47:3, pages 840-848.
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Crossref
Christian D. Young, Lisa J. Zimmerman, Daisuke Hoshino, Luigi Formisano, Ariella B. Hanker, Michael L. Gatza, Meghan M. Morrison, Preston D. Moore, Corbin A. Whitwell, Bhuvanesh Dave, Thomas Stricker, Neil E. Bhola, Grace O. Silva, Premal Patel, Dana M. Brantley-Sieders, Maren Levin, Marina Horiates, Norma A. Palma, Kai Wang, Philip J. Stephens, Charles M. Perou, Alissa M. Weaver, Joyce A. O'Shaughnessy, Jenny C. Chang, Ben Ho Park, Daniel C. Liebler, Rebecca S. Cook & Carlos L. Arteaga. (2015) Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer*. Molecular & Cellular Proteomics 14:7, pages 1959-1976.
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Adriana Zanetti, Roberta Affatato, Floriana Centritto, Maddalena Fratelli, Mami Kurosaki, Maria Monica Barzago, Marco Bolis, Mineko Terao, Enrico Garattini & Gabriela Paroni. (2015) All-trans-retinoic Acid Modulates the Plasticity and Inhibits the Motility of Breast Cancer Cells. Journal of Biological Chemistry 290:29, pages 17690-17709.
Crossref
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Crossref
Hyo Seon Lee, Bo Mi Park, Youngkyung Cho, Sauryang Kim, Chungho Kim, Moon Gyo Kim & Dongeun Park. (2014) Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme. Biochemical and Biophysical Research Communications 452:4, pages 1084-1090.
Crossref
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Crossref
J Moreno-Càceres, L Caja, J Mainez, R Mayoral, P Martín-Sanz, R Moreno-Vicente, M Á del Pozo, S Dooley, G Egea & I Fabregat. (2014) Caveolin-1 is required for TGF- β -induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17. Cell Death & Disease 5:7, pages e1326-e1326.
Crossref
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Crossref
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Crossref
Parul Gupta & Sanjay K. Srivastava. (2014) Inhibition of HER2-integrin signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression . Oncotarget 5:7, pages 1812-1828.
Crossref
Jianjun Ren, Tao Jiang & Rui Peng. (2014) Adverse reaction of a combined treatment for unresectable liver cancer. Open Medicine 9:2, pages 272-278.
Crossref
Carmen Berasain & Matías A. Avila. (2014) Amphiregulin. Seminars in Cell & Developmental Biology 28, pages 31-41.
Crossref
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Amanda G. Hansen, Shanna A. Arnold, Ming Jiang, Trenis D. Palmer, Tatiana Ketova, Alyssa Merkel, Michael Pickup, Susan Samaras, Yu Shyr, Harold L. Moses, Simon W. Hayward, Julie A. Sterling & Andries Zijlstra. (2014) ALCAM/CD166 Is a TGF-β–Responsive Marker and Functional Regulator of Prostate Cancer Metastasis to Bone. Cancer Research 74:5, pages 1404-1415.
Crossref
Carlos L. Arteaga & Jeffrey A. Engelman. (2014) ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics. Cancer Cell 25:3, pages 282-303.
Crossref
Matthew J. Niederst & Cyril H. Benes. (2014) EMT Twists the Road to PI3K. Cancer Discovery 4:2, pages 149-151.
Crossref
Ditte Brix, Knut Clemmensen & Tuula Kallunki. (2014) When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase. Cells 3:1, pages 53-78.
Crossref
Filippo Montemurro & Maurizio Scaltriti. (2014) Biomarkers of drugs targeting HER-family signalling in cancer. The Journal of Pathology 232:2, pages 219-229.
Crossref
Long Zhang, Fangfang Zhou & Peter ten Dijke. (2013) Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer. Trends in Biochemical Sciences 38:12, pages 612-620.
Crossref
Kanta TaniguchiLing XiaHoward J. GoldbergKen W.K. Lee, Anu Shah, Laura Stavar, Elodie A.Y. MassonAbdul Momen, Eric A. Shikatani, Rohan John, Mansoor Husain & I. George Fantus. (2013) Inhibition of Src Kinase Blocks High Glucose–Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice. Diabetes 62:11, pages 3874-3886.
Crossref
Michael Pickup, Sergey Novitskiy & Harold L. Moses. (2013) The roles of TGFβ in the tumour microenvironment. Nature Reviews Cancer 13:11, pages 788-799.
Crossref
Brent N. Rexer, Ritwik Ghosh, Archana Narasanna, Mónica Valeria Estrada, Anindita Chakrabarty, Youngchul Song, Jeffrey A. Engelman & Carlos L. Arteaga. (2013) Human Breast Cancer Cells Harboring a Gatekeeper T798M Mutation in HER2 Overexpress EGFR Ligands and Are Sensitive to Dual Inhibition of EGFR and HER2. Clinical Cancer Research 19:19, pages 5390-5401.
Crossref
Stefan Werner, Sabrina Frey, Sabine Riethdorf, Christian Schulze, Malik Alawi, Lea Kling, Vida Vafaizadeh, Guido Sauter, Luigi Terracciano, Udo Schumacher, Klaus Pantel & Volker Assmann. (2013) Dual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer. Journal of Biological Chemistry 288:32, pages 22993-23008.
Crossref
Josh Neman, Cecilia Choy, Claudia M. Kowolik, Athena Anderson, Vincent J. Duenas, Sarah Waliany, Bihong T. Chen, Mike Y. Chen & Rahul Jandial. (2013) Co-evolution of breast-to-brain metastasis and neural progenitor cells. Clinical & Experimental Metastasis 30:6, pages 753-768.
Crossref
Alessandra Ghigo, Fulvio Morello, Alessia Perino & Emilio Hirsch. (2013) Therapeutic applications of PI3K inhibitors in cardiovascular diseases. Future Medicinal Chemistry 5:4, pages 479-492.
Crossref
Jason J. Northey, Zhifeng Dong, Elaine Ngan, Andrew Kaplan, W. Rod Hardy, Tony Pawson & Peter M. Siegel. (2013) Distinct Phosphotyrosine-dependent Functions of the ShcA Adaptor Protein Are Required for Transforming Growth Factor β (TGFβ)-induced Breast Cancer Cell Migration, Invasion, and Metastasis. Journal of Biological Chemistry 288:7, pages 5210-5222.
Crossref
Elaine Ngan, Jason J. Northey, Claire M. Brown, Josie Ursini-Siegel & Peter M. Siegel. (2013) A complex containing LPP and α-Actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells. Journal of Cell Science.
Crossref
Vaughn Smider. 2013. Resistance to Immunotherapeutic Antibodies in Cancer. Resistance to Immunotherapeutic Antibodies in Cancer 167 181 .
James H. Finigan, Gregory P. Downey & Jeffrey A. Kern. (2012) Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury. American Journal of Respiratory Cell and Molecular Biology 47:4, pages 395-404.
Crossref
Yingwei Chen, Bao-Can Wang & Yongtao Xiao. (2012) PI3K: A potential therapeutic target for cancer. Journal of Cellular Physiology 227:7, pages 2818-2821.
Crossref
Fabio Puglisi, Alessandro Marco Minisini, Carmine De Angelis & Grazia Arpino. (2012) Overcoming Treatment Resistance in HER2-Positive Breast Cancer. Drugs 72:9, pages 1175-1193.
Crossref
Neil E. Bhola, Maria L. Freilino, Sonali C. Joyce, Malabika Sen, Sufi M. Thomas, Anirban Sahu, Andre Cassell, Ching-Shih Chen & Jennifer R. Grandis. (2012) Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer. Molecular Cancer Therapeutics 11:6, pages 1236-1246.
Crossref
Gongda Xue, David F. Restuccia, Qiang Lan, Debby Hynx, Stephan Dirnhofer, Daniel Hess, Curzio Rüegg & Brian A. Hemmings. (2012) Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes. Cancer Discovery 2:3, pages 248-259.
Crossref
Katherine C. Hall & Carl P. Blobel. (2012) Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735. PLoS ONE 7:2, pages e31600.
Crossref
Anindita ChakrabartyVioleta SánchezMaría G. Kuba, Cammie RinehartCarlos L. Arteaga. (2011) Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors. Proceedings of the National Academy of Sciences 109:8, pages 2718-2723.
Crossref
Xuyu Zu, Qinghai Zhang, Renxian Cao, Jianghua Liu, Jing Zhong, Gebo Wen & Deliang Cao. (2011) Transforming growth factor-β signaling in tumor initiation, progression and therapy in breast cancer: an update. Cell and Tissue Research 347:1, pages 73-84.
Crossref
Andrew Kasarskis, Xia Yang & Eric Schadt. (2011) Integrative genomics strategies to elucidate the complexity of drug response. Pharmacogenomics 12:12, pages 1695-1715.
Crossref
Laia Caja, Patricia Sancho, Esther Bertran, Conrad Ortiz, Jean S. Campbell, Nelson Fausto & Isabel Fabregat. (2011) The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms. Biochemical Pharmacology 82:11, pages 1583-1592.
Crossref
Charles Swanton & Stephen R. D. JohnstonJavier Cortés & Maurizio Scaltriti. 2011. Handbook of Metastatic Breast Cancer. Handbook of Metastatic Breast Cancer 035 049 .
Hilda Wong, Roland Leung, Ava KwongJoanne Chiu, Raymond Liang, Charles Swanton & Thomas Yau. (2011) Integrating Molecular Mechanisms and Clinical Evidence in the Management of Trastuzumab Resistant or Refractory HER-2+ Metastatic Breast Cancer. The Oncologist 16:11, pages 1535-1546.
Crossref
David Venet, Jacques E. Dumont & Vincent Detours. (2011) Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome. PLoS Computational Biology 7:10, pages e1002240.
Crossref
Laia Caja, Patricia Sancho, Esther Bertran & Isabel Fabregat. (2011) Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells. Journal of Hepatology 55:2, pages 351-358.
Crossref
Susy M. E. Scholl, Gemma Kenter, Christian Kurzeder & Philippe Beuzeboc. (2011) Pathway Profiling and Rational Trial Design for Studies in Advanced Stage Cervical Carcinoma: A Review and a Perspective. ISRN Oncology 2011, pages 1-13.
Crossref
Anja Brügmann & Boe S Sorensen. (2011) Identifying responders to trastuzumab therapy in breast cancer. Future Oncology 7:6, pages 767-773.
Crossref
Amy Chow, Carlos L. Arteaga & Shizhen Emily Wang. (2011) When Tumor Suppressor TGFβ Meets the HER2 (ERBB2) Oncogene. Journal of Mammary Gland Biology and Neoplasia 16:2, pages 81-88.
Crossref
Yabing Mu, Reshma Sundar, Noopur Thakur, Maria Ekman, Shyam Kumar Gudey, Mariya Yakymovych, Annika Hermansson, Helen Dimitriou, Maria Teresa Bengoechea-Alonso, Johan Ericsson, Carl-Henrik Heldin & Marene Landström. (2011) TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nature Communications 2:1.
Crossref
Carmen Berasain, María Ujue Latasa, Raquel Urtasun, Saioa Goñi, María Elizalde, Oihane Garcia-Irigoyen, María Azcona, Jesús Prieto & Matías A. Ávila. (2011) Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer. Cancers 3:2, pages 2444-2461.
Crossref
Shizhen Emily Wang. (2011) The Functional Crosstalk between HER2 Tyrosine Kinase and TGF- β Signaling in Breast Cancer Malignancy . Journal of Signal Transduction 2011, pages 1-8.
Crossref
Carlos Lizama, Andreas Ludwig & Ricardo D. Moreno. (2011) Etoposide induces apoptosis and upregulation of TACE/ADAM17 and ADAM10 in an in vitro male germ cell line model. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:1, pages 120-128.
Crossref
José Marín-GarcíaJosé Marín-García. 2011. Signaling in the Heart. Signaling in the Heart 371 403 .
M K Wendt, J A Smith & W P Schiemann. (2010) Transforming growth factor-β-induced epithelial–mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene 29:49, pages 6485-6498.
Crossref
Yang Yu, Yujun Wang, Xiubao Ren, Akihiro Tsuyada, Arthur Li, Liguang James Liu & Shizhen Emily Wang. (2010) Context-Dependent Bidirectional Regulation of the MutS Homolog 2 by Transforming Growth Factor β Contributes to Chemoresistance in Breast Cancer Cells. Molecular Cancer Research 8:12, pages 1633-1642.
Crossref
Carlos A. Castaneda, Hernán Cortes-Funes, Henry L. Gomez & Eva M. Ciruelos. (2010) The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer. Cancer and Metastasis Reviews 29:4, pages 751-759.
Crossref
Masahide Ebi, Hiromi Kataoka, Takaya Shimura, Eiji Kubota, Yoshikazu Hirata, Takashi Mizushima, Tsutomu Mizoshita, Mamoru Tanaka, Motoshi Mabuchi, Hironobu Tsukamoto, Satoshi Tanida, Takeshi Kamiya, Shigeki Higashiyama & Takashi Joh. (2010) TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells. Biochemical and Biophysical Research Communications 402:3, pages 449-454.
Crossref
S R Krig, J K Miller, S Frietze, L A Beckett, R M Neve, P J Farnham, P I Yaswen & C A Sweeney. (2010) ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. Oncogene 29:40, pages 5500-5510.
Crossref
Mahefatiana Andrianifahanana, Mark C. Wilkes, Claire E. Repellin, Maryanne Edens, Theodore J. Kottom, Rod A. Rahimi & Edward B. Leof. (2010) ERBB Receptor Activation Is Required for Profibrotic Responses to Transforming Growth Factor β. Cancer Research 70:19, pages 7421-7430.
Crossref
A Chakrabarty, B N Rexer, S E Wang, R S Cook, J A Engelman & C L Arteaga. (2010) H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3. Oncogene 29:37, pages 5193-5203.
Crossref
Jennifer Freytag, Cynthia E. Wilkins-Port, Craig E. Higgins, Stephen P. Higgins, Rohan Samarakoon & Paul J. Higgins. (2010) PAI-1 Mediates the TGF-β1+EGF-Induced “Scatter” Response in Transformed Human Keratinocytes. Journal of Investigative Dermatology 130:9, pages 2179-2190.
Crossref
A Singh & J Settleman. (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29:34, pages 4741-4751.
Crossref
Carlos Lizama, Diego Rojas-Benítez, Marcelo Antonelli, Andreas Ludwig, Ximena Bustamante-Marín, Jurriaan Brouwer-Visser & Ricardo D Moreno. (2010) TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis. REPRODUCTION 140:2, pages 305-317.
Crossref
S E Wang, Y Yu, T L Criswell, L M DeBusk, P C Lin, R Zent, D H Johnson, X Ren & C L Arteaga. (2010) Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Oncogene 29:23, pages 3335-3348.
Crossref
Yumiko Ishimatsu‐Tsuji, Tsutomu Soma & Jiro Kishimoto. (2009) Identification of novel hair‐growth inducers by means of connectivity mapping. The FASEB Journal 24:5, pages 1489-1496.
Crossref
Tim J. Kruser & Deric L. Wheeler. (2010) Mechanisms of resistance to HER family targeting antibodies. Experimental Cell Research 316:7, pages 1083-1100.
Crossref
Birgit Schoeberl, Anthony C. Faber, Danan Li, Mei-Chih Liang, Katherine Crosby, Matthew Onsum, Olga Burenkova, Emily Pace, Zandra Walton, Lin Nie, Aaron Fulgham, Youngchul Song, Ulrik B. Nielsen, Jeffrey A. Engelman & Kwok-Kin Wong. (2010) An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation. Cancer Research 70:6, pages 2485-2494.
Crossref
Xiaoping Huang, Lizhi Gao, Shuiliang Wang, James L. McManaman, Ann D. Thor, XiaoHe Yang, Francisco J. Esteva & Bolin Liu. (2010) Heterotrimerization of the Growth Factor Receptors erbB2, erbB3, and Insulin-like Growth Factor-I Receptor in Breast Cancer Cells Resistant to Herceptin. Cancer Research 70:3, pages 1204-1214.
Crossref
Joshua A. Bauer, A. Bapsi Chakravarthy, Jennifer M. Rosenbluth, Deming Mi, Erin H. Seeley, Nara De Matos Granja-Ingram, Maria G. Olivares, Mark C. Kelley, Ingrid A. Mayer, Ingrid M. Meszoely, Julie A. Means-Powell, Kimberly N. Johnson, Chiaojung Jillian Tsai, Gregory D. Ayers, Melinda E. Sanders, Robert J. Schneider, Silvia C. Formenti, Richard M. Caprioli & Jennifer A. Pietenpol. (2010) Identification of Markers of Taxane Sensitivity Using Proteomic and Genomic Analyses of Breast Tumors from Patients Receiving Neoadjuvant Paclitaxel and Radiation. Clinical Cancer Research 16:2, pages 681-690.
Crossref
Maija Hollmén & Klaus Elenius. (2010) Potential of ErbB4 antibodies for cancer therapy. Future Oncology 6:1, pages 37-53.
Crossref
Daniel R. Hyduke, Sally A. Amundson & Albert J. FornaceJr.Jr.. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2107 2125 .
Jaclyn A. Freudenberg, Qiang Wang, Makoto Katsumata, Jeffrey Drebin, Izumi Nagatomo & Mark I. Greene. (2009) The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies. Experimental and Molecular Pathology 87:1, pages 1-11.
Crossref
Carmen Berasain, Maria J. Perugorria, Maria Ujue Latasa, Josefa Castillo, Saioa Goñi, Mónica Santamaría, Jesús Prieto & Matías A. Avila. (2009) The Epidermal Growth Factor Receptor: A Link Between Inflammation and Liver Cancer. Experimental Biology and Medicine 234:7, pages 713-725.
Crossref
Brian Bierie, Christine H. Chung, Joel S. Parker, Daniel G. Stover, Nikki Cheng, Anna Chytil, Mary Aakre, Yu Shyr & Harold L. Moses. (2009) Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer. Journal of Clinical Investigation 119:6, pages 1571-1582.
Crossref
Sauveur-Michel MairaPascal FuretFrédéric Stauffer. (2009) Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Medicinal Chemistry 1:1, pages 137-155.
Crossref
Nancy E Hynes & Gwen MacDonald. (2009) ErbB receptors and signaling pathways in cancer. Current Opinion in Cell Biology 21:2, pages 177-184.
Crossref
Shidong Jia, Thomas M Roberts & Jean J Zhao. (2009) Should individual PI3 kinase isoforms be targeted in cancer?. Current Opinion in Cell Biology 21:2, pages 199-208.
Crossref
Shizhen Emily Wang, Bin Xiang, Roy Zent, Vito Quaranta, Ambra Pozzi & Carlos L. Arteaga. (2009) Transforming Growth Factor β Induces Clustering of HER2 and Integrins by Activating Src-Focal Adhesion Kinase and Receptor Association to the Cytoskeleton. Cancer Research 69:2, pages 475-482.
Crossref
Katharine H Wrighton, Xia Lin & Xin-Hua Feng. (2008) Phospho-control of TGF-β superfamily signaling. Cell Research 19:1, pages 8-20.
Crossref
Xing Guo & Xiao-Fan Wang. (2008) Signaling cross-talk between TGF-β/BMP and other pathways. Cell Research 19:1, pages 71-88.
Crossref
F. Morello, A. Perino & E. Hirsch. (2008) Phosphoinositide 3-kinase signalling in the vascular system. Cardiovascular Research 82:2, pages 261-271.
Crossref

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