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Article

Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences

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Pages 1620-1633 | Received 22 Jun 2009, Accepted 15 Jan 2010, Published online: 20 Mar 2023

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Elizabeth A. Fedak, Frederick R. Adler, Lisa M. Abegglen & Joshua D. Schiffman. (2021) ATM and ATR Activation Through Crosstalk Between DNA Damage Response Pathways. Bulletin of Mathematical Biology 83:4.
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Magdalena C. Liebl & Thomas G. Hofmann. (2019) Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road. BioEssays 41:12, pages 1900127.
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Katheryn Meek, Yao Xu, Caleb Bailie, Kefei Yu & Jessica A. Neal. (2016) The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends. The Journal of Immunology 197:8, pages 3165-3174.
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Sonja Matt & Thomas G. Hofmann. (2016) The DNA damage-induced cell death response: a roadmap to kill cancer cells. Cellular and Molecular Life Sciences 73:15, pages 2829-2850.
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Fiamma Mantovani, Alessandro Zannini, Alessandra Rustighi & Giannino Del Sal. (2015) Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:10, pages 2048-2060.
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David W. Meek. (2015) Regulation of the p53 response and its relationship to cancer. Biochemical Journal 469:3, pages 325-346.
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Awet Tecleab, Xiaolei Zhang & Said M. Sebti. (2014) Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation. Journal of Biological Chemistry 289:45, pages 31296-31309.
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Xiaona Ji, Qiang Huang, Long Yu, Ruth Nussinov & Buyong Ma. (2014) Bioinformatics Study of Cancer-Related Mutations within p53 Phosphorylation Site Motifs. International Journal of Molecular Sciences 15:8, pages 13275-13298.
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Małgorzata Krześniak, Artur Zajkowicz, Iwona Matuszczyk & Marek Rusin. (2014) Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. Mechanisms of Ageing and Development 139, pages 11-21.
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Hideya Igarashi, Hiroyasu Hirano, Ayano Yahagi, Taro Saika & Katsuhiko Ishihara. (2014) Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A. Clinical Immunology 150:1, pages 12-21.
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Ji-Hoon Lee, Michael R. Mand, Rajashree A. Deshpande, Eri Kinoshita, Soo-Hyun Yang, Claire Wyman & Tanya T. Paull. (2013) Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex. Journal of Biological Chemistry 288:18, pages 12840-12851.
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J de Lange, L V Ly, K Lodder, M Verlaan-de Vries, A F A S Teunisse, M J Jager & A G Jochemsen. (2011) Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma. Oncogene 31:9, pages 1105-1116.
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Veronika Mikitova & Timothy P. Levine. (2012) Analysis of the Key Elements of FFAT-Like Motifs Identifies New Proteins That Potentially Bind VAP on the ER, Including Two AKAPs and FAPP2. PLoS ONE 7:1, pages e30455.
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Alice GrisonFiamma MantovaniAnna ComelElena AgostoniStefano Gustincich, Francesca Persichetti & Giannino Del Sal. (2011) Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. Proceedings of the National Academy of Sciences 108:44, pages 17979-17984.
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N Sangster-Guity, B H Conrad, N Papadopoulos & F Bunz. (2011) ATR mediates cisplatin resistance in a p53 genotype-specific manner. Oncogene 30:22, pages 2526-2533.
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Leonie Smeenk, Simon J. van Heeringen, Max Koeppel, Bianca Gilbert, Eva Janssen-Megens, Hendrik G. Stunnenberg & Marion Lohrum. (2011) Role of p53 Serine 46 in p53 Target Gene Regulation. PLoS ONE 6:3, pages e17574.
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