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Molecular and Cellular Biology Volume 34, 2014 - Issue 19
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Article

HUWE1 Is a Molecular Link Controlling RAF-1 Activity Supported by the Shoc2 Scaffold

Eun Ryoung Janga Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
,
Ping Shia Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
,
Jamal Bryanta Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
,
Jing Chena Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
,
Vikas Dukhandea Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
,
Matthew S. Gentrya Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
,
HyeIn Janga Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
,
Myoungkun Jeounga Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA
&
Emilia Galperina Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USACorrespondence[email protected]
 show all
Pages 3579-3593 | Received 13 Jun 2014, Accepted 29 Jun 2014, Published online: 20 Mar 2023

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Jason J. Kwon & William C. Hahn. (2021) A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and Cellular Biology 41:4.
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Lasse Sommer Kristensen, Trine Line Hauge Okholm, Morten Trillingsgaard Venø & Jørgen Kjems. (2018) Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. RNA Biology 15:2, pages 280-291.
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Eun Ryoung Jang & Emilia Galperin. (2016) The function of Shoc2: A scaffold and beyond. Communicative & Integrative Biology 9:4.
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Sara Scinicariello, Adrian Soderholm, Markus Schäfer, Alexandra Shulkina, Irene Schwartz, Kathrin Hacker, Rebeca Gogova, Robert Kalis, Kimon Froussios, Valentina Budroni, Annika Bestehorn, Tim Clausen, Pavel Kovarik, Johannes Zuber & Gijs A Versteeg. (2023) HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation. eLife 12.
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Joan Sala-Gaston, Laura Costa-Sastre, Leonardo Pedrazza, Arturo Martinez-Martinez, Francesc Ventura & Jose Luis Rosa. (2023) Regulation of MAPK Signaling Pathways by the Large HERC Ubiquitin Ligases. International Journal of Molecular Sciences 24:5, pages 4906.
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Udeep Chawla & Deepak Chopra. (2022) Structural Advancement in Shoc2‐MAPK Signaling Pathways in the Treatment of Cancer and Other Diseases. ChemistrySelect 7:48.
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Rebecca G. Norcross, Lina Abdelmoti, Eric C. Rouchka, Kalina Andreeva, Olivia Tussey, Daileen Landestoy & Emilia Galperin. (2022) Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix. Developmental Biology 492, pages 156-171.
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Mingjia Tan, Yu Chang, Xiaoqiang Liu, Hua Li, Zaiming Tang, Mukesh K. Nyati & Yi Sun. (2022) The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model. Cell Reports 41:12, pages 111837.
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Hong-Beom Park, Sohyun Hwang & Kwang-Hyun Baek. (2022) USP7 regulates the ERK1/2 signaling pathway through deubiquitinating Raf-1 in lung adenocarcinoma. Cell Death & Disease 13:8.
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Hong-Beom Park & Kwang-Hyun Baek. (2022) E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:3, pages 188736.
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Yasuaki Ike, Masahiro Tomioka & Yuichi Iino. (2022) Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans . Genetics 220:4.
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Bao-Rui Zhao, Xin-Xin Wang & Xian-Wei Wang. (2022) Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate. PLOS Pathogens 18:1, pages e1010253.
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Patricia Wilson, Lina Abdelmoti, Rebecca Norcross, Eun Ryoung Jang, Malathy Palayam & Emilia Galperin. (2021) The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair. Journal of Cell Science 134:21.
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Simon Mathien, Chloé Tesnière & Sylvain Meloche. (2022) Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential. Pharmacological Reviews 73:4, pages 1434-1467.
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Vindya Ramanayake-Mudiyanselage, D. Maheeka Embogama & Mary Kay H. Pflum. (2021) Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling. Journal of Proteome Research 20:10, pages 4852-4861.
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HyeIn Jang, Payton Stevens, Tianyan Gao & Emilia Galperin. (2020) The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease. The FEBS Journal 288:3, pages 721-739.
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Vanessa Silva Silveira, Kleiton Silva Borges, Verena Silva Santos, Mariana Tannús Ruckert, Gabriela Maciel Vieira, Elton José Rosas Vasconcelos, Luis Fernando Peinado Nagano, Luiz Gonzaga Tone & Carlos Alberto Scrideli. (2020) SHOC2 scaffold protein modulates daunorubicin-induced cell death through p53 modulation in lymphoid leukemia cells. Scientific Reports 10:1.
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Lisa J. Crawford, David C. Campbell, Jonathan J. Morgan, Michelle A. Lawson, Jennifer M. Down, Dharminder Chauhan, Roisin M. McAvera, Treen C. Morris, Claudia Hamilton, Aswini Krishnan, Krishnaraj Rajalingam, Andrew D. Chantry & Alexandra E. Irvine. (2020) The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma. Oncogene 39:27, pages 5001-5014.
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HyeIn Jang, Patricia G. Wilson, Mary Sau, Udeep Chawla, David W. Rodgers & Emilia Galperin. (2020) Single-domain antibodies for functional targeting of the signaling scaffold Shoc2. Molecular Immunology 118, pages 110-116.
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Leonardo Pedrazza, Taiane Schneider, Ramon Bartrons, Francesc Ventura & Jose Luis Rosa. (2020) The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling. Scientific Reports 10:1.
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Solmi Cheon, Milan Dean & Maria Chahrour. (2019) The ubiquitin proteasome pathway in neuropsychiatric disorders. Neurobiology of Learning and Memory 165, pages 106791.
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Isabel Boned del RíoLucy C. YoungSibel SariGreg G. JonesBenjamin Ringham-Terry, Nicole HartigEwa RejnowiczWinnie LeiAmandeep Bhamra, Silvia Surinova & Pablo Rodriguez-Viciana. (2019) SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics. Proceedings of the National Academy of Sciences 116:27, pages 13330-13339.
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HyeIn Jang, Eun Ryoung Jang, Patricia G. Wilson, Daniel Anderson & Emilia Galperin. (2019) VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology. Molecular Biology of the Cell 30:14, pages 1655-1663.
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Chuan-Ming Xie, Mingjia Tan, Xiao-Tong Lin, Di Wu, Yihan Jiang, Ye Tan, Haomin Li, Yuanyuan Ma, Xiufang Xiong & Yi Sun. (2019) The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. Cell Reports 26:11, pages 3037-3050.e4.
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Christina McTavish, Wesley Bérubé-Janzen, Xu Wang, Matthew Maitland, Louisa Salemi, David Hess & Caroline Schild-Poulter. (2019) Regulation of c-Raf Stability through the CTLH Complex. International Journal of Molecular Sciences 20:4, pages 934.
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HyeIn Jang, Erin Oakley, Marie Forbes-Osborne, Melissa V Kesler, Rebecca Norcross, Ann C Morris & Emilia Galperin. (2019) Hematopoietic and neural crest defects in zebrafish shoc2 mutants: a novel vertebrate model for Noonan-like syndrome . Human Molecular Genetics 28:3, pages 501-514.
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Nishi Kumari, Patrick William Jaynes, Azad Saei, Prasanna Vasudevan Iyengar, John Lalith Charles Richard & Pieter Johan Adam Eichhorn. (2017) The roles of ubiquitin modifying enzymes in neoplastic disease. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:2, pages 456-483.
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Bryan King, Francesco Boccalatte, Kelly Moran-Crusio, Elmar Wolf, Jingjing Wang, Clarisse Kayembe, Charalampos Lazaris, Xiaofeng Yu, Beatriz Aranda-Orgilles, Anna Lasorella & Iannis Aifantis. (2016) The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells. Nature Immunology 17:11, pages 1312-1321.
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Marialetizia Motta, Giovanni Chillemi, Valentina Fodale, Serena Cecchetti, Simona Coppola, Silvia Stipo, Viviana Cordeddu, Pompeo Macioce, Bruce D. Gelb & Marco Tartaglia. (2016) SHOC2 subcellular shuttling requires the KEKE motif-rich region and N -terminal leucine-rich repeat domain and impacts on ERK signalling . Human Molecular Genetics 25:17, pages 3824-3835.
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Katherine N Choe, Claudia M Nicolae, Daniel Constantin, Yuka Imamura Kawasawa, Maria Rocio Delgado‐Diaz, Subhajyoti De, Raimundo Freire, Veronique AJ Smits & George‐Lucian Moldovan. (2016) HUWE 1 interacts with PCNA to alleviate replication stress . EMBO reports 17:6, pages 874-886.
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Myoungkun Jeoung, Eun Ryoung Jang, Jinpeng Liu, Chi Wang, Eric C. Rouchka, Xiaohong Li & Emilia Galperin. (2016) Shoc2-tranduced ERK1/2 motility signals — Novel insights from functional genomics. Cellular Signalling 28:5, pages 448-459.
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Eun Ryoung Jang, HyeIn Jang, Ping Shi, Gabriel Popa, Myoungkun Jeoung & Emilia Galperin. (2015) Spatial control of Shoc2 scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5. Journal of Cell Science.
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