28
Views
54
CrossRef citations to date
0
Altmetric
Article

Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1

, , &
Pages 3444-3452 | Received 22 Jun 2009, Accepted 29 Apr 2010, Published online: 20 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Zoleikha Goleij, Hamideh Mahmoodzadeh Hosseini, Mohsen Amin, Raheleh Halabian & Abbas Ali Imani Fooladi. (2017) Prokaryotic toxins provoke different types of cell deaths in the eukaryotic cells. Toxin Reviews 36:3, pages 242-256.
Read now

Articles from other publishers (53)

Yáiza Núñez, Annabel Garcia-León, Aïda Falgàs, Naroa Serna, Laura Sánchez-García, Ana Garrido, Jorge Sierra, Alberto Gallardo, Ugutz Unzueta, Esther Vázquez, Antonio Villaverde, Ramon Mangues & Isolda Casanova. (2023) T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo. Pharmaceutics 15:3, pages 727.
Crossref
Stephen J. Wood, Josef W. Goldufsky, Michelle Y. Seu, Amir H. Dorafshar & Sasha H. Shafikhani. (2023) Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses. Cells 12:1, pages 195.
Crossref
Radwa N Morgan, Sarra E Saleh, Hala A Farrag & Khaled M Aboshanab. (2023) New insights on Pseudomonas aeruginosa exotoxin A-based immunotoxins in targeted cancer therapeutic delivery . Therapeutic Delivery 14:1, pages 31-60.
Crossref
Julian S Rechberger & David J Daniels. (2022) Locoregional infusion of IL13Rα2-specific immunotoxins in children and adults with high-grade glioma. Therapeutic Delivery 13:8, pages 385-389.
Crossref
Julian S. Rechberger, Kendra A. Porath, Liang Zhang, Cody L. Nesvick, Randy S. Schrecengost, Jann N. Sarkaria & David J. Daniels. (2022) IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma. Pharmaceutics 14:5, pages 922.
Crossref
Robert J. Kreitman & Evgeny Arons. (2022) Diagnosis and treatment of hairy cell leukemia as the COVID-19 pandemic continues. Blood Reviews 51, pages 100888.
Crossref
Seyed Mehdi Havaei, Marc G. Aucoin & Ali Jahanian-Najafabadi. (2021) Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin. Frontiers in Oncology 11.
Crossref
Irene Jurado-Martín, Maite Sainz-Mejías & Siobhán McClean. (2021) Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors. International Journal of Molecular Sciences 22:6, pages 3128.
Crossref
Enayetul Islam. (2021) Development of chemokine CXCL12-dependent immunotoxin against small cell lung cancer using in silico approaches. Informatics in Medicine Unlocked 25, pages 100676.
Crossref
Miguel R. Lugo & Allan R. Merrill. (2020) Development of Anti-Virulence Therapeutics against Mono-ADP-Ribosyltransferase Toxins. Toxins 13:1, pages 16.
Crossref
Yan Corrêa Rodrigues, Ismari Perini Furlaneto, Arthur Henrique Pinto Maciel, Ana Judith Pires Garcia Quaresma, Eliseth Costa Oliveira de Matos, Marília Lima Conceição, Marcelo Cleyton da Silva Vieira, Giulia Leão da Cunha Brabo, Edilene do Socorro Nascimento Falcão Sarges, Luana Nepomuceno Godim Costa Lima & Karla Valéria Batista Lima. (2020) High prevalence of atypical virulotype and genetically diverse background among Pseudomonas aeruginosa isolates from a referral hospital in the Brazilian Amazon. PLOS ONE 15:9, pages e0238741.
Crossref
Robert J. Kreitman & Ira Pastan. (2020) Development of Recombinant Immunotoxins for Hairy Cell Leukemia. Biomolecules 10:8, pages 1140.
Crossref
Michael Dieffenbach & Ira Pastan. (2020) Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy. Biomolecules 10:7, pages 979.
Crossref
Robert J. Kreitman & Ira Pastan. (2020) Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia. The Oncologist 25:1, pages e170-e177.
Crossref
Sirijan Santajit, Watee Seesuay, Kodchakorn Mahasongkram, Nitat Sookrung, Sumate Ampawong, Onrapak Reamtong, Pornphan Diraphat, Wanpen Chaicumpa & Nitaya Indrawattana. (2019) Human single-chain antibodies that neutralize Pseudomonas aeruginosa-exotoxin A-mediated cellular apoptosis. Scientific Reports 9:1.
Crossref
Gopi Krishnan Gopala Krishnan, Aiswarya Sethumadhavan, Pavithra Vellaichamy & Maheswaran Mani. (2019) Pseudomonas aeruginosa infection stimulates mitogen‐activated protein kinases signaling pathway in human megakaryocytes . Microbiology and Immunology 63:6, pages 229-237.
Crossref
Daniel S Green, Syed R Husain, Chase L Johnson, Yuki Sato, Jing Han, Bharat Joshi, Stephen M Hewitt, Raj K Puri & Kathryn C Zoon. (2019) Combination immunotherapy with IL-4 Pseudomonas exotoxin and IFN-α and IFN-γ mediate antitumor effects in vitro and in a mouse model of human ovarian cancer . Immunotherapy 11:6, pages 483-496.
Crossref
Suji Kim, Myung Whan Oh, Woo Bin Park & Han Sang Yoo. (2019) Global Gene Networks in 3D4/31 Porcine Alveolar Macrophages Treated with Antigenic Epitopes of Actinobacillus pleuropneumoniae ApxIA, IIA, and IVA. Scientific Reports 9:1.
Crossref
Lina Han, Jeffrey L. Jorgensen, Chris Brooks, Ce Shi, Qi Zhang, Graciela M. Nogueras González, Antonio Cavazos, Rongqing Pan, Hong Mu, Sa A. Wang, Jin Zhou, Gheath AI-Atrash, Stefan O. Ciurea, Mike Rettig, John F. DiPersio, Jorge Cortes, Xuelin Huang, Hagop M. Kantarjian, Michael Andreeff, Farhad Ravandi & Marina Konopleva. (2017) Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia. Clinical Cancer Research 23:13, pages 3385-3395.
Crossref
Fabian Müller, Stephanie Stookey, Tyler Cunningham & Ira Pastan. (2017) Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies. Oncotarget 8:19, pages 30644-30655.
Crossref
Evgeniya Sokolova, Evgeniy Guryev, Andrey Yudintsev, Vladimir Vodeneev, Sergey Deyev & Irina Balalaeva. (2017) HER2-specific recombinant immunotoxin 4D5scFv-PE40 passes through retrograde trafficking route and forces cells to enter apoptosis. Oncotarget 8:13, pages 22048-22058.
Crossref
Emily Kolyvas, Michael Rudloff, Marianne Poruchynsky, Rebekah Landsman, Kevin Hollevoet, David Venzon & Christine Alewine. (2016) Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes. Oncotarget 8:6, pages 9189-9199.
Crossref
Xiu Fen LiuLaiman XiangQi ZhouJean-Philippe CarralotMarco PrunottoGerhard Niederfellner & Ira Pastan. (2016) Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis. Proceedings of the National Academy of Sciences 113:38, pages 10666-10671.
Crossref
Nathan Simon, Antonella Antignani, Robert Sarnovsky, Stephen M. Hewitt & David FitzGerald. (2016) Targeting a Cancer-Specific Epitope of the Epidermal Growth Factor Receptor in Triple-Negative Breast Cancer. Journal of the National Cancer Institute 108:8, pages djw028.
Crossref
Xiufen Liu, Fabian Müller, Alan S. Wayne & Ira Pastan. (2016) Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A–Based Immunotoxins . Molecular Cancer Therapeutics 15:5, pages 1053-1062.
Crossref
Seong H. Chow, Pankaj Deo & Thomas Naderer. (2016) Macrophage cell death in microbial infections. Cellular Microbiology 18:4, pages 466-474.
Crossref
Robert J. Kreitman & Ira Pastan. (2015) Immunoconjugates in the management of hairy cell leukemia. Best Practice & Research Clinical Haematology 28:4, pages 236-245.
Crossref
Marta Michalska & Philipp Wolf. (2015) Pseudomonas Exotoxin A: optimized by evolution for effective killing. Frontiers in Microbiology 6.
Crossref
Sebastian StahlAna Rita da Silva Mateus SeidlAxel DucretSabine Kux van GeijtenbeekSven MichelTomas RacekFabian BirzeleAlexander K. HaasRuediger RuegerMichael GergGerhard NiederfellnerIra Pastan & Ulrich Brinkmann. (2015) Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Proceedings of the National Academy of Sciences 112:34, pages 10732-10737.
Crossref
Kevin Hollevoet, Emily Mason-Osann, Fabian Müller & Ira Pastan. (2015) Methylation-Associated Partial Down-Regulation of Mesothelin Causes Resistance to Anti-Mesothelin Immunotoxins in a Pancreatic Cancer Cell Line. PLOS ONE 10:3, pages e0122462.
Crossref
Joshua L. Andersen & Jeffrey C. Rathmell. 2015. Mammalian Toxicology. Mammalian Toxicology 75 83 .
Alexis Broquet & Karim Asehnoune. (2014) Apoptosis induced by P seudomonas aeruginosa : a lonely killer? . Microbial Biotechnology 8:1, pages 49-51.
Crossref
Roland B. Walter. 2015. Resistance to Immunotoxins in Cancer Therapy. Resistance to Immunotoxins in Cancer Therapy 75 87 .
Sebastian Stahl, Fabian Mueller, Ira Pastan & Ulrich Brinkmann. 2015. Resistance to Immunotoxins in Cancer Therapy. Resistance to Immunotoxins in Cancer Therapy 57 73 .
Erin L. Boland, Crystal M. Van Dyken, Rachel M. Duckett, Andrew J. McCluskey & Gregory M.K. Poon. (2014) Structural Complementation of the Catalytic Domain of Pseudomonas Exotoxin A. Journal of Molecular Biology 426:3, pages 645-655.
Crossref
Xiu-Fen Liu, Laiman Xiang, David J. FitzGerald & Ira Pastan. (2014) Antitumor Effects of Immunotoxins Are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors . Molecular Cancer Therapeutics 13:1, pages 82-89.
Crossref
Xiaobo Hu, Hui Wei, Laiman Xiang, Oleg Chertov, Alan S. Wayne, Tapan K. Bera & Ira Pastan. (2013) Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8. Leukemia Research 37:11, pages 1551-1556.
Crossref
Sara Busacca, Alex D. Chacko, Astero Klabatsa, Kenneth Arthur, Michael Sheaff, Vignesh K. Gunasekharan, Julia J. Gorski, Mohamed El-Tanani, V. Courtney Broaddus, Giovanni Gaudino & Dean A. Fennell. (2013) BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma. PLoS ONE 8:6, pages e65489.
Crossref
Anna V. Miller, Mark A. Hicks, Wataru Nakajima, Amanda C. Richardson, Jolene J. Windle & Hisashi Harada. (2013) Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor. PLoS ONE 8:4, pages e60685.
Crossref
Xiu Fen Liu, David J. FitzGerald & Ira Pastan. (2013) The Insulin Receptor Negatively Regulates the Action of Pseudomonas Toxin-Based Immunotoxins and Native Pseudomonas Toxin . Cancer Research 73:7, pages 2281-2288.
Crossref
Shaan L. Gellatly & Robert E.W. Hancock. (2013) Pseudomonas aeruginosa : new insights into pathogenesis and host defenses . Pathogens and Disease 67:3, pages 159-173.
Crossref
Hui Wei, Tapan K. Bera, Alan S. Wayne, Laiman Xiang, Simona Colantonio, Oleg Chertov & Ira Pastan. (2013) A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene. Journal of Biological Chemistry 288:17, pages 12305-12312.
Crossref
Fernanda Faião-Flores, José Agustín Quincoces Suarez, Vanessa Soto-Cerrato, Margarita Espona-Fiedler, Ricardo Pérez-Tomás & Durvanei Augusto Maria. (2013) Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells. Tumor Biology 34:2, pages 1235-1243.
Crossref
Hui Wei, Laiman Xiang, Alan S. Wayne, Oleg Chertov, David J. FitzGerald, Tapan K. Bera & Ira Pastan. (2012) Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. Proceedings of the National Academy of Sciences 109:18, pages 6898-6903.
Crossref
Weiwei Zhang, Xiaoping Wang & Tongsheng Chen. (2012) Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells. Cellular Signalling 24:5, pages 1037-1046.
Crossref
Chris Zhiyi Zhang, Haitao Zhang, Jingping Yun, George Gong Chen & Paul Bo San Lai. (2012) Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo. Biochemical Pharmacology 83:9, pages 1278-1289.
Crossref
Eun-Ju Yang, Dong-Hyun Kim & Jeong-Hyun Chang. (2012) Extract of Listeria monocytogenes Induces the Apoptosis on the Human Promyelocytic Leukemia Cells, HL-60 Cells. The Journal of the Korea Contents Association 12:2, pages 339-348.
Crossref
John E. Weldon & Ira Pastan. (2011) A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. FEBS Journal 278:23, pages 4683-4700.
Crossref
Robert J. Kreitman & Ira Pastan. (2011) Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox. Clinical Cancer Research 17:20, pages 6398-6405.
Crossref
Kohei Ogura, Kinnosuke Yahiro, Hiroyasu Tsutsuki, Sayaka Nagasawa, Shinji Yamasaki, Joel Moss & Masatoshi Noda. (2011) Characterization of Cholix Toxin-induced Apoptosis in HeLa Cells. Journal of Biological Chemistry 286:43, pages 37207-37215.
Crossref
Xing Du, Laiman Xiang, Crystal Mackall & Ira Pastan. (2011) Killing of Resistant Cancer Cells with Low Bak by a Combination of an Antimesothelin Immunotoxin and a TRAIL Receptor 2 Agonist Antibody. Clinical Cancer Research 17:18, pages 5926-5934.
Crossref
Arjune Premsukh, Joelle M. Lavoie, Jeannick Cizeau, Joycelyn Entwistle & Glen C. MacDonald. (2011) Development of a GMP Phase III purification process for VB4-845, an immunotoxin expressed in E. coli using high cell density fermentation. Protein Expression and Purification 78:1, pages 27-37.
Crossref
Zachari Turgeon, René Jørgensen, Danielle Visschedyk, Patrick R. Edwards, Sarah Legree, Caroline McGregor, Robert J. Fieldhouse, Dev Mangroo, Matthieu Schapira & A. Rod Merrill. (2011) Newly Discovered and Characterized Antivirulence Compounds Inhibit Bacterial Mono-ADP-Ribosyltransferase Toxins. Antimicrobial Agents and Chemotherapy 55:3, pages 983-991.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.