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Article

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation

Marek A. Budzyńskia Department of Biosciences, Åbo Akademi University, Turku, Finland;b Turku Center for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland
,
Mikael C. Puustinena Department of Biosciences, Åbo Akademi University, Turku, Finland;b Turku Center for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland
,
Jenny Joutsena Department of Biosciences, Åbo Akademi University, Turku, Finland;b Turku Center for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland
&
Lea Sistonena Department of Biosciences, Åbo Akademi University, Turku, Finland;b Turku Center for Biotechnology, University of Turku, Åbo Akademi University, Turku, FinlandCorrespondence[email protected]
Pages 2530-2540 | Received 03 Aug 2014, Accepted 04 May 2015, Published online: 20 Mar 2023

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Toshiki Kijima, Thomas Prince, Len Neckers, Fumitaka Koga & Yasuhisa Fujii. (2019) Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress. Expert Opinion on Therapeutic Targets 23:5, pages 369-377.
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Xiongjie Jin, Aijun Qiao, Demetrius Moskophidis & Nahid F. Mivechi. (2018) Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance. Molecular and Cellular Biology 38:18.
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Sharadha Dayalan Naidu, Calum Sutherland, Ying Zhang, Ana Risco, Laureano de la Vega, Christopher J. Caunt, C. James Hastie, Douglas J. Lamont, Laura Torrente, Sudhir Chowdhry, Ivor J. Benjamin, Stephen M. Keyse, Ana Cuenda & Albena T. Dinkova-Kostova. (2016) Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases. Molecular and Cellular Biology 36:18, pages 2403-2417.
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Sahil, Radhika Keshan & Shabir A. Rather. 2021. Frontiers in Plant-Soil Interaction. Frontiers in Plant-Soil Interaction 107 134 .
Min Luo, Zhipeng Meng, Toshiro Moroishi, Kimberly C. Lin, Guobo Shen, Fei Mo, Bin Shao, Xiawei Wei, Ping Zhang, Yuquan Wei & Kun-Liang Guan. (2020) Heat stress activates YAP/TAZ to induce the heat shock transcriptome. Nature Cell Biology 22:12, pages 1447-1459.
Crossref
Yangyang Shen, Yan Zou, Jun Li, Fanghui Chen, Honglin Li & Yafei Cai. (2020) CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury. International Journal of Molecular Sciences 21:21, pages 8400.
Crossref
Anna E. Masser, Michela Ciccarelli & Claes Andréasson. (2020) Hsf1 on a leash – controlling the heat shock response by chaperone titration. Experimental Cell Research 396:1, pages 112246.
Crossref
Isabelle Meijer, Sabine Willems, Xiaomin Ni, Jan Heering, Apirat Chaikuad & Daniel Merk. (2020) Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics. International Journal of Molecular Sciences 21:21, pages 7895.
Crossref
Rhianna Williams, Mihails Laskovs, Rebecca I. Williams, Ananya Mahadevan & John Labbadia. (2020) A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse. Developmental Cell 54:6, pages 758-772.e5.
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Leonie Gellrich, Pascal Heitel, Jan Heering, Whitney Kilu, Julius Pollinger, Tamara Goebel, Astrid Kahnt, Silvia Arifi, Werner Pogoda, Alexander Paulke, Dieter Steinhilber, Ewgenij Proschak, Mario Wurglics, Manfred Schubert-Zsilavecz, Apirat Chaikuad, Stefan Knapp, Iris Bischoff, Robert Fürst & Daniel Merk. (2020) l -Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ . Journal of Medicinal Chemistry 63:13, pages 6727-6740.
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Mikael Christer Puustinen & Lea Sistonen. (2020) Molecular Mechanisms of Heat Shock Factors in Cancer. Cells 9:5, pages 1202.
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Srijit Das, Felicia K Ooi, Johnny Cruz Corchado, Leah C Fuller, Joshua A Weiner & Veena Prahlad. (2020) Serotonin signaling by maternal neurons upon stress ensures progeny survival. eLife 9.
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Crossref
Agathe Duchateau, Aurélie de Thonel, Rachid El Fatimy, Véronique Dubreuil & Valérie Mezger. (2020) The “HSF connection”: Pleiotropic regulation and activities of Heat Shock Factors shape pathophysiological brain development. Neuroscience Letters 725, pages 134895.
Crossref
Giorgio Gaglia, Rumana Rashid, Clarence Yapp, Gaurav N. Joshi, Carmen G. Li, Susan L. Lindquist, Kristopher A. Sarosiek, Luke Whitesell, Peter K. Sorger & Sandro Santagata. (2020) HSF1 phase transition mediates stress adaptation and cell fate decisions. Nature Cell Biology 22:2, pages 151-158.
Crossref
Rachel Kuta, Nancy Larochelle, Mario Fernandez, Arun Pal, Sandra Minotti, Michael Tibshirani, Kyle St. Louis, Benoit J. Gentil, Josephine N. Nalbantoglu, Andreas Hermann & Heather D. Durham. (2020) Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models. Cell Stress and Chaperones 25:1, pages 173-191.
Crossref
Milad J. Alasady & Marc L. Mendillo. 2020. HSF1 and Molecular Chaperones in Biology and Cancer. HSF1 and Molecular Chaperones in Biology and Cancer 69 85 .
David Pincus. 2020. HSF1 and Molecular Chaperones in Biology and Cancer. HSF1 and Molecular Chaperones in Biology and Cancer 41 50 .
Dipankar J. Dutta, Kazue Hashimoto-Torii & Masaaki Torii. 2021. Heat Shock Proteins in Inflammatory Diseases. Heat Shock Proteins in Inflammatory Diseases 213 240 .
Ryosuke Takii, Mitsuaki Fujimoto, Masaki Matsumoto, Pratibha Srivastava, Arpit Katiyar, Keiich I Nakayama & Akira Nakai. (2019) The pericentromeric protein shugoshin 2 cooperates with HSF 1 in heat shock response and RNA Pol II recruitment . The EMBO Journal 38:24.
Crossref
Sara Peffer, Davi Gonçalves & Kevin A. Morano. (2019) Regulation of the Hsf1-dependent transcriptome via conserved bipartite contacts with Hsp70 promotes survival in yeast. Journal of Biological Chemistry 294:32, pages 12191-12202.
Crossref
Jenny Joutsen & Lea Sistonen. (2019) Tailoring of Proteostasis Networks with Heat Shock Factors. Cold Spring Harbor Perspectives in Biology 11:4, pages a034066.
Crossref
Daisuke Tsukamoto, Tomoko Hasegawa, Shin-ichi Hirose, Yukina Sakurai, Michihiko Ito & Nobuhiko Takamatsu. (2019) Circadian transcription factor HSF1 regulates differential HSP70 gene transcription during the arousal-torpor cycle in mammalian hibernation. Scientific Reports 9:1.
Crossref
Simon Gutbier, Patrick May, Sylvie Berthelot, Abhimanyu Krishna, Timo Trefzer, Mehri Behbehani, Liudmila Efremova, Johannes Delp, Gerhard Gstraunthaler, Tanja Waldmann & Marcel Leist. (2018) Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift. Archives of Toxicology 92:12, pages 3487-3503.
Crossref
Natália Galdi Quel & Carlos H.I. Ramos. (2018) Heat Shock Factor (HSF): The Promoter of Chaperone Genes. A Mini Review. Current Proteomics 16:1, pages 22-30.
Crossref
Amanda O Veri, Nicole Robbins & Leah E Cowen. (2018) Regulation of the heat shock transcription factor Hsf1 in fungi: implications for temperature-dependent virulence traits. FEMS Yeast Research 18:5.
Crossref
Federica Rossin, Valeria Rachela Villella, Manuela D'Eletto, Maria Grazia Farrace, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Luca Occhigrossi, Vittoria Pagliarini, Claudio Sette, Giorgio Cozza, Nikolai A Barlev, Laura Falasca, Gian Maria Fimia, Guido Kroemer, Valeria Raia, Luigi Maiuri & Mauro Piacentini. (2018) TG2 regulates the heat‐shock response by the post‐translational modification of HSF1. EMBO reports 19:7.
Crossref
Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick H. Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. Budzynski, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart Calderwood & Len Neckers. (2018) HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation. Scientific Reports 8:1.
Crossref
Xu Zheng, Ali Beyzavi, Joanna Krakowiak, Nikit Patel, Ahmad S. Khalil & David Pincus. (2018) Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity. Cell Reports 22:12, pages 3099-3106.
Crossref
Rocio Gomez-Pastor, Eileen T. Burchfiel & Dennis J. Thiele. (2017) Regulation of heat shock transcription factors and their roles in physiology and disease. Nature Reviews Molecular Cell Biology 19:1, pages 4-19.
Crossref
Marek A. Budzyński, Tim Crul, Samu V. Himanen, Noemi Toth, Ferenc Otvos, Lea Sistonen & Laszlo Vigh. (2017) Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility. Cell Stress and Chaperones 22:5, pages 717-728.
Crossref
Sharadha Dayalan Naidu & Albena T. Dinkova‐Kostova. (2017) Regulation of the mammalian heat shock factor 1. The FEBS Journal 284:11, pages 1606-1627.
Crossref
Matthew D. Cheeseman, Nicola E. A. Chessum, Carl S. Rye, A. Elisa Pasqua, Michael J. Tucker, Birgit Wilding, Lindsay E. Evans, Susan Lepri, Meirion Richards, Swee Y. Sharp, Salyha Ali, Martin Rowlands, Lisa O’Fee, Asadh Miah, Angela Hayes, Alan T. Henley, Marissa Powers, Robert te Poele, Emmanuel De Billy, Loredana Pellegrino, Florence Raynaud, Rosemary Burke, Rob L. M. van Montfort, Suzanne A. Eccles, Paul Workman & Keith Jones. (2016) Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Journal of Medicinal Chemistry 60:1, pages 180-201.
Crossref
Athanasios Zovoilis, Catherine Cifuentes-Rojas, Hsueh-Ping Chu, Alfredo J. Hernandez & Jeannie T. Lee. (2016) Destabilization of B2 RNA by EZH2 Activates the Stress Response. Cell 167:7, pages 1788-1802.e13.
Crossref
Laura Le Breton & Matthias P Mayer. (2016) A model for handling cell stress. eLife 5.
Crossref
Xu Zheng, Joanna Krakowiak, Nikit Patel, Ali Beyzavi, Jideofor Ezike, Ahmad S Khalil & David Pincus. (2016) Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation. eLife 5.
Crossref
Chrisostomos Prodromou. (2016) Mechanisms of Hsp90 regulation. Biochemical Journal 473:16, pages 2439-2452.
Crossref
Xiao-Yan Pan, Wei Zhao, Xiao-Yun Zeng, Jian Lin, Min-Min Li, Xin-Tian Shen & Shu-Wen Liu. (2016) Heat Shock Factor 1 Mediates Latent HIV Reactivation. Scientific Reports 6:1.
Crossref
Nikolai Hentze, Laura Le Breton, Jan Wiesner, Georg Kempf & Matthias P Mayer. (2016) Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1. eLife 5.
Crossref
Eiichi Takaki & Akira Nakai. 2016. Heat Shock Factor. Heat Shock Factor 51 72 .
Federico Miozzo, Délara Sabéran-Djoneidi & Valérie Mezger. (2015) HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes. Journal of Molecular Biology 427:24, pages 3793-3816.
Crossref

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