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Molecular and Cellular Biology Volume 27, 2007 - Issue 5
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Article

Improper Organization of the Actin Cytoskeleton Affects Protein Synthesis at Initiation

Stephane R. GrossDepartment of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey08854
&
Terri Goss KinzyDepartment of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey08854Correspondence[email protected]
Pages 1974-1989 | Received 10 May 2006, Accepted 07 Dec 2006, Published online: 27 Mar 2023

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Mirela Spillane & Gianluca Gallo. (2014) Involvement of Rho-family GTPases in axon branching. Small GTPases 5:1.
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Stephane R. Gross. (2013) Actin binding proteins. Cell Adhesion & Migration 7:2, pages 199-213.
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Serafí Cambray, Neus Pedraza, Marta Rafel, Eloi Garí, Martí Aldea & Carme Gallego. (2009) Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation. Molecular and Cellular Biology 29:3, pages 726-735.
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Clive R. Bramham, Maria N. Alme, Margarethe Bittins, Sjoukje D. Kuipers, Rajeevkumar R. Nair, Balagopal Pai, Debabrata Panja, Manja Schubert, Jonathan Soule, Adrian Tiron & Karin Wibrand. (2009) The Arc of synaptic memory. Experimental Brain Research 200:2, pages 125-140.
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Crossref
Wendy Danielle Ransom-Hodgkins. (2009) The application of expression analysis in elucidating the eukaryotic elongation factor one alpha gene family in Arabidopsis thaliana. Molecular Genetics and Genomics 281:4, pages 391-405.
Crossref
Zhenghe Li, Judit Pogany, Tadas Panavas, Kai Xu, Anthony M. Esposito, Terri Goss Kinzy & Peter D. Nagy. (2009) Translation elongation factor 1A is a component of the tombusvirus replicase complex and affects the stability of the p33 replication co-factor. Virology 385:1, pages 245-260.
Crossref
Bryce A. Mendelsohn, James P. Malone, R. Reid Townsend & Jonathan D. Gitlin. (2009) Proteomic analysis of anoxia tolerance in the developing zebrafish embryo. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 4:1, pages 21-31.
Crossref
Dandan Zhong, Jingfeng Zhang, Shuai Yang, Unice J. K. Soh, Jan Paul Buschdorf, Yi Ting Zhou, Daiwen Yang & Boon Chuan Low. (2009) The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration. Journal of Cell Science 122:3, pages 414-424.
Crossref
Yvette R. Pittman, Kimberly Kandl, Marcus Lewis, Louis Valente & Terri Goss Kinzy. (2009) Coordination of Eukaryotic Translation Elongation Factor 1A (eEF1A) Function in Actin Organization and Translation Elongation by the Guanine Nucleotide Exchange Factor eEF1Bα. Journal of Biological Chemistry 284:7, pages 4739-4747.
Crossref
Khyobeni Mozhui, Daniel C. Ciobanu, Thomas Schikorski, Xusheng Wang, Lu Lu & Robert W. Williams. (2008) Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression. PLoS Genetics 4:11, pages e1000260.
Crossref
Clive R. Bramham, Paul F. Worley, Melissa J. Moore & John F. Guzowski. (2008) The Immediate Early Gene Arc / Arg3.1 : Regulation, Mechanisms, and Function . The Journal of Neuroscience 28:46, pages 11760-11767.
Crossref
Sandesh Regmi, Karen G. Rothberg, James G. Hubbard & Larry Ruben. (2008) The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis . Molecular Microbiology 70:3, pages 724-745.
Crossref
Hongfang Lu, Ying Yang, Emma M. Allister, Nadeeja Wijesekara & Michael B. Wheeler. (2008) The Identification of Potential Factors Associated with the Development of Type 2 Diabetes. Molecular & Cellular Proteomics 7:8, pages 1434-1451.
Crossref
Andrea Pellagatti, Eva Hellström-Lindberg, Aristoteles Giagounidis, Janet Perry, Luca Malcovati, Matteo G. Della Porta, Martin Jädersten, Sally Killick, Carrie Fidler, Mario Cazzola, James S. Wainscoat & Jacqueline Boultwood. (2008) Haploinsufficiency of RPS14 in 5q− syndrome is associated with deregulation of ribosomal- and translation-related genes. British Journal of Haematology 142:1, pages 57-64.
Crossref
Francisca P. G. Van HorckChristine E. Holt. (2008) A Cytoskeletal Platform for Local Translation in Axons. Science Signaling 1:8.
Crossref
Seyun Kim, Juliane Kellner, Chang-Hun Lee & Pierre A Coulombe. (2007) Interaction between the keratin cytoskeleton and eEF1Bγ affects protein synthesis in epithelial cells. Nature Structural & Molecular Biology 14:10, pages 982-983.
Crossref
Clive R. Bramham & David G. Wells. (2007) Dendritic mRNA: transport, translation and function. Nature Reviews Neuroscience 8:10, pages 776-789.
Crossref
Ashwini K. Mishra, Laxman Gangwani, Roger J. Davis & David G. Lambright. (2007) Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Proceedings of the National Academy of Sciences 104:35, pages 13930-13935.
Crossref

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