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Molecular and Cellular Biology Volume 27, 2007 - Issue 18
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Article

The Beyond 12/23 Restriction Is Imposed at the Nicking and Pairing Steps of DNA Cleavage during V(D)J Recombination

Anna H. Drejer-Teel1 Department of Genetics, Yale University School of Medicine, 330 Cedar St., New Haven, Connecticut06510
,
Sebastian D. Fugmann2 Department of Immunobiology, Yale University School of Medicine, 300 Cedar St., New Haven, Connecticut06510
&
David G. Schatz2 Department of Immunobiology, Yale University School of Medicine, 300 Cedar St., New Haven, Connecticut06510;3 Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut06510Correspondence[email protected]
Pages 6288-6299 | Received 11 May 2007, Accepted 09 Jul 2007, Published online: 27 Mar 2023

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Joydeep K. Banerjee & David G. Schatz. (2014) Synapsis Alters RAG-Mediated Nicking at Tcrb Recombination Signal Sequences: Implications for the “Beyond 12/23” Rule. Molecular and Cellular Biology 34:14, pages 2566-2580.
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Julien Bischerour, Catherine Lu, David B. Roth & Ronald Chalmers. (2009) Base Flipping in V(D)J Recombination: Insights into the Mechanism of Hairpin Formation, the 12/23 Rule, and the Coordination of Double-Strand Breaks. Molecular and Cellular Biology 29:21, pages 5889-5899.
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Articles from other publishers (19)

Glendon S. Wu, Katherine S. Yang-Iott, Morgann A. Klink, Katharina E. Hayer, Kyutae D. Lee & Craig H. Bassing. (2020) Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion. Journal of Experimental Medicine 217:9.
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Soichi Hirokawa, Griffin Chure, Nathan M Belliveau, Geoffrey A Lovely, Michael Anaya, David G Schatz, David Baltimore & Rob Phillips. (2020) Sequence-dependent dynamics of synthetic and endogenous RSSs in V(D)J recombination. Nucleic Acids Research 48:12, pages 6726-6739.
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Min-Sung Kim, Watchalee Chuenchor, Xuemin Chen, Yanxiang Cui, Xing Zhang, Z. Hong Zhou, Martin Gellert & Wei Yang. (2018) Cracking the DNA Code for V(D)J Recombination. Molecular Cell 70:2, pages 358-370.e4.
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Grace Teng & David G. Schatz. 2015. Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci. Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci 1 39 .
Alicia J. Little, Adam Matthews, Marjorie Oettinger, David B. Roth & David G. Schatz. 2015. Molecular Biology of B Cells. Molecular Biology of B Cells 13 34 .
Corentin Claeys Bouuaert, Neil Walker, Danxu Liu & Ronald Chalmers. (2014) Crosstalk between transposase subunits during cleavage of the mariner transposon. Nucleic Acids Research 42:9, pages 5799-5808.
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Alicia J. Little, Elizabeth Corbett, Fabian Ortega & David G. Schatz. (2013) Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA. Nucleic Acids Research 41:5, pages 3289-3301.
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Mayilaadumveettil Nishana & Sathees C. Raghavan. (2012) Role of recombination activating genes in the generation of antigen receptor diversity and beyond. Immunology 137:4, pages 271-281.
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Jennifer L. Stone, Ruth E. McMillan, David A. Skaar, Justin M. Bradshaw, Randy L. Jirtle & Michael L. Sikes. (2012) DNA Double-Strand Breaks Relieve USF-Mediated Repression of Dβ2 Germline Transcription in Developing Thymocytes. The Journal of Immunology 188:5, pages 2266-2275.
Crossref
David G. SchatzPatrick C. Swanson. (2011) V(D)J Recombination: Mechanisms of Initiation. Annual Review of Genetics 45:1, pages 167-202.
Crossref
Michael L. Sikes & Eugene M. Oltz. 2012. Epigenetic Regulation of Lymphocyte Development. Epigenetic Regulation of Lymphocyte Development 91 116 .
Stephen Desiderio. (2010) Temporal and spatial regulatory functions of the V(D)J recombinase. Seminars in Immunology 22:6, pages 362-369.
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Michael L. Sikes, Ruth E. McMillan & Justin M. Bradshaw. (2010) The Center of Accessibility: Dβ Control of V(D)J Recombination. Archivum Immunologiae et Therapiae Experimentalis 58:6, pages 427-433.
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Katherine S. Yang-Iott, Andrea C. Carpenter, Marta A. W. Rowh, Natalie Steinel, Brenna L. Brady, Konrad Hochedlinger, Rudolf Jaenisch & Craig H. Bassing. (2010) TCRβ Feedback Signals Inhibit the Coupling of Recombinationally Accessible Vβ14 Segments with DJβ Complexes. The Journal of Immunology 184:3, pages 1369-1378.
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Michael Lieber. 2001. eLS. eLS.
Uzodinma N. Uche, Christopher R. Huber, David H. Raulet & Na Xiong. (2009) Recombination Signal Sequence-Associated Restriction on TCRδ Gene Rearrangement Affects the Development of Tissue-Specific γδ T Cells. The Journal of Immunology 183:8, pages 4931-4939.
Crossref
Don-Marc Franchini, Touati Benoukraf, Sébastien Jaeger, Pierre Ferrier & Dominique Payet-Bornet. (2009) Initiation of V(D)J Recombination by Dβ-Associated Recombination Signal Sequences: A Critical Control Point in TCRβ Gene Assembly. PLoS ONE 4:2, pages e4575.
Crossref
Marie Bonnet, Pierre Ferrier & Salvatore Spicuglia. 2009. V(D)J Recombination. V(D)J Recombination 116 132 .
Thomas Perlot & Frederick W. Alt. 2008. 1 32 .

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