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Molecular and Cellular Biology Volume 31, 2011 - Issue 4
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Article

Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling

Danislav S. SpassovDepartments of Medicine, University of California, San Francisco, San Francisco, California94143;Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California94143
,
Ching Hang WongDepartments of Medicine, University of California, San Francisco, San Francisco, California94143;Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California94143
,
Natalia SerginaDepartments of Medicine, University of California, San Francisco, San Francisco, California94143;Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California94143
,
Deepika AhujaDepartments of Medicine, University of California, San Francisco, San Francisco, California94143;Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California94143
,
Michael FriedCancer Research Institute, University of California, San Francisco, San Francisco, California94143;Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California94143
,
Dean SheppardDepartments of Medicine, University of California, San Francisco, San Francisco, California94143;Lung Biology Center, University of California, San Francisco, San Francisco, California94143
&
Mark M. MoasserDepartments of Medicine, University of California, San Francisco, San Francisco, California94143;Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California94143Correspondence[email protected]
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Pages 766-782 | Received 21 Jul 2010, Accepted 06 Dec 2010, Published online: 20 Mar 2023

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Feng Luo, Guang Hong, Hiroyuki Matsui, Kosei Endo, Qianbing Wan & Keiichi Sasaki. (2018) Initial osteoblast adhesion and subsequent differentiation on zirconia surfaces are regulated by integrins and heparin-sensitive molecule. International Journal of Nanomedicine 13, pages 7657-7667.
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Danislav S. Spassov, Ching H. Wong & Mark M. Moasser. (2011) Trask phosphorylation defines the reverse mode of a phosphotyrosine signaling switch that underlies cell anchorage state <link xlink:href="file. Cell Cycle 10:8, pages 1225-1232.
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Articles from other publishers (26)

Christopher A. Bonham, Vinay Mandati, Rakesh K. Singh, Darryl J. Pappin & Nicholas K. Tonks. (2023) Coupling substrate-trapping with proximity-labeling to identify protein tyrosine phosphatase PTP1B signaling networks. Journal of Biological Chemistry 299:5, pages 104582.
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Lingjun Zhang, Nozha Borjini, Yu Lun, Sweta Parab, Gospel Asonye, Rupesh Singh, Brent A. Bell, Vera L. Bonilha, Andrei Ivanov, David A. Fox, Rachel Caspi & Feng Lin. (2022) CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis. JCI Insight 7:18.
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Xiao Qi, Jing Gao, Zihao Li, Guangxin Zhang, Jialin Li, Yilin Fu, Mingjun Cai, Hongda Wang & Ti Tong. (2022) CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer. Life Sciences 301, pages 120600.
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Masayoshi Ikeuchi, Ryuzaburo Yuki, Youhei Saito & Yuji Nakayama. (2020) The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner. The FASEB Journal 35:1.
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Xiaohua Guo, Rebecca A. Eitnier, Richard S. Beard, Jamie E. Meegan, Xiaoyuan Yang, Alexandra M. Aponte, Fang Wang, Peter R. Nelson & Mack H. Wu. (2020) Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments. PLOS ONE 15:4, pages e0231739.
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Amol K. Bhandage, Janet L. Cunningham, Zhe Jin, Qiujin Shen, Santiago Bongiovanni, Sergiy V. Korol, Mikaela Syk, Masood Kamali-Moghaddam, Lisa Ekselius & Bryndis Birnir. (2019) Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers. International Journal of Molecular Sciences 20:24, pages 6172.
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Moustafa A. Abousarie & Dina F. El-Yasergy. (2018) Value of CUB domain containing protein 1 expression in urothelial carcinoma. Egyptian Journal of Pathology 38:1, pages 92-96.
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Sara G. Pollan, Fangjin Huang, Jamie M. Sperger, Joshua M. Lang, Colm Morrissey, Anne E. Cress, C. Y. Chu, Neil A. Bhowmick, Sungyong You, Michael R. Freeman, Danislav S. Spassov, Mark M. Moasser, William G. Carter, Shakti Ranjan Satapathy, Kavita Shah & Beatrice S. Knudsen. (2018) Regulation of inside-out β1-integrin activation by CDCP1. Oncogene 37:21, pages 2817-2836.
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Anita A. Wasik & Herbert B. Schiller. (2017) Functional proteomics of cellular mechanosensing mechanisms. Seminars in Cell & Developmental Biology 71, pages 118-128.
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Gospel Enyindah-AsonyeYan Li, Jeffrey H. RuthDanislav S. SpassovKatie E. HebronAndries ZijlstraMark M. MoasserBenlian WangNora G. SingerHuadong CuiRay A. OharaStephanie M. RasmussenDavid A. Fox & Feng Lin. (2017) CD318 is a ligand for CD6. Proceedings of the National Academy of Sciences 114:33.
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H J Wright, J Arulmoli, M Motazedi, L J Nelson, F S Heinemann, L A Flanagan & O V Razorenova. (2016) CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Oncogene 35:36, pages 4762-4772.
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Jelani C. Zarif & Cindy K. Miranti. (2016) The importance of non-nuclear AR signaling in prostate cancer progression and therapeutic resistance. Cellular Signalling 28:5, pages 348-356.
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Hua Wu, Li-qun Shang, Rui-lin Chen, Shu-mei Yang, Shui-li Wang, Jun Wang & Gang Sun. (2015) Significance of Trask protein interactions in brain metastatic cohorts of lung cancers. Tumor Biology 36:6, pages 4181-4187.
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I-Hua Chen, Fang-Rong Chang, Yang-Chang Wu, Po-Hsiung Kung & Chin-Chung Wu. (2015) 3,4-Methylenedioxy-β-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppressing β1 integrin function and surface protein disulfide isomerase. Biochimie 110, pages 81-92.
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Genta Sawada, Yusuke Takahashi, Atsushi Niida, Teppei Shimamura, Junji Kurashige, Tae Matsumura, Hiroki Ueo, Ryutaro Uchi, Yuki Takano, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Yoshiaki Shinden, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Satoru Miyano, Yuichiro Doki, Masaki Mori & Koshi Mimori. (2014) Loss of CDCP1 Expression Promotes Invasiveness and Poor Prognosis in Esophageal Squamous Cell Carcinoma. Annals of Surgical Oncology 21:S4, pages 640-647.
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Yue Geng, Siddarth Chandrasekaran, Sivaprakash Agastin, Jiahe Li & Michael R. King. (2013) Dynamic Switch Between Two Adhesion Phenotypes in Colorectal Cancer Cells. Cellular and Molecular Bioengineering 7:1, pages 35-44.
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B Casar, I Rimann, H Kato, S J Shattil, J P Quigley & E I Deryugina. (2012) In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene 33:2, pages 255-268.
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Danislav S. Spassov, Ching Hang Wong, Sunny Y. Wong, Jeremy F. Reiter & Mark M. Moasser. (2013) Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells. Cancer Research 73:3, pages 1168-1179.
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Alaina P. Boyer, Timothy S. Collier, Ilan Vidavsky & Ron Bose. (2013) Quantitative Proteomics with siRNA Screening Identifies Novel Mechanisms of Trastuzumab Resistance in HER2 Amplified Breast Cancers. Molecular & Cellular Proteomics 12:1, pages 180-193.
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Gwendlyn Kollmorgen, Birgit Bossenmaier, Gerhard Niederfellner, Hans-Ulrich Häring & Reiner Lammers. (2012) Structural Requirements for Cub Domain Containing Protein 1 (CDCP1) and Src Dependent Cell Transformation. PLoS ONE 7:12, pages e53050.
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B Casar, Y He, M Iconomou, J D Hooper, J P Quigley & E I Deryugina. (2011) Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene 31:35, pages 3924-3938.
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C H Benes, G Poulogiannis, L C Cantley & S P Soltoff. (2011) The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Oncogene 31:5, pages 653-663.
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D S Spassov, C H Wong, G Harris, S McDonough, P Phojanakong, D Wang, B Hann, A V Bazarov, P Yaswen, E Khanafshar & M M Moasser. (2011) A tumor-suppressing function in the epithelial adhesion protein Trask. Oncogene 31:4, pages 419-431.
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V. Andasari & M.A.J. Chaplain. (2012) Intracellular Modelling of Cell-Matrix Adhesion during Cancer Cell Invasion. Mathematical Modelling of Natural Phenomena 7:1, pages 29-48.
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Andreas Wortmann, Yaowu He, Melinda E. Christensen, MayLa Linn, John W. Lumley, Pamela M. Pollock, Nigel J. Waterhouse & John D. Hooper. (2011) Cellular Settings Mediating Src Substrate Switching between Focal Adhesion Kinase Tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) Tyrosine 734. Journal of Biological Chemistry 286:49, pages 42303-42315.
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