Advanced search
Publication Cover
Molecular and Cellular Biology Volume 29, 2009 - Issue 13
Submit an article Journal homepage
20
Views
41
CrossRef citations to date
0
Altmetric
Article

Dynamin Reduces Pyk2 Y402 Phosphorylation and Src Binding in Osteoclasts

Angela Bruzzaniti1 Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, Indiana46202;2 Department of Orthopedics, Yale University School of Medicine, New Haven, Connecticut06510Correspondence[email protected] [email protected]
,
Lynn Neff2 Department of Orthopedics, Yale University School of Medicine, New Haven, Connecticut06510;3 Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts02115
,
Amanda Sandoval2 Department of Orthopedics, Yale University School of Medicine, New Haven, Connecticut06510
,
Liping Du1 Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, Indiana46202
,
William C. Horne2 Department of Orthopedics, Yale University School of Medicine, New Haven, Connecticut06510;3 Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts02115
&
Roland Baron2 Department of Orthopedics, Yale University School of Medicine, New Haven, Connecticut06510;3 Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts02115;4 Department of Medicine, Harvard Medical School, Boston, Massachusetts02115Correspondence[email protected] [email protected]
Pages 3644-3656 | Received 28 May 2008, Accepted 03 Apr 2009, Published online: 21 Mar 2023

Citations (41)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Dan Georgess, Irma Machuca-Gayet, Anne Blangy & Pierre Jurdic. (2014) Podosome organization drives osteoclast-mediated bone resorption. Cell Adhesion & Migration 8:3, pages 192-204.
Read now
Martin Biosse Duplan, Detina Zalli, Sebastien Stephens, Serhan Zenger, Lynn Neff, J. Margit Oelkers, Frank P. L. Lai, William Horne, Klemens Rottner & Roland Baron. (2014) Microtubule Dynamic Instability Controls Podosome Patterning in Osteoclasts through EB1, Cortactin, and Src. Molecular and Cellular Biology 34:1, pages 16-29.
Read now

Articles from other publishers (39)

Zhong-Hua Chen, Jun-Jie Wu, Dan-Yang Guo, Yue-Yue Li, Meng-Nan Chen, Zhen-Yu Zhang, Zheng-Dong Yuan, Kai-Wen Zhang, Wei-Wei Chen, Fan Tian, Jun-Xing Ye, Xia Li & Feng-Lai Yuan. (2023) Physiological functions of podosomes: From structure and function to therapy implications in osteoclast biology of bone resorption. Ageing Research Reviews 85, pages 101842.
Crossref
Yonggang Ma, Di Ran, Hongyan Zhao, Xueni Shi, Ruilong Song, Hui Zou & Zongping Liu. (2022) The effect of P2X7R- mediated Ca2+ and MAPK signaling in OPG-induced duck embryo osteoclasts differentiation and adhesive structure damage. Life Sciences 293, pages 120337.
Crossref
Benoit de Pins, Tiago Mendes, Albert Giralt & Jean-Antoine Girault. (2021) The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases. Frontiers in Synaptic Neuroscience 13.
Crossref
Jun Sun, Pierre P. Eleniste, Achint Utreja, Hakan Turkkahraman, Sean Shih‐Yao Liu & Angela Bruzzaniti. (2020) Pyk2 deficiency enhances bone mass during midpalatal suture expansion. Orthodontics & Craniofacial Research 23:4, pages 501-508.
Crossref
Takuma Matsubara, Tatsuki Yaginuma, William N. Addison, Yuko Fujita, Kouji Watanabe, Izumi Yoshioka, Hisako Hikiji, Kenshi Maki, Roland Baron & Shoichiro Kokabu. (2020) Plectin stabilizes microtubules during osteoclastic bone resorption by acting as a scaffold for Src and Pyk2. Bone 132, pages 115209.
Crossref
Hidetada Matsuoka, Keita Harada, Keisuke Mashima & Masumi Inoue. (2020) Muscarinic receptor stimulation induces TASK1 channel endocytosis through a PKC-Pyk2-Src pathway in PC12 cells. Cellular Signalling 65, pages 109434.
Crossref
Meenakshi A. Chellaiah. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 236 250 .
Sumana Posritong, Regina Flores Chavez, Tien-Min Gabriel Chu & Angela Bruzzaniti. (2019) A Pyk2 inhibitor incorporated into a PEGDA-gelatin hydrogel promotes osteoblast activity and mineral deposition. Biomedical Materials 14:2, pages 025015.
Crossref
Shunsuke Uehara, Nobuyuki Udagawa & Yasuhiro Kobayashi. (2018) Non-canonical Wnt signals regulate cytoskeletal remodeling in osteoclasts. Cellular and Molecular Life Sciences 75:20, pages 3683-3692.
Crossref
Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai & Tadahiro Iimura. (2017) The HIV co-receptor CCR5 regulates osteoclast function. Nature Communications 8:1.
Crossref
Chinatsu Suzuki, Akihiro Nakamura, Noriko Miura, Kuniyoshi Fukai, Naohito Ohno, Tomoyo Yahata, Akiko Okamoto-Hamaoka, Maiko Fujii, Ayako Yoshioka, Yuki Kuchitsu, Kazuyuki Ikeda & Kenji Hamaoka. (2017) Non-receptor type, proline-rich protein tyrosine kinase 2 (Pyk2) is a possible therapeutic target for Kawasaki disease. Clinical Immunology 179, pages 17-24.
Crossref
Felix J. Eppler, Thomas Quast & Waldemar Kolanus. (2017) Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLOS ONE 12:3, pages e0172443.
Crossref
Sarit Batsir, Benjamin Geiger & Zvi Kam. (2017) Dynamics of the sealing zone in cultured osteoclasts. Cytoskeleton 74:2, pages 72-81.
Crossref
Niroshani Surangika Soysa & Neil Alles. (2016) Osteoclast function and bone-resorbing activity: An overview. Biochemical and Biophysical Research Communications 476:3, pages 115-120.
Crossref
Gnanasagar J. Thirukonda, Shunsuke Uehara, Takahiro Nakayama, Teruhito Yamashita, Yukio Nakamura, Toshihide Mizoguchi, Naoyuki Takahashi, Kimitoshi Yagami, Nobuyuki Udagawa & Yasuhiro Kobayashi. (2015) The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts. Journal of Bone and Mineral Metabolism 34:4, pages 395-405.
Crossref
Pierre P. Eleniste, Vruti Patel, Sumana Posritong, Odette Zero, Heather Largura, Ying‐Hua Cheng, Evan R. Himes, Matthew Hamilton, Jenna T. B. Ekwealor, Melissa A. Kacena & Angela Bruzzaniti. (2015) Pyk2 and Megakaryocytes Regulate Osteoblast Differentiation and Migration Via Distinct and Overlapping Mechanisms. Journal of Cellular Biochemistry 117:6, pages 1396-1406.
Crossref
Tomas E. Meijome, Jenna T. B. Ekwealor, R. Adam Hooker, Ying‐Hua Cheng, Wendy A. Ciovacco, Sanjeev M. Balamohan, Trishya L. Srinivasan, Brahmananda R. Chitteti, Pierre P. Eleniste, Mark C. Horowitz, Edward F. Srour, Angela Bruzzaniti, Robyn K. Fuchs & Melissa A. Kacena. (2015) C‐Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis. Journal of Cellular Biochemistry 117:4, pages 959-969.
Crossref
Yukari Shiwaku, Lynn Neff, Kenichi Nagano, Ken-Ichi Takeyama, Joost de Bruijn, Michel Dard, Francesca Gori & Roland Baron. (2015) The Crosstalk between Osteoclasts and Osteoblasts Is Dependent upon the Composition and Structure of Biphasic Calcium Phosphates. PLOS ONE 10:7, pages e0132903.
Crossref
Michelle T. Barati, Janice Lukenbill, Rui Wu, Madhavi J. Rane & Jon B. Klein. (2015) Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABABR-mediated chemotaxis. Cellular Signalling 27:6, pages 1178-1185.
Crossref
Santosh K. VermaEvgenia LeikinaKamran MelikovLeonid V. Chernomordik. (2014) Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin. Biochemical Journal 464:3, pages 293-300.
Crossref
Nah-Young Shin, Hyewon Choi, Lynn Neff, Yumei Wu, Hiroaki Saito, Shawn M. Ferguson, Pietro De Camilli & Roland Baron. (2014) Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts. Journal of Cell Biology 207:1, pages 73-89.
Crossref
Zhao Zhang, Yun Zhang, Zheng Mou, Shifeng Chu, Xiaoyu Chen, Wenbin He, Xiaofeng Guo, Yuhe Yuan, Masami Takahashi & Naihong Chen. (2014) Tyrosine 402 Phosphorylation of Pyk2 Is Involved in Ionomycin-Induced Neurotransmitter Release. PLoS ONE 9:4, pages e94574.
Crossref
Pierre P. Eleniste, Su Huang, Kornchanok Wayakanon, Heather W. Largura & Angela Bruzzaniti. (2014) Osteoblast differentiation and migration are regulated by dynamin GTPase activity. The International Journal of Biochemistry & Cell Biology 46, pages 9-18.
Crossref
Laura Briñas, Stéphane Vassilopoulos, Gisèle Bonne, Pascale Guicheney & Marc Bitoun. (2013) Role of dynamin 2 in the disassembly of focal adhesions. Journal of Molecular Medicine 91:7, pages 803-809.
Crossref
Ying-Hua Cheng, R Adam Hooker, Khanh Nguyen, Rita Gerard-O'Riley, David L Waning, Brahmananda R Chitteti, Tomas E Meijome, Hui Lin Chua, Artur P Plett, Christie M Orschell, Edward F Srour, Lindsey D Mayo, Fredrick M Pavalko, Angela Bruzzaniti & Melissa A Kacena. (2013) Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation. Journal of Bone and Mineral Research 28:6, pages 1434-1445.
Crossref
Brianne J Ray, Keena Thomas, Cynthia S Huang, Michael F Gutknecht, Edward A Botchwey & Amy H Bouton. (2012) Regulation of osteoclast structure and function by FAK family kinases. Journal of Leukocyte Biology 92:5, pages 1021-1028.
Crossref
Pierre P. Eleniste & Angela Bruzzaniti. (2012) Focal Adhesion Kinases in Adhesion Structures and Disease. Journal of Signal Transduction 2012, pages 1-12.
Crossref
Pierre P. Eleniste, Liping Du, Mahesh Shivanna & Angela Bruzzaniti. (2012) Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts. The International Journal of Biochemistry & Cell Biology 44:5, pages 790-800.
Crossref
Martin Biosse-Duplan, William C. Horne & Roland Baron. 2012. Mineralized Tissues in Oral and Craniofacial Science. Mineralized Tissues in Oral and Craniofacial Science 17 27 .
Luigi Racioppi, Pamela K. Noeldner, Fumin Lin, Stephanie Arvai & Anthony R. Means. (2012) Calcium/Calmodulin-dependent Protein Kinase Kinase 2 Regulates Macrophage-mediated Inflammatory Responses. Journal of Biological Chemistry 287:14, pages 11579-11591.
Crossref
Nicole K. Nickerson, Khalid S. Mohammad, Jennifer L. Gilmore, Erin Crismore, Angela Bruzzaniti, Theresa A. Guise & John Foley. (2012) Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad. PLoS ONE 7:1, pages e30255.
Crossref
Fraser P. Coxon. 2012. Bone Research Protocols. Bone Research Protocols 401 424 .
Brendan Boyce & Lianping Xing. (2011) Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data. Clinical Investigation 1:12, pages 1695-1706.
Crossref
Takahiro Nakayama, Toshihide Mizoguchi, Shunsuke Uehara, Teruhito Yamashita, Ichiro Kawahara, Yasuhiro Kobayashi, Yoshinori Moriyama, Saburo Kurihara, Noriyuki Sahara, Hidehiro Ozawa, Nobuyuki Udagawa & Naoyuki Takahashi. (2011) Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices — A simple method for identifying polarized osteoclasts. Bone 49:6, pages 1331-1339.
Crossref
Athanassios Dovas & Dianne Cox. (2011) Signaling networks regulating leukocyte podosome dynamics and function. Cellular Signalling 23:8, pages 1225-1234.
Crossref
Danielle A. Murphy & Sara A. Courtneidge. (2011) The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nature Reviews Molecular Cell Biology 12:7, pages 413-426.
Crossref
Laura C. Kelley, Amanda Gatesman Ammer, Karen E. Hayes, Karen H. Martin, Kazuya Machida, Lin Jia, Bruce J. Mayer & Scott A. Weed. (2010) Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation. Journal of Cell Science 123:22, pages 3923-3932.
Crossref
Xinchun Shen, Gang Xi, Yashwanth Radhakrishnan & David R. Clemmons. (2010) Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells. Cellular and Molecular Life Sciences 67:22, pages 3893-3903.
Crossref
Anne-Cécile Durieux, Bernard Prudhon, Pascale Guicheney & Marc Bitoun. (2010) Dynamin 2 and human diseases. Journal of Molecular Medicine 88:4, pages 339-350.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.