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Molecular and Cellular Biology Volume 29, 2009 - Issue 3
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Article

Sustained Platelet-Derived Growth Factor Receptor α Signaling in Osteoblasts Results in Craniosynostosis by Overactivating the Phospholipase C-γ Pathway

Anne Moenning1 Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
,
Richard Jäger1 Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
,
Angela Egert1 Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
,
Wolfram Kress3 Institut für Humangenetik, Biozentrum, Würzburg, Germany
,
Eva Wardelmann2 Institute of Pathology, University of Bonn, Bonn, Germany
&
Hubert Schorle1 Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, GermanyCorrespondence[email protected]
Pages 881-891 | Received 04 Jun 2008, Accepted 20 Nov 2008, Published online: 21 Mar 2023

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Pierre J. Marie, Hichem Miraoui & Nicolas Sévère. (2012) FGF/FGFR signaling in bone formation: Progress and perspectives. Growth Factors 30:2, pages 117-123.
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Pierre J. Marie, Marja Hurley & David M. Ornitz. 2020. Principles of Bone Biology. Principles of Bone Biology 1113 1140 .
Toshiki Takenouchi, Hironobu Okuno & Kenjiro Kosaki. (2019) Kosaki overgrowth syndrome: A newly identified entity caused by pathogenic variants in platelet‐derived growth factor receptor‐beta. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 181:4, pages 650-657.
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David M. Ornitz & Pierre J. Marie. 2019. Vertebrate Skeletal Development. Vertebrate Skeletal Development 195 234 .
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Kevin K. L. Lee, Emma Peskett, Charlotte M. Quinn, Rosanna Aiello, Liliya Adeeva, Dale A. Moulding, Philip Stanier & Erwin Pauws. (2018) Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse . Disease Models & Mechanisms.
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Fenglei He & Philippe Soriano. (2017) Deregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development.
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David M. Ornitz & Pierre J. Marie. (2015) Fibroblast growth factor signaling in skeletal development and disease. Genes & Development 29:14, pages 1463-1486.
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N Haas, T Riedt, Z Labbaf, K Baßler, D Gergis, H Fröhlich, I Gütgemann, V Janzen & H Schorle. (2014) Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver. Cell Death & Differentiation 22:5, pages 790-800.
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Pierre J. Marie. (2014) Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies. Cellular and Molecular Life Sciences 72:7, pages 1347-1361.
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Brian Skriver Nielsen, Raj Rajeshwar Malinda, Fabian Marc Schmid, Stine Falsig Pedersen, Søren Tvorup Christensen & Lotte Bang Pedersen. (2015) PDGFRβ and oncogenic, mutant PDGFRα D842V promote disassembly of primary cilia by a PLCγ and AURKA dependent mechanism. Journal of Cell Science.
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Mamoru Ishii, Jingjing Sun, Man-Chun Ting & Robert E. Maxson. 2015. Craniofacial Development. Craniofacial Development 131 156 .
Martin Holcmann, Nicole Amberg, Barbara Drobits, Elisabeth Glitzner, Karin Komposch, Jonathan Robson, Fabio Savarese, Sriram Srivatsa, Gabriel Stulnig & Maria Sibilia. 2015. Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease. Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease 279 438 .
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Sun-Don KimGarima YagnikMichael L. CunninghamJinoh KimSimeon A. Boyadjiev. (2014) MAPK/ERK Signaling Pathway Analysis in Primary Osteoblasts from Patients with Nonsyndromic Sagittal Craniosynostosis. The Cleft Palate-Craniofacial Journal 51:1, pages 115-119.
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Antonio Di Ieva, Emiliano Bruner, Jennilee Davidson, Patrizia Pisano, Thomas Haider, Scellig S. Stone, Michael D. Cusimano, Manfred Tschabitscher & Fabio Grizzi. (2013) Cranial sutures: a multidisciplinary review. Child's Nervous System 29:6, pages 893-905.
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María Belén Sánchez-Ilárduya, Elodie Trouche, Ricardo Tejero, Gorka Orive, Ilya Reviakine & Eduardo Anitua. (2013) Time-dependent release of growth factors from implant surfaces treated with plasma rich in growth factors. Journal of Biomedical Materials Research Part A 101A:5, pages 1478-1488.
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Saida Mebarek, Abdelkarim Abousalham, David Magne, Le Do, Joanna Bandorowicz-Pikula, Slawomir Pikula & René Buchet. (2013) Phospholipases of Mineralization Competent Cells and Matrix Vesicles: Roles in Physiological and Pathological Mineralizations. International Journal of Molecular Sciences 14:3, pages 5036-5129.
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Greg Holmes. (2012) The role of vertebrate models in understanding craniosynostosis. Child's Nervous System 28:9, pages 1471-1481.
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Hiroyuki Suzuki, Naoto Suda, Momotoshi Shiga, Yukiho Kobayashi, Masataka Nakamura, Sachiko Iseki & Keiji Moriyama. (2012) Apert syndrome mutant FGFR2 and its soluble form reciprocally alter osteogenesis of primary calvarial osteoblasts. Journal of Cellular Physiology 227:9, pages 3267-3277.
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Sun-Don Kim, Jia Lie Liu, Tony Roscioli, Michael F. Buckley, Garima Yagnik, Simeon A. Boyadjiev & Jinoh Kim. (2012) Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. FEBS Letters 586:10, pages 1516-1521.
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Pierre J. Marie. (2012) Fibroblast growth factor signaling controlling bone formation: An update. Gene 498:1, pages 1-4.
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Hainan Chen, Xueying Gu, Yinghua Liu, Jing Wang, Stacey E. Wirt, Rita Bottino, Hubert Schorle, Julien Sage & Seung K. Kim. (2011) PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature 478:7369, pages 349-355.
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Nicolas Sévère, Hichem Miraoui & Pierre J. Marie. (2011) The Casitas B Lineage Lymphoma (Cbl) Mutant G306E Enhances Osteogenic Differentiation in Human Mesenchymal Stromal Cells in Part by Decreased Cbl-mediated Platelet-derived Growth Factor Receptor α and Fibroblast Growth Factor Receptor 2 Ubiquitination. Journal of Biological Chemistry 286:27, pages 24443-24450.
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Hai-Yun Yen, Man-Chun Ting & Robert E. Maxson. (2010) Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells. Developmental Biology 347:2, pages 258-270.
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R. Detsch, D. Hagmeyer, M. Neumann, S. Schaefer, A. Vortkamp, M. Wuelling, G. Ziegler & M. Epple. (2010) The resorption of nanocrystalline calcium phosphates by osteoclast-like cells. Acta Biomaterialia 6:8, pages 3223-3233.
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H. Miraoui, J. Ringe, T. Haupl & P. J. Marie. (2010) Increased EFG- and PDGF -receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis. Human Molecular Genetics 19:9, pages 1678-1689.
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Patricia Kurth, Anne Moenning, Richard Jäger, Gaby Beine & Hubert Schorle. (2009) An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system. Developmental Dynamics 238:5, pages 1064-1072.
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