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Molecular and Cellular Biology Volume 30, 2010 - Issue 12
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Article

Integrin α1β1 Regulates Epidermal Growth Factor Receptor Activation by Controlling Peroxisome Proliferator-Activated Receptor γ-Dependent Caveolin-1 Expression

Xiwu Chen1 Departments of Medicine (Division of Nephrology)Correspondence[email protected] [email protected]
,
Carrie Whiting1 Departments of Medicine (Division of Nephrology)
,
Corina Borza1 Departments of Medicine (Division of Nephrology)
,
Wen Hu1 Departments of Medicine (Division of Nephrology)
,
Stacey Mont2 Cancer Biology
,
Nada Bulus1 Departments of Medicine (Division of Nephrology)
,
Ming-Zhi Zhang1 Departments of Medicine (Division of Nephrology)
,
Raymond C. Harris1 Departments of Medicine (Division of Nephrology)
,
Roy Zent1 Departments of Medicine (Division of Nephrology);2 Cancer Biology;3 Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee37232;4 Department of Medicine, Veterans Affairs Hospitals, Nashville, Tennessee37232
&
Ambra Pozzi1 Departments of Medicine (Division of Nephrology);2 Cancer Biology;4 Department of Medicine, Veterans Affairs Hospitals, Nashville, Tennessee37232Correspondence[email protected] [email protected]
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Pages 3048-3058 | Received 08 Jul 2009, Accepted 11 Mar 2010, Published online: 20 Mar 2023

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Elke Burgermeister, Teresa Friedrich, Ivana Hitkova, Ivonne Regel, Henrik Einwächter, Wolfgang Zimmermann, Christoph Röcken, Aurel Perren, Matthew B. Wright, Roland M. Schmid, Rony Seger & Matthias P. A. Ebert. (2011) The Ras Inhibitors Caveolin-1 and Docking Protein 1 Activate Peroxisome Proliferator-Activated Receptor γ through Spatial Relocalization at Helix 7 of Its Ligand-Binding Domain. Molecular and Cellular Biology 31:16, pages 3497-3510.
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Articles from other publishers (34)

Alicia L. Black, James Haskins, Ambra Pozzi & Andrea L. Clark. (2023) Sexual dimorphism in reactive oxygen species production and a role for integrin α1β1 in estrogen receptor α and β expression in articular cartilage. Journal of Orthopaedic Surgery and Research 18:1.
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Jyrki Heino & Elina Siljamäki. 2023. Integrins in Health and Disease. Integrins in Health and Disease 3 25 .
Jungwhoi Lee, Jungsul Lee, Woogwang Sim & Jae-Hoon Kim. (2022) Soluble TGFBI aggravates the malignancy of cholangiocarcinoma through activation of the ITGB1 dependent PPARγ signalling pathway. Cellular Oncology 45:2, pages 275-291.
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Horacio Maldonado & James S. Hagood. (2021) Cooperative signaling between integrins and growth factor receptors in fibrosis. Journal of Molecular Medicine 99:2, pages 213-224.
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Manuel Chiusa, Wen Hu, Jozef Zienkiewicz, Xiwu Chen, Ming-Zhi Zhang, Raymond C. Harris, Roberto M. Vanacore, Jennifer A. Bentz, Giuseppe Remuzzi, Ariela Benigni, Agnes B. Fogo, Wentian Luo, Stavroula Mili, Matthew H. Wilson, Roy Zent, Jacek Hawiger & Ambra Pozzi. (2020) EGF receptor–mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling. Journal of Cell Biology 219:9.
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Erin J. Plosa, John T. Benjamin, Jennifer M. Sucre, Peter M. Gulleman, Linda A. Gleaves, Wei Han, Seunghyi Kook, Vasiliy V. Polosukhin, Scott M. Haake, Susan H. Guttentag, Lisa R. Young, Ambra Pozzi, Timothy S. Blackwell & Roy Zent. (2020) β1 Integrin regulates adult lung alveolar epithelial cell inflammation. JCI Insight 5:2.
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Dania Haddad, Ashraf Al Madhoun, Rasheeba Nizam & Fahd Al-Mulla. (2020) Role of Caveolin-1 in Diabetes and Its Complications. Oxidative Medicine and Cellular Longevity 2020, pages 1-20.
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Huocong HuangWenting DuRolf A. Brekken. (2017) Extracellular Matrix Induction of Intracellular Reactive Oxygen Species. Antioxidants & Redox Signaling 27:12, pages 774-784.
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Kim Cuc Thi NguyenKyung A Cho. (2017) Versatile Functions of Caveolin-1 in Aging-related Diseases. Chonnam Medical Journal 53:1, pages 28.
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Xiaowu Gu, Alaina M. Reagan, Mark E. McClellan & Michael H. Elliott. (2017) Caveolins and caveolae in ocular physiology and pathophysiology. Progress in Retinal and Eye Research 56, pages 84-106.
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Daniela Bianconi, Matthias Unseld & Gerald Prager. (2016) Integrins in the Spotlight of Cancer. International Journal of Molecular Sciences 17:12, pages 2037.
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S.Y. Shin, A. Pozzi, S.K. Boyd & A.L. Clark. (2016) Integrin α1β1 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling. Osteoarthritis and Cartilage 24:10, pages 1795-1806.
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Nuno Miranda Coelho & Christopher A. McCulloch. (2016) Contribution of collagen adhesion receptors to tissue fibrosis. Cell and Tissue Research 365:3, pages 521-538.
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Jianchun Chen, Fenghua Zeng, Steven J. Forrester, Satoru Eguchi, Ming-Zhi Zhang & Raymond C. Harris. (2016) Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease. Physiological Reviews 96:3, pages 1025-1069.
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Beata Mickiewicz, Sung Y. Shin, Ambra Pozzi, Hans J. Vogel & Andrea L. Clark. (2016) Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis. Journal of Proteome Research 15:3, pages 815-825.
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Allison M. Andrews & Victor Rizzo. (2016) Microparticle-Induced Activation of the Vascular Endothelium Requires Caveolin-1/Caveolae. PLOS ONE 11:2, pages e0149272.
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Cédric Zeltz & Donald Gullberg. (2016) The integrin–collagen connection – a glue for tissue repair?. Journal of Cell Science.
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Hongtao Wang, Xiwu Chen, Yan Su, Paisit Paueksakon, Wen Hu, Ming-Zhi Zhang, Raymond C. Harris, Timothy S. Blackwell, Roy Zent & Ambra Pozzi. (2015) p47phox contributes to albuminuria and kidney fibrosis in mice. Kidney International 87:5, pages 948-962.
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Corina M. Borza, Xiwu Chen, Roy Zent & Ambra Pozzi. 2015. Basement Membranes. Basement Membranes 231 253 .
Xiwu Chen, Hongtao Wang, Hong-Jun Liao, Wen Hu, Leslie Gewin, Glenda Mernaugh, Sheng Zhang, Zhong-Yin Zhang, Lorenzo Vega-Montoto, Roberto M. Vanacore, Reinhard Fässler, Roy Zent & Ambra Pozzi. (2014) Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. Journal of Clinical Investigation 124:8, pages 3295-3310.
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Paulina Moreno-Layseca & Charles H. Streuli. (2014) Signalling pathways linking integrins with cell cycle progression. Matrix Biology 34, pages 144-153.
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Jonathan P. Celli, Imran Rizvi, Adam R. Blanden, Iqbal Massodi, Michael D. Glidden, Brian W. Pogue & Tayyaba Hasan. (2014) An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Scientific Reports 4:1.
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Jyrki Heino. 2014. I Domain Integrins. I Domain Integrins 143 155 .
Mikko Ylilauri, Elina Mattila, Elisa M. Nurminen, Jarmo Käpylä, Sanna P. Niinivehmas, Juha A. Määttä, Ulla Pentikäinen, Johanna Ivaska & Olli T. Pentikäinen. (2013) Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:10, pages 1988-1997.
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Ambra Pozzi & Roy Zent. (2013) Integrins in Kidney Disease. Journal of the American Society of Nephrology 24:7, pages 1034-1039.
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Paula S. Ramos, Miranda C. Marion, Carl D. Langefeld, Jill P. Buyon & Robert M. Clancy. (2012) Brief Report: Enrichment of associations in genes with fibrosis, apoptosis, and innate immunity functions with cardiac manifestations of neonatal lupus. Arthritis & Rheumatism 64:12, pages 4060-4065.
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Mingjian Shi, Vadim Pedchenko, Briana H. Greer, Wade D. Van Horn, Samuel A. Santoro, Charles R. Sanders, Billy G. Hudson, Brandt F. Eichman, Roy Zent & Ambra Pozzi. (2012) Enhancing Integrin α1 Inserted (I) Domain Affinity to Ligand Potentiates Integrin α1β1-mediated Down-regulation of Collagen Synthesis. Journal of Biological Chemistry 287:42, pages 35139-35152.
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Nada Bulus, Chloe Feral, Ambra Pozzi & Roy Zent. (2012) CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs. PLoS ONE 7:6, pages e40026.
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Corina M. Borza, Yan Su, Xiwu Chen, Ling Yu, Stacey Mont, Sergei Chetyrkin, Paul Voziyan, Billy G. Hudson, Paul C. Billings, Hyunil Jo, Joel S. Bennett, William F. DeGrado, Beate Eckes, Roy Zent & Ambra Pozzi. (2012) Inhibition of Integrin α2β1 Ameliorates Glomerular Injury. Journal of the American Society of Nephrology 23:6, pages 1027-1038.
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Ling Yu, Yan Su, Paisit Paueksakon, Huifang Cheng, Xiwu Chen, Hongtao Wang, Raymond C. Harris, Roy Zent & Ambra Pozzi. (2012) Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney International 81:11, pages 1086-1097.
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Corina M. Borza & Ambra Pozzi. (2012) The role of cell–extracellular matrix interactions in glomerular injury. Experimental Cell Research 318:9, pages 1001-1010.
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Federica Sotgia, Ubaldo E. Martinez-OutschoornAnthony Howell, Richard G. PestellStephanos Pavlides & Michael P. Lisanti. (2012) Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms. Annual Review of Pathology: Mechanisms of Disease 7:1, pages 423-467.
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Deniz B. Hizal, Erika Ohsfeldt, Sunny Mai & Michael J. Betenbaugh. 2011. Production of Membrane Proteins. Production of Membrane Proteins 139 165 .
Corina M. Borza, Xiwu Chen, Sijo Mathew, Stacey Mont, Charles R. Sanders, Roy Zent & Ambra Pozzi. (2010) Integrin α1β1 Promotes Caveolin-1 Dephosphorylation by Activating T Cell Protein-tyrosine Phosphatase. Journal of Biological Chemistry 285:51, pages 40114-40124.
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