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Molecular and Cellular Biology Volume 29, 2009 - Issue 3
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Article

rRNA Suppressor of a Eukaryotic Translation Initiation Factor 5B/Initiation Factor 2 Mutant Reveals a Binding Site for Translational GTPases on the Small Ribosomal Subunit

Byung-Sik Shin1 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland20892
,
Joo-Ran Kim1 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland20892
,
Michael G. Acker2 Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland21205
,
Kathryn N. Maher1 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland20892
,
Jon R. Lorsch2 Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland21205
&
Thomas E. Dever1 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland20892Correspondence[email protected]
Pages 808-821 | Received 05 Jun 2008, Accepted 13 Nov 2008, Published online: 21 Mar 2023

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Hiroyuki Hiraishi, Byung-Sik Shin, Tsuyoshi Udagawa, Naoki Nemoto, Wasimul Chowdhury, Jymie Graham, Christian Cox, Megan Reid, Susan J. Brown & Katsura Asano. (2013) Interaction between 25S rRNA A Loop and Eukaryotic Translation Initiation Factor 5B Promotes Subunit Joining and Ensures Stringent AUG Selection. Molecular and Cellular Biology 33:18, pages 3540-3548.
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Articles from other publishers (15)

Ramy Kazan, Gabrielle Bourgeois, Christine Lazennec-Schurdevin, Pierre-Damien Coureux, Yves Mechulam & Emmanuelle Schmitt. (2023) Structural insights into the evolution of late steps of translation initiation in the three domains of life. Biochimie.
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Ramy Kazan, Gabrielle Bourgeois, Christine Lazennec-Schurdevin, Eric Larquet, Yves Mechulam, Pierre-Damien Coureux & Emmanuelle Schmitt. (2022) Role of aIF5B in archaeal translation initiation. Nucleic Acids Research 50:11, pages 6532-6548.
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Jinfan Wang, Jing Wang, Byung-Sik Shin, Joo-Ran Kim, Thomas E. Dever, Joseph D. Puglisi & Israel S. Fernández. (2020) Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex. Nature Communications 11:1.
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Bridget Y. Huang & Israel S. Fernández. (2020) Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation. Proceedings of the National Academy of Sciences 117:3, pages 1429-1437.
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Thomas E Dever, Terri Goss Kinzy & Graham D Pavitt. (2016) Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae . Genetics 203:1, pages 65-107.
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Hiroshi Yamamoto, Anett Unbehaun, Justus Loerke, Elmar Behrmann, Marianne Collier, Jörg Bürger, Thorsten Mielke & Christian M T Spahn. (2014) Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA. Nature Structural & Molecular Biology 21:8, pages 721-727.
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Alan G. Hinnebusch. (2014) The Scanning Mechanism of Eukaryotic Translation Initiation. Annual Review of Biochemistry 83:1, pages 779-812.
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Israel S. FernándezXiao-Chen BaiTanweer HussainAnn C. KelleyJon R. LorschV. RamakrishnanSjors H. W. Scheres. (2013) Molecular Architecture of a Eukaryotic Translational Initiation Complex. Science 342:6160.
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Attilio Fabbretti, Letizia Brandi, Pohl Milón, Roberto Spurio, Cynthia L. Pon & Claudio O. Gualerzi. (2012) Translation initiation without IF2-dependent GTP hydrolysis. Nucleic Acids Research 40:16, pages 7946-7955.
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Simon Lebaron, Claudia Schneider, Robert W van Nues, Agata Swiatkowska, Dietrich Walsh, Bettina Böttcher, Sander Granneman, Nicholas J Watkins & David Tollervey. (2012) Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits. Nature Structural & Molecular Biology 19:8, pages 744-753.
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Byung-Sik Shin, Joo-Ran Kim, Sarah E Walker, Jinsheng Dong, Jon R Lorsch & Thomas E Dever. (2011) Initiation factor eIF2γ promotes eIF2–GTP–Met-tRNAiMet ternary complex binding to the 40S ribosome. Nature Structural & Molecular Biology 18:11, pages 1227-1234.
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Kristen M. Bartoli, Jelena Jakovljevic, John L. WoolfordJr.Jr. & William S. Saunders. (2011) Kinesin molecular motor Eg5 functions during polypeptide synthesis. Molecular Biology of the Cell 22:18, pages 3420-3430.
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Byung-Sik Shin, Michael G. Acker, Joo-Ran Kim, Kathryn N. Maher, Shamsul M. Arefin, Jon R. Lorsch & Thomas E. Dever. (2011) Structural integrity of α-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability. RNA 17:4, pages 687-696.
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Ivan Topisirovic, Yuri V. Svitkin, Nahum Sonenberg & Aaron J. Shatkin. (2011) Cap and cap-binding proteins in the control of gene expression. Wiley Interdisciplinary Reviews: RNA 2:2, pages 277-298.
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Enrico Caserta, Carlotta Ferrara, Pohl Milon, Attilio Fabbretti, Alessandra Rocchetti, Jerneja Tomšic, Cynthia L. Pon, Claudio O. Gualerzi & Anna La Teana. (2010) Ribosomal Interaction of Bacillus stearothermophilus Translation Initiation Factor IF2: Characterization of the Active Sites. Journal of Molecular Biology 396:1, pages 118-129.
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