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Molecular and Cellular Biology Volume 28, 2008 - Issue 23
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Article

The p85α Subunit of Class IA Phosphatidylinositol 3-Kinase Regulates the Expression of Multiple Genes Involved in Osteoclast Maturation and Migration

Veerendra Munugalavadla1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
,
Sasidhar Vemula1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
,
Emily Catherine Sims1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
,
Subha Krishnan1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
,
Shi Chen1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
,
Jincheng Yan1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
,
Huijie Li1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
,
Paul J. Niziolek2 Departments of Anatomy and Cell Biology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana
,
Clifford Takemoto3 Division of Pediatric Hematology, The Johns Hopkins University, Baltimore, Maryland
,
Alexander G. Robling2 Departments of Anatomy and Cell Biology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana
,
Feng-Chun Yang1 Department of Biochemistry and Molecular Biology;4 Department of Pediatrics
&
Reuben Kapur1 Department of Biochemistry and Molecular Biology;4 Department of PediatricsCorrespondence[email protected]
 show all
Pages 7182-7198 | Received 09 Jun 2008, Accepted 11 Sep 2008, Published online: 27 Mar 2023

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Peilin Ma, Sasidhar Vemula, Veerendra Munugalavadla, Jinbiao Chen, Emily Sims, Jovencio Borneo, Takako Kondo, Baskar Ramdas, Raghuveer Singh Mali, Shuo Li, Eri Hashino, Clifford Takemoto & Reuben Kapur. (2011) Balanced Interactions between Lyn, the p85α Regulatory Subunit of Class IA Phosphatidylinositol-3-Kinase, and SHIP Are Essential for Mast Cell Growth and Maturation. Molecular and Cellular Biology 31:19, pages 4052-4062.
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Articles from other publishers (27)

Hyun-Ju Kim, Dong-Kyo Lee, Xian Jin, Xiangguo Che, Sung Ho Ryu & Je-Yong Choi. (2022) Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration and microtubule stability. Experimental & Molecular Medicine 54:8, pages 1146-1155.
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Dávid S. Győri & Attila Mócsai. (2020) Osteoclast Signal Transduction During Bone Metastasis Formation. Frontiers in Cell and Developmental Biology 8.
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Jeong-Tae Yeon, Kwang-Jin Kim, Young-Jin Son, Sang-Joon Park & Seong Hwan Kim. (2019) Idelalisib inhibits osteoclast differentiation and pre-osteoclast migration by blocking the PI3Kδ-Akt-c-Fos/NFATc1 signaling cascade. Archives of Pharmacal Research 42:8, pages 712-721.
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Nan Su, Xiaogang Li, Yubin Tang, Jing Yang, Xuan Wen, Jingyuan Guo, Junzhou Tang, Xiaolan Du & Lin Chen. (2016) Deletion of FGFR3 in Osteoclast Lineage Cells Results in Increased Bone Mass in Mice by Inhibiting Osteoclastic Bone Resorption. Journal of Bone and Mineral Research 31:9, pages 1676-1687.
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Rajendra KedlayaKyung Shin KangJung Min HongVidya BettagereKyung-Eun LimDaniel HoranPaola Divieti-PajevicAlexander G. Robling. (2016) Adult-Onset Deletion of β-Catenin in 10kbDmp1-Expressing Cells Prevents Intermittent PTH-Induced Bone Gain. Endocrinology 157:8, pages 3047-3057.
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Jeong-Tae Yeon, Byung Jun Ryu, Sik-Won Choi, Jin-Chul Heo, Kwang-Jin Kim, Young-Jin Son & Seong Hwan Kim. (2014) Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways. Amino Acids 46:11, pages 2605-2614.
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Naga Suresh Adapala, Mary F. Barbe, Alexander Y. Tsygankov, Joseph A. Lorenzo & Archana Sanjay. (2014) Loss of Cbl-PI3K Interaction Enhances Osteoclast Survival due to p21-Ras Mediated PI3K Activation Independent of Cbl-b. Journal of Cellular Biochemistry 115:7, pages 1277-1289.
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V Munugalavadla, S Mariathasan, D Slaga, C Du, L Berry, G Del Rosario, Y Yan, M Boe, L Sun, L S Friedman, M Chesi, P Leif Bergsagel & A Ebens. (2013) The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma. Oncogene 33:3, pages 316-325.
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Yusuke Kameda, Masahiko Takahata, Miki Komatsu, Shintaro Mikuni, Shigetsugu Hatakeyama, Tomohiro Shimizu, Takashi Angata, Masataka Kinjo, Akio Minami & Norimasa Iwasaki. (2013) Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12. Journal of Bone and Mineral Research 28:12, pages 2463-2475.
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Tsukasa Oikawa, Yukiko Kuroda & Koichi Matsuo. (2013) Regulation of osteoclasts by membrane-derived lipid mediators. Cellular and Molecular Life Sciences 70:18, pages 3341-3353.
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Masahiro Shinohara, Masaki Nakamura, Hironari Masuda, Jun Hirose, Yuho Kadono, Mitsuyasu Iwasawa, Yuuichi Nagase, Kohjiro Ueki, Takashi Kadowaki, Takehiko Sasaki, Shigeaki Kato, Hiroaki Nakamura, Sakae Tanaka & Hiroshi Takayanagi. (2012) Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport. Journal of Bone and Mineral Research 27:12, pages 2464-2475.
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Xianglan Li, Masako Akiyama, Ken-ichi Nakahama, Taro Koshiishi, Satoru Takeda & Ikuo Morita. (2012) Role of intercellular adhesion molecule-2 in osteoclastogenesis. Genes to Cells 17:7, pages 568-575.
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Xian Wu, Zhenxi Li, Zhengfeng Yang, Chunbing Zheng, Ji Jing, Yihua Chen, Xiyun Ye, Xiaoyuan Lian, Wenwei Qiu, Fan Yang, Jie Tang, Jianru Xiao, Mingyao Liu & Jian Luo. (2012) Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca2+-nuclear fact. Journal of Bone and Mineral Research 27:6, pages 1298-1308.
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Martin Biosse-Duplan, William C. Horne & Roland Baron. 2012. Mineralized Tissues in Oral and Craniofacial Science. Mineralized Tissues in Oral and Craniofacial Science 17 27 .
Jean Vacher. (2012) Inositol phosphatase et masse osseuse. médecine/sciences 28:2, pages 152-153.
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Victoria E DeMambro, Laura Maile, Christine Wai, Masanobu Kawai, Teresa Cascella, Clifford J Rosen & David Clemmons. (2012) Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation. Journal of Bone and Mineral Research 27:2, pages 390-400.
Crossref
Subha Krishnan, Raghuveer Singh Mali, Karl R. Koehler, Sasidhar Vemula, Anindya Chatterjee, Joydeep Ghosh, Baskar Ramdas, Peilin Ma, Eri Hashino & Reuben Kapur. (2012) Class IA PI3Kinase Regulatory Subunit, p85α, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes. PLoS ONE 7:1, pages e28979.
Crossref
Takumi Matsumoto, Yuichi Nagase, Mitsuyasu Iwasawa, Tetsuro Yasui, Hironari Masuda, Yuho Kadono, Kozo Nakamura & Sakae Tanaka. (2011) Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the Akt pathway and the ERK/Bim axis. Arthritis & Rheumatism 63:12, pages 3908-3917.
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Xiaohua Wu, Shi Chen, Yongzheng He, Steven D. Rhodes, Khalid S. Mohammad, Xiaohong Li, Xianlin Yang, Li Jiang, Grzegorz Nalepa, Paige Snider, Alexander G. Robling, D. Wade Clapp, Simon J. Conway, Theresa A. Guise & Feng-Chun Yang. (2011) The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1. PLoS ONE 6:9, pages e24917.
Crossref
Peilin MaRaghuveer Singh MaliVeerendra MunugalavadlaSubha KrishnanBaskar RamdasEmily SimsHolly MartinJoydeep GhoshShuo LiRebecca J. ChanGerald KrystalAndrew W. Craig, Clifford Takemoto & Reuben Kapur. (2011) The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood 118:13, pages 3459-3469.
Crossref
Yongzheng He, Karl Staser, Steven D. Rhodes, Yaling Liu, Xiaohua Wu, Su-Jung Park, Jin Yuan, Xianlin Yang, Xiaohong Li, Li Jiang, Shi Chen & Feng-Chun Yang. (2011) Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity. PLoS ONE 6:9, pages e24780.
Crossref
Xiaohua Wu, Shi Chen, Selina A. Orlando, Jin Yuan, Edward T. Kim, Veerendra Munugalavadla, Raghuveer S. Mali, Reuben Kapur & Feng-Chun Yang. (2011) p85α Regulates Osteoblast Differentiation by Cross-talking with the MAPK Pathway. Journal of Biological Chemistry 286:15, pages 13512-13521.
Crossref
Naga Suresh Adapala, Mary F. Barbe, Wallace Y. Langdon, Mary C. Nakamura, Alexander Y. Tsygankov & Archana Sanjay. (2010) The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival. Journal of Biological Chemistry 285:47, pages 36745-36758.
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Xiang-Hong Xu, Shan-Shan Dong, Yan Guo, Tie-Lin Yang, Shu-Feng Lei, Christopher J. Papasian, Ming Zhao & Hong-Wen Deng. (2010) Molecular Genetic Studies of Gene Identification for Osteoporosis: The 2009 Update. Endocrine Reviews 31:4, pages 447-505.
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Heeseog KangWoochul ChangMarja Hurley, Agnès Vignery & Dianqing Wu. (2010) Important roles of PI3Kγ in osteoclastogenesis and bone homeostasis. Proceedings of the National Academy of Sciences 107:29, pages 12901-12906.
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Amel GuezGuez, Virginie Prod'homme, Xavier Mouska, Alice Baudot, Claudine Blin-Wakkach, Robert Rottapel & Marcel Deckert. (2010) 3BP2 Adapter Protein Is Required for Receptor Activator of NFκB Ligand (RANKL)-induced Osteoclast Differentiation of RAW264.7 Cells. Journal of Biological Chemistry 285:27, pages 20952-20963.
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Cédric Boudot, Zuzana Saidak, Abdel Krim Boulanouar, Laurent Petit, Fabrice Gouilleux, Ziad Massy, Michel Brazier, Romuald Mentaverri & Saïd Kamel. (2010) Implication of the calcium sensing receptor and the Phosphoinositide 3-kinase/Akt pathway in the extracellular calcium-mediated migration of RAW 264.7 osteoclast precursor cells. Bone 46:5, pages 1416-1423.
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