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Article

Changes in the Distributions and Dynamics of Polycomb Repressive Complexes during Embryonic Stem Cell Differentiation

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Pages 2884-2895 | Received 29 May 2007, Accepted 20 Feb 2008, Published online: 27 Mar 2023

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Thierry Cheutin & Giacomo Cavalli. (2019) The multiscale effects of polycomb mechanisms on 3D chromatin folding. Critical Reviews in Biochemistry and Molecular Biology 54:5, pages 399-417.
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Fouziya R. Shah, Younus A. Bhat & Ajazul H. Wani. (2018) Subnuclear distribution of proteins: Links with genome architecture. Nucleus 9:1, pages 42-55.
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Xiaojun Ren & Tom K. Kerppola. (2011) REST Interacts with Cbx Proteins and Regulates Polycomb Repressive Complex 1 Occupancy at RE1 Elements. Molecular and Cellular Biology 31:10, pages 2100-2110.
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Hui Liu, Zhuoming Li & Liang Li. (2018) The molecular selectivity of UNC3866 inhibitor for Polycomb CBX7 protein from molecular dynamics simulation. Computational Biology and Chemistry 74, pages 339-346.
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Roubina Tatavosian, Huy Nguyen Duc, Thao Ngoc Huynh, Dong Fang, Benjamin Schmitt, Xiaodong Shi, Yiming Deng, Christopher Phiel, Tingting Yao, Zhiguo Zhang, Haobin Wang & Xiaojun Ren. (2018) Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nature Communications 9:1.
Crossref
Louise Matheson & Sarah Elderkin. 2018. Nuclear Architecture and Dynamics. Nuclear Architecture and Dynamics 297 320 .
Karina Jácome-López & Mayra Furlan-Magaril. 2018. Mouse Embryogenesis. Mouse Embryogenesis 157 175 .
Roubina Tatavosian & Xiaojun Ren. 2018. Chromatin Immunoprecipitation. Chromatin Immunoprecipitation 113 126 .
Takayuki Kawaguchi, Shinichi Machida, Hitoshi Kurumizaka, Hideaki Tagami & Jun-ichi Nakayama. (2017) Phosphorylation of CBX2 controls its nucleosome-binding specificity. The Journal of Biochemistry 162:5, pages 343-355.
Crossref
Jianxin Tao, Liping Shi, Longchang Huang, Haoze Shi, Hang Chen, Yixin Wang & Tong Wang. (2017) EZH2 is involved in silencing of WNT5A during epithelial–mesenchymal transition of colon cancer cell line. Journal of Cancer Research and Clinical Oncology 143:11, pages 2211-2219.
Crossref
Hao Zheng, Wei-hua Jiang, Tao Tian, Hai-song Tan, Ying Chen, Guang-lei Qiao, Jun Han, Sheng-yu Huang, Yuan Yang, Shuai Li, Zhen-guang Wang, Rong Gao, Hao Ren, Hao Xing, Jun-sheng Ni, Lin-Hui Wang, Li-jun Ma & Wei-ping Zhou. (2017) CBX6 overexpression contributes to tumor progression and is predictive of a poor prognosis in hepatocellular carcinoma. Oncotarget 8:12, pages 18872-18884.
Crossref
Son C Nguyen, Stephanie Yu, Elaine Oberlick & Chao-ting Wu. (2017) An Unexpected Regulatory Cascade Governs a Core Function of the Drosophila PRC1 Chromatin Protein Su(z)2 . Genetics 205:2, pages 551-558.
Crossref
Katelyn E. Connelly & Emily C. Dykhuizen. (2017) Compositional and functional diversity of canonical PRC1 complexes in mammals. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860:2, pages 233-245.
Crossref
Vincenzo Pirrotta. 2017. Handbook of Epigenetics. Handbook of Epigenetics 93 110 .
Srilatha Jasty & Subramanian Krishnakumar. (2016) Profiling of DNA and histone methylation reveals epigenetic-based regulation of gene expression during retinal differentiation of stem/progenitor cells isolated from the ciliary pigment epithelium of human cadaveric eyes. Brain Research 1651, pages 1-10.
Crossref
Jacob I. Stuckey, Catherine Simpson, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Junghyun Lee, Ryan Pasca, Nancy Cheng, Bradley M. Dickson, Kenneth H. Pearce, Stephen V. Frye & Lindsey I. James. (2016) Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains. Journal of Medicinal Chemistry 59:19, pages 8913-8923.
Crossref
Chao Yu Zhen, Roubina Tatavosian, Thao Ngoc Huynh, Huy Nguyen Duc, Raibatak Das, Marko Kokotovic, Jonathan B Grimm, Luke D Lavis, Jun Lee, Frances J Mejia, Yang Li, Tingting Yao & Xiaojun Ren. (2016) Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin. eLife 5.
Crossref
Jacob I Stuckey, Bradley M Dickson, Nancy Cheng, Yanli Liu, Jacqueline L Norris, Stephanie H Cholensky, Wolfram Tempel, Su Qin, Katherine G Huber, Cari Sagum, Karynne Black, Fengling Li, Xi-Ping Huang, Bryan L Roth, Brandi M Baughman, Guillermo Senisterra, Samantha G Pattenden, Masoud Vedadi, Peter J Brown, Mark T Bedford, Jinrong Min, Cheryl H Arrowsmith, Lindsey I James & Stephen V Frye. (2016) A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology 12:3, pages 180-187.
Crossref
Claudia Stein, René Reiner Nötzold, Stefanie Riedl, Caroline Bouchard & Uta-Maria Bauer. (2016) The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLOS ONE 11:2, pages e0148892.
Crossref
J.C. Eissenberg. 2016. Chromatin Signaling and Diseases. Chromatin Signaling and Diseases 113 125 .
Vincenzo Pirrotta. 2016. The Functional Nucleus. The Functional Nucleus 157 173 .
Tianyi Zhang, Sarah Cooper & Neil Brockdorff. (2015) The interplay of histone modifications – writers that read. EMBO reports 16:11, pages 1467-1481.
Crossref
Divya Tej Sowpati, Senthilkumar Ramamoorthy & Rakesh K. Mishra. (2015) Expansion of the polycomb system and evolution of complexity. Mechanisms of Development 138, pages 97-112.
Crossref
Zhao Xun-wu, Zheng Peng, Huang Zhi-jun, Zeng Yue, E O Adegoke & Zhang Gui-xue. (2015) Preparation of Mouse Embryonic Stem Cells and Cardiomyocyte Differentiation Induced with Retinoic Acid and Ascorbic Acid. Journal of Northeast Agricultural University (English Edition) 22:3, pages 62-66.
Crossref
Stefania del Prete, Pawel Mikulski, Daniel Schubert & Valérie Gaudin. (2015) One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation. Genes 6:3, pages 520-542.
Crossref
Kristi E. Miller, Yeonsoo Kim, Won-Ki Huh & Hay-Oak Park. (2015) Bimolecular Fluorescence Complementation (BiFC) Analysis: Advances and Recent Applications for Genome-Wide Interaction Studies. Journal of Molecular Biology 427:11, pages 2039-2055.
Crossref
Andreas I Papadakis, Chong Sun, Theo A Knijnenburg, Yibo Xue, Wipawadee Grernrum, Michael Hölzel, Wouter Nijkamp, Lodewyk FA Wessels, Roderick L Beijersbergen, Rene Bernards & Sidong Huang. (2015) SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer. Cell Research 25:4, pages 445-458.
Crossref
Andrea Bianchi & Chiara Lanzuolo. (2015) Into the chromatin world: Role of nuclear architecture in epigenome regulation. AIMS Biophysics 2:4, pages 585-612.
Crossref
Roubina Tatavosian, Chao Yu Zhen & Xiaojun Ren. 2015. Recent Progress in Colloid and Surface Chemistry with Biological Applications. Recent Progress in Colloid and Surface Chemistry with Biological Applications 129 136 .
Aissa Benyoucef & Marjorie Brand. 2015. Epigenetic Gene Expression and Regulation. Epigenetic Gene Expression and Regulation 149 181 .
Alejandro Lomniczi, Juan Manuel Castellano, Hollis Wright, Basak Selcuk, Kemal Sonmez & Sergio R. Ojeda. 2015. Brain Crosstalk in Puberty and Adolescence. Brain Crosstalk in Puberty and Adolescence 97 119 .
Chao Yu Zhen, Huy Nguyen Duc, Marko Kokotovic, Christopher J. Phiel & Xiaojun Ren. (2014) Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Molecular Biology of the Cell 25:23, pages 3726-3739.
Crossref
Rong-gang Ma, Yang Zhang, Ting-ting Sun & Bo Cheng. (2014) Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. Journal of Zhejiang University SCIENCE B 15:5, pages 412-428.
Crossref
Bernard Vandenbunder, Nicolas Fourré, Aymeric Leray, Florian Mueller, Pamela Völkel, Pierre-Olivier Angrand & Laurent Héliot. (2014) PRC1 components exhibit different binding kinetics in Polycomb bodies. Biology of the Cell 106:4, pages 111-125.
Crossref
Thierry Cheutin & Giacomo Cavalli. (2014) Polycomb silencing: from linear chromatin domains to 3D chromosome folding. Current Opinion in Genetics & Development 25, pages 30-37.
Crossref
Yuri B. Schwartz & Vincenzo Pirrotta. (2013) A new world of Polycombs: unexpected partnerships and emerging functions. Nature Reviews Genetics 14:12, pages 853-864.
Crossref
Moisés MalloClaudio R. Alonso. (2013) The regulation of Hox gene expression during animal development. Development 140:19, pages 3951-3963.
Crossref
Kristian B. Laursen, Nigel P. Mongan, Yong Zhuang, Mary M. Ng, Yannick D. Benoit & Lorraine J. Gudas. (2013) Polycomb recruitment attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene. Nucleic Acids Research 41:13, pages 6430-6443.
Crossref
Pearl A. Campbell & Michael A. Rudnicki. (2013) Oct4 Interaction with Hmgb2 Regulates Akt Signaling and Pluripotency. Stem Cells 31:6, pages 1107-1120.
Crossref
Philipp A. Steffen, João Pedro Fonseca, Cornelia Gänger, Eva Dworschak, Tobias Kockmann, Christian Beisel & Leonie Ringrose. (2013) Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin. Nucleic Acids Research 41:10, pages 5235-5250.
Crossref
Chiara LanzuoloValerio Orlando. (2012) Memories from the Polycomb Group Proteins. Annual Review of Genetics 46:1, pages 561-589.
Crossref
Maram Yousefi, Vahid Hajihoseini, Woojin Jung, Batol Hosseinpour, Hassan Rassouli, Bonghee Lee, Hossein Baharvand, KiYoung Lee & Ghasem Hosseini Salekdeh. (2012) Embryonic Stem Cell Interactomics: The Beginning of a Long Road to Biological Function. Stem Cell Reviews and Reports 8:4, pages 1138-1154.
Crossref
Philipp A. Steffen, João P. Fonseca & Leonie Ringrose. (2012) Epigenetics meets mathematics: Towards a quantitative understanding of chromatin biology. BioEssays 34:10, pages 901-913.
Crossref
Marjorie Brand & F. J. Dilworth. 2012. Toxicology and Epigenetics. Toxicology and Epigenetics 511 538 .
João Pedro Fonseca, Philipp A. Steffen, Stefan Müller, James Lu, Anna Sawicka, Christian Seiser & Leonie Ringrose. (2012) In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells. Genes & Development 26:8, pages 857-871.
Crossref
Vincenzo Pirrotta & Hua-Bing Li. (2012) A view of nuclear Polycomb bodies. Current Opinion in Genetics & Development 22:2, pages 101-109.
Crossref
Thierry Cheutin & Giacomo Cavalli. (2012) Progressive Polycomb Assembly on H3K27me3 Compartments Generates Polycomb Bodies with Developmentally Regulated Motion. PLoS Genetics 8:1, pages e1002465.
Crossref
Xiaolei DingQiong LinRoberto Ensenat-WaserStefan Rose-JohnMartin Zenke. (2012) Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from Embryonic Stem Cells. Stem Cells and Development 21:1, pages 121-132.
Crossref
Daniel J. Grau, Brad A. Chapman, Joe D. Garlick, Mark Borowsky, Nicole J. Francis & Robert E. Kingston. (2011) Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge. Genes & Development 25:20, pages 2210-2221.
Crossref
Julien Vandamme, Pamela Völkel, Claire Rosnoblet, Perrine Le Faou & Pierre-Olivier Angrand. (2011) Interaction Proteomics Analysis of Polycomb Proteins Defines Distinct PRC1 Complexes in Mammalian Cells. Molecular & Cellular Proteomics 10:4, pages M110.002642.
Crossref
Kyoko L. Yap & Ming-Ming Zhou. (2011) Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription. Biochemistry 50:12, pages 1966-1980.
Crossref
Vasundhra Kashyap, Lorraine J. Gudas, Fabienne Brenet, Patricia Funk, Agnes Viale & Joseph M. Scandura. (2011) Epigenomic Reorganization of the Clustered Hox Genes in Embryonic Stem Cells Induced by Retinoic Acid. Journal of Biological Chemistry 286:5, pages 3250-3260.
Crossref
Frédéric Bantignies, Virginie Roure, Itys Comet, Benjamin Leblanc, Bernd Schuettengruber, Jérôme Bonnet, Vanessa Tixier, André Mas & Giacomo Cavalli. (2011) Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila. Cell 144:2, pages 214-226.
Crossref
Mario Calderon, David Laperrière, Sylvie MADER & John White. (2010) LCoR. AfCS-Nature Molecule Pages.
Crossref
Mark N. Cruickshank, Paul Besant & Daniela Ulgiati. (2010) The impact of histone post-translational modifications on developmental gene regulation. Amino Acids 39:5, pages 1087-1105.
Crossref
Ho-Pi Lin, Claudius Vincenz, Kevin W. Eliceiri, Tom K. Kerppola & Brenda M. Ogle. (2010) Bimolecular fluorescence complementation analysis of eukaryotic fusion products. Biology of the Cell 102:9, pages 525-537.
Crossref
Masamitsu Negishi, Atsunori Saraya, Shinobu Mochizuki, Kristian Helin, Haruhiko Koseki & Atsushi Iwama. (2010) A Novel Zinc Finger Protein Zfp277 Mediates Transcriptional Repression of the Ink4a/Arf Locus through Polycomb Repressive Complex 1. PLoS ONE 5:8, pages e12373.
Crossref
Takaaki Konuma, Hideyuki Oguro & Atsushi Iwama. (2010) Role of the polycomb group proteins in hematopoietic stem cells. Development, Growth & Differentiation 52:6, pages 505-516.
Crossref
Atsushi Hatano, Masaki Matsumoto, Toru Higashinakagawa & Keiichi I. Nakayama. (2010) Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3. Biochemical and Biophysical Research Communications 397:1, pages 93-99.
Crossref
Kelly J. Morris, Mita Chotalia & Ana Pombo. 2010. The Cell Biology of Stem Cells. The Cell Biology of Stem Cells 14 25 .
Tom K. Kerppola. (2009) Polycomb group complexes – many combinations, many functions. Trends in Cell Biology 19:12, pages 692-704.
Crossref
Pablo Aranda, Xabier Agirre, Esteban Ballestar, Enrique J. Andreu, José Román-Gómez, Inés Prieto, José Ignacio Martín-Subero, Juan Cruz Cigudosa, Reiner Siebert, Manel Esteller & Felipe Prosper. (2009) Epigenetic Signatures Associated with Different Levels of Differentiation Potential in Human Stem Cells. PLoS ONE 4:11, pages e7809.
Crossref
Ana Palijan, Isabelle Fernandes, Mark Verway, Maria Kourelis, Yolande Bastien, Luz E. Tavera-Mendoza, Aaron Sacheli, Veronique Bourdeau, Sylvie Mader & John H. White. (2009) Ligand-dependent Corepressor LCoR Is an Attenuator of Progesterone-regulated Gene Expression. Journal of Biological Chemistry 284:44, pages 30275-30287.
Crossref
Tom K. Kerppola. (2009) Visualization of molecular interactions using bimolecular fluorescence complementation analysis: Characteristics of protein fragment complementation. Chemical Society Reviews 38:10, pages 2876.
Crossref
Malte Wachsmuth, Maïwen Caudron-Herger & Karsten Rippe. (2008) Genome organization: Balancing stability and plasticity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:11, pages 2061-2079.
Crossref
Claudius Vincenz & Tom K. Kerppola. (2008) Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. Proceedings of the National Academy of Sciences 105:43, pages 16572-16577.
Crossref

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