Advanced search
Publication Cover
Molecular and Cellular Biology Volume 31, 2011 - Issue 7
Submit an article Journal homepage
21
Views
29
CrossRef citations to date
0
Altmetric
Article

FLASH Is Required for the Endonucleolytic Cleavage of Histone Pre-mRNAs but Is Dispensable for the 5′ Exonucleolytic Degradation of the Downstream Cleavage Product

Xiao-cui YangDepartment of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Bing XuDepartment of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Ivan SabathDepartment of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Lalitha KunduruDepartment of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Brandon D. BurchDepartment of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
William F. MarzluffDepartment of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
&
Zbigniew DominskiDepartment of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599Correspondence[email protected]
 show all
Pages 1492-1502 | Received 20 Aug 2010, Accepted 10 Jan 2011, Published online: 20 Mar 2023

Citations (29)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Yadong Sun, Keith Hamilton & Liang Tong. (2020) Recent molecular insights into canonical pre-mRNA 3’-end processing. Transcription 11:2, pages 83-96.
Read now
Connor O'Sullivan, Jennifer Christie, Marcus Pienaar, Jake Gambling, Philip E. B. Nickerson, Spencer C. Alford, Robert L. Chow & Perry L. Howard. (2015) Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis. Molecular and Cellular Biology 35:21, pages 3753-3767.
Read now
Valentina Romeo, Esther Griesbach & Daniel Schümperli. (2014) CstF64: Cell Cycle Regulation and Functional Role in 3′ End Processing of Replication-Dependent Histone mRNAs. Molecular and Cellular Biology 34:23, pages 4272-4284.
Read now
Rocío Juárez-Velázquez, Adriana Reyes-León, Consuelo Salas-Labadía, Roberto Rivera-Luna, Liliana Velasco-Hidalgo, Gerardo López-Hernández, Norma López-Santiago, Rogelio Paredes-Aguilera, Aarón Domínguez-López, Roberto Bernáldez & Patricia Pérez-Vera. (2014) Significance of CASP8AP2 and H2AFZ expression in survival and risk of relapse in children with acute lymphoblastic leukemia. Leukemia & Lymphoma 55:10, pages 2305-2311.
Read now
Astrid Vennemann & Thomas Hofmann. (2013) SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2. Cell Cycle 12:12, pages 1914-1921.
Read now
Xiao-Cui Yang, Ivan Sabath, Jan Dębski, Magdalena Kaus-Drobek, Michał Dadlez, William F. Marzluff & Zbigniew Dominski. (2013) A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3′-End Processing. Molecular and Cellular Biology 33:1, pages 28-37.
Read now

Articles from other publishers (23)

Zbigniew DominskiLiang Tong. (2021) U7 deciphered: the mechanism that forms the unusual 3′ end of metazoan replication-dependent histone mRNAs. Biochemical Society Transactions 49:5, pages 2229-2240.
Crossref
Pedro A. Gutierrez, Kirk Baughman, Yadong Sun & Liang Tong. (2021) A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3′-end processing. RNA 27:10, pages 1148-1154.
Crossref
Claire Armstrong & Sabrina L. Spencer. (2021) Replication-dependent histone biosynthesis is coupled to cell-cycle commitment. Proceedings of the National Academy of Sciences 118:31.
Crossref
Søren Lykke-Andersen, Jérôme O. Rouvière & Torben Heick Jensen. (2021) ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control. Biochemical Society Transactions 49:3, pages 1325-1336.
Crossref
Jennifer Michelle Potter-Birriel, Graydon B. Gonsalvez & William F. Marzluff. (2021) A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into the Drosophila egg . Journal of Cell Science 134:3.
Crossref
Yadong Sun, Wei Shen Aik, Xiao-Cui Yang, William F. Marzluff, Zbigniew Dominski & Liang Tong. 2021. mRNA 3' End Processing and Metabolism. mRNA 3' End Processing and Metabolism 291 324 .
Xiao-cui Yang, Yadong Sun, Wei Shen Aik, William F. Marzluff, Liang Tong & Zbigniew Dominski. (2020) Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5′–3′ exonuclease. RNA 26:10, pages 1345-1359.
Crossref
Katarzyna Bucholc, Wei Shen Aik, Xiao-cui Yang, Kaituo Wang, Z Hong Zhou, Michał Dadlez, William F Marzluff, Liang Tong & Zbigniew Dominski. (2020) Composition and processing activity of a semi-recombinant holo U7 snRNP. Nucleic Acids Research 48:3, pages 1508-1530.
Crossref
Yadong Sun, Yixiao Zhang, Wei Shen Aik, Xiao-Cui YangWilliam F. Marzluff, Thomas WalzZbigniew Dominski & Liang Tong. (2020) Structure of an active human histone pre-mRNA 3′-end processing machinery. Science 367:6478, pages 700-703.
Crossref
Aleksandra Brzek, Marlena Cichocka, Jakub Dolata, Wojciech Juzwa, Daniel Schümperli & Katarzyna Dorota Raczynska. (2018) Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression. BMC Molecular Biology 19:1.
Crossref
Aleksandra Skrajna, Xiao-cui Yang, Michał Dadlez, William F Marzluff & Zbigniew Dominski. (2018) Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker. Nucleic Acids Research 46:9, pages 4752-4770.
Crossref
Wei Shen Aik, Min-Han Lin, Dazhi Tan, Ashutosh Tripathy, William F. Marzluff, Zbigniew Dominski, Chi-Yuan Chou & Liang Tong. (2017) The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing. PLOS ONE 12:10, pages e0186034.
Crossref
William F. Marzluff & Kaitlin P. Koreski. (2017) Birth and Death of Histone mRNAs. Trends in Genetics 33:10, pages 745-759.
Crossref
Aleksandra Skrajna, Xiao-cui Yang, Katarzyna Bucholc, Jun Zhang, Traci M. Tanaka Hall, Michał Dadlez, William F. Marzluff & Zbigniew Dominski. (2017) U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem–loop binding protein. RNA 23:6, pages 938-951.
Crossref
Aleksandra Skrajna, Xiao-cui Yang, Krzysztof Tarnowski, Kinga Fituch, William F. Marzluff, Zbigniew Dominski & Michał Dadlez. (2016) Mapping the Interaction Network of Key Proteins Involved in Histone mRNA Generation: A Hydrogen/Deuterium Exchange Study. Journal of Molecular Biology 428:6, pages 1180-1196.
Crossref
Katarzyna Dorota Raczynska, Marc-David Ruepp, Aleksandra Brzek, Stefan Reber, Valentina Romeo, Barbara Rindlisbacher, Manfred Heller, Zofia Szweykowska-Kulinska, Artur Jarmolowski & Daniel Schümperli. (2015) FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factors. Nucleic Acids Research, pages gkv794.
Crossref
Xiao-cui Yang, Ivan Sabath, Lalitha Kunduru, Andre J. van Wijnen, William F. Marzluff & Zbigniew Dominski. (2014) A Conserved Interaction That Is Essential for the Biogenesis of Histone Locus Bodies. Journal of Biological Chemistry 289:49, pages 33767-33782.
Crossref
Ashley R. Jurado, Dazhi Tan, Xinfu Jiao, Megerditch Kiledjian & Liang Tong. (2014) Structure and Function of Pre-mRNA 5′-End Capping Quality Control and 3′-End Processing. Biochemistry 53:12, pages 1882-1898.
Crossref
Ivan Sabath, Aleksandra Skrajna, Xiao-cui Yang, Michał Dadlez, William F. Marzluff & Zbigniew Dominski. (2013) 3′-End processing of histone pre-mRNAs in Drosophila : U7 snRNP is associated with FLASH and polyadenylation factors . RNA 19:12, pages 1726-1744.
Crossref
Zhi-Gang Li, Ying Jiao, Wei-Jing Li, Guo-Ren Deng, Lei Cui, Chao Gao, Xiao-Xi Zhao, Min-Yuan Wu & Hong-Ti Jia. (2013) Hypermethylation of two CpG sites upstream of CASP8AP2 promoter influences gene expression and treatment outcome in childhood acute lymphoblastic leukemia. Leukemia Research 37:10, pages 1287-1293.
Crossref
Zbigniew Dominski, Agamemnon J. Carpousis & Béatrice Clouet-d'Orval. (2013) Emergence of the β-CASP ribonucleases: Highly conserved and ubiquitous metallo-enzymes involved in messenger RNA maturation and degradation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:6-7, pages 532-551.
Crossref
Li-Jun Liu, Ronglin Xie, Sadiq Hussain, Jane B. Lian, Jaime Rivera-Perez, Stephen N. Jones, Janet L. Stein, Gary S. Stein & Andre J. van Wijnen. (2011) Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development. Gene 483:1-2, pages 1-10.
Crossref
Brandon D. Burch, Ashley C. Godfrey, Pamela Y. Gasdaska, Harmony R. Salzler, Robert J. Duronio, William F. Marzluff & Zbigniew Dominski. (2011) Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila . RNA 17:6, pages 1132-1147.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.