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Molecular and Cellular Biology Volume 35, 2015 - Issue 11
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Article

Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation

Chaowei Wua Department of Microbiology, New York University School of Medicine, New York, New York, USA
,
Maryem A. Husseina Department of Microbiology, New York University School of Medicine, New York, New York, USA
,
Elina Shresthaa Department of Microbiology, New York University School of Medicine, New York, New York, USA
,
Sarah Leonea Department of Microbiology, New York University School of Medicine, New York, New York, USA
,
Mohammed S. Aiyegbob Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA
,
W. Marcus Lamberta Department of Microbiology, New York University School of Medicine, New York, New York, USA
,
Benoit Pourcetc Centre for Clinical Pharmacology, Division of Medicine, University College London, London, United Kingdom
,
Timothy Cardozob Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA
,
Jan-Ake Gustafsond Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
,
Edward A. Fishere Department of Medicine, Division of Cardiology, Mark and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, New York, USA
,
Ines Pineda-Torrac Centre for Clinical Pharmacology, Division of Medicine, University College London, London, United KingdomCorrespondence[email protected] [email protected]
&
Michael J. Garabediana Department of Microbiology, New York University School of Medicine, New York, New York, USACorrespondence[email protected] [email protected]
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Pages 2024-2034 | Received 29 Jul 2014, Accepted 19 Mar 2015, Published online: 20 Mar 2023

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Susana Beceiro, Attila Pap, Zsolt Czimmerer, Tamer Sallam, Jose A. Guillén, Germán Gallardo, Cynthia Hong, Noelia A-Gonzalez, Carlos Tabraue, Mercedes Diaz, Felix Lopez, Jonathan Matalonga, Annabel F. Valledor, Pilar Dominguez, Carlos Ardavin, Cristina Delgado-Martin, Santiago Partida-Sanchez, Jose Luis Rodriguez-Fernandez, Laszlo Nagy, Peter Tontonoz & Antonio Castrillo. (2018) Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis. Molecular and Cellular Biology 38:10.
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Beyza Vurusaner, Prashanth Thevkar-Nages, Ravneet Kaur, Chiara Giannarelli, Michael J. Garabedian & Edward A. Fisher. (2022) Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice. Scientific Reports 12:1.
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James L. Thorne & Giorgia Cioccoloni. 2022. Nuclear Receptors in Human Health and Disease. Nuclear Receptors in Human Health and Disease 83 105 .
Priscilia Lianto, Samantha A. Hutchinson, J. Bernadette Moore, Thomas A. Hughes & James L. Thorne. (2021) Characterization and prognostic value of LXR splice variants in triple-negative breast cancer. iScience 24:10, pages 103212.
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Lin Zhao, Wangrui Lei, Chao Deng, Zhen Wu, Meng Sun, Zhenxiao Jin, Yanbin Song, Zhi Yang, Shuai Jiang, Mingzhi Shen & Yang Yang. (2020) The roles of liver X receptor α in inflammation and inflammation‐associated diseases. Journal of Cellular Physiology 236:7, pages 4807-4828.
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Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Mélanie Mahé, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Inés Pineda-Torra, Edward A. Fisher & Michael J. Garabedian. (2021) Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice. Communications Biology 4:1.
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Zsolt Czimmerer, Laszlo Halasz & Laszlo Nagy. (2020) Unorthodox Transcriptional Mechanisms of Lipid-Sensing Nuclear Receptors in Macrophages: Are We Opening a New Chapter?. Frontiers in Endocrinology 11.
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Maud Voisin, Matthew C Gage, Natalia Becares, Elina Shrestha, Edward A Fisher, Ines Pineda-Torra & Michael J Garabedian. (2020) LXRα Phosphorylation in Cardiometabolic Disease: Insight From Mouse Models. Endocrinology 161:7.
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Jihye Lee & Jae-Hoon Choi. (2020) Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis. Immune Network 20:3.
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Aicha Saadane, Natalia Mast, George Trichonas, Dibyendu Chakraborty, Sandra Hammer, Julia V. Busik, Maria B. Grant & Irina A. Pikuleva. (2019) Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal. The American Journal of Pathology 189:2, pages 405-425.
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Natalia Becares, Matthew C. Gage, Maud Voisin, Elina Shrestha, Lucia Martin-Gutierrez, Ning Liang, Rikah Louie, Benoit Pourcet, Oscar M. Pello, Tu Vinh Luong, Saioa Goñi, Cesar Pichardo-Almarza, Hanne Røberg-Larsen, Vanessa Diaz-Zuccarini, Knut R. Steffensen, Alastair O’Brien, Michael J. Garabedian, Krista Rombouts, Eckardt Treuter & Inés Pineda-Torra. (2019) Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease. Cell Reports 26:4, pages 984-995.e6.
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M. C. GageN. BécaresR. LouieK. E. WaddingtonY. ZhangT. H. TittanegroS. Rodríguez-LorenzoA. JathannaB. PourcetO. M. PelloJ. V. De la Rosa, A. Castrillo & I. Pineda-Torra. (2018) Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Proceedings of the National Academy of Sciences 115:28.
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Natalia Becares, Matthew C. Gage & Inés Pineda-Torra. (2017) Posttranslational Modifications of Lipid-Activated Nuclear Receptors: Focus on Metabolism. Endocrinology 158:2, pages 213-225.
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Dimitry A. Chistiakov, Veronika A. Myasoedova, Victor V. Revin, Alexander N. Orekhov & Yuri V. Bobryshev. (2017) The phenomenon of atherosclerosis reversal and regression: Lessons from animal models. Experimental and Molecular Pathology 102:1, pages 138-145.
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Kiwon Park, Zbigniew Mikulski, Goo-Young Seo, Aleksander Y. Andreyev, Paola Marcovecchio, Amy Blatchley, Mitchell Kronenberg & Catherine C. Hedrick. (2016) The transcription factor NR4A3 controls CD103+ dendritic cell migration. Journal of Clinical Investigation 126:12, pages 4603-4615.
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James P. Hamilton, Lahari Koganti, Abigael Muchenditsi, Venkata S. Pendyala, David Huso, Joseph Hankin, Robert C. Murphy, Dominik Huster, Uta Merle, Christopher Mangels, Nan Yang, James J. Potter, Esteban Mezey & Svetlana Lutsenko. (2016) Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice. Hepatology 63:6, pages 1828-1841.
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Myron I. CybulskyCheolho CheongClinton S. Robbins. (2016) Macrophages and Dendritic Cells. Circulation Research 118:4, pages 637-652.
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Kirsty E. WaddingtonElizabeth C. JuryInés Pineda-Torra. (2015) Liver X receptors in immune cell function in humans. Biochemical Society Transactions 43:4, pages 752-757.
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