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Molecular and Cellular Biology Volume 28, 2008 - Issue 3
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Article

The MLE Subunit of the Drosophila MSL Complex Uses Its ATPase Activity for Dosage Compensation and Its Helicase Activity for Targeting

Rosa Morra1 Department of Biology
,
Edwin R. Smith2 Department of Cell Biology
,
Ruth Yokoyama1 Department of Biology
&
John C. Lucchesi1 Department of Biology;3 Program in Genetics and Molecular Biology, Emory University, Atlanta, Georgia30322Correspondence[email protected]
Pages 958-966 | Received 05 Jun 2007, Accepted 05 Nov 2007, Published online: 27 Mar 2023

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Catherine Fromental-Ramain, Philippe Ramain & Ali Hamiche. (2017) The DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation. Molecular and Cellular Biology 37:12.
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Articles from other publishers (28)

J. V. Nikolenko, S. G. Georgieva & D. V. Kopytova. (2023) Diversity of MLE Helicase Functions in the Regulation of Gene Expression in Higher Eukaryotes. Molecular Biology 57:1, pages 7-18.
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Akanksha Bhatnagar, Ashley M. Karnay & Felice Elefant. 2023. Handbook of Epigenetics. Handbook of Epigenetics 215 247 .
Wladyslaw A. Krajewski & Oleg L. Vassiliev. (2019) Analysis of histone ubiquitylation by MSL1/MSL2 proteins in vitro. Archives of Biochemistry and Biophysics 666, pages 22-30.
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Mengqi Lv, Yixiang Yao, Fudong Li, Ling Xu, Lingna Yang, Qingguo Gong, Yong-Zhen Xu, Yunyu Shi, Yu-Jie Fan & Yajun Tang. (2019) Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila . Nucleic Acids Research 47:6, pages 3142-3157.
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Qingyun Diao, Liangxian Sun, Huajun Zheng, Zhijiang Zeng, Shengyue Wang, Shufa Xu, Huoqing Zheng, Yanping Chen, Yuanyuan Shi, Yuezhu Wang, Fei Meng, Qingliang Sang, Lianfei Cao, Fang Liu, Yongqiang Zhu, Wenfeng Li, Zhiguo Li, Congjie Dai, Minjun Yang, Shenglu Chen, Runsheng Chen, Shaowu Zhang, Jay D. Evans, Qiang Huang, Jie Liu, Fuliang Hu, Songkun Su & Jie Wu. (2018) Genomic and transcriptomic analysis of the Asian honeybee Apis cerana provides novel insights into honeybee biology. Scientific Reports 8:1.
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Ashley M. Karnay & Felice Elefant. 2017. Handbook of Epigenetics. Handbook of Epigenetics 205 229 .
Mitzi I Kuroda, Andres Hilfiker & John C Lucchesi. (2016) Dosage Compensation in Drosophila —a Model for the Coordinate Regulation of Transcription . Genetics 204:2, pages 435-450.
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J. Rajan Prabu, Marisa Müller, Andreas W. Thomae, Steffen Schüssler, Fabien Bonneau, Peter B. Becker & Elena Conti. (2015) Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling. Molecular Cell 60:3, pages 487-499.
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Manasi S. Apte & Victoria H. Meller. (2015) Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors. PLOS ONE 10:6, pages e0128114.
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Simona Cugusi, Satish Kallappagoudar, Huiping Ling & John C. Lucchesi. (2015) The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation*. Molecular & Cellular Proteomics 14:6, pages 1478-1488.
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Hayriye Verda Erkizan, Jeffrey A. Schneider, Kamal Sajwan, Garrett T. Graham, Brittany Griffin, Sergey Chasovskikh, Sarah E. Youbi, Abraham Kallarakal, Maksymilian Chruszcz, Radhakrishnan Padmanabhan, John L. Casey, Aykut Üren & Jeffrey A. Toretsky. (2015) RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1. Nucleic Acids Research 43:2, pages 1069-1080.
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Cristina Militti, Sylvain Maenner, Peter B. Becker & Fátima Gebauer. (2014) UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. Nature Communications 5:1.
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Kyle A. McElroy, Hyuckjoon Kang & Mitzi I. Kuroda. (2014) Are we there yet? Initial targeting of the Male-Specific Lethal and Polycomb group chromatin complexes in Drosophila . Open Biology 4:3, pages 140006.
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Jessica Chery & Erica Larschan. (2014) X-marks the spot: X-chromosome identification during dosage compensation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1839:3, pages 234-240.
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Sylvain Maenner, Marisa Müller, Jonathan Fröhlich, Diana Langer & Peter B. Becker. (2013) ATP-Dependent roX RNA Remodeling by the Helicase maleless Enables Specific Association of MSL Proteins. Molecular Cell 51:2, pages 174-184.
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Chiat Koo Lim & Richard L. Kelley. (2013) The Drosophila Over Compensating Males Gene Genetically Inhibits Dosage Compensation in Males. PLoS ONE 8:4, pages e60450.
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Tobias Straub, Angelika Zabel, Gregor D. Gilfillan, Christian Feller & Peter B. Becker. (2013) Different chromatin interfaces of the Drosophila dosage compensation complex revealed by high-shear ChIP-seq . Genome Research 23:3, pages 473-485.
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Sylvain Maenner, Marisa Müller & Peter B. Becker. (2012) Roles of long, non-coding RNA in chromosome-wide transcription regulation: Lessons from two dosage compensation systems. Biochimie 94:7, pages 1490-1498.
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Thomas Conrad & Asifa Akhtar. (2012) Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews Genetics 13:2, pages 123-134.
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Rosa Morra, Ruth Yokoyama, Huiping Ling & John C Lucchesi. (2011) Role of the ATPase/helicase maleless (MLE) in the assembly, targeting, spreading and function of the male-specific lethal (MSL) complex of Drosophila. Epigenetics & Chromatin 4:1.
Crossref
Min Zhao, Xing-Fu Zha, Jin Liu, Wen-Ji Zhang, Ning-Jia He, Dao-Jun Cheng, Ya Dai, Zhong-Huai Xiang & Qing-You Xia. (2011) Global expression profile of silkworm genes from larval to pupal stages: Toward a comprehensive understanding of sexual differences. Insect Science 18:6, pages 607-618.
Crossref
Antoine Graindorge, Cristina Militti & Fátima Gebauer. (2011) Posttranscriptional control of X-chromosome dosage compensation. Wiley Interdisciplinary Reviews: RNA 2:4, pages 534-545.
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John C. Lucchesi. 2011. Handbook of Epigenetics. Handbook of Epigenetics 203 232 .
Mahalakshmi Prabhakaran & Richard L Kelley. (2010) A new strategy for isolating genes controlling dosage compensation in Drosophilausing a simple epigenetic mosaic eye phenotype. BMC Biology 8:1.
Crossref
John C Lucchesi. (2009) The structure–function link of compensated chromatin in Drosophila. Current Opinion in Genetics & Development 19:6, pages 550-556.
Crossref
Erinc Hallacli & Asifa Akhtar. (2009) X chromosomal regulation in flies: when less is more. Chromosome Research 17:5.
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Marnie E. GelbartMitzi I. Kuroda. (2009) Drosophila dosage compensation: a complex voyage to the X chromosome . Development 136:9, pages 1399-1410.
Crossref
Solenn PatalanoMarija MihailovichYaiza BelacortuNuria ParicioFátima Gebauer. (2009) Dual sex-specific functions of Drosophila Upstream of N-ras in the control of X chromosome dosage compensation . Development 136:4, pages 689-698.
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