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Molecular and Cellular Biology Volume 34, 2014 - Issue 24
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Article

An Absence of Nuclear Lamins in Keratinocytes Leads to Ichthyosis, Defective Epidermal Barrier Function, and Intrusion of Nuclear Membranes and Endoplasmic Reticulum into the Nuclear Chromatin

Hea-Jin Junga Molecular Biology Institute, University of California, Los Angeles, California, USA
,
Angelica Tatarb Department of Medicine, University of California, Los Angeles, California, USA
,
Yiping Tub Department of Medicine, University of California, Los Angeles, California, USA
,
Chika Nobumorib Department of Medicine, University of California, Los Angeles, California, USA
,
Shao H. Yangb Department of Medicine, University of California, Los Angeles, California, USA
,
Chris N. Goulbourneb Department of Medicine, University of California, Los Angeles, California, USA
,
Harald Herrmannc German Cancer Research Center, Heidelberg, Germany
,
Loren G. Fongb Department of Medicine, University of California, Los Angeles, California, USACorrespondence[email protected] [email protected]
&
Stephen G. Younga Molecular Biology Institute, University of California, Los Angeles, California, USA;b Department of Medicine, University of California, Los Angeles, California, USA;d Department of Human Genetics, University of California, Los Angeles, California, USACorrespondence[email protected] [email protected]
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Pages 4534-4544 | Received 30 Jul 2014, Accepted 03 Oct 2014, Published online: 20 Mar 2023

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Natalie Y. Chen, Paul H. Kim, Loren G. Fong & Stephen G. Young. (2020) Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies. Nucleus 11:1, pages 237-249.
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Ewa Markiewicz & Olusola Clement Idowu. (2018) Involvement of the nuclear structural proteins in aging-related responses of human skin to the environmental stress. Clinical, Cosmetic and Investigational Dermatology 11, pages 297-307.
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Articles from other publishers (18)

Sirio Dupont & Sara A. Wickström. (2022) Mechanical regulation of chromatin and transcription. Nature Reviews Genetics 23:10, pages 624-643.
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Natalie Y. Chen, Paul H. Kim, Yiping Tu, Ye YangPatrick J. HeizerStephen G. Young & Loren G. Fong. (2021) Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin–deficient neurons and fibroblasts. Proceedings of the National Academy of Sciences 118:25.
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Eve Hunter-Featherstone, Natalie Young, Kathryn Chamberlain, Pablo Cubillas, Ben Hulette, Xingtao Wei, Jay P. Tiesman, Charles C. Bascom, Adam M. Benham, Martin W. Goldberg, Gabriele Saretzki & Iakowos Karakesisoglou. (2021) Culturing Keratinocytes on Biomimetic Substrates Facilitates Improved Epidermal Assembly In Vitro. Cells 10:5, pages 1177.
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Emma Carley, Rachel M Stewart, Abigail Zieman, Iman Jalilian, Diane E King, Amanda Zubek, Samantha Lin, Valerie Horsley & Megan C King. (2021) The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. eLife 10.
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Navjot Kaur Gill, Chau Ly, Paul H. Kim, Cosmo A. Saunders, Loren G. Fong, Stephen G. Young, G. W. Gant Luxton & Amy C. Rowat. (2019) DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces. Frontiers in Cell and Developmental Biology 7.
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Melanie MaurerJan Lammerding. (2019) The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease. Annual Review of Biomedical Engineering 21:1, pages 443-468.
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Vidya Murthy, Toma Tebaldi, Toshimi Yoshida, Serkan Erdin, Teresa Calzonetti, Ravi Vijayvargia, Takshashila Tripathi, Emanuela Kerschbamer, Ihn Sik Seong, Alessandro Quattrone, Michael E. Talkowski, James F. Gusella, Katia Georgopoulos, Marcy E. MacDonald & Marta Biagioli. (2019) Hypomorphic mutation of the mouse Huntington’s disease gene orthologue. PLOS Genetics 15:3, pages e1007765.
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Donata Orioli & Elena Dellambra. (2018) Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases. Cells 7:12, pages 268.
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Natalie Y. ChenPaul Kim, Thomas A. WestonLovelyn EdilloYiping TuLoren G. FongStephen G. Young. (2018) Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. Proceedings of the National Academy of Sciences 115:40, pages 10100-10105.
Crossref
Rachel M. Stewart, Megan C. King & Valerie Horsley. 2018. Epigenetic Regulation of Skin Development and Regeneration. Epigenetic Regulation of Skin Development and Regeneration 263 292 .
Valentina Rapisarda, Igor Malashchuk, Inemo E. Asamaowei, Krzysztof Poterlowicz, Michael Y. Fessing, Andrey A. Sharov, Iakowos Karakesisoglou, Vladimir A. Botchkarev & Andrei Mardaryev. (2017) p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. Journal of Investigative Dermatology 137:10, pages 2157-2167.
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David Razafsky, Candace Ward, Chloe Potter, Wanqiu Zhu, Yunlu Xue, Vladimir J. Kefalov, Loren G. Fong, Stephen G. Young & Didier Hodzic. (2016) Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development. Molecular Biology of the Cell 27:12, pages 1928-1937.
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Lori L Wallrath, Jens Bohnekamp & Thomas M Magin. (2016) Cross talk between the cytoplasm and nucleus during development and disease. Current Opinion in Genetics & Development 37, pages 129-136.
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Lidija D. Vuković, Predrag Jevtić, Lisa J. Edens & Daniel L. Levy. 2016. 1 59 .
Marlon R. Schneider, Shasha Zhang & Peng Li. (2015) Lipid droplets and associated proteins in the skin: basic research and clinical perspectives. Archives of Dermatological Research 308:1, pages 1-6.
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Predrag Jevtić, Lisa J. Edens, Xiaoyang Li, Thang Nguyen, Pan Chen & Daniel L. Levy. (2015) Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells. Journal of Biological Chemistry 290:46, pages 27557-27571.
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Agustín Sola Carvajal, Tomás McKenna, Emelie Wallén Arzt & Maria Eriksson. (2015) Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation. PLOS ONE 10:6, pages e0128917.
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Selma Osmanagic-Myers, Thomas Dechat & Roland Foisner. (2015) Lamins at the crossroads of mechanosignaling. Genes & Development 29:3, pages 225-237.
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