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Article

The 5′ Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

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Pages 736-743 | Received 03 Sep 2010, Accepted 29 Nov 2010, Published online: 20 Mar 2023

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Deqiang Ding, Chao Wei, Kunzhe Dong, Jiali Liu, Alexander Stanton, Chao Xu, Jinrong Min, Jian Hu & Chen Chen. (2020) LOTUS domain is a novel class of G-rich and G-quadruplex RNA binding domain. Nucleic Acids Research 48:16, pages 9262-9272.
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Prakash Kharel, Sumirtha Balaratnam, Nathan Beals & Soumitra Basu. (2019) The role of RNA G‐quadruplexes in human diseases and therapeutic strategies. WIREs RNA 11:1.
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Rafah A. A. Alnafakh, Meera Adishesh, Lucy Button, Gabriele Saretzki & Dharani K. Hapangama. (2019) Telomerase and Telomeres in Endometrial Cancer. Frontiers in Oncology 9.
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Michael C. Chen, Ramreddy Tippana, Natalia A. Demeshkina, Pierre Murat, Shankar Balasubramanian, Sua Myong & Adrian R. Ferré-D’Amaré. (2018) Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature 558:7710, pages 465-469.
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Wei-Fei Chen, Stephane Rety, Hai-Lei Guo, Yang-Xue Dai, Wen-Qiang Wu, Na-Nv Liu, Daniel Auguin, Qian-Wen Liu, Xi-Miao Hou, Shuo-Xing Dou & Xu-Guang Xi. (2018) Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model. Structure 26:3, pages 403-415.e4.
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Cherie Musgrove, Linnea I. Jansson & Michael D. Stone. (2017) New perspectives on telomerase RNA structure and function. WIREs RNA 9:2.
Crossref
Philip M. Yangyuoru, Devin A. Bradburn, Zhonghua Liu, Tsan Sam Xiao & Rick Russell. (2018) The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism. Journal of Biological Chemistry 293:6, pages 1924-1932.
Crossref
Abhishek Dey & Kausik Chakrabarti. (2018) Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites. International Journal of Molecular Sciences 19:2, pages 333.
Crossref
Sangsoon Park, Hae-Eun H. Park, Heehwa G. Son & Seung-Jae V. Lee. (2017) The role of RNA helicases in aging and lifespan regulation. Translational Medicine of Aging 1, pages 24-31.
Crossref
Chun Kit Kwok & Catherine J. Merrick. (2017) G-Quadruplexes: Prediction, Characterization, and Biological Application. Trends in Biotechnology 35:10, pages 997-1013.
Crossref
Marta M. Fay, Shawn M. Lyons & Pavel Ivanov. (2017) RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms. Journal of Molecular Biology 429:14, pages 2127-2147.
Crossref
R. Alex WuHeather E. UptonJacob M. VoganKathleen Collins. (2017) Telomerase Mechanism of Telomere Synthesis. Annual Review of Biochemistry 86:1, pages 439-460.
Crossref
William J. Martin & Nicholas J. Reiter. (2016) Structural Roles of Noncoding RNAs in the Heart of Enzymatic Complexes. Biochemistry 56:1, pages 3-13.
Crossref
Zhaowen Zhu, Huy Tran, M. Meleah Mathahs, Thomas O. Moninger & Warren N. Schmidt. (2017) HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes. PLOS ONE 12:1, pages e0166853.
Crossref
Wanpei Cai, Zhi Xiong Chen, Grishma Rane, Shikha Satendra Singh, Zhang’e Choo, Chao Wang, Yi Yuan, Tuan Zea Tan, Frank Arfuso, Celestial T. Yap, Lorinc S. Pongor, Henry Yang, Martin B. Lee, Boon Cher Goh, Gautam Sethi, Touati Benoukraf, Vinay Tergaonkar & Alan Prem Kumar. (2017) Wanted DEAD/H or Alive: Helicases Winding Up in Cancers. Journal of the National Cancer Institute 109:6, pages djw278.
Crossref
Mrinmoyee Majumder, Reniqua House, Nallasivam Palanisamy, Shuo Qie, Terrence A. Day, David Neskey, J. Alan Diehl & Viswanathan Palanisamy. (2016) RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. PLOS Genetics 12:9, pages e1006306.
Crossref
Jacob M Vogan, Xiaozhu Zhang, Daniel T Youmans, Samuel G Regalado, Joshua Z Johnson, Dirk Hockemeyer & Kathleen Collins. (2016) Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies. eLife 5.
Crossref
Greg M. Arndt & Karen L. MacKenzie. (2016) New prospects for targeting telomerase beyond the telomere. Nature Reviews Cancer 16:8, pages 508-524.
Crossref
Oscar Mendoza, Anne Bourdoncle, Jean-Baptiste Boulé, Robert M. BroshJrJr & Jean-Louis Mergny. (2016) G-quadruplexes and helicases. Nucleic Acids Research 44:5, pages 1989-2006.
Crossref
Evan P. Booy, Ewan K.S. McRae, Ryan Howard, Soumya R. Deo, Emmanuel O. Ariyo, Edis Dzananovic, Markus Meier, Jörg Stetefeld & Sean A. McKenna. (2016) RNA Helicase Associated with AU-rich Element (RHAU/DHX36) Interacts with the 3′-Tail of the Long Non-coding RNA BC200 (BCYRN1). Journal of Biological Chemistry 291:10, pages 5355-5372.
Crossref
Joshua D. Podlevsky, Yang Li & Julian J.-L. Chen. (2016) Structure and function of echinoderm telomerase RNA. RNA 22:2, pages 204-215.
Crossref
Daniela Rhodes & Hans J. Lipps. (2015) G-quadruplexes and their regulatory roles in biology. Nucleic Acids Research 43:18, pages 8627-8637.
Crossref
Philip J. Smaldino, Eric D. Routh, Jung H. Kim, Banabihari Giri, Steven D. Creacy, Roy R. Hantgan, Steven A. Akman & James P. Vaughn. (2015) Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3’-Tail Sequences Are Sufficient for Tight and Complete Binding. PLOS ONE 10:7, pages e0132668.
Crossref
Aaron L. Moye, Karina C. Porter, Scott B. Cohen, Tram Phan, Katherine G. Zyner, Natsuki Sasaki, George O. Lovrecz, Jennifer L. Beck & Tracy M. Bryan. (2015) Telomeric G-quadruplexes are a substrate and site of localization for human telomerase. Nature Communications 6:1.
Crossref
David MonchaudAaron L Moye & Tracy M Bryan. 2015. Biological Relevance & Therapeutic Applications of DNA- & RNA-Quadruplexes. Biological Relevance & Therapeutic Applications of DNA- & RNA-Quadruplexes 100 117 .
Chun Kit Kwok & Shankar Balasubramanian. (2015) Targeted Detection of G-Quadruplexes in Cellular RNAs. Angewandte Chemie International Edition 54:23, pages 6751-6754.
Crossref
Chun Kit Kwok & Shankar Balasubramanian. (2015) Targeted Detection of G-Quadruplexes in Cellular RNAs. Angewandte Chemie 127:23, pages 6855-6858.
Crossref
X Gao, W Ma, J Nie, C Zhang, J Zhang, G Yao, J Han, J Xu, B Hu, Y Du, Q Shi, Z Yang, X Huang & Y Zhang. (2015) A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell Death & Disease 6:1, pages e1610-e1610.
Crossref
Prachi AgarwalaSatyaprakash PandeySouvik Maiti. (2015) The tale of RNA G-quadruplex. Organic & Biomolecular Chemistry 13:20, pages 5570-5585.
Crossref
Evan P. Booy, Ewan K. S. McRae & Sean A. McKenna. 2015. RNA Remodeling Proteins. RNA Remodeling Proteins 125 135 .
Inga JarmoskaiteRick Russell. (2014) RNA Helicase Proteins as Chaperones and Remodelers. Annual Review of Biochemistry 83:1, pages 697-725.
Crossref
Herry Martadinata & Anh Tuân Phan. (2014) Formation of a Stacked Dimeric G-Quadruplex Containing Bulges by the 5′-Terminal Region of Human Telomerase RNA (hTERC). Biochemistry 53:10, pages 1595-1600.
Crossref
Evan P. Booy, Ryan Howard, Oksana Marushchak, Emmanuel O. Ariyo, Markus Meier, Stefanie K. Novakowski, Soumya R. Deo, Edis Dzananovic, Jörg Stetefeld & Sean A. McKenna. (2014) The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. Nucleic Acids Research 42:5, pages 3346-3361.
Crossref
Andrew F. Brown, Joshua D. Podlevsky & Julian J.-L. Chen. 2014. Nucleic Acid Polymerases. Nucleic Acid Polymerases 215 235 .
Markus Meier, Trushar R. Patel, Evan P. Booy, Oksana Marushchak, Natalie Okun, Soumya Deo, Ryan Howard, Kevin McEleney, Stephen E. Harding, Jörg Stetefeld & Sean A. McKenna. (2013) Binding of G-quadruplexes to the N-terminal Recognition Domain of the RNA Helicase Associated with AU-rich Element (RHAU). Journal of Biological Chemistry 288:49, pages 35014-35027.
Crossref
Kyle R. Hukezalie & Judy M. Y. Wong. (2013) Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme. FEBS Journal 280:14, pages 3194-3204.
Crossref
Francis Robert & Jerry Pelletier. (2013) Perturbations of RNA helicases in cancer. Wiley Interdisciplinary Reviews: RNA 4:4, pages 333-349.
Crossref
Emily D. Egan & Kathleen Collins. (2012) Biogenesis of telomerase ribonucleoproteins. RNA 18:10, pages 1747-1759.
Crossref
John M. Nicoludis, Steven P. Barrett, Jean-Louis Mergny & Liliya A. Yatsunyk. (2012) Interaction of human telomeric DNA with N- methyl mesoporphyrin IX. Nucleic Acids Research 40:12, pages 5432-5447.
Crossref
Stefania Millevoi, Hervé Moine & Stéphan Vagner. (2012) G-quadruplexes in RNA biology. Wiley Interdisciplinary Reviews: RNA 3:4, pages 495-507.
Crossref
A. Bugaut & S. Balasubramanian. (2012) 5'-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Research 40:11, pages 4727-4741.
Crossref
E. P. Booy, M. Meier, N. Okun, S. K. Novakowski, S. Xiong, J. Stetefeld & S. A. McKenna. (2012) The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary. Nucleic Acids Research 40:9, pages 4110-4124.
Crossref
Joshua D. Podlevsky & Julian J.-L. Chen. (2012) It all comes together at the ends: Telomerase structure, function, and biogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 730:1-2, pages 3-11.
Crossref
Simon Lattmann, Michael B. Stadler, James P. Vaughn, Steven A. Akman & Yoshikuni Nagamine. (2011) The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Research 39:21, pages 9390-9404.
Crossref
Chang-yue Chen, Quan Wang, Jia-quan Liu, Yu-hua Hao & Zheng Tan. (2011) Contribution of Telomere G-Quadruplex Stabilization to the Inhibition of Telomerase-Mediated Telomere Extension by Chemical Ligands. Journal of the American Chemical Society 133:38, pages 15036-15044.
Crossref
Claudia Sissi, Barbara Gatto & Manlio Palumbo. (2011) The evolving world of protein-G-quadruplex recognition: A medicinal chemist’s perspective. Biochimie 93:8, pages 1219-1230.
Crossref
Gavin W. Collie & Gary N. Parkinson. (2011) The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chemical Society Reviews 40:12, pages 5867.
Crossref

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