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Molecular and Cellular Biology Volume 28, 2008 - Issue 23
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Article

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

Chang Liu1 Vollum Institute;2 Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon97201
,
Maho Takahashi1 Vollum Institute;3 Tumor Endocrinology Project, National Cancer Center Research Institute, Tokyo104-0045, Japan
,
Yanping Li1 Vollum Institute
,
Shuang Song4 Vision Science, School of Optometry, University of California, Berkeley, California94701
,
Tara J. Dillon1 Vollum Institute
,
Ujwal Shinde5 Department of Biochemistry, Oregon Health & Science University, Portland, Oregon97201
&
Philip J. S. Stork1 Vollum Institute;2 Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon97201Correspondence[email protected]
 show all
Pages 7109-7125 | Received 07 Jul 2008, Accepted 23 Sep 2008, Published online: 27 Mar 2023

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Martijn Gloerich, Bas Ponsioen, Marjolein J. Vliem, Zhongchun Zhang, Jun Zhao, Matthijs R. Kooistra, Leo S. Price, Laila Ritsma, Fried J. Zwartkruis, Holger Rehmann, Kees Jalink & Johannes L. Bos. (2010) Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins. Molecular and Cellular Biology 30:22, pages 5421-5431.
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Chang Liu, Maho Takahashi, Yanping Li, Tara J. Dillon, Stefanie Kaech & Philip J. S. Stork. (2010) The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope. Molecular and Cellular Biology 30:16, pages 3956-3969.
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Bas Ponsioen, Martijn Gloerich, Laila Ritsma, Holger Rehmann, Johannes L. Bos & Kees Jalink. (2009) Direct Spatial Control of Epac1 by Cyclic AMP. Molecular and Cellular Biology 29:10, pages 2521-2531.
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Articles from other publishers (46)

Muhammad Bilal Ahmed, Abdullah A. A. Alghamdi, Salman Ul Islam, Joon-Seok Lee & Young-Sup Lee. (2022) cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach. Cells 11:13, pages 2020.
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Zhuofu Ni & Xiaodong Cheng. (2021) Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis. Cells 10:10, pages 2750.
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Urooj Qureshi, M. Israr Khan, Sajda Ashraf, Abdul Hameed, Rahman M. Hafizur, Rafaila Rafique, Khalid Mohammed Khan & Zaheer Ul-Haq. (2020) Identification of novel Epac2 antagonists through in silico and in vitro analyses. European Journal of Pharmaceutical Sciences 153, pages 105492.
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Nadine Wehbe, Hasan Slika, Joelle Mesmar, Suzanne A. Nasser, Gianfranco Pintus, Serine Baydoun, Adnan Badran, Firas Kobeissy, Ali H. Eid & Elias Baydoun. (2020) The Role of Epac in Cancer Progression. International Journal of Molecular Sciences 21:18, pages 6489.
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Nadine Wehbe, Suzanne Awni Nasser, Yusra Al-Dhaheri, Rabah Iratni, Alessandra Bitto, Ahmed F. El-Yazbi, Adnan Badran, Firas Kobeissy, Elias Baydoun & Ali H. Eid. (2020) EPAC in Vascular Smooth Muscle Cells. International Journal of Molecular Sciences 21:14, pages 5160.
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Seidu A. Richard. (2020) EPAC2: A new and promising protein for glioma pathogenesis and therapy. Oncology Reviews 14:1.
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Francisco Llavero, Miriam Luque Montoro, Alazne Arrazola Sastre, David Fernández-Moreno, Hadriano M. Lacerda, Luis A. Parada, Alejandro Lucia & José L. Zugaza. (2019) Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family. Journal of Biological Chemistry 294:12, pages 4345-4358.
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William G. RobichauxIIIIII & Xiaodong Cheng. (2018) Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. Physiological Reviews 98:2, pages 919-1053.
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Ida Alenkvist, Nikhil R. Gandasi, Sebastian Barg & Anders Tengholm. (2017) Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis. Diabetes 66:10, pages 2610-2622.
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Naveen Kumar, Sonal Gupta, Surbhi Dabral, Shailja Singh & Seema Sehrawat. (2017) Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis. Molecular and Cellular Biochemistry 430:1-2, pages 115-125.
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Maho Takahashi, Yanping Li, Tara J. Dillon & Philip J.S. Stork. (2017) Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. Journal of Biological Chemistry 292:4, pages 1449-1461.
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Bhavin Shah & Andreas W. Püschel. (2016) Regulation of Rap GTPases in mammalian neurons. Biological Chemistry 397:10, pages 1055-1069.
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Yanping Li, Tara J. Dillon, Maho Takahashi, Keith T. Earley & Philip J.S. Stork. (2016) Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. Journal of Biological Chemistry 291:41, pages 21584-21595.
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Aurélia E. Lewis, Reidun Aesoy & Marit Bakke. (2016) Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells. Frontiers in Endocrinology 7.
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Todd A. Clason, Beatrice M. Girard, Victor May & Rodney L. Parsons. (2016) Activation of MEK/ERK Signaling by PACAP in Guinea Pig Cardiac Neurons. Journal of Molecular Neuroscience 59:2, pages 309-316.
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Frank Lezoualc’hLoubina FazalMarion LaudetteCaroline Conte. (2016) Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease. Circulation Research 118:5, pages 881-897.
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Kenji Sugawara, Tadao Shibasaki, Harumi Takahashi & Susumu Seino. (2016) Structure and functional roles of Epac2 (Rapgef4). Gene 575:2, pages 577-583.
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Loren M. Brown, Kathleen E. Rogers, Nakon Aroonsakool, J. Andrew McCammon & Paul A. Insel. (2014) Allosteric Inhibition of Epac. Journal of Biological Chemistry 289:42, pages 29148-29157.
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Loren M. Brown, Kathleen E. Rogers, J. Andrew McCammon & Paul A. Insel. (2014) Identification and Validation of Modulators of Exchange Protein Activated by cAMP (Epac) Activity. Journal of Biological Chemistry 289:12, pages 8217-8230.
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Willem-Jan Pannekoek & Johannes L. Bos. 2014. Ras Superfamily Small G Proteins: Biology and Mechanisms 1. Ras Superfamily Small G Proteins: Biology and Mechanisms 1 233 255 .
Toshimasa TakahashiTadao ShibasakiHarumi TakahashiKenji SugawaraAika OnoNaoko InoueToshio FuruyaSusumu Seino. (2013) Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A. Science Signaling 6:298.
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Maho Takahashi, Tara J. Dillon, Chang Liu, Yumi Kariya, Zhiping Wang & Philip J.S. Stork. (2013) Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration. Journal of Biological Chemistry 288:39, pages 27712-27723.
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Yanping Li, Maho Takahashi & Philip J.S. Stork. (2013) Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation. Journal of Biological Chemistry 288:38, pages 27646-27657.
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Erling A. Hoivik, Solveig L. Witsoe, Inger R. Bergheim, Yunjian Xu, Ida Jakobsson, Anders Tengholm, Stein Ove Doskeland & Marit Bakke. (2013) DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms. PLoS ONE 8:7, pages e67925.
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Olof Idevall-HagrenIda JakobssonYunjian XuAnders Tengholm. (2013) Spatial Control of Epac2 Activity by cAMP and Ca 2+ -Mediated Activation of Ras in Pancreatic β Cells . Science Signaling 6:273.
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Martina Schmidt, Frank J. Dekker & Harm Maarsingh. (2013) Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions. Pharmacological Reviews 65:2, pages 670-709.
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Magali Berthouze-Duquesnes, Alexandre Lucas, Aude Saulière, Yuan Yan Sin, Anne-Coline Laurent, Céline Galés, George Baillie & Frank Lezoualc'h. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling 25:4, pages 970-980.
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Minoru Tada, Keiko Gengyo-Ando, Tetsuo Kobayashi, Masamitsu Fukuyama, Shohei Mitani, Kenji Kontani & Toshiaki Katada. (2012) Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans . Genes to Cells 17:9, pages 778-789.
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Wenting Zhang, Asmita Tingare, David Chi-Heng Ng, Hong W. Johnson, Michael J. Schell, Rebecca L. Lord & Sangeeta Chawla. (2012) IP3-dependent intracellular Ca2+ release is required for cAMP-induced c-fos expression in hippocampal neurons. Biochemical and Biophysical Research Communications 425:2, pages 450-455.
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Yves Jossin & Jonathan A Cooper. (2011) Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex. Nature Neuroscience 14:6, pages 697-703.
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Ju Hwan Cho, Mee-Sup Yoon, Jun Bon Koo, Yong Seok Kim, Ki-Sung Lee, Jung Han Lee & Joong-Soo Han. (2011) The progesterone receptor as a transcription factor regulates phospholipase D1 expression through independent activation of protein kinase A and Ras during 8-Br-cAMP-induced decidualization in human endometrial stromal cells. Biochemical Journal 436:1, pages 181-191.
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M. Pertuit, D. Romano, C. Zeiller, A. Barlier, A. Enjalbert & C. Gerard. (2011) The gsp Oncogene Disrupts Ras/ERK-Dependent Prolactin Gene Regulation in gsp Inducible Somatotroph Cell Line. Endocrinology 152:4, pages 1234-1243.
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Andrew G. Peace & Derryck A. Shewan. (2011) New perspectives in cyclic AMP-mediated axon growth and guidance: The emerging epoch of Epac. Brain Research Bulletin 84:4-5, pages 280-288.
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Takao Kurooka, Yasunori Yamamoto, Yoshimi Takai & Toshiaki Sakisaka. (2011) Dual Regulation of RA-RhoGAP Activity by Phosphatidic Acid and Rap1 during Neurite Outgrowth. Journal of Biological Chemistry 286:8, pages 6832-6843.
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