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Molecular and Cellular Biology Volume 28, 2008 - Issue 21
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Article

Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master Regulators of Hematopoiesis

Ryan J. Wozniak1 Departments of Pharmacology
,
Sunduz Keles2 Biostatistics and Medical Bioinformatics;3 Statistics
,
Jesse J. Lugus5 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri63110
,
Ken H. Young4 Pathology, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, Wisconsin53706
,
Meghan E. Boyer1 Departments of Pharmacology
,
Tuan M. Tran1 Departments of Pharmacology
,
Kyunghee Choi5 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri63110
&
Emery H. Bresnick1 Departments of PharmacologyCorrespondence[email protected]
 show all
Pages 6681-6694 | Received 08 Jul 2008, Accepted 28 Aug 2008, Published online: 27 Mar 2023

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G. Celine Han, Vinesh Vinayachandran, Alain R. Bataille, Bongsoo Park, Ka Yim Chan-Salis, Cheryl A. Keller, Maria Long, Shaun Mahony, Ross C. Hardison & B. Franklin Pugh. (2016) Genome-Wide Organization of GATA1 and TAL1 Determined at High Resolution. Molecular and Cellular Biology 36:1, pages 157-172.
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Andrew W. DeVilbiss, Rajendran Sanalkumar, Bryan D. R. Hall, Koichi R. Katsumura, Isabela Fraga de Andrade & Emery H. Bresnick. (2015) Epigenetic Determinants of Erythropoiesis: Role of the Histone Methyltransferase SetD8 in Promoting Erythroid Cell Maturation and Survival. Molecular and Cellular Biology 35:12, pages 2073-2087.
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Shin'ya Ohmori, Jun Takai, Yasushi Ishijima, Mikiko Suzuki, Takashi Moriguchi, Sjaak Philipsen, Masayuki Yamamoto & Kinuko Ohneda. (2012) Regulation of GATA Factor Expression Is Distinct between Erythroid and Mast Cell Lineages. Molecular and Cellular Biology 32:23, pages 4742-4755.
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Charu Mehta, Isabela Fraga de Andrade, Daniel R Matson, Colin N Dewey & Emery H Bresnick. (2021) RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis. Nucleic Acids Research 49:16, pages 9007-9025.
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Crossref
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Crossref
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Crossref
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Crossref
Vijay G. Sankaran, Jian Xu & Stuart H. Orkin. (2010) Advances in the understanding of haemoglobin switching. British Journal of Haematology 149:2, pages 181-194.
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