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Article

IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400

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Pages 4684-4690 | Received 03 Aug 2012, Accepted 10 Sep 2012, Published online: 20 Mar 2023

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Teneema Kuriakose, Balázs Rada & Wendy T. Watford. (2014) Tumor Progression Locus 2-dependent Oxidative Burst Drives Phosphorylation of Extracellular Signal-regulated Kinase during TLR3 and 9 Signaling. Journal of Biological Chemistry 289:52, pages 36089-36100.
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Kazuhiro Iwai, Hiroaki Fujita & Yoshiteru Sasaki. (2014) Linear ubiquitin chains: NF-κB signalling, cell death and beyond. Nature Reviews Molecular Cell Biology 15:8, pages 503-508.
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