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Molecular and Cellular Biology Volume 34, 2014 - Issue 24
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Article

Genetic Dissection of the Vav2-Rac1 Signaling Axis in Vascular Smooth Muscle Cells

Salvatore Fabbianoa Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain;b Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain
,
Mauricio Menacho-Márqueza Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain;b Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain
,
María A. Sevillac Departamento de Fisiología y Farmacología, University of Salamanca, Campus Unamuno, Salamanca, Spain
,
Julián Albarrán-Juárezd Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
,
Yi Zhenge Division of Experimental Hematology and Cancer Biology, Children's Hospital Research Foundation, Cincinnati, Ohio, USA
,
Stefan Offermannsd Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
,
María J. Monteroc Departamento de Fisiología y Farmacología, University of Salamanca, Campus Unamuno, Salamanca, Spain
&
Xosé R. Busteloa Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain;b Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9398-6072
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Pages 4404-4419 | Received 18 Aug 2014, Accepted 26 Sep 2014, Published online: 20 Mar 2023

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Xosé R Bustelo. (2014) Vav family exchange factors: an integrated regulatory and functional view. Small GTPases 5:2.
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L. Francisco Lorenzo-Martín, Mauricio Menacho-Márquez, Natalia Fernández-Parejo, Sonia Rodríguez-Fdez, Gloria Pascual, Antonio Abad, Piero Crespo, Mercedes Dosil, Salvador A. Benitah & Xosé R. Bustelo. (2022) The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function. Oncogene 41:24, pages 3341-3354.
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Sonia Rodríguez-Fdez & Xosé R. Bustelo. (2021) Rho GTPases in Skeletal Muscle Development and Homeostasis. Cells 10:11, pages 2984.
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Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Salvatore Fabbiano, Mauricio Menacho-Márquez, Vincent Sauzeau, Mercedes Dosil & Xosé R. Bustelo. (2021) New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System. Biology 10:9, pages 857.
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L. E. Anselmino, M. V. Baglioni, F. Malizia, N. Cesatti Laluce, C. Borini Etichetti, V. L. Martínez Marignac, V. Rozados, O. G. Scharovsky, J. Girardini, M. J. Rico & M. Menacho Márquez. (2021) Repositioning metformin and propranolol for colorectal and triple negative breast cancers treatment. Scientific Reports 11:1.
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Bo Chen, Aiping Hou, Lin Zhao, Ying Liu, Xin Shi, Bowen Du, Yu Yu, Pengjun Zhao & Ying Gao. (2020) Next Generation Sequencing Identify Rare Copy Number Variants in Non-syndromic Patent Ductus Arteriosus. Frontiers in Genetics 11.
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L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Mauricio Menacho-Márquez, Sonia Rodríguez-Fdez, Javier Robles-Valero, Sonia Zumalave, Salvatore Fabbiano, Gloria Pascual, Juana M. García-Pedrero, Antonio Abad, María C. García-Macías, Nazareno González, Pablo Lorenzano-Menna, Miguel A. Pavón, Rogelio González-Sarmiento, Carmen Segrelles, Jesús M. Paramio, José M. C. Tubío, Juan P. Rodrigo, Salvador A. Benitah, Myriam Cuadrado & Xosé R. Bustelo. (2020) VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Nature Communications 11:1.
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Luis Francisco Lorenzo-Martín, Mauricio Menacho-Márquez & Xosé R. Bustelo. (2020) Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer. Cancers 12:9, pages 2498.
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L. Francisco Lorenzo-Martín, Sonia Rodríguez-Fdez, Salvatore Fabbiano, Antonio Abad, María C. García-Macías, Mercedes Dosil, Myriam Cuadrado, Javier Robles-Valero & Xosé R. Bustelo. (2020) Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor. Oncogene 39:28, pages 5098-5111.
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David NgaiMarsel LinoKatheryn E. RothenbergCraig A. SimmonsRodrigo Fernandez-GonzalezMichelle P. Bendeck. (2020) DDR1 (Discoidin Domain Receptor-1)-RhoA (Ras Homolog Family Member A) Axis Senses Matrix Stiffness to Promote Vascular Calcification. Arteriosclerosis, Thrombosis, and Vascular Biology 40:7, pages 1763-1776.
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Xin Shi, Tao Huang, Jing Wang, Yulai Liang, Chang Gu, Yuejuan Xu, Jing Sun, Yanan Lu, Kun Sun, Sun Chen & Yu Yu. (2018) Next-generation sequencing identifies novel genes with rare variants in total anomalous pulmonary venous connection. eBioMedicine 38, pages 217-227.
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Gwennan André-Grégoire, Florian Dilasser, Julie Chesné, Faouzi Braza, Antoine Magnan, Gervaise Loirand & Vincent Sauzeau. (2018) Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness. Journal of Allergy and Clinical Immunology 142:3, pages 824-833.e3.
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Vijaya KaroorMehdi A. FiniZoe LoomisTimothy SullivanLouis B. HershEvgenia GerasimovskayaDavid IrwinEdward C. Dempsey. (2018) Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arteriosclerosis, Thrombosis, and Vascular Biology 38:1, pages 154-163.
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Nikhlesh K. Singh, Jagadeesh Janjanam & Gadiparthi N. Rao. (2017) p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine–induced vascular smooth muscle cell migration and proliferation. Journal of Biological Chemistry 292:34, pages 14080-14091.
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María Rico, María Baglioni, Maryna Bondarenko, Nahuel Cesatti Laluce, Viviana Rozados, Nicolas André, Manon Carré, O. Graciela Scharovsky & Mauricio Menacho Márquez. (2016) Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. Oncotarget 8:2, pages 2874-2889.
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Lauren Porter, Mark Holt, Daniel Soong, Catherine Shanahan & Derek Warren. (2016) Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells. Cells 5:4, pages 41.
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Chien-Yu Cho, Kuo-Ting Lee, Wei-Ching Chen, Chih-Yang Wang, Yung-Sheng Chang, Hau-Lun Huang, Hui-Ping Hsu, Meng-Chi Yen, Ming-Zong Lai & Ming-Derg Lai. (2016) MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer. Oncotarget 7:12, pages 14586-14604.
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