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Molecular and Cellular Biology Volume 34, 2014 - Issue 9
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Article

Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis

Anatoly A. SoshilovDepartment of Environmental Toxicology, University of California, Davis, California, USA
&
Michael S. DenisonDepartment of Environmental Toxicology, University of California, Davis, California, USACorrespondence[email protected]
Pages 1707-1719 | Received 09 Sep 2013, Accepted 21 Feb 2014, Published online: 20 Mar 2023

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Martha Cecilia Rosales-Hernández, Martiniano Bello, Jazziel Velazquez Toledano, Barbara Citlali Escudero Feregrino, José Correa Basurto, Leticia Guadalupe Fragoso Morales & Mónica Adriana Torres-Ramos. (2023) Molecular dynamics simulations depict structural motions of the whole human aryl hydrocarbon receptor influencing its binding of ligands and HSP90. Journal of Biomolecular Structure and Dynamics 41:22, pages 13138-13153.
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Crossref
Kumaraswamy Naidu Chitrala, Xiaoming Yang, Prakash Nagarkatti & Mitzi Nagarkatti. (2018) Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study. BMC Structural Biology 18:1.
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Rossella Di Giaimo, Tamara Durovic, Pablo Barquin, Anita Kociaj, Tjasa Lepko, Sven Aschenbroich, Christopher T. Breunig, Martin Irmler, Filippo M. Cernilogar, Gunnar Schotta, Joana S. Barbosa, Dietrich Trümbach, Emily Violette Baumgart, Andrea M. Neuner, Johannes Beckers, Wolfgang Wurst, Stefan H. Stricker & Jovica Ninkovic. (2018) The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis. Cell Reports 25:12, pages 3241-3251.e5.
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Kristin Bianchini & Christy A. Morrissey. (2018) Assessment of Shorebird Migratory Fueling Physiology and Departure Timing in Relation to Polycyclic Aromatic Hydrocarbon Contamination in the Gulf of Mexico. Environmental Science & Technology 52:22, pages 13562-13573.
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Crossref
Stephen Safe, Huajun Han, Jennifer Goldsby, Kumaravel Mohankumar & Robert S. Chapkin. (2018) Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies. Current Opinion in Toxicology 11-12, pages 10-20.
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Crossref
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Crossref
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Crossref
Lisbeth A. Boule, Catherine G. Burke, Guang-Bi Jin & B. Paige Lawrence. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Scientific Reports 8:1.
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Crossref
C-I Ko & A Puga. 2018. Comprehensive Toxicology. Comprehensive Toxicology 101 124 .
Aditya D. Joshi, Ekram Hossain & Cornelis J. Elferink. (2017) Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression. Molecular Pharmacology 92:3, pages 366-374.
Crossref
Zdenek Dvorak. (2017) Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation. Food and Chemical Toxicology 107, pages 523-525.
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Benjamin J. Moyer, Itzel Y. Rojas, Joanna S. Kerley-Hamilton, Krishnamurthy V. Nemani, Heidi W. Trask, Carol S. Ringelberg, Barjor Gimi, Eugene Demidenko & Craig R. Tomlinson. (2017) Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice. Nutrition Research 44, pages 38-50.
Crossref
Daniel W. Nebert. (2017) Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per - Arnt - sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals. Progress in Lipid Research 67, pages 38-57.
Crossref
Siva Kumar Kolluri, Un-Ho Jin & Stephen Safe. (2017) Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology 91:7, pages 2497-2513.
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Crossref
Sarah Kado, W. L. William Chang, Aimy Nguyen Chi, Monika Wolny, David M. Shepherd & Christoph F. A. Vogel. (2016) Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells. Archives of Toxicology 91:5, pages 2209-2221.
Crossref
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Crossref
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Crossref
Stephen Safe, Yating Cheng & Un-Ho Jin. (2017) The aryl hydrocarbon receptor (AhR) as a drug target for cancer chemotherapy. Current Opinion in Toxicology 2, pages 24-29.
Crossref
Michael S. Denison & Samantha C. Faber. (2017) And now for something completely different: Diversity in ligand-dependent activation of Ah receptor responses. Current Opinion in Toxicology 2, pages 124-131.
Crossref
Majorie B.M. van Duursen, Karin I. van Ede & Martin van den Berg. (2017) One TEF concept does not fit all: The case for human risk assessment of polychlorinated biphenyls. Current Opinion in Toxicology 2, pages 103-108.
Crossref
Saimi Tokunaga, Bruce R. Woodin & John J. Stegeman. (2016) Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities. Food and Chemical Toxicology 96, pages 160-166.
Crossref
Dario Corrada, Anatoly A. Soshilov, Michael S. Denison & Laura Bonati. (2016) Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation. PLOS Computational Biology 12:6, pages e1004981.
Crossref
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Crossref
Emma Wincent, Akira Kubota, Alicia Timme-Laragy, Maria E. Jönsson, Mark E. Hahn & John J. Stegeman. (2016) Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochemical Pharmacology 110-111, pages 117-129.
Crossref
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Crossref
Dániel Szöllősi, Áron Erdei, Gergely Gyimesi, Csaba Magyar & Tamás Hegedűs. (2016) Access Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhR. PLOS ONE 11:1, pages e0146066.
Crossref
Maria E. Jönsson, Anna Mattsson, Siraz Shaik & Björn Brunström. (2016) Toxicity and cytochrome P450 1A mRNA induction by 6-formylindolo[3,2- b ]carbazole (FICZ) in chicken and Japanese quail embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 179, pages 125-136.
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Rebecca Justiniano & Georg T. Wondrak. 2016. Skin Stress Response Pathways. Skin Stress Response Pathways 325 359 .
Jennifer C. Brennan, Guochun He, Tomoaki Tsutsumi, Jing Zhao, Edward Wirth, Michael H. Fulton & Michael S. Denison. (2015) Development of Species-Specific Ah Receptor-Responsive Third Generation CALUX Cell Lines with Enhanced Responsiveness and Improved Detection Limits. Environmental Science & Technology 49:19, pages 11903-11912.
Crossref
B. C. Goodale, J. La Du, S. C. Tilton, C. M. Sullivan, W. H. Bisson, K. M. Waters & R. L. Tanguay. (2015) Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs. Toxicological Sciences 147:2, pages 397-411.
Crossref
Ekaterina A. Korobkova. (2015) Effect of Natural Polyphenols on CYP Metabolism: Implications for Diseases. Chemical Research in Toxicology 28:7, pages 1359-1390.
Crossref
Jenny Shoots, Domenico Fraccalvieri, Diana G. Franks, Michael S. Denison, Mark E. Hahn, Laura Bonati & Wade H. Powell. (2015) An Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo -p -dioxin . Environmental Science & Technology 49:11, pages 6993-7001.
Crossref
Charlotte Esser & Agneta Rannug. (2015) The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology. Pharmacological Reviews 67:2, pages 259-279.
Crossref
Emma Wincent, John J. Stegeman & Maria E. Jönsson. (2015) Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. Toxicology and Applied Pharmacology 284:2, pages 163-179.
Crossref
Roberto Nuti, Marco Gargaro, Davide Matino, Daniela Dolciami, Ursula Grohmann, Paolo Puccetti, Francesca Fallarino & Antonio Macchiarulo. (2014) Ligand Binding and Functional Selectivity of l -Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) . Journal of Chemical Information and Modeling 54:12, pages 3373-3383.
Crossref
Arden Perkins, Jessica Phillips, Nancy Kerkvliet, Robert Tanguay, Gary Perdew, Siva Kolluri & William Bisson. (2014) A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain. Biology 3:4, pages 645-669.
Crossref

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