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Molecular and Cellular Biology Volume 26, 2006 - Issue 23

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Ca²⁺/Calmodulin Kinase Kinase α Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice

Keiko Mizuno1 Wolfson Institute for Biomedical Research, University College London, LondonWC1E 6BT, United Kingdom

Laurence Ris2 Department of Neurosciences, University of Mons—Hainaut, 7000Mons, Belgium

Amelia Sánchez-Capelo1 Wolfson Institute for Biomedical Research, University College London, LondonWC1E 6BT, United Kingdom

Emile Godaux2 Department of Neurosciences, University of Mons—Hainaut, 7000Mons, Belgium

K. Peter Giese1 Wolfson Institute for Biomedical Research, University College London, LondonWC1E 6BT, United KingdomCorrespondence[email protected]

Pages 9094-9104 | Received 06 Jul 2006, Accepted 18 Sep 2006, Published online: 27 Mar 2023

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https://doi.org/10.1128/MCB.01221-06

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Ashley A. Keiser & Marcelo A. Wood. (2019) Examining the contribution of histone modification to sex differences in learning and memory. Learning & Memory 26:9, pages 318-331.
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Kevin K. Caldwell, Elizabeth R. Solomon, Jane J.W. Smoake, Chrys D. Djatche de Kamgaing & Andrea M. Allan. (2018) Sex-specific deficits in biochemical but not behavioral responses to delay fear conditioning in prenatal alcohol exposure mice. Neurobiology of Learning and Memory 156, pages 1-16.
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Da Chen, Fangming Zhong & Ye Chen. (2017) Association of calcium/calmodulin-dependent protein kinase kinase1 rs7214723 polymorphism with lung cancer risk in a Chinese population. Bioscience Reports 37:4.
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James Dachtler & Kevin Fox. (2017) Do cortical plasticity mechanisms differ between males and females?. Journal of Neuroscience Research 95:1-2, pages 518-526.
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Ashley A Keiser, Lacie M Turnbull, Mara A Darian, Dana E Feldman, Iris Song & Natalie C Tronson. (2016) Sex Differences in Context Fear Generalization and Recruitment of Hippocampus and Amygdala during Retrieval. Neuropsychopharmacology 42:2, pages 397-407.
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Snehajyoti Chatterjee & Ted Abel. 2017. Learning and Memory: A Comprehensive Reference. Learning and Memory: A Comprehensive Reference 329 343 .

Kathrina L. Marcelo, Anthony R. Means & Brian York. (2016) The Ca 2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft. Trends in Endocrinology & Metabolism 27:10, pages 706-718.
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Ashley A. Keiser & Natalie C. Tronson. 2016. Sex Differences in the Central Nervous System. Sex Differences in the Central Nervous System 27 51 .

Brett A. Simms, Ivana A. Souza, Renata Rehak & Gerald W. Zamponi. (2014) The Cav1.2 N terminus contains a CaM kinase site that modulates channel trafficking and function. Pflügers Archiv - European Journal of Physiology 467:4, pages 677-686.
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Lin Liu, Louise McCullough & Jun Li. (2014) Genetic deletion of calcium/calmodulin-dependent protein kinase kinase β (CaMKK β) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice. BMC Neuroscience 15:1.
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Karl Peter Giese & Keiko Mizuno. (2013) The roles of protein kinases in learning and memory. Learning & Memory 20:10, pages 540-552.
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Luigi Racioppi & Anthony R. Means. (2012) Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology. Journal of Biological Chemistry 287:38, pages 31658-31665.
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K. Mizuno, E. Dempster, J. Mill & K. P. Giese. (2012) Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes, Brain and Behavior 11:6, pages 651-659.
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Chris J. Tinsley, Katherine E. Narduzzo, Malcolm W. Brown & E. Clea Warburton. (2012) A role for the CAMKK pathway in visual object recognition memory. Hippocampus 22:3, pages 466-476.
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Subimal Datta, Matthew W. O'Malley & Elissa H. Patterson. (2011) Calcium/Calmodulin Kinase II in the Pedunculopontine Tegmental Nucleus Modulates the Initiation and Maintenance of Wakefulness. The Journal of Neuroscience 31:47, pages 17007-17016.
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Taku Kaitsuka, Sheng-Tian Li, Kenji Nakamura, Keizo Takao, Tsuyoshi Miyakawa & Masayuki Matsushita. (2011) Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory. Neurobiology of Learning and Memory 96:2, pages 238-247.
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Michelle F. Green, John W. Scott, Rohan Steel, Jonathan S. Oakhill, Bruce E. Kemp & Anthony R. Means. (2011) Ca2+/Calmodulin-dependent Protein Kinase Kinase β Is Regulated by Multisite Phosphorylation. Journal of Biological Chemistry 286:32, pages 28066-28079.
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Renée J. Turner, Cheryl D. Bushnell, Thomas C. Register & Frank R. Sharp. (2011) Gender-Dependent Correlations of Carotid Intima–Media Thickness with Gene Expression in Blood. Translational Stroke Research 2:2, pages 171-178.
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Josh D. Hawk & Ted Abel. (2011) The role of NR4A transcription factors in memory formation. Brain Research Bulletin 85:1-2, pages 21-29.
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Franck Oury, Vijay K. Yadav, Ying Wang, Bin Zhou, X. Sherry Liu, X. Edward Guo, Laurence H. Tecott, Günther Schutz, Anthony R. Means & Gerard Karsenty. (2010) CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes & Development 24:20, pages 2330-2342.
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Sayaka Takemoto-Kimura, Kanzo Suzuki, Satoshi Kamijo, Natsumi Ageta-Ishihara, Hajime Fujii, Hiroyuki Okuno & Haruhiko Bito. (2010) Differential roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits. European Journal of Neuroscience 32:2, pages 224-230.
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Keiko Mizuno & K. Peter Giese. (2010) Towards a molecular understanding of sex differences in memory formation. Trends in Neurosciences 33:6, pages 285-291.
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Karl Peter Giese. (2009) GSK-3: A key player in neurodegeneration and memory. IUBMB Life 61:5, pages 516-521.
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Gary A. Wayman, Yong-Seok Lee, Hiroshi Tokumitsu, Alcino Silva & Thomas R. Soderling. (2008) Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity. Neuron 59:6, pages 914-931.
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Long-Jun Wu, Xue-Han Zhang, Hotaka Fukushima, Fuxing Zhang, Hansen Wang, Hiroki Toyoda, Bao-Ming Li, Satoshi Kida & Min Zhuo. (2008) Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca 2+ /calmodulin-dependent protein kinase IV . European Journal of Neuroscience 27:8, pages 1923-1932.
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Tomohito FujimotoSaki YurimotoNaoya HatanoNaohito NozakiNoriyuki SueyoshiIsamu KameshitaAkihiro MizutaniKatsuhiko MikoshibaRyoji KobayashiHiroshi Tokumitsu. (2008) Activation of SAD Kinase by Ca 2+ /Calmodulin-Dependent Protein Kinase Kinase . Biochemistry 47:13, pages 4151-4159.
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Ana Antunes-Martins, Keiko Mizuno, Elaine E. Irvine, Eve M. Lepicard & K. Peter Giese. (2007) Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation. Learning & Memory 14:10, pages 693-702.
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Akifumi Kamata, Hiroyuki Sakagami, Hiroshi Tokumitsu, Masashi Sanda, Yuji Owada, Kohji Fukunaga & Hisatake Kondo. (2007) Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formation. Neuroscience Letters 423:2, pages 143-148.
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K. Mizuno, A. Antunes-Martins, L. Ris, M. Peters, E. Godaux & K.P. Giese. (2007) Calcium/calmodulin kinase kinase β has a male-specific role in memory formation. Neuroscience 145:2, pages 393-402.
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Victor A. Derkach, Michael C. Oh, Eric S. Guire & Thomas R. Soderling. (2007) Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nature Reviews Neuroscience 8:2, pages 101-113.
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J. COLOMER & A.R. MEANS. 2007. Calcium Signalling and Disease. Calcium Signalling and Disease 169 214 .

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Ca²⁺/Calmodulin Kinase Kinase α Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice

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Ca2+/Calmodulin Kinase Kinase α Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice

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Ca²⁺/Calmodulin Kinase Kinase α Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice