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Article

Mechanism of R-Loop Formation at Immunoglobulin Class Switch Sequences

Deepankar RoyUSC Norris Comprehensive Cancer Ctr., Rm. 5428, and Departments of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Biological Sciences, University of Southern California Keck School of Medicine, 1441 Eastlake Ave., MC9176, Los Angeles, California90089-9176
,
Kefei YuUSC Norris Comprehensive Cancer Ctr., Rm. 5428, and Departments of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Biological Sciences, University of Southern California Keck School of Medicine, 1441 Eastlake Ave., MC9176, Los Angeles, California90089-9176
&
Michael R. LieberUSC Norris Comprehensive Cancer Ctr., Rm. 5428, and Departments of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Biological Sciences, University of Southern California Keck School of Medicine, 1441 Eastlake Ave., MC9176, Los Angeles, California90089-9176Correspondence[email protected]
Pages 50-60 | Received 12 Jul 2007, Accepted 09 Oct 2007, Published online: 27 Mar 2023

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Eric J. Wigton & K. Mark Ansel. (2021) Noncoding RNAs in B cell responses. RNA Biology 18:5, pages 633-639.
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Kefei Yu & Michael R. Lieber. (2019) Current insights into the mechanism of mammalian immunoglobulin class switch recombination. Critical Reviews in Biochemistry and Molecular Biology 54:4, pages 333-351.
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Amanda C. Hall, Lauren A. Ostrowski, Violena Pietrobon & Karim Mekhail. (2017) Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes. Nucleus 8:2, pages 162-181.
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J Gowrishankar, J Krishna Leela & K Anupama. (2013) R-loops in bacterial transcription. Transcription 4:4, pages 153-157.
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Jianbo Sun, Gerson Rothschild, Evangelos Pefanis & Uttiya Basu. (2013) Transcriptional stalling in B-lymphocytes. Transcription 4:3, pages 127-135.
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Yunfu Lin & John H. Wilson. (2011) Transcription-induced DNA toxicity at trinucleotide repeats. Cell Cycle 10:4, pages 611-618.
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Ana Maria Poveda, Mikael Le Clech & Philippe Pasero. (2010) Transcription and replication. Transcription 1:2, pages 99-102.
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Elizabeth I. McIvor, Urszula Polak & Marek Napierala. (2010) New insights into repeat instability. RNA Biology 7:5, pages 551-558.
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Deepankar Roy, Zheng Zhang, Zhengfei Lu, Chih-Lin Hsieh & Michael R. Lieber. (2010) Competition between the RNA Transcript and the Nontemplate DNA Strand during R-Loop Formation In Vitro: a Nick Can Serve as a Strong R-Loop Initiation Site. Molecular and Cellular Biology 30:1, pages 146-159.
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Deepankar Roy & Michael R. Lieber. (2009) G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter. Molecular and Cellular Biology 29:11, pages 3124-3133.
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Yi Gong & Yie Liu. (2023) R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular Consequence. Cancers 15:7, pages 2178.
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Natalie Laspata, Parminder Kaur, Sofiane Yacine Mersaoui, Daniela Muoio, Zhiyan Silvia Liu, Maxwell Henry Bannister, Hai Dang Nguyen, Caroline Curry, John M Pascal, Guy G Poirier, Hong Wang, Jean-Yves Masson & Elise Fouquerel. (2023) PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Research 51:5, pages 2215-2237.
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Samuel Jianjie Yeo, Chen Ying, Melissa Jane Fullwood & Vinay Tergaonkar. (2023) Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains. Trends in Genetics 39:3, pages 217-232.
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Hongchang Zhao, Stella R Hartono, Kirtney Mae Flores de Vera, Zheyuan Yu, Krishni Satchi, Tracy Zhao, Roger Sciammas, Lionel Sanz, Frédéric Chédin & Jacqueline Barlow. (2022) Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination. eLife 11.
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Charlotte Hodson, Sylvie van Twest, Malgorzata Dylewska, Julienne J. O’Rourke, Winnie Tan, Vincent J. Murphy, Mannu Walia, Lara Abbouche, Jadwiga Nieminuszczy, Elyse Dunn, Rohan Bythell-Douglas, Jörg Heierhorst, Wojciech Niedzwiedz & Andrew J. Deans. (2022) Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal. Cell Reports 41:10, pages 111749.
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Na Young Cheon, Subin Kim & Ja Yil Lee. 2022. Gene Expression. Gene Expression.
Yujin Kang, Soyeong An, Duyoung Min & Ja Yil Lee. (2022) Single-molecule fluorescence imaging techniques reveal molecular mechanisms underlying deoxyribonucleic acid damage repair. Frontiers in Bioengineering and Biotechnology 10.
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Boris P. Belotserkovskii & Philip C. Hanawalt. (2022) Topology and kinetics of R-loop formation. Biophysical Journal 121:18, pages 3345-3357.
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Ryan P. Mackay, Paul M. Weinberger, John A. Copland, Elahe Mahdavian & Qinqin Xu. (2022) YM155 Induces DNA Damage and Cell Death in Anaplastic Thyroid Cancer Cells by Inhibiting DNA Topoisomerase IIα at the ATP-Binding Site. Molecular Cancer Therapeutics 21:6, pages 925-935.
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Xiping Zhang, Mengdie Yin & Jinchuan Hu. (2022) Nucleotide excision repair: a versatile and smart toolkit. Acta Biochimica et Biophysica Sinica 54:6, pages 807-819.
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Catherine Tang, Artem Krantsevich & Thomas MacCarthy. (2022) Deep learning model of somatic hypermutation reveals importance of sequence context beyond hotspot targeting. iScience 25:1, pages 103668.
Crossref
Xuan Zhang, Yajing Hao & Xiang-Dong Fu. 2022. R-Loops. R-Loops 359 372 .
Emmanuel Odame, Yuan Chen, Shuailong Zheng, Dinghui Dai, Bismark Kyei, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li & Hongping Zhang. (2021) Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis. Cellular & Molecular Biology Letters 26:1.
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Arum Kim & Gang Greg Wang. (2021) R-loop and its functions at the regulatory interfaces between transcription and (epi)genome. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1864:11-12, pages 194750.
Crossref
Frédéric Chédin, Stella R Hartono, Lionel A Sanz & Vincent Vanoosthuyse. (2021) Best practices for the visualization, mapping, and manipulation of R‐loops. The EMBO Journal 40:4.
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IA Zanyatkin, AG Titova & AV Bayov. (2021) Modern methods for analysis of changes to epigenetic landscape caused by exposure to environmental pollutants. Medicine of Extreme Situations:(1)2021.
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Natas̆a Jonoska, Nida Obatake, Svetlana Poznanović, Candice Price, Manda Riehl & Mariel Vazquez. 2021. Using Mathematics to Understand Biological Complexity. Using Mathematics to Understand Biological Complexity 35 54 .
Justin J. King & Mani Larijani. (2020) Structural plasticity of substrate selection by activation‐induced cytidine deaminase as a regulator of its genome‐wide mutagenic activity. FEBS Letters 595:1, pages 3-13.
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Helene M. Gylling, Cristina Gonzalez-Aguilera, Martin A. Smith, Dominik C. Kaczorowski, Anja Groth & Anders H. Lund. (2020) Repeat RNAs associate with replication forks and post-replicative DNA. RNA 26:9, pages 1104-1117.
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Arijit Dutta, Robert Hromas & Patrick Sung. 2020. Amyotrophic Lateral Sclerosis - Recent Advances and Therapeutic Challenges. Amyotrophic Lateral Sclerosis - Recent Advances and Therapeutic Challenges.
Arpita Saha, Vishal P. Nanavaty & Bibo Li. (2020) Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes. Journal of Molecular Biology 432:15, pages 4167-4185.
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Sangin Kim, Nalae Kang, Su Hyung Park, James Wells, Taejoo Hwang, Eunjin Ryu, Byung-gyu Kim, Sunyoung Hwang, Seong-jung Kim, Sukhyun Kang, Semin Lee, Peter Stirling, Kyungjae Myung & Kyoo-young Lee. (2020) ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork. Nucleic Acids Research.
Crossref
Prasun Chakraborty. (2020) New insight into the biology of R-loops. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 821, pages 111711.
Crossref
Thidathip Wongsurawat, Arundhati Gupta, Piroon Jenjaroenpun, Shana Owens, James Craig Forrest & Intawat Nookaew. (2020) R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses. Scientific Reports 10:1.
Crossref
Frederic Chedin & Craig J. Benham. (2020) Emerging roles for R-loop structures in the management of topological stress. Journal of Biological Chemistry 295:14, pages 4684-4695.
Crossref
Alessandra Brambati, Luca Zardoni, Eleonora Nardini, Achille Pellicioli & Giordano Liberi. (2020) The dark side of RNA:DNA hybrids. Mutation Research/Reviews in Mutation Research 784, pages 108300.
Crossref
Lekha Nair, Hachung Chung & Uttiya Basu. (2020) Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery. Nature Reviews Molecular Cell Biology 21:3, pages 123-136.
Crossref
Maika Malig, Stella R. Hartono, Jenna M. Giafaglione, Lionel A. Sanz & Frederic Chedin. (2020) Ultra-deep Coverage Single-molecule R-loop Footprinting Reveals Principles of R-loop Formation. Journal of Molecular Biology 432:7, pages 2271-2288.
Crossref
Rachel J. O’Neill. (2020) Seq’ing identity and function in a repeat-derived noncoding RNA world. Chromosome Research 28:1, pages 111-127.
Crossref
Julien Brochu, Émilie-Vlachos Breton & Marc Drolet. (2020) Supercoiling, R-Loops, Replication and the Functions of Bacterial Type 1A Topoisomerases. Genes 11:3, pages 249.
Crossref
Irina V. Grishchenko, Yana V. Purvinsh & Dmitry V. Yudkin. 2020. Mechanisms of Genome Protection and Repair. Mechanisms of Genome Protection and Repair 101 124 .
Boris P. Belotserkovskii, Sum-yan Ng & Philip C. Hanawalt. 2020. Peptide Nucleic Acids. Peptide Nucleic Acids 141 155 .
Marc Drolet & Julien Brochu. (2019) R-loop-dependent replication and genomic instability in bacteria. DNA Repair 84, pages 102693.
Crossref
Qingqing Yan, Emily J. Shields, Roberto Bonasio & Kavitha Sarma. (2019) Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach. Cell Reports 29:5, pages 1369-1380.e5.
Crossref
Nayun Kim. (2019) The Interplay between G-quadruplex and Transcription. Current Medicinal Chemistry 26:16, pages 2898-2917.
Crossref
Yeraldinne Carrasco-Salas, Amélie Malapert, Shaheen Sulthana, Bastien Molcrette, Léa Chazot-Franguiadakis, Pascal Bernard, Frédéric Chédin, Cendrine Faivre-Moskalenko & Vincent Vanoosthuyse. (2019) The extruded non-template strand determines the architecture of R-loops. Nucleic Acids Research 47:13, pages 6783-6795.
Crossref
Jia-Yu Chen, Xuan Zhang, Xiang-Dong Fu & Liang Chen. (2019) R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1. Nature Protocols 14:5, pages 1661-1685.
Crossref
Robert StolzShaheen SulthanaStella R. HartonoMaika MaligCraig J. Benham & Frederic Chedin. (2019) Interplay between DNA sequence and negative superhelicity drives R-loop structures. Proceedings of the National Academy of Sciences 116:13, pages 6260-6269.
Crossref
Boris P. Belotserkovskii, Silvia Tornaletti, Alicia D. D’Souza & Philip C. Hanawalt. (2018) R-loop generation during transcription: Formation, processing and cellular outcomes. DNA Repair 71, pages 69-81.
Crossref
Vladimir A Kuznetsov, Vladyslav Bondarenko, Thidathip Wongsurawat, Surya P Yenamandra & Piroon Jenjaroenpun. (2018) Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers. Nucleic Acids Research 46:15, pages 7566-7585.
Crossref
Svend Petersen‐Mahrt, Silvestro Conticello & Uday Munagala. 2001. eLS. eLS 1 12 .
Claudia Ribeiro de Almeida, Somdutta Dhir, Ashish Dhir, Amin E. Moghaddam, Quentin Sattentau, Anton Meinhart & Nicholas J. Proudfoot. (2018) RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Molecular Cell 70:4, pages 650-662.e8.
Crossref
Alicia D. D'Souza, Boris P. Belotserkovskii & Philip C. Hanawalt. (2018) A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1861:2, pages 158-166.
Crossref
Makisha Martel, Aurélien Balleydier, Julien Brochu & Marc Drolet. 2018. DNA Topoisomerases. DNA Topoisomerases 131 138 .
Nicholas R. Pannunzio & Michael R. Lieber. (2017) AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones. Molecular Cell 68:5, pages 901-912.e3.
Crossref
Liang Chen, Jia-Yu Chen, Xuan Zhang, Ying Gu, Rui Xiao, Changwei Shao, Peng Tang, Hao Qian, Daji Luo, Hairi Li, Yu Zhou, Dong-Er Zhang & Xiang-Dong Fu. (2017) R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters. Molecular Cell 68:4, pages 745-757.e5.
Crossref
Ke-wei Zheng, Yi-de He, Hong-he Liu, Xin-min Li, Yu-hua Hao & Zheng Tan. (2017) Superhelicity Constrains a Localized and R-Loop-Dependent Formation of G-Quadruplexes at the Upstream Region of Transcription. ACS Chemical Biology 12:10, pages 2609-2618.
Crossref
Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Waheba Elsayed, Vera Lukashchuk, Shih-Chieh Chiang, Swagat Ray, Padraig J Mulcahy, Mateusz Jurga, Ioannis Tsagakis, Tommaso Iannitti, Jayanth Chandran, Ian Coldicott, Kurt J De Vos, Mohamed K Hassan, Adrian Higginbottom, Pamela J Shaw, Guillaume M Hautbergue, Mimoun Azzouz & Sherif F El-Khamisy. (2017) C9orf72 expansion disrupts ATM-mediated chromosomal break repair. Nature Neuroscience 20:9, pages 1225-1235.
Crossref
Nayun Kim & Sue Jinks-Robertson. (2017) The Top1 paradox: Friend and foe of the eukaryotic genome. DNA Repair 56, pages 33-41.
Crossref
Boris P. Belotserkovskii, Jane Hae Soo Shin & Philip C. Hanawalt. (2017) Strong transcription blockage mediated by R-loop formation within a G-rich homopurine–homopyrimidine sequence localized in the vicinity of the promoter. Nucleic Acids Research 45:11, pages 6589-6599.
Crossref
Rushad Pavri. (2017) R Loops in the Regulation of Antibody Gene Diversification. Genes 8:6, pages 154.
Crossref
William T. Yewdell & Jayanta Chaudhuri. (2017) A transcriptional serenAID: the role of noncoding RNAs in class switch recombination. International Immunology 29:4, pages 183-196.
Crossref
Piroon Jenjaroenpun, Thidathip Wongsurawat, Sawannee Sutheeworapong & Vladimir A. Kuznetsov. (2017) R-loopDB: a database for R-loop forming sequences (RLFS) and R-loops. Nucleic Acids Research 45:D1, pages D119-D127.
Crossref
Wenyi Feng. (2016) Mec1/ATR, the Program Manager of Nucleic Acids Inc.. Genes 8:1, pages 10.
Crossref
Frédéric Chédin. (2016) Nascent Connections: R-Loops and Chromatin Patterning. Trends in Genetics 32:12, pages 828-838.
Crossref
Edward J. Steele. (2016) Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures. DNA Repair 45, pages 1-24.
Crossref
Nicholas R. Pannunzio & Michael R. Lieber. (2016) RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure. Molecular Cell 62:3, pages 327-334.
Crossref
Valentine Usongo, Makisha Martel, Aurélien Balleydier & Marc Drolet. (2016) Mutations reducing replication from R-loops suppress the defects of growth, chromosome segregation and DNA supercoiling in cells lacking topoisomerase I and RNase HI activity. DNA Repair 40, pages 1-17.
Crossref
Jessica Marinello, Stefania Bertoncini, Iris Aloisi, Agnese Cristini, Guidantonio Malagoli Tagliazucchi, Mattia Forcato, Olivier Sordet & Giovanni Capranico. (2016) Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters. PLOS ONE 11:1, pages e0147053.
Crossref
N. Sakaguchi & K. Maeda. 2016. 135 186 .
Zheng Z Zhang, Nicholas R Pannunzio, Chih-Lin Hsieh, Kefei Yu & Michael R Lieber. (2015) Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids. BMC Research Notes 8:1.
Crossref
Julie Nadel, Rodoniki Athanasiadou, Christophe Lemetre, N. Ari Wijetunga, Pilib Ó Broin, Hanae Sato, Zhengdong Zhang, Jeffrey Jeddeloh, Cristina Montagna, Aaron Golden, Cathal Seoighe & John M. Greally. (2015) RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships. Epigenetics & Chromatin 8:1.
Crossref
Makisha Martel, Aurélien Balleydier, Alexandre Sauriol & Marc Drolet. (2015) Constitutive stable DNA replication in Escherichia coli cells lacking type 1A topoisomerase activity. DNA Repair 35, pages 37-47.
Crossref
Zheng Z. Zhang, Nicholas R. Pannunzio, Zhengfei Lu, Ellen Hsu, Kefei Yu & Michael R. Lieber. (2015) The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombination. Molecular Immunology 67:2, pages 524-531.
Crossref
Zheng Z. Zhang, Chih-Lin Hsieh, Cindy Yen Okitsu, Li Han, Kefei Yu & Michael R. Lieber. (2015) Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination. Molecular Immunology 66:2, pages 284-289.
Crossref
Lorenzo Costantino & Douglas Koshland. (2015) The Yin and Yang of R-loop biology. Current Opinion in Cell Biology 34, pages 39-45.
Crossref
Joyce K. Hwang, Frederick W. Alt & Leng-Siew Yeap. 2015. Mobile DNA III. Mobile DNA III 325 348 .
Jonathan D. Williams, Sara Fleetwood, Alexandra Berroyer, Nayun Kim & Erik D. Larson. (2015) Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro. Frontiers in Genetics 6.
Crossref
Joyce K. Hwang*, Frederick W. Alt* & Leng-Siew Yeap. (2015) Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiology Spectrum 3:1.
Crossref
Fei-Long Meng, Frederick W. Alt & Ming Tian. 2015. Molecular Biology of B Cells. Molecular Biology of B Cells 345 362 .
Kate Senger, Jason Hackney, Jian Payandeh & Ali A. Zarrin. 2015. Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations. Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations 295 324 .
Pei Tong & Duane R. Wesemann. 2015. IgE Antibodies: Generation and Function. IgE Antibodies: Generation and Function 21 37 .
Zheng Z. Zhang, Nicholas R. Pannunzio, Chih-Lin Hsieh, Kefei Yu & Michael R. Lieber. (2014) The role of G-density in switch region repeats for immunoglobulin class switch recombination. Nucleic Acids Research 42:21, pages 13186-13193.
Crossref
Stephan Hamperl & Karlene A. Cimprich. (2014) The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability. DNA Repair 19, pages 84-94.
Crossref
Zheng Z. Zhang, Nicholas R. Pannunzio, Li Han, Chih-Lin Hsieh, Kefei Yu & Michael R. Lieber. (2014) The Strength of an Ig Switch Region Is Determined by Its Ability to Drive R Loop Formation and Its Number of WGCW Sites. Cell Reports 8:2, pages 557-569.
Crossref
Erick W. Loomis, Lionel A. Sanz, Frédéric Chédin & Paul J. Hagerman. (2014) Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region. PLoS Genetics 10:4, pages e1004294.
Crossref
Jessica Marinello, Giovanni Chillemi, Susana Bueno, Stefano G. Manzo & Giovanni Capranico. (2013) Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation. Nucleic Acids Research 41:22, pages 10110-10123.
Crossref
Boris P. Belotserkovskii, Sergei M. Mirkin & Philip C. Hanawalt. (2013) DNA Sequences That Interfere with Transcription: Implications for Genome Function and Stability. Chemical Reviews 113:11, pages 8620-8637.
Crossref
Yu-Pu Kao, Wen-Chuan Hsieh, Shu-Ting Hung, Chiun-Wei Huang, Michael R. Lieber & Feng-Ting Huang. (2013) Detection and characterization of R-loops at the murine immunoglobulin Sα region. Molecular Immunology 54:2, pages 208-216.
Crossref
Boris P. Belotserkovskii, Alexander J. Neil, Syed Shayon Saleh, Jane Hae Soo Shin, Sergei M. Mirkin & Philip C. Hanawalt. (2013) Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks. Nucleic Acids Research 41:3, pages 1817-1828.
Crossref
Celia Keim, David Kazadi, Gerson Rothschild & Uttiya Basu. (2013) Regulation of AID, the B-cell genome mutator. Genes & Development 27:1, pages 1-17.
Crossref
André Maicher, Lisa Kastner, Martina Dees & Brian Luke. (2012) Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Research 40:14, pages 6649-6659.
Crossref
Paul A. Ginno, Paul L. Lott, Holly C. Christensen, Ian Korf & Frédéric Chédin. (2012) R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters. Molecular Cell 45:6, pages 814-825.
Crossref
T. Wongsurawat, P. Jenjaroenpun, C. K. Kwoh & V. Kuznetsov. (2011) Quantitative model of R-loop forming structures reveals a novel level of RNA-DNA interactome complexity. Nucleic Acids Research 40:2, pages e16-e16.
Crossref
Nayun Kim & Sue Jinks-Robertson. (2011) Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. DNA Repair 10:9, pages 953-960.
Crossref
Andrew J. Rennekamp & Paul M. Lieberman. (2011) Initiation of Epstein-Barr Virus Lytic Replication Requires Transcription and the Formation of a Stable RNA-DNA Hybrid Molecule at OriLyt. Journal of Virology 85:6, pages 2837-2850.
Crossref
Kaalak Reddy, Mandy Tam, Richard P. Bowater, Miriam Barber, Matthew Tomlinson, Kerrie Nichol Edamura, Yuh-Hwa Wang & Christopher E. Pearson. (2011) Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Research 39:5, pages 1749-1762.
Crossref
José F. Ruiz, Belén Gómez-González & Andrés Aguilera. (2011) AID Induces Double-Strand Breaks at Immunoglobulin Switch Regions and c-MYC Causing Chromosomal Translocations in Yeast THO Mutants. PLoS Genetics 7:2, pages e1002009.
Crossref
Uttiya Basu, Fei-Long Meng, Celia Keim, Veronika Grinstein, Evangelos Pefanis, Jennifer Eccleston, Tingting Zhang, Darienne Myers, Caitlyn R. Wasserman, Duane R. Wesemann, Kurt Januszyk, Richard I. Gregory, Haiteng Deng, Christopher D. Lima & Frederick W. Alt. (2011) The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates. Cell 144:3, pages 353-363.
Crossref
Boris P. Belotserkovskii & Philip C. Hanawalt. (2011) Anchoring Nascent RNA to the DNA Template Could Interfere with Transcription. Biophysical Journal 100:3, pages 675-684.
Crossref
Rahul M. Kohli, Robert W. Maul, Amy F. Guminski, Rhonda L. McClure, Kiran S. Gajula, Huseyin Saribasak, Moira A. McMahon, Robert F. Siliciano, Patricia J. Gearhart & James T. Stivers. (2010) Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification. Journal of Biological Chemistry 285:52, pages 40956-40964.
Crossref
Boris P. BelotserkovskiiRichard LiuSilvia TornalettiMaria M. Krasilnikova, Sergei M. Mirkin & Philip C. Hanawalt. (2010) Mechanisms and implications of transcription blockage by guanine-rich DNA sequences. Proceedings of the National Academy of Sciences 107:29, pages 12816-12821.
Crossref
Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A. Begum, Yoko Kitawaki, Mikiyo Nakata, Andre Stanlie, Tomomitsu Doi, Lucia Kato, Il-mi Okazaki, Reiko Shinkura, Masamichi Muramatsu, Kazuo Kinoshita & Tasuku Honjo. (2009) AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination. Proceedings of the National Academy of Sciences 106:52, pages 22375-22380.
Crossref
Lili Wang, Robert Wuerffel, Scott Feldman, Ahmed Amine Khamlichi & Amy L. Kenter. (2009) S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination. Journal of Experimental Medicine 206:8, pages 1817-1830.
Crossref
Grace Teng & F. Nina Papavasiliou. 2009. 25 50 .
Jason A. Hackney, Shahram Misaghi, Kate Senger, Christopher Garris, Yonglian Sun, Maria N. Lorenzo & Ali A. Zarrin. 2009. 163 189 .
Kevin M. McBride, Anna Gazumyan, Eileen M. Woo, Tanja A. Schwickert, Brian T. Chait & Michel C. Nussenzweig. (2008) Regulation of class switch recombination and somatic mutation by AID phosphorylation. Journal of Experimental Medicine 205:11, pages 2585-2594.
Crossref
Rachel E. Rigby, Andrea Leitch & Andrew P. Jackson. (2008) Nucleic acid-mediated inflammatory diseases. BioEssays 30:9, pages 833-842.
Crossref
Paz Polak & Peter F. Arndt. (2008) Transcription induces strand-specific mutations at the 5′ end of human genes. Genome Research 18:8, pages 1216-1223.
Crossref
Julian L. Huppert. (2008) Thermodynamic prediction of RNA–DNA duplex-forming regions in the human genome. Molecular BioSystems 4:6, pages 686.
Crossref

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