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Molecular and Cellular Biology Volume 27, 2007 - Issue 22
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Article

The Rap GTPase Activator Drosophila PDZ-GEF Regulates Cell Shape in Epithelial Migration and Morphogenesis

Benjamin BoettnerCold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York11724
&
Linda Van AelstCold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York11724Correspondence[email protected]
Pages 7966-7980 | Received 16 Jul 2007, Accepted 30 Aug 2007, Published online: 27 Mar 2023

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Tai Young Kim, Priscila F. Siesser, Kent L. Rossman, Dennis Goldfarb, Kathryn Mackinnon, Feng Yan, XianHua Yi, Michael J. MacCoss, Randall T. Moon, Channing J. Der & Michael B. Major. (2015) Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase. Molecular and Cellular Biology 35:1, pages 167-181.
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Kia Z. Perez-Vale, Kristi D. Yow, Noah J. Gurley, Melissa Greene & Mark Peifer. (2023) Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms. Molecular Biology of the Cell 34:1.
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Michael D Rotelli, Anna M Bolling, Andrew W Killion, Abraham J Weinberg, Michael J Dixon & Brian R Calvi. (2019) An RNAi Screen for Genes Required for Growth of Drosophila Wing Tissue . G3 Genes|Genomes|Genetics 9:10, pages 3087-3100.
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Shenghong MaZhipeng MengRui ChenKun-Liang Guan. (2019) The Hippo Pathway: Biology and Pathophysiology. Annual Review of Biochemistry 88:1, pages 577-604.
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Qanber Raza, Jae Young Choi, Yang Li, Roisin M. O’Dowd, Simon C. Watkins, Maria Chikina, Yang Hong, Nathan L. Clark & Adam V. Kwiatkowski. (2019) Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. PLOS Genetics 15:2, pages e1007720.
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Mengzhu Ou, Su Wang, Mingkuan Sun, Jinsong An, Huihui Lv, Xiankun Zeng, Steven X. Hou & Wei Xie. (2019) The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction. Experimental Cell Research 374:2, pages 342-352.
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Ketki Sawant, Yujun Chen, Nirupama Kotian, Kevin M. Preuss & Jocelyn A. McDonald. (2018) Rap1 GTPase promotes coordinated collective cell migration in vivo. Molecular Biology of the Cell 29:22, pages 2656-2673.
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Rhian F. Walther, Mubarik Burki, Noelia Pinal, Clare Rogerson & Franck Pichaud. (2018) Rap1, canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor . Journal of Cell Science.
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Keunjung Heo, Minyeop Nahm, Min-Jung Lee, Young-Eun Kim, Chang-Seok Ki, Seung Hyun Kim & Seungbok Lee. (2017) The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling. Molecular Brain 10:1.
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Teresa T. Bonello, Kia Z. Perez-Vale, Kaelyn D. Sumigray & Mark Peifer. (2017) Rap1 acts via multiple mechanisms to position Canoe/Afadin and adherens junctions and mediate apical-basal polarity establishment. Development.
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Dibakar Chakrabarty & Angshuman Sarkar. 2017. Snake Venoms. Snake Venoms 327 342 .
Adam Navis & Celeste M. Nelson. (2016) Pulling together: Tissue-generated forces that drive lumen morphogenesis. Seminars in Cell & Developmental Biology 55, pages 139-147.
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Suresh Marada, Ashley Truong & Stacey K. Ogden. (2016) The small GTPase Rap1 is a modulator of Hedgehog signaling. Developmental Biology 409:1, pages 84-94.
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Dibakar Chakrabarty & Angshuman Sarkar. 2015. Snake Venoms. Snake Venoms 1 16 .
Rupalatha Maddala, Tharkika Nagendran, Richard A. Lang, Alexei Morozov & Ponugoti V. Rao. (2015) Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Developmental Biology 406:1, pages 74-91.
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Erika S. Wittchen, Eiichi Nishimura, Manabu McCloskey, Haibo Wang, Lawrence A. Quilliam, Magdalena Chrzanowska-Wodnicka & M. Elizabeth Hartnett. (2013) Rap1 GTPase Activation and Barrier Enhancement in RPE Inhibits Choroidal Neovascularization In Vivo. PLoS ONE 8:9, pages e73070.
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Andrew C. EmeryMaribeth V. EidenTomris MustafaLee E. Eiden. (2013) Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells. Science Signaling 6:281.
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Yu-Chiun Wang, Zia Khan & Eric F. Wieschaus. (2013) Distinct Rap1 Activity States Control the Extent of Epithelial Invagination via α-Catenin. Developmental Cell 25:3, pages 299-309.
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Jakub K. Famulski & David J. Solecki. (2013) New spin on an old transition: epithelial parallels in neuronal adhesion control. Trends in Neurosciences 36:3, pages 163-173.
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Philipp Spahn, Alice Ott & Rolf Reuter. (2012) The PDZ-GEF Dizzy regulates the establishment of adherens junctions required for ventral furrow formation in Drosophila . Journal of Cell Science.
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Tony J.C. Harris. 2012. 45 83 .
Sandrine Etienne-Manneville. 2012. Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease. Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease 225 249 .
Ferenc Jankovics, László Henn, Ágnes Bujna, Péter Vilmos, Nóra Kiss & Miklós Erdélyi. (2011) A Functional Genomic Screen Combined with Time-Lapse Microscopy Uncovers a Novel Set of Genes Involved in Dorsal Closure of Drosophila Embryos. PLoS ONE 6:7, pages e22229.
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Michael Smutny, Hayley L. Cox, Joanne M. Leerberg, Eva M. Kovacs, Mary Anne Conti, Charles Ferguson, Nicholas A. Hamilton, Robert G. Parton, Robert S. Adelstein & Alpha S. Yap. (2010) Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nature Cell Biology 12:7, pages 696-702.
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E.W. Frische & F.J.T. Zwartkruis. (2010) Rap1, a mercenary among the Ras-like GTPases. Developmental Biology 340:1, pages 1-9.
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Benjamin Boettner & Linda Van Aelst. (2009) Control of cell adhesion dynamics by Rap1 signaling. Current Opinion in Cell Biology 21:5, pages 684-693.
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Florian Ulrich & Carl-Philipp Heisenberg. (2009) Trafficking and Cell Migration. Traffic 10:7, pages 811-818.
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Willem-Jan Pannekoek, Matthijs R.H. Kooistra, Fried J.T. Zwartkruis & Johannes L. Bos. (2009) Cell–cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors. Biochimica et Biophysica Acta (BBA) - Biomembranes 1788:4, pages 790-796.
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Tony J.C. Harris, Jessica K. Sawyer & Mark Peifer. 2009. 55 85 .
Aron B. Jaffe, Noriko Kaji, Joanne Durgan & Alan Hall. (2008) Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. Journal of Cell Biology 183:4, pages 625-633.
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Sirisha Asuri, Jingliang Yan, Nivanka C. Paranavitana & Lawrence A. Quilliam. (2008) E-cadherin dis-engagement activates the Rap1 GTPase. Journal of Cellular Biochemistry 105:4, pages 1027-1037.
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Sophie Quintin, Christelle Gally & Michel Labouesse. (2008) Epithelial morphogenesis in embryos: asymmetries, motors and brakes. Trends in Genetics 24:5, pages 221-230.
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