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Molecular and Cellular Biology Volume 33, 2013 - Issue 1
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Article

Hsp70 Is a Novel Posttranscriptional Regulator of Gene Expression That Binds and Stabilizes Selected mRNAs Containing AU-Rich Elements

Aparna Kishora Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
,
Bishal Tandukara Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
,
Yann V. Lya Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
,
Eric A. Totha Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA;b Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
,
Yvelisse Suarezc Department of Biochemistry and Molecular Biology, RWJMS-UMDNJ, Piscataway, New Jersey, USA
,
Gary Brewerc Department of Biochemistry and Molecular Biology, RWJMS-UMDNJ, Piscataway, New Jersey, USA
&
Gerald M. Wilsona Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA;b Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USACorrespondence[email protected]
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Pages 71-84 | Received 17 Sep 2012, Accepted 17 Oct 2012, Published online: 20 Mar 2023

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Ahyun Son, Scott Horowitz & Baik L. Seong. (2021) Chaperna: linking the ancient RNA and protein worlds. RNA Biology 18:1, pages 16-23.
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Scott Horowitz & James C.A. Bardwell. (2016) RNAs as chaperones. RNA Biology 13:12, pages 1228-1231.
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Mei-Ling Li, Jennifer Defren & Gary Brewer. (2013) Hsp27 and F-Box Protein β-TrCP Promote Degradation of mRNA Decay Factor AUF1. Molecular and Cellular Biology 33:11, pages 2315-2326.
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Line B. Dalgaard, Niels Ørtenblad, Lars G. Hvid & Kasper D. Gejl. (2022) The expression of HSP70 in skeletal muscle is not associated with glycogen availability during recovery following prolonged exercise in elite endurance athletes. European Journal of Applied Physiology 122:8, pages 1831-1842.
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Waleed S. Albihlal & André P. Gerber. (2018) Unconventional RNA ‐binding proteins: an uncharted zone in RNA biology . FEBS Letters 592:17, pages 2917-2931.
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Benjamin J. Lang, Kristina M. Holton, Jianlin Gong & Stuart K. Calderwood. 2018. Chaperones. Chaperones 233 252 .
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Elizabeth J.F. White, Aerielle E. Matsangos & Gerald M. Wilson. (2017) AUF1 regulation of coding and noncoding RNA. Wiley Interdisciplinary Reviews: RNA 8:2, pages e1393.
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Devki Nandan, Sneha A. Thomas, Anne Nguyen, Kyung-Mee Moon, Leonard J. Foster & Neil E. Reiner. (2017) Comprehensive Identification of mRNA-Binding Proteins of Leishmania donovani by Interactome Capture. PLOS ONE 12:1, pages e0170068.
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S. Yu Funikov, S. S. Ryazansky, A. A. Kanapin, M. D. Logacheva, A. A. Penin, A. V. Snezhkina, V. Yu. Shilova, D. G. Garbuz, M. B. Evgen'ev & O. G. Zatsepina. (2016) Interplay between RNA interference and heat shock response systems in Drosophila melanogaster . Open Biology 6:10, pages 160224.
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Wei Zhang, Deting Xue, Houfa Yin, Shengdong Wang, Chao Li, Erman Chen, Dongcai Hu, Yiqing Tao, Jiawei Yu, Qiang Zheng, Xiang Gao & Zhijun Pan. (2016) Overexpression of HSPA1A enhances the osteogenic differentiation of bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signaling pathway. Scientific Reports 6:1.
Crossref
N. N. Rumzhum & A. J. Ammit. (2016) Cyclooxygenase 2: its regulation, role and impact in airway inflammation. Clinical & Experimental Allergy 46:3, pages 397-410.
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Ye Qiu, Xin Ye, Paul J. Hanson, Huifang Mary Zhang, Jeff Zong, Brian Cho & Decheng Yang. (2015) Hsp70-1: upregulation via selective phosphorylation of heat shock factor 1 during coxsackieviral infection and promotion of viral replication via the AU-rich element. Cellular and Molecular Life Sciences 73:5, pages 1067-1084.
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Hervé Prats & Christian Touriol. 2016. Post-transcriptional Mechanisms in Endocrine Regulation. Post-transcriptional Mechanisms in Endocrine Regulation 157 180 .
Michael R. White & Elsa D. Garcin. (2015) The sweet side of RNA regulation: glyceraldehyde‐3‐phosphate dehydrogenase as a noncanonical RNA ‐binding protein . WIREs RNA 7:1, pages 53-70.
Crossref
J Gong, D Weng, T Eguchi, A Murshid, M Y Sherman, B Song & S K Calderwood. (2015) Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene 34:43, pages 5460-5471.
Crossref
Bernd L. Fiebich, Shamima Akter & Ravi Shankar Akundi. (2014) The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain. Frontiers in Cellular Neuroscience 8.
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Ashley L. Cornett & Carol S. Lutz. (2014) Regulation of COX-2 expression by miR-146a in lung cancer cells. RNA 20:9, pages 1419-1430.
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Petr Klus, Benedetta Bolognesi, Federico Agostini, Domenica Marchese, Andreas Zanzoni & Gian Gaetano Tartaglia. (2014) The cleverSuite approach for protein characterization: predictions of structural properties, solubility, chaperone requirements and RNA-binding abilities. Bioinformatics 30:11, pages 1601-1608.
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Andreas Zanzoni, Domenica Marchese, Federico Agostini, Benedetta Bolognesi, Davide Cirillo, Maria Botta-Orfila, Carmen Maria Livi, Silvia Rodriguez-Mulero & Gian Gaetano Tartaglia. (2013) Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein. Nucleic Acids Research 41:22, pages 9987-9998.
Crossref
C.A. Ramírez, M.A. Dea-Ayuela, M.D. Gutiérrez-Blázquez, F. Bolas-Fernández, J.M. Requena & C.J. Puerta. (2013) Identification of proteins interacting with HSP70 mRNAs in Leishmania braziliensis. Journal of Proteomics 94, pages 124-137.
Crossref
Beth E. Zucconi & Gerald M. Wilson. (2013) Assembly of Functional Ribonucleoprotein Complexes by AU-rich Element RNA-binding Protein 1 (AUF1) Requires Base-dependent and -independent RNA Contacts. Journal of Biological Chemistry 288:39, pages 28034-28048.
Crossref
Carol S. Lutz & Ashley L. Cornett. (2013) Regulation of genes in the arachidonic acid metabolic pathway by RNA processing and  RNA ‐mediated mechanisms . WIREs RNA 4:5, pages 593-605.
Crossref
Margrit Hollborn, Rui Chen, Peter Wiedemann, Andreas Reichenbach, Andreas Bringmann & Leon Kohen. (2013) Cytotoxic Effects of Curcumin in Human Retinal Pigment Epithelial Cells. PLoS ONE 8:3, pages e59603.
Crossref

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