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Article

Degradation of Newly Synthesized Polypeptides by Ribosome-Associated RACK1/c-Jun N-Terminal Kinase/Eukaryotic Elongation Factor 1A2 Complex

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Pages 2510-2526 | Received 07 Oct 2012, Accepted 05 Apr 2013, Published online: 20 Mar 2023

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Philippe P. Roux & Ivan Topisirovic. (2018) Signaling Pathways Involved in the Regulation of mRNA Translation. Molecular and Cellular Biology 38:12.
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Kerstin Schmitt, Nadine Smolinski, Piotr Neumann, Samantha Schmaul, Verena Hofer-Pretz, Gerhard H. Braus & Oliver Valerius. (2017) Asc1p/RACK1 Connects Ribosomes to Eukaryotic Phosphosignaling. Molecular and Cellular Biology 37:3.
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Valentina Gandin & Ivan Topisirovic. (2014) Co-translational mechanisms of quality control of newly synthesized polypeptides. Translation 2:1.
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Crossref
Andrey L. Karamyshev & Zemfira N. Karamysheva. (2018) Lost in Translation: Ribosome-Associated mRNA and Protein Quality Controls. Frontiers in Genetics 9.
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Stephen DiGiuseppe, Madeline G. Rollins, Elizabeth T. Bartom & Derek Walsh. (2018) ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis. Cell Reports 23:5, pages 1249-1258.
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Gloria Lozano, Rosario Francisco-Velilla & Encarnacion Martinez-Salas. (2018) Ribosome-dependent conformational flexibility changes and RNA dynamics of IRES domains revealed by differential SHAPE. Scientific Reports 8:1.
Crossref
Nadine Opitz, Kerstin Schmitt, Verena Hofer-Pretz, Bettina Neumann, Heike Krebber, Gerhard H. Braus & Oliver Valerius. (2017) Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast. Molecular & Cellular Proteomics 16:12, pages 2199-2218.
Crossref
Graeme B. Bolger. (2017) The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1. Cellular Signalling 35, pages 256-263.
Crossref
Maja Holch Nielsen, Rasmus Kock Flygaard & Lasse Bohl Jenner. (2017) Structural analysis of ribosomal RACK1 and its role in translational control. Cellular Signalling 35, pages 272-281.
Crossref
Arianna Russo, Raffaella Scardigli, Federico La Regina, Melissa E. Murray, Nicla Romano, Dennis W. Dickson, Benjamin Wolozin, Antonino Cattaneo & Marcello Ceci. (2017) Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes. Human Molecular Genetics 26:8, pages 1407-1418.
Crossref
Verónica Cánovas, Matilde Lleonart, Juan Morote & Rosanna Paciucci. (2016) The role of prostate tumor overexpressed 1 in cancer progression. Oncotarget 8:7, pages 12451-12471.
Crossref
András Zeke, Mariya Misheva, Attila Reményi & Marie A. Bogoyevitch. (2016) JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiology and Molecular Biology Reviews 80:3, pages 793-835.
Crossref
Ilyas Singec, Andrew M. Crain, Junjie Hou, Brian T.D. Tobe, Maria Talantova, Alicia A. Winquist, Kutbuddin S. Doctor, Jennifer Choy, Xiayu Huang, Esther La Monaca, David M. Horn, Dieter A. Wolf, Stuart A. Lipton, Gustavo J. Gutierrez, Laurence M. Brill & Evan Y. Snyder. (2016) Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports 7:3, pages 527-542.
Crossref
Xiaojian Yin & Setsuko Komatsu. (2016) Plant nuclear proteomics for unraveling physiological function. New Biotechnology 33:5, pages 644-654.
Crossref
Qiuzhen Zhu, Yuefan Zhang, Yulan Liu, Hao Cheng, Jing Wang, Yue Zhang, Yaocheng Rui & Tiejun Li. (2016) MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2. PLOS ONE 11:2, pages e0149965.
Crossref
Palaniraja Thandapani, Jingwen Song, Valentina Gandin, Yutian Cai, Samuel G Rouleau, Jean-Michel Garant, Francois-Michel Boisvert, Zhenbao Yu, Jean-Pierre Perreault, Ivan Topisirovic & Stéphane Richard. (2015) Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes. eLife 4.
Crossref
Rya Ero, Valya Tenusheva Dimitrova, Yun Chen, Wenting Bu, Shu Feng, Tongbao Liu, Ping Wang, Chaoyang Xue, Suet Mien Tan & Yong-Gui Gao. (2015) Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans. Scientific Reports 5:1.
Crossref
Karen S. Browning & Julia Bailey-Serres. (2015) Mechanism of Cytoplasmic mRNA Translation. The Arabidopsis Book 13, pages e0176.
Crossref
Tali Rosenberg, Shunit Gal-Ben-Ari, Daniela C. Dieterich, Michael R. Kreutz, Noam E. Ziv, Eckart D. Gundelfinger & Kobi Rosenblum. (2014) The roles of protein expression in synaptic plasticity and memory consolidation. Frontiers in Molecular Neuroscience 7.
Crossref
Mariya Misheva, Gurpreet Kaur, Kevin R.W. Ngoei, Yvonne Y. Yeap, Ivan H.W. Ng, Kylie M. Wagstaff, Dominic C.H. Ng, David A. Jans & Marie A. Bogoyevitch. (2014) Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:2, pages 253-264.
Crossref
Dinesh C Soares & Catherine M Abbott. (2013) Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translationalmodification with significant enrichment around localised sites of sequence variation. Biology Direct 8:1.
Crossref

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