21
Views
61
CrossRef citations to date
0
Altmetric
Article

Regulation of Neuron Survival through an Intersectin-Phosphoinositide 3′-Kinase C2β-AKT Pathway

, , , , , , , & show all
Pages 7906-7917 | Received 30 Jul 2007, Accepted 04 Sep 2007, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Miriam Martini, Maria Chiara De Santis, Laura Braccini, Federico Gulluni & Emilio Hirsch. (2014) PI3K/AKT signaling pathway and cancer: an updated review. Annals of Medicine 46:6, pages 372-383.
Read now
Mustafa Nazir Okur, Angela Russo & John P. O'Bryan. (2014) Receptor Tyrosine Kinase Ubiquitylation Involves the Dynamic Regulation of Cbl-Spry2 by Intersectin 1 and the Shp2 Tyrosine Phosphatase. Molecular and Cellular Biology 34:2, pages 271-279.
Read now
Zhao Zhong Chong, Yan Chen Shang, Yanling Mu, Shuxiang Cui, Qingqiang Yao & Kenneth Maiese. (2013) Targeting erythropoietin for chronic neurodegenerative diseases. Expert Opinion on Therapeutic Targets 17:6, pages 707-720.
Read now
Mustafa Nazir Okur, Jolene Ooi, Chee Wai Fong, Natalia Martinez, Carlota Garcia-Dominguez, Jose M. Rojas, Graeme Guy & John P. O'Bryan. (2012) Intersectin 1 Enhances Cbl Ubiquitylation of Epidermal Growth Factor Receptor through Regulation of Sprouty2-Cbl Interaction. Molecular and Cellular Biology 32:4, pages 817-825.
Read now

Articles from other publishers (57)

Paula Samsó, Philipp A. Koch, York Posor, Wen-Ting Lo, Hassane Belabed, Marc Nazare, Jocelyn Laporte & Volker Haucke. (2022) Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model. Proceedings of the National Academy of Sciences 119:40.
Crossref
York Posor, Charis Kampyli, Benoit Bilanges, Sushila Ganguli, Philipp A. Koch, Alexander Wallroth, Daniele Morelli, Michalina Jenkins, Samira Alliouachene, Elitza Deltcheva, Buzz Baum, Volker Haucke & Bart Vanhaesebroeck. (2022) Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover. Developmental Cell 57:14, pages 1694-1711.e7.
Crossref
Emily Yan Zhi Heng & Tania Maffucci. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 51 68 .
Philipp Alexander Koch, Gillian Leigh Dornan, Manuel Hessenberger & Volker Haucke. (2021) The molecular mechanisms mediating class II PI 3‐kinase function in cell physiology. The FEBS Journal 288:24, pages 7025-7042.
Crossref
Randall W. Treffy, Sriivatsan G. Rajan, Xinghang Jiang, Lynne M. Nacke, Usama A. Malkana, L.A. Naiche, Dani E. Bergey, Dianicha Santana, Vinodh Rajagopalan, Jan K. Kitajewski, John P. O’Bryan & Ankur Saxena. (2021) Neuroblastoma differentiation in vivo excludes cranial tumors. Developmental Cell 56:19, pages 2752-2764.e6.
Crossref
Nicola Cotugno, Sonia Zicari, Elena Morrocchi, Lesley R. de Armas, Suresh Pallikkuth, Stefano Rinaldi, Alessandra Ruggiero, Emma Concetta Manno, Paola Zangari, Maria Chiriaco, Stefania Bernardi, Sarah F. Andrews, Alberto Cagigi, Paolo Rossi, Adrian B. McDermott, Savita Pahwa & Paolo Palma. (2020) Higher PIK3C2B gene expression of H1N1+ specific B-cells is associated with lower H1N1 immunogenicity after trivalent influenza vaccination in HIV infected children. Clinical Immunology 215, pages 108440.
Crossref
Nakisa Malakooti, Melanie A. Pritchard, Feng Chen, Yong Yu, Charlotte Sgambelloni, Paul A. Adlard & David I. Finkelstein. (2020) The Long Isoform of Intersectin-1 Has a Role in Learning and Memory. Frontiers in Behavioral Neuroscience 14.
Crossref
Olga Gubar, Pauline Croisé, Sergii Kropyvko, Tetyana Gryaznova, Petra Toth, Anne Blangy, Nicolas Vitale, Alla Rynditch, Stéphane Gasman & Stéphane Ory. (2020) The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways. Journal of Cell Science.
Crossref
Alia Ghoneum & Neveen Said. (2019) PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. Cancers 11:7, pages 949.
Crossref
Federico Gulluni, Maria Chiara De Santis, Jean Piero Margaria, Miriam Martini & Emilio Hirsch. (2019) Class II PI3K Functions in Cell Biology and Disease. Trends in Cell Biology 29:4, pages 339-359.
Crossref
Jean Piero Margaria, Edoardo Ratto, Luca Gozzelino, Huayi Li & Emilio Hirsch. (2019) Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking. Biomolecules 9:3, pages 104.
Crossref
Khin Thuzar Aung, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Noriko Takuwa & Yoh Takuwa. (2018) The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells. The Journal of Physiological Sciences 69:2, pages 263-280.
Crossref
Oleksandr Dergai, Mykola Dergai & Alla Rynditch. (2018) Ubiquitin-ligase AIP4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN1. FEBS Letters 592:13, pages 2259-2267.
Crossref
Ameet S. Sengar, Michael W. Salter & Sean E. Egan. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 2737 2745 .
Jamie Harris, Erika Herrero-Garcia, Angela Russo, Andre Kajdacsy-Balla, John P. O’Bryan & Bill Chiu. (2017) Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice. Journal of Pediatric Hematology/Oncology 39:8, pages e413-e418.
Crossref
Monal Patel, Dan Predescu, Cristina Bardita, Jiwang Chen, Niranjan Jeganathan, Melanie Pritchard, Salvatore DiBartolo, Roberto Machado & Sanda Predescu. (2017) Modulation of Intersectin-1s Lung Expression Induces Obliterative Remodeling and Severe Plexiform Arteriopathy in the Murine Pulmonary Vascular Bed. The American Journal of Pathology 187:3, pages 528-542.
Crossref
Xiaozhu Wang, Shikai Liu, Chen Jiang, Xin Geng, Tao Zhou, Ning Li, Lisui Bao, Yun Li, Jun Yao, Yujia Yang, Xiaoxiao Zhong, Yulin Jin, Rex Dunham & Zhanjiang Liu. (2016) Multiple across-strain and within-strain QTLs suggest highly complex genetic architecture for hypoxia tolerance in channel catfish. Molecular Genetics and Genomics 292:1, pages 63-76.
Crossref
Erika Herrero-Garcia & John P. O'Bryan. (2017) Intersectin scaffold proteins and their role in cell signaling and endocytosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:1, pages 23-30.
Crossref
Colin Valet, Sonia Severin, Gaëtan Chicanne, Pierre Alexandre Laurent, Frédérique Gaits-Iacovoni, Marie-Pierre Gratacap & Bernard Payrastre. (2016) The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis. Advances in Biological Regulation 61, pages 33-41.
Crossref
Feng Gu, Huikun Zhang, Fengxia Qin, Xiaoli Liu, Wenliang Li, Li Fu, Guoguang Ying, Binghui Li, Ming Zhang & Yongjie Ma. (2015) Intersectin1-s, A multidomain adapter protein, Is essential for malignant glioma proliferation. Glia 63:9, pages 1595-1605.
Crossref
Angela Russo, Mustafa Nazir Okur, Maarten Bosland & John P. O'Bryan. (2015) Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2β) isoform contributes to neuroblastoma tumorigenesis. Cancer Letters 359:2, pages 262-268.
Crossref
Steve Jean & Amy A. Kiger. (2014) Classes of phosphoinositide 3-kinases at a glance. Journal of Cell Science 127:5, pages 923-928.
Crossref
Monal Patel, Dan Predescu, Rajive Tandon, Cristina Bardita, Jennifer Pogoriler, Sangeeta Bhorade, Minhua Wang, Suzy Comhair, Anna Ryan-Hemnes, Jiwang Chen, Roberto Machado, Aliya Husain, Serpil Erzurum & Sanda Predescu. (2013) A Novel p38 Mitogen-activated Protein Kinase/Elk-1 Transcription Factor-dependent Molecular Mechanism Underlying Abnormal Endothelial Cell Proliferation in Plexogenic Pulmonary Arterial Hypertension. Journal of Biological Chemistry 288:36, pages 25701-25716.
Crossref
L. O. Tsyba, M. V. Dergai, I. Ya. Skrypkina, O. V. Nikolaienko, O. V. Dergai, S. V. Kropyvko, O. V. Novokhatska, D. Ye. Morderer, T. A. Gryaznova, O. S. Gubar & A. V. Rynditch. (2013) ITSN protein family: regulation of diversity, role in signalling and pathology. Biopolymers and Cell 29:3, pages 244-251.
Crossref
Michael Hunter, Angela Russo & John O'Bryan. (2013) Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways. International Journal of Molecular Sciences 14:4, pages 7829-7852.
Crossref
A Russo & J P O'Bryan. (2012) Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene 31:46, pages 4828-4834.
Crossref
John G. Foster, Matthew D. Blunt, Edward Carter & Stephen G. Ward. (2012) Inhibition of PI3K Signaling Spurs New Therapeutic Opportunities in Inflammatory/Autoimmune Diseases and Hematological Malignancies. Pharmacological Reviews 64:4, pages 1027-1054.
Crossref
Fletcher B. Moore & James D. Baleja. (2012) Molecular remodeling mechanisms of the neural somatodendritic compartment. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1823:10, pages 1720-1730.
Crossref
O. S. Gubar, S. Houy, P. Billuart, S. V. Kropyvko, L. O. Tsyba, S. Gasman & A. V. Rynditch. (2012) GTPase-activating protein oligophrenin 1 is a new partner of multifunctional adapter protein intersectin 1. Biopolymers and Cell 28:5, pages 357-362.
Crossref
Mathilde SchindlerChristine FabreJan de WeilleSerge Carreau, Marcel MerselNorbert Bakalara. (2012) Disruption of Nongenomic Testosterone Signaling in a Model of Spinal and Bulbar Muscular Atrophy. Molecular Endocrinology 26:7, pages 1102-1116.
Crossref
Marco FalascaTania Maffucci. (2012) Regulation and cellular functions of class II phosphoinositide 3-kinases. Biochemical Journal 443:3, pages 587-601.
Crossref
Katy A. Wong, Jessica Wilson, Angela Russo, Li Wang, Mustafa Nazir Okur, Xuerong Wang, Negin P. Martin, Erica Scappini, Graeme K. Carnegie & John P. O'Bryan. (2012) Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks. PLoS ONE 7:4, pages e36023.
Crossref
Xinjiang CaiShekhar SrivastavaYi SunZhai LiHaiyan Wu, Ljiljana Zuvela-Jelaska, Jun Li, Rachel S. Salamon, Jonathan M. Backer & Edward Y. Skolnik. (2011) Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proceedings of the National Academy of Sciences 108:50, pages 20072-20077.
Crossref
Ivana Knezevic, Dan Predescu, Cristina Bardita, Minhua Wang, Tiffany Sharma, Barbara Keith, Radu Neamu, Asrar B. Malik & Sanda Predescu. (2011) Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s. Journal of Cellular and Molecular Medicine 15:11, pages 2364-2376.
Crossref
Michael P. Hunter, Marianela Nelson, Michael Kurzer, Xuerong Wang, Richard J. Kryscio, Elizabeth Head, Graziano Pinna & John P. O’Bryan. (2011) Intersectin 1 contributes to phenotypes in vivo. NeuroReport 22:15, pages 767-772.
Crossref
Mykola Dergai, Inessa Skrypkina, Oleksandr Dergai, Liudmyla Tsyba, Olga Novokhatska, Valeriy Filonenko, Lyudmyla Drobot & Alla Rynditch. (2011) Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1. Gene 485:2, pages 120-129.
Crossref
Z Liu, C Sun, Y Zhang, Z Ji & G Yang. (2011) Phosphatidylinositol 3-Kinase-C2β Inhibits Cisplatin-Mediated Apoptosis via the Akt Pathway in Oesophageal Squamous Cell Carcinoma. Journal of International Medical Research 39:4, pages 1319-1332.
Crossref
M. V. Dergai, O. V. Dergai, L. O. Tsyba, O. V. Novokhatska, I. Ya. Skrypkina & A. V. Rynditch. (2011) Novel isoform of adaptor protein ITSN1 forms homodimers via its C-terminus. Biopolymers and Cell 27:4, pages 306-309.
Crossref
Yongjie Ma, Bingbing Wang, Wenliang Li, Xiaoli Liu, Jing Wang, Ting Ding, Jiao Zhang, Guoguang Ying, Li Fu & Feng Gu. (2011) Intersectin1-s is involved in migration and invasion of human glioma cells. Journal of Neuroscience Research 89:7, pages 1079-1090.
Crossref
Liudmyla Tsyba, Oleksii Nikolaienko, Oleksandr Dergai, Mykola Dergai, Olga Novokhatska, Inessa Skrypkina & Alla Rynditch. (2011) Intersectin multidomain adaptor proteins: Regulation of functional diversity. Gene 473:2, pages 67-75.
Crossref
John P. O’Bryan. (2010) INTERSECTINg Pathways in Cell Biology. Science Signaling 3:152.
Crossref
Oleksandr Dergai, Olga Novokhatska, Mykola Dergai, Inessa Skrypkina, Liudmyla Tsyba, Jacques Moreau & Alla Rynditch. (2010) Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits. Biochemical and Biophysical Research Communications 402:2, pages 408-413.
Crossref
Yongjie Ma, Bingbing Wang, Wenliang Li, Guoguang Ying, Li Fu, Ruifang Niu & Feng Gu. (2010) Reduction of intersectin1-s induced apoptosis of human glioblastoma cells. Brain Research 1351, pages 222-228.
Crossref
Fubito Nakatsu, Rushika M. Perera, Louise Lucast, Roberto Zoncu, Jan Domin, Frank B. Gertler, Derek Toomre & Pietro De Camilli. (2010) The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. Journal of Cell Biology 190:3, pages 307-315.
Crossref
Mykola Dergai, Lyudmila Tsyba, Oleksandr Dergai, Igor Zlatskii, Inessa Skrypkina, Vitalii Kovalenko & Alla Rynditch. (2010) Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface. Biochemical and Biophysical Research Communications 399:2, pages 307-312.
Crossref
Sergii Kropyvko, Dmytro Gerasymchuk, Inessa Skrypkina, Mykola Dergai, Oleksandr Dergai, Oleksii Nikolaienko, Alla Rynditch & Liudmyla Tsyba. (2009) Structural diversity and differential expression of novel human intersectin 1 isoforms. Molecular Biology Reports 37:6, pages 2789-2796.
Crossref
Bart Vanhaesebroeck, Julie Guillermet-Guibert, Mariona Graupera & Benoit Bilanges. (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nature Reviews Molecular Cell Biology 11:5, pages 329-341.
Crossref
S. Li, D. Carpenter, C. Hsiang, S. L. Wechsler & C. Jones. (2009) Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels. Journal of General Virology 91:4, pages 858-866.
Crossref
Kathryn Waite & Britta J. Eickholt. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 245 265 .
Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki & Akira Suzuki. (2009) Mammalian phosphoinositide kinases and phosphatases. Progress in Lipid Research 48:6, pages 307-343.
Crossref
Roger WilliamsAlex BerndtSimon MillerWai-Ching HonXuxiao Zhang. (2009) Form and flexibility in phosphoinositide 3-kinases. Biochemical Society Transactions 37:4, pages 615-626.
Crossref
Beata Pyrzynska, Iwona Pilecka & Marta Miaczynska. (2009) Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis. Molecular Oncology 3:4, pages 321-338.
Crossref
Oleksii Nikolaienko, Inessa Skrypkina, Liudmyla Tsyba, Yaroslav Fedyshyn, Dmytro Morderer, Vladimir Buchman, Susana de la Luna, Lyudmyla Drobot & Alla Rynditch. (2009) Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation. Cellular Signalling 21:5, pages 753-759.
Crossref
Yong Yu, Po-Yin Chu, David N. Bowser, Damien J. Keating, Daphne Dubach, Ian Harper, Josephine Tkalcevic, David I. Finkelstein & Melanie A. Pritchard. (2008) Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities. Human Molecular Genetics 17:21, pages 3281-3290.
Crossref
A. Siddiqui, T. Lacroix, M. R. Stasko, J. J. Scott-McKean, A. C. S. Costa & K. J. Gardiner. (2008) Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes, Brain and Behavior 7:7, pages 810-820.
Crossref
Liudmyla Tsyba, Tetyana Gryaznova, Oleksandr Dergai, Mykola Dergai, Inessa Skrypkina, Sergiy Kropyvko, Oleksiy Boldyryev, Oleksii Nikolaienko, Olga Novokhatska & Alla Rynditch. (2008) Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons. Biochemical and Biophysical Research Communications 372:4, pages 929-934.
Crossref
Wei Wang, Magali Bouhours, Elena O. Gracheva, Edward H. Liao, Keli Xu, Ameet S. Sengar, Xiaofeng Xin, John Roder, Charles Boone, Janet E. Richmond, Mei Zhen & Sean E. Egan. (2008) ITSN-1 Controls Vesicle Recycling at the Neuromuscular Junction and Functions in Parallel with DAB-1. Traffic 9:5, pages 742-754.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.