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Article

RNA Editing in Trypanosoma brucei Requires Three Different Editosomes

Jason Carnes1 Seattle Biomedical Research Institute, Seattle, Washington98109;2 Department of Pathobiology, University of Washington, Seattle, Washington98195
,
James Raffaello Trotter1 Seattle Biomedical Research Institute, Seattle, Washington98109
,
Adam Peltan3 Immunology and Infection Unit, Department of Biology, University of York, Heslington, YorkYO10 5YW, United Kingdom
,
Michele Fleck1 Seattle Biomedical Research Institute, Seattle, Washington98109
&
Kenneth Stuart1 Seattle Biomedical Research Institute, Seattle, Washington98109;2 Department of Pathobiology, University of Washington, Seattle, Washington98195Correspondence[email protected]
Pages 122-130 | Received 31 Jul 2007, Accepted 08 Oct 2007, Published online: 27 Mar 2023

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Suzanne M. McDermott, Jason Carnes & Kenneth Stuart. (2015) Identification by Random Mutagenesis of Functional Domains in KREPB5 That Differentially Affect RNA Editing between Life Cycle Stages of . Molecular and Cellular Biology 35:23, pages 3945-3961.
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Inna Aphasizheva, Liye Zhang, Xiaorong Wang, Robyn M. Kaake, Lan Huang, Stefano Monti & Ruslan Aphasizhev. (2014) RNA Binding and Core Complexes Constitute the U-Insertion/Deletion Editosome. Molecular and Cellular Biology 34:23, pages 4329-4342.
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Robert V Swift & Rommie E Amaro. (2009) Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms. Expert Opinion on Drug Discovery 4:12, pages 1281-1294.
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John C. Fisk, Vladimir Presnyak, Michelle L. Ammerman & Laurie K. Read. (2009) Distinct and Overlapping Functions of MRP1/2 and RBP16 in Mitochondrial RNA Metabolism. Molecular and Cellular Biology 29:19, pages 5214-5225.
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Xuemin Guo, Nancy Lewis Ernst & Kenneth D. Stuart. (2008) The KREPA3 Zinc Finger Motifs and OB-Fold Domain Are Essential for RNA Editing and Survival of Trypanosoma brucei. Molecular and Cellular Biology 28:22, pages 6939-6953.
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Vadim S. Alatortsev, Jorge Cruz-Reyes, Alevtina G. Zhelonkina & Barbara Sollner-Webb. (2008) Trypanosoma brucei RNA Editing: Coupled Cycles of U Deletion Reveal Processive Activity of the Editing Complex. Molecular and Cellular Biology 28:7, pages 2437-2445.
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Articles from other publishers (88)

Ashutosh P Dubey, Brianna L Tylec, Amartya Mishra, Katherine Sortino, Runpu Chen, Yijun Sun & Laurie K Read. (2023) KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing. Nucleic Acids Research.
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Jason Carnes, Claire Gendrin, Suzanne M. McDermott & Kenneth Stuart. (2023) KRGG1 function in RNA editing in Trypanosoma brucei . RNA 29:2, pages 228-240.
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Jason Carnes, Suzanne M McDermott, Isaac Lewis, Maxwell Tracy & Kenneth Stuart. (2022) Domain function and predicted structure of three heterodimeric endonuclease subunits of RNA editing catalytic complexes in Trypanosoma brucei . Nucleic Acids Research 50:17, pages 10123-10139.
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Evgeny S. Gerasimov, Dmitry A. Afonin, Oksana A. Korzhavina, Julius Lukeš, Ross Low, Neil Hall, Kevin Tyler, Vyacheslav Yurchenko & Sara L. Zimmer. (2022) Mitochondrial RNA editing in Trypanoplasma borreli: New tools, new revelations. Computational and Structural Biotechnology Journal 20, pages 6388-6402.
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Ashutosh P Dubey, Brianna L Tylec, Natalie M McAdams, Katherine Sortino & Laurie K Read. (2021) Trypanosome RNAEditing Substrate Binding Complex integrity and function depends on the upstream action of RESC10. Nucleic Acids Research 49:6, pages 3557-3572.
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Inna Aphasizheva, Juan Alfonzo, Jason Carnes, Igor Cestari, Jorge Cruz-Reyes, H. Ulrich Göringer, Stephen Hajduk, Julius Lukeš, Susan Madison-Antenucci, Dmitri A. Maslov, Suzanne M. McDermott, Torsten Ochsenreiter, Laurie K. Read, Reza Salavati, Achim Schnaufer, André Schneider, Larry Simpson, Kenneth Stuart, Vyacheslav Yurchenko, Z. Hong Zhou, Alena Zíková, Liye Zhang, Sara Zimmer & Ruslan Aphasizhev. (2020) Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes. Trends in Parasitology 36:4, pages 337-355.
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Natalie M. McAdams, Gregory L. Harrison, Brianna L. Tylec, Michelle L. Ammerman, Runpu Chen, Yijun Sun & Laurie K. Read. (2019) MRB10130 is a RESC assembly factor that promotes kinetoplastid RNA editing initiation and progression. RNA 25:9, pages 1177-1191.
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Suzanne M. McDermott, Jason Carnes & Kenneth Stuart. (2019) Editosome RNase III domain interactions are essential for editing and differ between life cycle stages in Trypanosoma brucei . RNA 25:9, pages 1150-1163.
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Dmitri A. Maslov. (2019) Separating the Wheat from the Chaff: RNA Editing and Selection of Translatable mRNA in Trypanosome Mitochondria. Pathogens 8:3, pages 105.
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Dmitri A. Maslov, Fred R. Opperdoes, Alexei Y. Kostygov, Hassan Hashimi, Julius Lukeš & Vyacheslav Yurchenko. (2018) Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution. Parasitology 146:1, pages 1-27.
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Natalie M. McAdams, Rachel M. Simpson, Runpu Chen, Yijun Sun & Laurie K. Read. (2018) MRB7260 is essential for productive protein–RNA interactions within the RNA editing substrate binding complex during trypanosome RNA editing. RNA 24:4, pages 540-556.
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Jason Carnes, Suzanne M. McDermott & Kenneth Stuart. (2018) RNase III Domain of KREPB9 and KREPB10 Association with Editosomes in Trypanosoma brucei. mSphere 3:1.
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Vahid H. Gazestani, Marshall Hampton, Aubie K. Shaw, Reza Salavati & Sara L. Zimmer. (2018) Tail characteristics of Trypanosoma brucei mitochondrial transcripts are developmentally altered in a transcript-specific manner. International Journal for Parasitology 48:2, pages 179-189.
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Suzanne M. McDermott & Kenneth Stuart. (2017) The essential functions of KREPB4 are developmentally distinct and required for endonuclease association with editosomes. RNA 23:11, pages 1672-1684.
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Brianna Norris-Mullins & Miguel A. Morales. 2017. Drug Discovery for Leishmaniasis. Drug Discovery for Leishmaniasis 235 247 .
Rachel M. Simpson, Andrew E. Bruno, Runpu Chen, Kaylen Lott, Brianna L. Tylec, Jonathan E. Bard, Yijun Sun, Michael J. Buck & Laurie K. Read. (2017) Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization. Nucleic Acids Research 45:13, pages 7965-7983.
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Jason Carnes, Suzanne McDermott, Atashi Anupama, Brian G. Oliver, D. Noah Sather & Kenneth Stuart. (2017) In vivo cleavage specificity of Trypanosoma brucei editosome endonucleases. Nucleic Acids Research 45:8, pages 4667-4686.
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Suzanne M. McDermottJie Luo, Jason CarnesJeff A. Ranish & Kenneth Stuart. (2016) The Architecture of Trypanosoma brucei editosomes . Proceedings of the National Academy of Sciences 113:42.
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David Roy SmithPatrick J. Keeling. (2016) Protists and the Wild, Wild West of Gene Expression: New Frontiers, Lawlessness, and Misfits. Annual Review of Microbiology 70:1, pages 161-178.
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Rachel M. Simpson, Andrew E. Bruno, Jonathan E. Bard, Michael J. Buck & Laurie K. Read. (2016) High-throughput sequencing of partially edited trypanosome mRNAs reveals barriers to editing progression and evidence for alternative editing. RNA 22:5, pages 677-695.
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Aubie K. Shaw, Murat C. Kalem & Sara L. Zimmer. (2016) Mitochondrial Gene Expression Is Responsive to Starvation Stress and Developmental Transition in Trypanosoma cruzi. mSphere 1:2.
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Inna Aphasizheva & Ruslan Aphasizhev. (2016) U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in Sight. Trends in Parasitology 32:2, pages 144-156.
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Laurie K. Read, Julius Lukeš & Hassan Hashimi. (2015) Trypanosome RNA editing: the complexity of getting U in and taking U out . WIREs RNA 7:1, pages 33-51.
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Vojtěch David, Pavel Flegontov, Evgeny Gerasimov, Goro Tanifuji, Hassan Hashimi, Maria D. Logacheva, Shinichiro Maruyama, Naoko T. Onodera, Michael W. Gray, John M. Archibald & Julius Lukeš. (2015) Gene Loss and Error-Prone RNA Editing in the Mitochondrion of Perkinsela , an Endosymbiotic Kinetoplastid . mBio 6:6.
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Zhenqiu Huang, Drahomíra Faktorová, Adéla Křížová, Lucie Kafková, Laurie K. Read, Julius Lukeš & Hassan Hashimi. (2015) Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing. RNA 21:12, pages 2088-2102.
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Suzanne M. McDermott, Xuemin Guo, Jason Carnes & Kenneth Stuart. (2015) Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei. Journal of Biological Chemistry 290:41, pages 24914-24931.
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Porsha L. R. Shaw, Natalie M. McAdams, Michael A. Hast, Michelle L. Ammerman, Laurie K. Read & Maria A. Schumacher. (2015) Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold . Nucleic Acids Research 43:14, pages 7096-7109.
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Jason Carnes, Melissa Lerch, Irina Kurtz & Ken Stuart. (2015) Bloodstream form Trypanosoma brucei do not require mRPN1 for gRNA processing . RNA 21:1, pages 28-35.
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Houtan Moshiri, Vaibhav Mehta, Chun Wai Yip & Reza Salavati. (2015) Pilot-Scale Compound Screening against RNA Editing Identifies Trypanocidal Agents. SLAS Discovery 20:1, pages 92-100.
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Hassan Hashimi, Sara L. Zimmer, Michelle L. Ammerman, Laurie K. Read & Julius Lukeš. (2013) Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex. Trends in Parasitology 29:2, pages 91-99.
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H. Ulrich Göringer. (2012) ‘Gestalt,’ Composition and Function of the Trypanosoma brucei Editosome . Annual Review of Microbiology 66:1, pages 65-82.
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Bardees M. Foda, Kurtis M. Downey, John C. Fisk & Laurie K. Read. (2012) Multifunctional G-Rich and RRM-Containing Domains of TbRGG2 Perform Separate yet Essential Functions in Trypanosome RNA Editing. Eukaryotic Cell 11:9, pages 1119-1131.
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Cordula Böhm, Venkata Subbaraju Katari, Michael Brecht & H. Ulrich Göringer. (2012) Trypanosoma brucei 20 S Editosomes Have One RNA Substrate-binding Site and Execute RNA Unwinding Activity. Journal of Biological Chemistry 287:31, pages 26268-26277.
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