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Molecular and Cellular Biology Volume 33, 2013 - Issue 13
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Article

αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation

Xinjun Jia Departments of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Ji Wanc Interdepartmental Graduate Program in Genetics, University of Iowa, Iowa City, Iowa, USA;d Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
,
Melanie Vishnua Departments of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Yi Xingd Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA;e Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USACorrespondence[email protected] [email protected]
&
Stephen A. Liebhabera Departments of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;b Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USACorrespondence[email protected] [email protected]
Pages 2560-2573 | Received 10 Oct 2012, Accepted 08 Apr 2013, Published online: 20 Mar 2023

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Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R. Ghanem, Andrew Kromer, Christopher Duncan-Lewis, Elizabeth Traxler, Mitchell J. Weiss, Yoseph Barash & Stephen A. Liebhaber. (2021) RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis. Molecular and Cellular Biology 41:9.
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Margarita I. Zarudnaya, Iryna M. Kolomiets, Andriy L. Potyahaylo & Dmytro M. Hovorun. (2019) Structural transitions in poly(A), poly(C), poly(U), and poly(G) and their possible biological roles. Journal of Biomolecular Structure and Dynamics 37:11, pages 2837-2866.
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Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Xinjun Ji, Matthew Gazzara, Nhu Nguyen, Gabrielle Aguilar, Massimo Martinelli, Yoseph Barash & Stephen A. Liebhaber. (2018) Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Molecular and Cellular Biology 38:16.
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Jonathan Neve, Radhika Patel, Zhiqiao Wang, Alastair Louey & André Martin Furger. (2017) Cleavage and polyadenylation: Ending the message expands gene regulation. RNA Biology 14:7, pages 865-890.
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Fengmin Li, Kimberly Z. Bullough, Ajay A. Vashisht, James A. Wohlschlegel & Caroline C. Philpott. (2016) Poly(rC)-Binding Protein 2 Regulates Hippo Signaling To Control Growth in Breast Epithelial Cells. Molecular and Cellular Biology 36:16, pages 2121-2131.
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Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Priya Chatterji, Elizabeth Traxler, Alfredo Penzo-Mendez, Mitchell J. Weiss, Ben Z. Stanger & Stephen A. Liebhaber. (2016) The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Molecular and Cellular Biology 36:2, pages 304-319.
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Articles from other publishers (27)

Massimo Martinelli, Gabrielle Aguilar, David S.M. Lee, Andrew Kromer, Nhu Nguyen, Benjamin J. Wilkins, Tatiana Akimova, Ulf H. Beier & Louis R. Ghanem. (2023) The poly(C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation. iScience 26:1, pages 105860.
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Sibylle Mitschka & Christine Mayr. (2022) Context-specific regulation and function of mRNA alternative polyadenylation. Nature Reviews Molecular Cell Biology 23:12, pages 779-796.
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Yi Zhang, Lian Liu, Qiongzi Qiu, Qing Zhou, Jinwang Ding, Yan Lu & Pengyuan Liu. (2021) Alternative polyadenylation: methods, mechanism, function, and role in cancer. Journal of Experimental & Clinical Cancer Research 40:1.
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Yun Cao, Wei Zhang, Yi-Ting Jin & Qiang Zou. (2020) Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma. International Journal of Genomics 2020, pages 1-17.
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Andreas J. Gruber & Mihaela Zavolan. (2019) Alternative cleavage and polyadenylation in health and disease. Nature Reviews Genetics 20:10, pages 599-614.
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Breege V. Howley & Philip H. Howe. (2019) TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1. Cytokine 118, pages 19-26.
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Xinjun Ji, Jesse Humenik & Stephen A. Liebhaber. (2019) A cytosine-rich splice regulatory determinant enforces functional processing of the human α-globin gene transcript. Blood 133:21, pages 2338-2347.
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Ting Shen, Huan Li, Yifang Song, Li Li, Jinzhong Lin, Gang Wei & Ting Ni. (2019) Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence. Aging 11:5, pages 1356-1388.
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Andreas J. Gruber, Ralf Schmidt, Souvik Ghosh, Georges Martin, Andreas R. Gruber, Erik van Nimwegen & Mihaela Zavolan. (2018) Discovery of physiological and cancer-related regulators of 3′ UTR processing with KAPAC. Genome Biology 19:1.
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Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang & Haihe Wang. (2018) PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation. Journal of Experimental & Clinical Cancer Research 37:1.
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Zhizhang Wang, Weijie Yin, Lizhen Zhu, Jia Li, Yikun Yao, Feifei Chen, Mengmeng Sun, Jiayuan Zhang, Nan Shen, Yan Song & Xing Chang. (2018) Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production. Immunity 49:1, pages 80-92.e7.
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Xinjun Ji, Jesse Humenik, Daphne Yang & Stephen A Liebhaber. (2018) PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing. Nucleic Acids Research 46:4, pages 2030-2044.
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Encarnación Rodríguez-Cazorla, Samanta Ortuño-Miquel, Héctor Candela, Lindsay J. Bailey-Steinitz, Martin F. Yanofsky, Antonio Martínez-Laborda, Juan-José Ripoll & Antonio Vera. (2018) Ovule identity mediated by pre-mRNA processing in Arabidopsis. PLOS Genetics 14:1, pages e1007182.
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Panagiotis Ntostis, Deborah Carter, David Iles, John Huntriss, Maria Tzetis & David Miller. (2017) Potential sperm contributions to the murine zygote predicted by in silico analysis. Reproduction 154:6, pages 777-788.
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Andreas J. Gruber, Ralf Schmidt, Andreas R. Gruber, Georges Martin, Souvik Ghosh, Manuel Belmadani, Walter Keller & Mihaela Zavolan. (2016) A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation. Genome Research 26:8, pages 1145-1159.
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Thomas Geuens, Delphine Bouhy & Vincent Timmerman. (2016) The hnRNP family: insights into their role in health and disease. Human Genetics 135:8, pages 851-867.
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Sawsan Napthine, Emmely E. Treffers, Susanne Bell, Ian Goodfellow, Ying Fang, Andrew E. Firth, Eric J. Snijder & Ian Brierley. (2016) A novel role for poly(C) binding proteins in programmed ribosomal frameshifting. Nucleic Acids Research 44:12, pages 5491-5503.
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Xinjun Ji, Juw Won Park, Emad Bahrami-Samani, Lan Lin, Christopher Duncan-Lewis, Gordon Pherribo, Yi Xing & Stephen A. Liebhaber. (2016) αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome. Nucleic Acids Research 44:5, pages 2283-2297.
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Encarnación Rodríguez-Cazorla, Juan José Ripoll, Alfonso Andújar, Lindsay J. Bailey, Antonio Martínez-Laborda, Martin F. Yanofsky & Antonio Vera. (2015) K-homology Nuclear Ribonucleoproteins Regulate Floral Organ Identity and Determinacy in Arabidopsis. PLOS Genetics 11:2, pages e1004983.
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Katharine R Grabek, Cecilia Diniz Behn, Gregory S Barsh, Jay R Hesselberth & Sandra L Martin. (2015) Enhanced stability and polyadenylation of select mRNAs support rapid thermogenesis in the brown fat of a hibernator. eLife 4.
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Marlon Stoeckius, Dominic Grün, Marieluise Kirchner, Salah Ayoub, Francesca Torti, Fabio Piano, Margareta Herzog, Matthias Selbach & Nikolaus Rajewsky. (2014) Global characterization of the oocyte‐to‐embryo transition in C aenorhabditis elegans uncovers a novel m RNA clearance mechanism . The EMBO Journal 33:16, pages 1751-1766.
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Ryan Davis & Yongsheng Shi. (2014) The polyadenylation code: a unified model for the regulation of mRNA alternative poly adenylation. Journal of Zhejiang University SCIENCE B 15:5, pages 429-437.
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Louis R. Ghanem, Priya Chatterji & Stephen A. Liebhaber. (2014) Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa. Gene Expression Patterns 14:2, pages 78-87.
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Andreas R. Gruber, Georges Martin, Walter Keller & Mihaela Zavolan. (2014) Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Wiley Interdisciplinary Reviews: RNA 5:2, pages 183-196.
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Thomas W. Bebee, Benjamin W. Cieply & Russ P. Carstens. 2014. Systems Biology of RNA Binding Proteins. Systems Biology of RNA Binding Proteins 267 302 .
Dinghai Zheng & Bin Tian. 2014. Systems Biology of RNA Binding Proteins. Systems Biology of RNA Binding Proteins 97 127 .
Qishan Chen, Min Jin, Jianhua Zhu, Qingzhong Xiao & Li Zhang. (2013) Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation. BioMed Research International 2013, pages 1-12.
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