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Molecular and Cellular Biology Volume 27, 2007 - Issue 3
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Article

Intramolecular Regulation of Phospholipase C-γ1 by Its C-Terminal Src Homology 2 Domain

Karen DeBell1 Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Drugs Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
,
Laurie Graham1 Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Drugs Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
,
Ilona Reischl1 Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Drugs Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
,
Carmen Serrano1 Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Drugs Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
,
Ezio Bonvini2 MacroGenics, Inc., 1500 East Gude Drive, Rockville, Maryland
&
Barbara Rellahan1 Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Drugs Evaluation and Research, Food and Drug Administration, Bethesda, MarylandCorrespondence[email protected]
Pages 854-863 | Received 31 Jul 2006, Accepted 11 Nov 2006, Published online: 27 Mar 2023

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Katy L. Everett, Anja Buehler, Tom D. Bunney, Anca Margineanu, Rhona W. Baxendale, Petra Vatter, Michael Retlich, Claudia Walliser, Hugh B. Manning, Mark A. A. Neil, Christopher Dunsby, Paul M. W. French, Peter Gierschik & Matilda Katan. (2011) Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase Cγ2 . Molecular and Cellular Biology 31:6, pages 1240-1251.
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Edhriz Siraliev-Perez, Jordan TB Stariha, Reece M Hoffmann, Brenda RS Temple, Qisheng Zhang, Nicole Hajicek, Meredith L Jenkins, John E Burke & John Sondek. (2022) Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes. eLife 11.
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Chi-Chuan Lin, Kin Man Suen, Polly-Anne Jeffrey, Lukasz Wieteska, Jessica A. Lidster, Peng Bao, Alistair P. Curd, Amy Stainthorp, Caroline Seiler, Hans Koss, Eric Miska, Zamal Ahmed, Stephen D. Evans, Carmen Molina-París & John E. Ladbury. (2022) Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state. Molecular Cell 82:6, pages 1089-1106.e12.
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Dongying Chen & Michael Simons. (2021) Emerging roles of PLCγ1 in endothelial biology. Science Signaling 14:694.
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Masayuki Shiseki, Mayuko Ishii, Mari Miyazaki, Satoko Osanai, Yan‐Hua Wang, Kentaro Yoshinaga, Naoki Mori & Junji Tanaka. (2019) Reduced PLCG1 expression is associated with inferior survival for myelodysplastic syndromes . Cancer Medicine 9:2, pages 460-468.
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Hans Koss, Tom D. Bunney, Diego Esposito, Marta Martins, Matilda Katan & Paul C. Driscoll. (2018) Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR. Biophysical Journal 115:1, pages 31-45.
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Amy H. AndreottiRaji E. JosephJames M. ConleyJanet IwasaLeslie J. Berg. (2018) Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response. Annual Review of Immunology 36:1, pages 549-578.
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Rakhi P. Jattani, Julia M. Tritapoe & Joel L. Pomerantz. (2016) Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements. Journal of Biological Chemistry 291:16, pages 8324-8336.
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Silvia Gramolelli, Magdalena Weidner-Glunde, Bizunesh Abere, Abel Viejo-Borbolla, Kiran Bala, Jessica Rückert, Elisabeth Kremmer & Thomas F. Schulz. (2015) Inhibiting the Recruitment of PLCγ1 to Kaposi’s Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells. PLOS Pathogens 11:8, pages e1005105.
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Sujan Devkota, Raji E. Joseph, Lie Min, D. Bruce Fulton & Amy H. Andreotti. (2015) Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. Journal of Molecular Biology 427:17, pages 2734-2747.
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Hans Koss, Tom D. Bunney, Sam Behjati & Matilda Katan. (2014) Dysfunction of phospholipase Cγ in immune disorders and cancer. Trends in Biochemical Sciences 39:12, pages 603-611.
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Jing WangHaewon SohnGuangping SunJoshua D. MilnerSusan K. Pierce. (2014) The autoinhibitory C-terminal SH2 domain of phospholipase C–γ2 stabilizes B cell receptor signalosome assembly. Science Signaling 7:343.
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Lily A. Chylek, Vyacheslav Akimov, Jörn Dengjel, Kristoffer T. G. Rigbolt, Bin Hu, William S. Hlavacek & Blagoy Blagoev. (2014) Phosphorylation Site Dynamics of Early T-cell Receptor Signaling. PLoS ONE 9:8, pages e104240.
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Corinne Niger, Maria A Luciotti, Atum M Buo, Carla Hebert, Vy Ma & Joseph P Stains. (2013) The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade. Journal of Bone and Mineral Research 28:6, pages 1468-1477.
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Tom D. Bunney, Diego Esposito, Corine Mas-Droux, Ekatarina Lamber, Rhona W. Baxendale, Marta Martins, Ambrose Cole, Dmitri Svergun, Paul C. Driscoll & Matilda Katan. (2012) Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure 20:12, pages 2062-2075.
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Qing Lu, Jiang Yu, Jing Yan, Zhiyi Wei & Mingjie Zhang. (2011) Structural basis of the myosin X PH1 N -PH2-PH1 C tandem as a specific and acute cellular PI(3,4,5)P 3 sensor . Molecular Biology of the Cell 22:22, pages 4268-4278.
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Rodolfo SilvaSusan MoirLela KardavaKaren DebellVenkateswara R. SimhadriSara Ferrando-Martínez, Manuel Leal, José Peña, John E. ColiganFrancisco Borrego. (2011) CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection. Blood 117:22, pages 5870-5880.
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Seo-Jin Lee, Patricia S Tsang, Tere M Diaz, Bei-yang Wei & William George Stetler-Stevenson. (2010) TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells. Laboratory Investigation 90:3, pages 374-382.
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Sang-Hee ChungSung-Kuk KimJung Kuk KimYong-Ryoul YangPann-Ghill SuhJong-Soo Chang. (2010) A double point mutation in PCL-γ1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation. Experimental and Molecular Medicine 42:3, pages 216.
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Katy L. Everett, Tom D. Bunney, Youngdae Yoon, Fernando Rodrigues-Lima, Richard Harris, Paul C. Driscoll, Koichiro Abe, Helmut Fuchs, Martin Hrabé de Angelis, Philipp Yu, Wohnwa Cho & Matilda Katan. (2009) Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations. Journal of Biological Chemistry 284:34, pages 23083-23093.
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Ian K. Townley, Erin Schuyler, Michelle Parker-Gür & Kathy R. Foltz. (2009) Expression of multiple Src family kinases in sea urchin eggs and their function in Ca2+ release at fertilization. Developmental Biology 327:2, pages 465-477.
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Jian-Jiang Hao, Yin Liu, Michael Kruhlak, Karen E. Debell, Barbara L. Rellahan & Stephen Shaw. (2009) Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane. Journal of Cell Biology 184:3, pages 451-462.
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Claudia Walliser, Michael Retlich, Richard Harris, Katy L. Everett, Michelle B. Josephs, Petra Vatter, Diego Esposito, Paul C. Driscoll, Matilda Katan, Peter Gierschik & Tom D. Bunney. (2008) Rac Regulates Its Effector Phospholipase Cγ2 through Interaction with a Split Pleckstrin Homology Domain. Journal of Biological Chemistry 283:44, pages 30351-30362.
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Wenyu Wen, Wei Liu, Jing Yan & Mingjie Zhang. (2008) Structure Basis and Unconventional Lipid Membrane Binding Properties of the PH-C1 Tandem of Rho Kinases. Journal of Biological Chemistry 283:38, pages 26263-26273.
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