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Molecular and Cellular Biology Volume 30, 2010 - Issue 11
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Article

DDB2, an Essential Mediator of Premature Senescence

Nilotpal Roy1 Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, Illinois60607Correspondence[email protected] [email protected]
,
Tanya Stoyanova1 Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, Illinois60607
,
Carmen Dominguez-Brauer1 Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, Illinois60607
,
Hyun Jung Park1 Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, Illinois60607
,
Srilata Bagchi2 Center of Molecular Biology of Oral Diseases (M/C 860), College of Dentistry, Cancer Center, University of Illinois at Chicago, 801 S. Paulina Ave., Chicago, Illinois60612Correspondence[email protected] [email protected]
&
Pradip Raychaudhuri1 Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, Illinois60607Correspondence[email protected] [email protected]
Pages 2681-2692 | Received 12 Nov 2009, Accepted 21 Mar 2010, Published online: 20 Mar 2023

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Anna Roth, Karine Boulay, Matthias Groß, Maria Polycarpou-Schwarz, Frédérick A. Mallette, Marine Regnier, Or Bida, Doron Ginsberg, Arne Warth, Philipp A. Schnabel, Thomas Muley, Michael Meister, Heike Zabeck, Hans Hoffmann & Sven Diederichs. (2018) Targeting LINC00673 expression triggers cellular senescence in lung cancer. RNA Biology 15:12, pages 1499-1511.
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Paola Perucca, Sabrina Sommatis, Roberto Mocchi, Ennio Prosperi, Lucia Anna Stivala & Ornella Cazzalini. (2015) A DDB2 mutant protein unable to interact with PCNA promotes cell cycle progression of human transformed embryonic kidney cells. Cell Cycle 14:24, pages 3920-3928.
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Xavier Deschênes-Simard, Frédéric Lessard, Marie-France Gaumont-Leclerc, Nabeel Bardeesy & Gerardo Ferbeyre. (2014) Cellular senescence and protein degradation. Cell Cycle 13:12, pages 1840-1858.
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Nilotpal Roy, Indira Elangovan, Dragana Kopanja, Srilata Bagchi & Pradip Raychaudhuri. (2013) Tumor regression by phenethyl isothiocyanate involves DDB2. Cancer Biology & Therapy 14:2, pages 108-116.
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Articles from other publishers (28)

Xinshu Wang, Zhiyuan Huang, Lei Li, Yuntong Yang, Jiyuan Zhang, Li Wang, Jian Yuan & Yunhui Li. (2022) The Role of Alternative Splicing Factors, DDB2-Related Ageing and DNA Damage Repair in the Progression and Prognosis of Stomach Adenocarcinoma Patients. Genes 14:1, pages 39.
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Ning Bao, Jiguang Han & Huimin Zhou. (2022) A protein with broad functions: damage-specific DNA-binding protein 2. Molecular Biology Reports 49:12, pages 12181-12192.
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Steffen Schubert & Steffen Emmert. 2019. Harper's Textbook of Pediatric Dermatology. Harper's Textbook of Pediatric Dermatology 1743 1768 .
Zhi Chen, Yingchao Han, Chao Deng, Wei Chen, Linyu Jin, Hao Chen, Kun Wang, Hongxing Shen & Lie Qian. (2019) Inflammation‐dependent downregulation of miR‐194‐5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B. Journal of Cellular Physiology 234:11, pages 19977-19989.
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Amit K. Srivastava, Ananya Banerjee, Tiantian Cui, Chunhua Han, Shurui Cai, Lu Liu, Dayong Wu, Ri Cui, Zaibo Li, Xiaoli Zhang, Guozhen Xie, Karuppaiyah Selvendiran, Srinivas Patnaik, Adam R. Karpf, Jinsong Liu, David E. Cohn & Qi-En Wang. (2019) Inhibition of miR-328–3p Impairs Cancer Stem Cell Function and Prevents Metastasis in Ovarian Cancer. Cancer Research 79:9, pages 2314-2326.
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Tiantian Cui, Amit Kumar Srivastava, Chunhua Han, Dayong Wu, Nissar Wani, Lu Liu, Zhiqin Gao, Meihua Qu, Ning Zou, Xiaoli Zhang, Ping Yi, Jianhua Yu, Erica H. Bell, Shyh-Ming Yang, David J. Maloney, Yanfang Zheng, Altaf A. Wani & Qi-En Wang. (2018) DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1. Cell Death & Disease 9:5.
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Damiano Fantini, Shuo Huang, John M. Asara, Srilata Bagchi & Pradip Raychaudhuri. (2017) Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Molecular Biology of the Cell 28:1, pages 192-200.
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Ning Zou, Guozhen Xie, Tiantian Cui, Amit Kumar Srivastava, Meihua Qu, Linlin Yang, Shaozhong Wei, Yanfang Zheng & Qi-En Wang. (2016) DDB2 increases radioresistance of NSCLC cells by enhancing DNA damage responses. Tumor Biology 37:10, pages 14183-14191.
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Ling Zhang & Feng Gong. (2016) The emerging role of deubiquitination in nucleotide excision repair. DNA Repair 44, pages 118-122.
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. (2016) Publisher’s Note. DNA Repair 43, pages 34.
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Andrew Magimaidas, Priyanka Madireddi, Silvia Maifrede, Kaushiki Mukherjee, Barbara Hoffman & Dan A. Liebermann. (2016) Gadd45b deficiency promotes premature senescence and skin aging. Oncotarget 7:19, pages 26935-26948.
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Ran Zhao, Tiantian Cui, Chunhua Han, Xiaoli Zhang, Jinshan He, Amit Kumar Srivastava, Jianhua Yu, Altaf A. Wani & Qi-En Wang. (2015) DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L. Nucleic Acids Research 43:16, pages 7838-7849.
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Changchang Liu, Stephen La Rosa & Engda G. Hagos. (2015) Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4. Molecular Carcinogenesis 54:9, pages 889-899.
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Dragana Kopanja, Akshay Pandey, Megan Kiefer, Zebin Wang, Neha Chandan, Janai R. Carr, Roberta Franks, Dae-Yeul Yu, Grace Guzman, Ajay Maker & Pradip Raychaudhuri. (2015) Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features. Journal of Hepatology 63:2, pages 429-436.
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Pan WangLimin HanHong ShenPengfeng WangCuicui LvGanye ZhaoJing Niu, Lixiang XueQiming Jane Wang, Tanjun TongJun Chen. (2014) Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation. Proceedings of the National Academy of Sciences 111:21, pages 7683-7688.
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Chunhua Han, Ran Zhao, Xingluo Liu, Amit Srivastava, Li Gong, Hsiaoyin Mao, Meihua Qu, Weiqiang Zhao, Jianhua Yu & Qi-En Wang. (2014) DDB2 Suppresses Tumorigenicity by Limiting the Cancer Stem Cell Population in Ovarian Cancer. Molecular Cancer Research 12:5, pages 784-794.
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Marjo-Riitta Puumalainen, Davor Lessel, Peter Rüthemann, Nina Kaczmarek, Karin Bachmann, Kristijan Ramadan & Hanspeter Naegeli. (2014) Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity. Nature Communications 5:1.
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Suiquan Wang, Miaoni Zhou, Fuquan Lin, Dongyin Liu, Weisong Hong, Liangjun Lu, Yiping Zhu & Aie Xu. (2014) Interferon-γ Induces Senescence in Normal Human Melanocytes. PLoS ONE 9:3, pages e93232.
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Ran Zhao, Chunhua Han, Eric Eisenhauer, John Kroger, Weiqiang Zhao, Jianhua Yu, Karuppaiyah Selvendiran, Xingluo Liu, Altaf A. Wani & Qi-En Wang. (2014) DNA Damage-Binding Complex Recruits HDAC1 to Repress Bcl-2 Transcription in Human Ovarian Cancer Cells. Molecular Cancer Research 12:3, pages 370-380.
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Marie Ennen, Rémi Klotz, Nadège Touche, Sophie Pinel, Claire Barbieux, Vanessa Besancenot, Emilie Brunner, Denise Thiebaut, Alain C. Jung, Sonia Ledrappier, Lionel Domenjoud, Joseph Abecassis, François Plénat, Stéphanie Grandemange & Philippe Becuwe. (2013) DDB2: A Novel Regulator of NF-κB and Breast Tumor Invasion. Cancer Research 73:16, pages 5040-5052.
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Nilotpal Roy, Prashant V. Bommi, Uppoor G. Bhat, Shaumick Bhattacharjee, Indira Elangovan, Jing Li, Krushna C. Patra, Dragana Kopanja, Adam Blunier, Richard Benya, Srilata Bagchi & Pradip Raychaudhuri. (2013) DDB2 Suppresses Epithelial-to-Mesenchymal Transition in Colon Cancer. Cancer Research 73:12, pages 3771-3782.
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Brian D. Melanson, Miguel A. Cabrita, Reetesh Bose, Jeffrey D. Hamill, Elysia Pan, Christian Brochu, Kristen A. Marcellus, Tong T. Zhao, Martin Holcik & Bruce C. McKay. (2013) A novel cis -acting element from the 3′UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression. Nucleic Acids Research 41:11, pages 5692-5703.
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Xiaoman Li, Hongde Xu, Chongan Xu, Meina Lin, Xiaoyu Song, Fei Yi, Yanling Feng, Kathleen Coughlan, William Cho, Sang Kim & Liu Cao. (2013) The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence. International Journal of Molecular Sciences 14:2, pages 2431-2448.
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Nilotpal Roy & Pradip Raychaudhuri. 2013. Tumor Dormancy, Quiescence, and Senescence, Volume 1. Tumor Dormancy, Quiescence, and Senescence, Volume 1 141 151 .
Nilotpal Roy, Srilata Bagchi & Pradip Raychaudhuri. (2012) Damaged DNA Binding Protein 2 in Reactive Oxygen Species (ROS) Regulation and Premature Senescence. International Journal of Molecular Sciences 13:9, pages 11012-11026.
Crossref
Seiji Nakamura, Kozo Kawai, Yumie Takeshita, Masao Honda, Toshinari Takamura, Shuichi Kaneko, Ryo Matoba & Kenichi Matsubara. (2012) Identification of blood biomarkers of aging by transcript profiling of whole blood. Biochemical and Biophysical Research Communications 418:2, pages 313-318.
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Tanya Stoyanova, Nilotpal Roy, Shaumick Bhattacharjee, Dragana Kopanja, Ted Valli, Srilata Bagchi & Pradip Raychaudhuri. (2012) p21 Cooperates with DDB2 Protein in Suppression of Ultraviolet Ray-induced Skin Malignancies. Journal of Biological Chemistry 287:5, pages 3019-3028.
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Müge Ogrunc & Fabrizio d’Adda di Fagagna. (2011) Never-ageing cellular senescence. European Journal of Cancer 47:11, pages 1616-1622.
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