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Molecular and Cellular Biology Volume 33, 2013 - Issue 9
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Article

ATM- and ATR-Mediated Phosphorylation of XRCC3 Regulates DNA Double-Strand Break-Induced Checkpoint Activation and Repair

Kumar Somyajita Department of Biochemistry, Indian Institute of Science, Bangalore, India
,
Shivakumar Basavarajua Department of Biochemistry, Indian Institute of Science, Bangalore, India
,
Ralph Scullyb Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
&
Ganesh Nagarajua Department of Biochemistry, Indian Institute of Science, Bangalore, IndiaCorrespondence[email protected]
Pages 1830-1844 | Received 28 Dec 2012, Accepted 18 Feb 2013, Published online: 20 Mar 2023

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Anup Mishra, Sneha Saxena, Anjali Kaushal & Ganesh Nagaraju. (2018) RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity of the Mitochondrial Genome. Molecular and Cellular Biology 38:3.
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Kimiyoshi Yano & Bunsyo Shiotani. (2023) Emerging strategies for cancer therapy by ATR inhibitors . Cancer Science.
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Debanjali Bhattacharya, Satyaranjan Sahoo, Tarun Nagraj, Suruchi Dixit, Harsh Kumar Dwivedi & Ganesh Nagaraju. (2022) RAD51 paralogs: Expanding roles in replication stress responses and repair. Current Opinion in Pharmacology 67, pages 102313.
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Semer Maksoud. (2022) The DNA Double-Strand Break Repair in Glioma: Molecular Players and Therapeutic Strategies. Molecular Neurobiology 59:9, pages 5326-5365.
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Julian Spies, Hana Polasek-Sedlackova, Jiri Lukas & Kumar Somyajit. (2021) Homologous Recombination as a Fundamental Genome Surveillance Mechanism during DNA Replication. Genes 12:12, pages 1960.
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Sarmi Nath & Ganesh Nagaraju. (2020) FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks. PLOS Genetics 16:4, pages e1008701.
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Sneha Saxena, Suruchi Dixit, Kumar Somyajit & Ganesh Nagaraju. (2019) ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response. Cell Reports 29:3, pages 551-559.e4.
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Michael Charles Lanz, Diego Dibitetto & Marcus Bustamante Smolka. (2019) DNA damage kinase signaling: checkpoint and repair at 30 years . The EMBO Journal 38:18.
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Robert A. Baldock, Catherine A. Pressimone, Jared M. Baird, Anton Khodakov, Thong T. Luong, McKenzie K. Grundy, Chelsea M. Smith, Yoav Karpenshif, Dominique S. Bratton-Palmer, Rohit Prakash, Maria Jasin, Edwige B. Garcin, Stéphanie Gon, Mauro Modesti & Kara A. Bernstein. (2019) RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination. DNA Repair 76, pages 99-107.
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Khadijeh S. Alnajjar & Joann B. Sweasy. (2019) A new perspective on oxidation of DNA repair proteins and cancer. DNA Repair 76, pages 60-69.
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Nicole M. Reilly, Brian D. Yard & Douglas L. Pittman. 2019. DNA Repair. DNA Repair 3 29 .
Sneha Saxena, Kumar Somyajit & Ganesh Nagaraju. (2018) XRCC2 Regulates Replication Fork Progression during dNTP Alterations. Cell Reports 25:12, pages 3273-3282.e6.
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Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K. Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser & Massimo Lopes. (2018) ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links. Cell Reports 24:10, pages 2629-2642.e5.
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Xiao-qin Li, Jin Ren, Ping Chen, Yu-jiao Chen, Min Wu, Yan Wu, Kang Chen & Jian Li. (2018) Co-inhibition of Pol η and ATR sensitizes cisplatin-resistant non-small cell lung cancer cells to cisplatin by impeding DNA damage repair. Acta Pharmacologica Sinica 39:8, pages 1359-1372.
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Wynand P. Roos, Larissa Frohnapfel, Steve Quiros, Florian Ringel & Bernd Kaina. (2018) XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair. Cancer Letters 424, pages 119-126.
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Yuan Chun Ding, Aaron W. Adamson, Linda Steele, Adam M. Bailis, Esther M. John, Gail Tomlinson & Susan L. Neuhausen. (2017) Discovery of mutations in homologous recombination genes in African-American women with breast cancer. Familial Cancer 17:2, pages 187-195.
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Li-Yun Fann, Ying Chen, Da-Chen Chu, Shao-Ju Weng, Heng-Cheng Chu, Alexander T.H. Wu, Jiann-Fong Lee, Ahmed Atef Ahmed Ali, Tsung-Chih Chen, Hsu-Shan Huang & Kuo-Hsing Ma. (2017) Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget 9:15, pages 11922-11937.
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He-Guo Jiang, Ping Chen, Jin-Yu Su, Ming Wu, Hai Qian, Yi Wang & Jian Li. (2017) Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells. Journal of Cellular Physiology 232:12, pages 3433-3443.
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Kumar Somyajit, Rajat GuptaHana SedlackovaKai John NeelsenFena OchsMaj-Britt RaskChunaram ChoudharyJiri Lukas. (2017) Redox-sensitive alteration of replisome architecture safeguards genome integrity. Science 358:6364, pages 797-802.
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Gireedhar Venkatachalam, Uttam Surana & Marie-Véronique Clément. (2017) Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress. Nucleic Acids Research 45:18, pages 10564-10582.
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Joshua C. Saldivar, David Cortez & Karlene A. Cimprich. (2017) The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Reviews Molecular Cell Biology 18:10, pages 622-636.
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Sarmi Nath, Kumar Somyajit, Anup Mishra, Ralph Scully & Ganesh Nagaraju. (2017) FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids. Nucleic Acids Research 45:15, pages 8886-8900.
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Stephanie A. Yazinski, Valentine Comaills, Rémi Buisson, Marie-Michelle Genois, Hai Dang Nguyen, Chu Kwen Ho, Tanya Todorova Kwan, Robert Morris, Sam Lauffer, André Nussenzweig, Sridhar Ramaswamy, Cyril H. Benes, Daniel A. Haber, Shyamala Maheswaran, Michael J. Birrer & Lee Zou. (2017) ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. Genes & Development 31:3, pages 318-332.
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Fena Ochs, Kumar Somyajit, Matthias Altmeyer, Maj-Britt Rask, Jiri Lukas & Claudia Lukas. (2016) 53BP1 fosters fidelity of homology-directed DNA repair. Nature Structural & Molecular Biology 23:8, pages 714-721.
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Kumar Somyajit, Bhabatosh Banik, Sneha Saxena, Sharath Babu, Manoor Prakash Hande, Akhil R. Chakravarty & Ganesh Nagaraju. (2016) Trans -dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy . Carcinogenesis 37:2, pages 145-156.
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Xing Zhong, Guomin Luo, Xiaojuan Zhou, Wen Luo, Xia Wu, Renming Zhong, Yanping Wang, Feng Xu & Jin Wang. (2015) R ad51 in regulating the radiosensitivity of non‐small cell lung cancer with different epidermal growth factor receptor mutation status . Thoracic Cancer 7:1, pages 50-60.
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Yongzhi Yang, Lizhong Wang, Jin Han, Xiaolong Tang, Ming Ma, Kun Wang, Xiao Zhang, Qian Ren, Qiang Chen & Qiang Qiu. (2015) Comparative transcriptomic analysis revealed adaptation mechanism of Phrynocephalus erythrurus, the highest altitude Lizard living in the Qinghai-Tibet Plateau. BMC Evolutionary Biology 15:1.
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Kumar Somyajit, Sneha Saxena, Sharath Babu, Anup Mishra & Ganesh Nagaraju. (2015) Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. Nucleic Acids Research, pages gkv880.
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Yiai Tong, Diana Merino, Birgit Nimmervoll, Kirti Gupta, Yong-Dong Wang, David Finkelstein, James Dalton, David W. Ellison, Xiaotu Ma, Jinghui Zhang, David Malkin & Richard J. Gilbertson. (2015) Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes. Cancer Cell 27:5, pages 712-727.
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Kumar Somyajit, Anup Mishra, Aida Jameei & Ganesh Nagaraju. (2015) Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. Carcinogenesis 36:1, pages 13-24.
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Shauna M. McKelvey, Karina A. Horgan & Richard A. Murphy. (2015) Chemical form of selenium differentially influences DNA repair pathways following exposure to lead nitrate. Journal of Trace Elements in Medicine and Biology 29, pages 151-169.
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Manuela Tumiati, Annabrita Hemmes, Sanna Uusivirta, Sonja Koopal, Matti Kankainen, Eero Lehtonen & Sergey G Kuznetsov. (2015) Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53 -mutant mice . The Journal of Pathology 235:1, pages 136-146.
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Jen-Wei Huang, Yemin Wang, Kiranjit K. Dhillon, Philamer Calses, Emily Villegas, Patrick S. Mitchell, Muneesh Tewari, Christopher J. Kemp & Toshiyasu Taniguchi. (2013) Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity. Molecular Cancer Research 11:12, pages 1564-1573.
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James D. Cauwood, Anthony L. Johnson, Alexander Widger & Rita S. Cha. (2013) Recombinogenic Conditions Influence Partner Choice in Spontaneous Mitotic Recombination. PLoS Genetics 9:11, pages e1003931.
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Pierre-Marie Girard, Dany Graindorge, Violetta Smirnova, Pascal Rigolet, Stefania Francesconi, Susan Scanlon & Evelyne Sage. (2013) Oxidative Stress in Mammalian Cells Impinges on the Cysteines Redox State of Human XRCC3 Protein and on Its Cellular Localization. PLoS ONE 8:10, pages e75751.
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