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Article

Phosphorylation of Liver X Receptor α Selectively Regulates Target Gene Expression in Macrophages

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Pages 2626-2636 | Received 27 Aug 2007, Accepted 28 Jan 2008, Published online: 27 Mar 2023

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Shreya R. Savla, Kedar S Prabhavalkar & Lokesh K Bhatt. (2022) Liver X receptor: a potential target in the treatment of atherosclerosis. Expert Opinion on Therapeutic Targets 26:7, pages 645-658.
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Chaowei Wu, Maryem A. Hussein, Elina Shrestha, Sarah Leone, Mohammed S. Aiyegbo, W. Marcus Lambert, Benoit Pourcet, Timothy Cardozo, Jan-Ake Gustafson, Edward A. Fisher, Ines Pineda-Torra & Michael J. Garabedian. (2015) Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation. Molecular and Cellular Biology 35:11, pages 2024-2034.
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Knut R Steffensen, Tomas Jakobsson & Jan-Åke Gustafsson. (2013) Targeting liver X receptors in inflammation. Expert Opinion on Therapeutic Targets 17:8, pages 977-990.
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Crossref
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Crossref
Wahiba Berrabah, Pierrette Aumercier, Philippe Lefebvre & Bart Staels. (2011) Control of nuclear receptor activities in metabolism by post-translational modifications. FEBS Letters 585:11, pages 1640-1650.
Crossref
Etimad A. Huwait, Kirsty R. Greenow, Nishi N. Singh & Dipak P. Ramji. (2011) A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. Cellular Signalling 23:3, pages 542-549.
Crossref
Chang Yeob HanSung Hwan KiYoung Woo KimKyoung NohDa Yeon LeeBomi KangJae-Ha RyuRaok JeonEun Hyun KimSe Jin HwangSang Geon Kim. (2011) Ajoene, A Stable Garlic By-Product, Inhibits High Fat Diet-Induced Hepatic Steatosis and Oxidative Injury Through LKB1-Dependent AMPK Activation. Antioxidants & Redox Signaling 14:2, pages 187-202.
Crossref
Denis A. Mogilenko, Vladimir S. Shavva, Ella B. Dizhe, Sergey V. Orlov & Andrej P. Perevozchikov. (2010) PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells. Biochemical and Biophysical Research Communications 402:3, pages 477-482.
Crossref
Maaike H. Oosterveer, Aldo Grefhorst, Albert K. Groen & Folkert Kuipers. (2010) The liver X receptor: Control of cellular lipid homeostasis and beyond. Progress in Lipid Research 49:4, pages 343-352.
Crossref
Jeffrey M. Sturek, J. David Castle, Anthony P. Trace, Laura C. Page, Anna M. Castle, Carmella Evans-Molina, John S. Parks, Raghavendra G. Mirmira & Catherine C. Hedrick. (2010) An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells. Journal of Clinical Investigation 120:7, pages 2575-2589.
Crossref
A. N. Smirnov. (2010) Lipid signaling in the atherogenesis context. Biochemistry (Moscow) 75:7, pages 793-810.
Crossref
Elin Holter Anthonisen, Lise Berven, Sverre Holm, Maria Nygård, Hilde I. Nebb & Line M. Grønning-Wang. (2010) Nuclear Receptor Liver X Receptor Is O-GlcNAc-modified in Response to Glucose. Journal of Biological Chemistry 285:3, pages 1607-1615.
Crossref
Jerzy Bełtowski & Andrzej Semczuk. (2010) Liver X receptor (LXR) and the reproductive system – a potential novel target for therapeutic intervention. Pharmacological Reports 62:1, pages 15-27.
Crossref
G. Chinetti-Gbaguidi & B. Staels. (2009) Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791:6, pages 486-493.
Crossref
Seong Hwan Hwahng, Sung Hwan Ki, Eun Ju Bae, Hyun Eun Kim & Sang Geon Kim. (2009) Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology 49:6, pages 1913-1925.
Crossref
Inés Pineda Torra, Julia A. Staverosky, Susan Ha, Susan K. Logan & Michael J. Garabedian. 2009. The Nuclear Receptor Superfamily. The Nuclear Receptor Superfamily 221 235 .
Melissa H. NagelinSuseela SrinivasanJianyi LeeJerry L. NadlerCatherine C. Hedrick. (2008) 12/15-Lipoxygenase Activity Increases the Degradation of Macrophage ATP-Binding Cassette Transporter G1. Arteriosclerosis, Thrombosis, and Vascular Biology 28:10, pages 1811-1819.
Crossref
Weiwei Chen, Thoa Dang, Raymond D. Blind, Zhen Wang, Claudio N. Cavasotto, Adam B. Hittelman, Inez Rogatsky, Susan K. Logan & Michael J. Garabedian. (2008) Glucocorticoid Receptor Phosphorylation Differentially Affects Target Gene Expression. Molecular Endocrinology 22:8, pages 1754-1766.
Crossref
Eun Kyung LeeYoung Joo Park. (2008) Metabolic Regulation of Nuclear Receptors. Journal of Korean Endocrine Society 23:3, pages 155.
Crossref

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