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Molecular and Cellular Biology Volume 26, 2006 - Issue 11
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Article

Phosphorylation of Jak2 on Ser523 InhibitsJak2-Dependent Leptin ReceptorSignaling

Ryoko Ishida-Takahashi1 Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan48109
,
Felicia Rosario2 Research Division, Joslin Diabetes Center, Boston, Massachusetts02215
,
Yusong Gong1 Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan48109
,
Keely Kopp1 Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan48109
,
Zlatina Stancheva1 Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan48109
,
Xiaohong Chen2 Research Division, Joslin Diabetes Center, Boston, Massachusetts02215
,
Edward P. Feener2 Research Division, Joslin Diabetes Center, Boston, Massachusetts02215Correspondence[email protected] [email protected]
&
Martin G. Myers Jr.1 Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan48109Correspondence[email protected] [email protected]
 show all
Pages 4063-4073 | Received 17 Aug 2005, Accepted 08 Mar 2006, Published online: 27 Mar 2023

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Hiu Kiu & Sandra E. Nicholson. (2012) Biology and significance of the JAK/STAT signalling pathways. Growth Factors 30:2, pages 88-106.
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Scott A. Robertson, Rositsa I. Koleva, Lawrence S. Argetsinger, Christin Carter-Su, Jarrod A. Marto, Edward P. Feener & Martin G. Myers$suffix/text()$suffix/text(). (2009) Regulation of Jak2 Function by Phosphorylation of Tyr317 and Tyr637 during Cytokine Signaling. Molecular and Cellular Biology 29:12, pages 3367-3378.
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Megumi Funakoshi-Tago, Stéphane Pelletier, Hiroshi Moritake, Evan Parganas & James N. Ihle. (2008) Jak2 FERM Domain Interaction with the Erythropoietin Receptor Regulates Jak2 Kinase Activity. Molecular and Cellular Biology 28:5, pages 1792-1801.
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Lei Nie, S. Scott Perry, Ying Zhao, Jiaxue Huang, Paul W. Kincade, Michael A. Farrar & Xiao-Hong Sun. (2008) Regulation of Lymphocyte Development by Cell-Type-Specific Interpretation of Notch Signals. Molecular and Cellular Biology 28:6, pages 2078-2090.
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Anna M. Mazurkiewicz-Munoz, Lawrence S. Argetsinger, Jean-Louis K. Kouadio, Allan Stensballe, Ole N. Jensen, Joel M. Cline & Christin Carter-Su. (2006) Phosphorylation of JAK2 at Serine 523: a Negative Regulator of JAK2 That Is Stimulated by GrowthHormone and Epidermal Growth Factor. Molecular and Cellular Biology 26:11, pages 4052-4062.
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Friederike Pastore, Aishwarya Krishnan, Henrik M. Hammarén, Olli SilvennoinenBenedict YanRoss L. Levine. (2020) JAK2S523L, a novel gain-of-function mutation in a critical autoregulatory residue in JAK2V617F− MPNs. Blood Advances 4:18, pages 4554-4559.
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Yibing Shan, Kavitha Gnanasambandan, Daniela Ungureanu, Eric T Kim, Henrik Hammarén, Kazuo Yamashita, Olli Silvennoinen, David E Shaw & Stevan R Hubbard. (2014) Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase. Nature Structural & Molecular Biology 21:7, pages 579-584.
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Stefan N. Constantinescu, Emilie Leroy, Vitalina Gryshkova, Christian Pecquet & Alexandra Dusa. (2013) Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers. Biochemical Society Transactions 41:4, pages 1048-1054.
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Graeme Williams. (2012) Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-α and GPER signalling. Molecular and Cellular Endocrinology 351:2, pages 269-278.
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