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Molecular and Cellular Biology Volume 34, 2014 - Issue 18
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Article

Caveolin-1 Is Required for Kinase Suppressor of Ras 1 (KSR1)-Mediated Extracellular Signal-Regulated Kinase 1/2 Activation, H-RasV12-Induced Senescence, and Transformation

Robert L. KortumEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
,
Mario R. FernandezEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
,
Diane L. Costanzo-GarveyEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
,
Heidi J. JohnsonEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
,
Kurt W. FisherEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
,
Deanna J. VolleEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
&
Robert E. LewisEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USACorrespondence[email protected]
 show all
Pages 3461-3472 | Received 10 Dec 2013, Accepted 25 Jun 2014, Published online: 20 Mar 2023

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Jianyun Ge, Yulin Huang, Yi Zhang, Lin Liu, Tianyu Gu, Xu Liu, Lei Yao, Mengmeng Cai, Jiafeng Sun & Jie Song. (2020) Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1. Drug Design, Development and Therapy 14, pages 1561-1569.
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Beth K. Neilsen, Danielle E. Frodyma, Robert E. Lewis & Kurt W. Fisher. (2017) KSR as a therapeutic target for Ras-dependent cancers. Expert Opinion on Therapeutic Targets 21:5, pages 499-509.
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Articles from other publishers (21)

Ion C. Cirstea, Herwig P. Moll & Jan Tuckermann. (2022) Glucocorticoid receptor and RAS: an unexpected couple in cancer. Trends in Cell Biology.
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Sheetal Pathania, Mohd Imran Khan, Sabyasachi Bandyopadhyay, Suneet Shekhar Singh, Komal Rani, Tanvi Ramesh Parashar, Jnaneshwari Jayaram, Piyush Ranjan Mishra, Anurag Srivastava, Sandeep Mathur, Smriti Hari, Perumal Vanamail & Gururao Hariprasad. (2022) iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer. Scientific Reports 12:1.
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Dongsheng Shang, Tianchu Zhou, Xinying Zhuang, Yanfang Wu, Hanqing Liu & Zhigang Tu. (2022) Molecular dissection on inhibition of Ras-induced cellular senescence by small t antigen of SV40. Cellular and Molecular Life Sciences 79:5.
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Mehdi Sanati, Samaneh Aminyavari, Amir R. Afshari & Amirhossein Sahebkar. (2022) Mechanistic insight into the role of metformin in Alzheimer's disease. Life Sciences 291, pages 120299.
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You Zhou, Qi Wang, Haifeng Deng, Bin Xu, Yi Zhou, Jian Liu, Yingting Liu, Yufang Shi, Xiao Zheng & Jingting Jiang. (2022) N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m6A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics. Cell Death & Disease 13:1.
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Yu-Chen S. H. Yang, Po-Jui Ko, Yi-Shin Pan, Hung-Yun Lin, Jacqueline Whang-Peng, Paul J. Davis & Kuan Wang. (2021) Role of thyroid hormone-integrin αvβ3-signal and therapeutic strategies in colorectal cancers. Journal of Biomedical Science 28:1.
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Hyuk Moon & Simon Weonsang Ro. (2021) Ras Mitogen-activated Protein Kinase Signaling and Kinase Suppressor of Ras as Therapeutic Targets for Hepatocellular Carcinoma. Journal of Liver Cancer 21:1, pages 1-11.
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Chao Han, Ya-Jun Wang, Ya-Chen Wang, Xin Guan, Liang Wang, Li-Ming Shen, Wei Zou & Jing Liu. (2021) Caveolin-1 downregulation promotes the dopaminergic neuron-like differentiation of human adipose-derived mesenchymal stem cells. Neural Regeneration Research 16:4, pages 714.
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Sydney R. Resnik, Andjela Egger, Beatriz Abdo Abujamra & Ivan Jozic. (2020) Clinical Implications of Cellular Senescence on Wound Healing. Current Dermatology Reports 9:4, pages 286-297.
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Daniela Volonte & Ferruccio Galbiati. (2020) Caveolin-1, a master regulator of cellular senescence. Cancer and Metastasis Reviews 39:2, pages 397-414.
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Wei Zhong, Yong-Chang Li, Qian-Yi Huang & Xiang-Qi Tang. (2020) lncRNA ANRIL Ameliorates Oxygen and Glucose Deprivation (OGD) Induced Injury in Neuron Cells via miR-199a-5p/CAV-1 Axis. Neurochemical Research 45:4, pages 772-782.
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Ching-Yi Chen, Po-Lin Liao, Chi-Hao Tsai, Yen-Ju Chan, Yu-Wen Cheng, Ling-Ling Hwang, Kuan-Hung Lin, Ting-Ling Yen & Ching-Hao Li. (2019) Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity. Particle and Fibre Toxicology 16:1.
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Montserrat Llanses MartinezElena Rainero. (2019) Membrane dynamics in cell migration. Essays in Biochemistry 63:5, pages 469-482.
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Yingying Gao, Luo Li, Ting Li, Lei Ma, Mengjuan Yuan, Wei Sun, Hong Cheng, Lingfang Niu, Zhongbo Du, Zhen Quan, Yanru Fan, Jiaxin Fan, Chunli Luo & Xiaohou Wu. (2019) Simvastatin delays castration‑resistant prostate cancer metastasis and androgen receptor antagonist resistance by regulating the expression of caveolin‑1. International Journal of Oncology.
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Lei Ding, Qingmin Zeng, Jingping Wu, Defang Li, Houlei Wang, Wei Lu, Zengxin Jiang & Guoxiong Xu. (2017) Caveolin-1 regulates oxidative stress-induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in vitro. Molecular Medicine Reports 16:6, pages 9521-9527.
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Byung-Kyu Ryu, Min-Goo Lee, Nam-Hoon Kim, Kil Yeon Lee, Shin-Ju Oh, Jung-Rock Moon, Hyo Jong Kim & Sung-Gil Chi. (2017) Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression. BMC Cancer 17:1.
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Danielle Frodyma, Beth Neilsen, Diane Costanzo-Garvey, Kurt Fisher & Robert Lewis. (2017) Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras. F1000Research 6, pages 1621.
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Lili XuLiumin WangZhuoyu WenLi Wu, Yongjun JiangLian Yang, Lulu XiaoYi XieMinmin MaWusheng ZhuRuidong YeXinfeng Liu. (2016) Caveolin-1 is a checkpoint regulator in hypoxia-induced astrocyte apoptosis via Ras/Raf/ERK pathway. American Journal of Physiology-Cell Physiology 310:11, pages C903-C910.
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Preeyaporn Plaimee Phiboonchaiyanan, Chayanin Kiratipaiboon & Pithi Chanvorachote. (2016) Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chemico-Biological Interactions 250, pages 1-11.
Crossref
SHI-QUAN LIU, CHUN-YAN XU, MENG-BIN QIN, LIN TAN, CHUN-FENG ZHUGE, YE-BO MAO, MING-YU LAI & JIE-AN HUANG. (2015) Ginkgo biloba extract enhances chemotherapy sensitivity and reverses chemoresistance through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer cells. Oncology Reports 33:6, pages 2871-2882.
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Brittany D. Conroy, Tyler A. Herek, Timothy D. Shew, Matthew Latner, Joshua J. Larson, Laura Allen, Paul H. Davis, Tomáš Helikar & Christine E. Cutucache. (2014) Design, Assessment, and in vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4+ T-lymphocytes. Frontiers in Immunology 5.
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