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Molecular and Cellular Biology Volume 34, 2014 - Issue 15
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Article

A PEX7-Centered Perspective on the Peroxisomal Targeting Signal Type 2-Mediated Protein Import Pathway

Tony A. Rodriguesa Organelle Biogenesis and Function Group, Instituto de Biologia Celular e Molecular (IBMC), Universidade do Porto, Porto, Portugal;b Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
,
Inês S. Alencastrea Organelle Biogenesis and Function Group, Instituto de Biologia Celular e Molecular (IBMC), Universidade do Porto, Porto, Portugal;b Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
,
Tânia Franciscoa Organelle Biogenesis and Function Group, Instituto de Biologia Celular e Molecular (IBMC), Universidade do Porto, Porto, Portugal;b Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
,
Pedro Britesc Nerve Regeneration Group, Instituto de Biologia Celular e Molecular (IBMC), Universidade do Porto, Porto, Portugal
,
Marc Fransend Departement Cellulaire en Moleculaire Geneeskunde, Katholieke Universiteit Leuven, Leuven, Belgium
,
Cláudia P. Groua Organelle Biogenesis and Function Group, Instituto de Biologia Celular e Molecular (IBMC), Universidade do Porto, Porto, Portugal
&
Jorge E. Azevedoa Organelle Biogenesis and Function Group, Instituto de Biologia Celular e Molecular (IBMC), Universidade do Porto, Porto, Portugal;b Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, PortugalCorrespondence[email protected]
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Pages 2917-2928 | Received 30 Dec 2013, Accepted 20 May 2014, Published online: 20 Mar 2023

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Marcus Nordgren, Tânia Francisco, Celien Lismont, Lore Hennebel, Chantal Brees, Bo Wang, Paul P Van Veldhoven, Jorge E Azevedo & Marc Fransen. (2015) Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts. Autophagy 11:8, pages 1326-1340.
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Articles from other publishers (26)

Yuqing Lei, Ying Gao, Xuehong Li, Xiaoying Luo, Lan Wang, Wenjin Wu, Guangquan Xiong, Shang Chu & Shugang Li. (2023) Integrating transcriptomic and proteomics revealed the response mechanism of red swamp crayfish ( Procambarus clarkii ) muscle under cold stress . Food Science of Animal Products.
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Delara Akhter, Yuchan Zhang, Jianping Hu & Ronghui Pan. (2023) Protein ubiquitination in plant peroxisomes. Journal of Integrative Plant Biology 65:2, pages 371-380.
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Ana G. Pedrosa, Tânia Francisco, Tony A. Rodrigues, Maria J. Ferreira, Gerbrand J. van der Heden van Noort & Jorge E. Azevedo. (2023) The Extraction Mechanism of Monoubiquitinated PEX5 from the Peroxisomal Membrane. Journal of Molecular Biology 435:2, pages 167896.
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Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Tânia Francisco & Jorge E. Azevedo. 2023. Peroxisomes. Peroxisomes 333 343 .
Yukio Fujiki, Kanji Okumoto, Masanori Honsho & Yuichi Abe. (2022) Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1869:11, pages 119330.
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Ryan M. Judy, Connor J. Sheedy & Brooke M. Gardner. (2022) Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis. Cells 11:13, pages 2067.
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Mu-Xiu Wu, Yuan Zou, Ying-Hao Yu, Bai-Xiong Chen, Qian-Wang Zheng, Zhi-Wei Ye, Tao Wei, Si-Qiang Ye, Li-Qiong Guo & Jun-Fang Lin. (2021) Comparative transcriptome and proteome provide new insights into the regulatory mechanisms of the postharvest deterioration of Pleurotus tuoliensis fruitbodies during storage. Food Research International 147, pages 110540.
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Muhammad Ali, Shahid Y. Khan, Tony A. Rodrigues, Tânia Francisco, Xiaodong Jiao, Hang Qi, Firoz Kabir, Bushra Irum, Bushra Rauf, Asma A. Khan, Azra Mehmood, Muhammad Asif Naeem, Muhammad Zaman Assir, Muhammad Hassaan Ali, Mohsin Shahzad, Khaled K. Abu-Amero, Shehla Javed Akram, Javed Akram, Sheikh Riazuddin, Saima Riazuddin, Michael L. Robinson, Myriam Baes, Jorge E. Azevedo, J. Fielding Hejtmancik & S. Amer Riazuddin. (2021) A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes. Human Genetics 140:4, pages 649-666.
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Markus Kunze. (2020) The type-2 peroxisomal targeting signal. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867:2, pages 118609.
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Ana G. Pedrosa, Tânia Francisco, Maria J. Ferreira, Tony A. Rodrigues, Aurora Barros-Barbosa & Jorge E. Azevedo. (2019) A Mechanistic Perspective on PEX1 and PEX6, Two AAA+ Proteins of the Peroxisomal Protein Import Machinery. International Journal of Molecular Sciences 20:21, pages 5246.
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Satoru Mukai, Takashi Matsuzaki & Yukio Fujiki. (2019) The cytosolic peroxisome-targeting signal (PTS)-receptors, Pex7p and Pex5pL, are sufficient to transport PTS2 proteins to peroxisomes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:3, pages 441-449.
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Aurora Barros‐Barbosa, Tony A. Rodrigues, Maria J. Ferreira, Ana G. Pedrosa, Nélson R. Teixeira, Tânia Francisco & Jorge E. Azevedo. (2018) The intrinsically disordered nature of the peroxisomal protein translocation machinery. The FEBS Journal 286:1, pages 24-38.
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Aurora Barros‐Barbosa, Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Cláudia P. Grou, Manuel P. Pinto, Marc Fransen, Tânia Francisco & Jorge E. Azevedo. (2018) Membrane topologies of PEX 13 and PEX 14 provide new insights on the mechanism of protein import into peroxisomes . The FEBS Journal 286:1, pages 205-222.
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Alexander Watson-Lazowski, Alexie Papanicolaou, Robert Sharwood & Oula Ghannoum. (2018) Investigating the NAD-ME biochemical pathway within C4 grasses using transcript and amino acid variation in C4 photosynthetic genes. Photosynthesis Research 138:2, pages 233-248.
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Daniel Schwerter, Immanuel Grimm, Wolfgang Girzalsky & Ralf Erdmann. (2018) Receptor recognition by the peroxisomal AAA complex depends on the presence of the ubiquitin moiety and is mediated by Pex1p. Journal of Biological Chemistry 293:40, pages 15458-15470.
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Ana G. Pedrosa, Tânia Francisco, Diana Bicho, Ana F. Dias, Aurora Barros-Barbosa, Vera Hagmann, Gabriele Dodt, Tony A. Rodrigues & Jorge E. Azevedo. (2018) Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol. Journal of Biological Chemistry 293:29, pages 11553-11563.
Crossref
Tânia Francisco, Tony A. Rodrigues, Ana F. Dias, Aurora Barros-Barbosa, Diana Bicho & Jorge E. Azevedo. (2017) Protein transport into peroxisomes: Knowns and unknowns. BioEssays 39:10, pages 1700047.
Crossref
Ana F. Dias, Tony A. Rodrigues, Ana G. Pedrosa, Aurora Barros-Barbosa, Tânia Francisco & Jorge E. Azevedo. (2017) The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo. Journal of Biological Chemistry 292:37, pages 15287-15300.
Crossref
Tony A Rodrigues, Tânia Francisco, Ana F Dias, Ana G Pedrosa, Cláudia P Grou & Jorge E Azevedo. (2016) A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery. Nature Protocols 11:12, pages 2454-2469.
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Immanuel Grimm, Ralf Erdmann & Wolfgang Girzalsky. (2016) Role of AAA + -proteins in peroxisome biogenesis and function. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:5, pages 828-837.
Crossref
Han-Sol ParkJung Eun JangMyoung Seok KoSung Hoon WooBum Joong KimHyun Sik KimHye Sun ParkIn-Sun ParkEun Hee KohKi-Up Lee. (2016) Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice. Diabetes & Metabolism Journal 40:5, pages 376.
Crossref
Markus Kunze & Johannes Berger. (2015) The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevance. Frontiers in Physiology 6.
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Tony A. Rodrigues, Cláudia P. Grou & Jorge E. Azevedo. (2015) Revisiting the intraperoxisomal pathway of mammalian PEX7. Scientific Reports 5:1.
Crossref
Marta O. Freitas, Tânia Francisco, Tony A. Rodrigues, Celien Lismont, Pedro Domingues, Manuel P. Pinto, Cláudia P. Grou, Marc Fransen & Jorge E. Azevedo. (2015) The peroxisomal protein import machinery displays a preference for monomeric substrates. Open Biology 5:4, pages 140236.
Crossref
P.K. Kim & E.H. Hettema. (2015) Multiple Pathways for Protein Transport to Peroxisomes. Journal of Molecular Biology 427:6, pages 1176-1190.
Crossref
Alison Baker & Rupesh Paudyal. (2014) The life of the peroxisome: from birth to death. Current Opinion in Plant Biology 22, pages 39-47.
Crossref

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