43
Views
78
CrossRef citations to date
0
Altmetric
Article

Regulation of Transcription Factor NFAT by ADP-Ribosylation

, , , , , , , & show all
Pages 2860-2871 | Received 24 Sep 2007, Accepted 15 Feb 2008, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Anna D. Staniszewska, Joshua Armenia, Matthew King, Chrysiis Michaloglou, Avinash Reddy, Maneesh Singh, Maryann San Martin, Laura Prickett, Zena Wilson, Theresa Proia, Deanna Russell, Morgan Thomas, Oona Delpuech, Mark J. O’Connor, Elisabetta Leo, Helen Angell & Viia Valge-Archer. (2022) PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors. OncoImmunology 11:1.
Read now
Martina Catalano, Luigi Francesco Iannone, Federica Cosso, Daniele Generali, Enrico Mini & Giandomenico Roviello. (2022) Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment. Expert Opinion on Therapeutic Targets 26:11, pages 923-936.
Read now
Raffaela Zaffini, Giovanni Gotte & Marta Menegazzi. (2018) Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach. Drug Design, Development and Therapy 12, pages 281-293.
Read now

Articles from other publishers (75)

Xiao-Fang Yi, Ruo-Lin Gao, Li Sun, Zhi-Xuan Wu, Shu-Ling Zhang, Le-Tian Huang, Cheng-Bo Han & Jie-Tao Ma. (2023) Dual antitumor immunomodulatory effects of PARP inhibitor on the tumor microenvironment: A counterbalance between anti-tumor and pro-tumor. Biomedicine & Pharmacotherapy 163, pages 114770.
Crossref
Ruo-Yu Zhao, Peng-Ju Wei, Xin Sun, Dian-Hui Zhang, Qian-Yan He, Jie Liu, Jun-Lei Chang, Yi Yang & Zhen-Ni Guo. (2023) Role of lipocalin 2 in stroke. Neurobiology of Disease 179, pages 106044.
Crossref
Jyotika Rajawat, Poorwa Awasthi & Monisha Banerjee. (2023) PARP inhibitor olaparib induced differential protein expression in cervical cancer cells. Journal of Proteomics 275, pages 104823.
Crossref
Fernando Macian. 2023. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 409 416 .
Qiu-Hua Zhong, Si-Wei Zha, Andy T. Y. Lau & Yan-Ming Xu. (2022) Recent knowledge of NFATc4 in oncogenesis and cancer prognosis. Cancer Cell International 22:1.
Crossref
Ornella Franzese & Grazia Graziani. (2022) Role of PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints. Cancers 14:22, pages 5633.
Crossref
Nirashaa T. Bound, Cassandra J. Vandenberg, Apriliana E. R. Kartikasari, Magdalena Plebanski & Clare L. Scott. (2022) Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune system. Frontiers in Genetics 13.
Crossref
Wentao Li, Lin Liang, Qianjin Liao, Yanling Li & Yanhong Zhou. (2022) CD38: An important regulator of T cell function. Biomedicine & Pharmacotherapy 153, pages 113395.
Crossref
Wen Zong, Yamin Gong, Wenli Sun, Tangliang Li & Zhao-Qi Wang. (2022) PARP1: Liaison of Chromatin Remodeling and Transcription. Cancers 14:17, pages 4162.
Crossref
Gabriel Alves Bonafé, Jéssica Silva dos Santos, Jussara Vaz Ziegler, Fernando Augusto Lima Marson, Thalita Rocha & Manoela Marques Ortega. (2022) Dipotassium Glycyrrhizinate on Melanoma Cell Line: Inhibition of Cerebral Metastases Formation by Targeting NF-kB Genes-Mediating MicroRNA-4443 and MicroRNA-3620—Dipotassium Glycyrrhizinate Effect on Melanoma. International Journal of Molecular Sciences 23:13, pages 7251.
Crossref
Yan Wang, David Pleasure, Wenbin Deng & Fuzheng Guo. (2021) Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting. Advanced Science 9:5, pages 2102853.
Crossref
Zhaozhen Wu, Pengfei Cui, Haitao Tao, Sujie Zhang, Junxun Ma, Zhefeng Liu, Jinliang Wang, Yuanyu Qian, Shixue Chen, Ziwei Huang, Xuan Zheng, Di Huang & Yi Hu. (2021) The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors. Clinical Medicine Insights: Oncology 15, pages 117955492199628.
Crossref
Yunjuan Nie, Teja Srinivas Nirujogi, Ravi Ranjan, Brenda F. Reader, Sangwoon Chung, Megan N. Ballinger, Joshua A. Englert, John W. Christman & Manjula Karpurapu. (2021) PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury. Journal of Innate Immunity 13:2, pages 83-93.
Crossref
Fernando Macian. 2021. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 1119 1126 .
Fernando Macian. 2020. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 1 9 .
Anwesha Kar, Shikhar Mehrotra & Shilpak Chatterjee. (2020) CD38: T Cell Immuno-Metabolic Modulator. Cells 9:7, pages 1716.
Crossref
Wanjing Lei, Han Zeng, Hua Feng, Xufang Ru, Qiang Li, Ming Xiao, Huiru Zheng, Yujie Chen & Le Zhang. (2020) Development of an Early Prediction Model for Subarachnoid Hemorrhage With Genetic and Signaling Pathway Analysis. Frontiers in Genetics 11.
Crossref
Chun Wang, Jianqiu Xiao, Kathrin Nowak, Kapila Gunasekera, Yael Alippe, Sheree Speckman, Tong Yang, Dustin Kress, Yousef Abu‐Amer, Michael O. Hottiger & Gabriel Mbalaviele. (2020) PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation. Journal of Bone and Mineral Research 35:4, pages 776-788.
Crossref
Juan Manuel Martí, Mónica Fernández-Cortés, Santiago Serrano-Sáenz, Esteban Zamudio-Martinez, Daniel Delgado-Bellido, Angel Garcia-Diaz & Francisco Javier Oliver. (2020) The Multifactorial Role of PARP-1 in Tumor Microenvironment. Cancers 12:3, pages 739.
Crossref
Dae-Seok Kim, Sridevi Challa, Aarin Jones & W. Lee Kraus. (2020) PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis. Genes & Development 34:5-6, pages 302-320.
Crossref
Elizabeth K. Lee & Panagiotis A. Konstantinopoulos. (2020) PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers. Therapeutic Advances in Medical Oncology 12, pages 175883592094411.
Crossref
Wang & Mbalaviele. (2019) Role of APD-Ribosylation in Bone Health and Disease. Cells 8:10, pages 1201.
Crossref
Ke, Wang, Zhang, Zhong, Wang, Zeng & Ba. (2019) The Role of PARPs in Inflammation—and Metabolic—Related Diseases: Molecular Mechanisms and Beyond. Cells 8:9, pages 1047.
Crossref
Yueshuang Ke, Jing Zhang, Xueping Lv, Xianlu Zeng & Xueqing Ba. (2019) Novel insights into PARPs in gene expression: regulation of RNA metabolism. Cellular and Molecular Life Sciences 76:17, pages 3283-3299.
Crossref
Kaishun Hu, Wenjing Wu, Yu Li, Lehang Lin, Dong Chen, Haiyan Yan, Xing Xiao, Hengxing Chen, Zhen Chen, Yin Zhang, Shuangbing Xu, Yabin Guo, H Phillip Koeffler, Erwei Song & Dong Yin. (2019) Poly( ADP ‐ribosyl)ation of BRD 7 by PARP 1 confers resistance to DNA ‐damaging chemotherapeutic agents . EMBO reports 20:5.
Crossref
Qian LI, Zhuo-ming LI, Shu-ya SUN, Lu-ping WANG, Pan-xia WANG, Zhen GUO, Han-wei YANG, Jian-tao YE, Jing LU & Pei-qing LIU. (2018) PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy. Acta Pharmacologica Sinica 40:5, pages 589-598.
Crossref
Puchong Thirawatananond, Robert Lyle McPherson, Jasmine Malhi, Sara Nathan, Michael J. Lambrecht, Matthew Brichacek, Paul J. Hergenrother, Anthony K. L. Leung & Sandra B. Gabelli. (2019) Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Scientific Reports 9:1.
Crossref
Pamlea N. Brady, Anupam Goel & Margaret A. Johnson. (2019) Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity. Microbiology and Molecular Biology Reviews 83:1.
Crossref
Luping Wang, Zhuoming Li, Yinzi Tan, Qian Li, Hanwei Yang, Panxia Wang, Jing Lu & Peiqing Liu. (2018) PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy. Molecular and Cellular Endocrinology 474, pages 137-150.
Crossref
Bryan A. Gibson, Lesley B. Conrad, Dan Huang & W. Lee Kraus. (2017) Generation and Characterization of Recombinant Antibody-like ADP-Ribose Binding Proteins. Biochemistry 56:48, pages 6305-6316.
Crossref
Nasir Javaid & Sangdun Choi. (2017) Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets. Genes 8:8, pages 196.
Crossref
Tina Jubin, Ashlesha Kadam, Amina Rafath Gani, Mala Singh, Mitesh Dwivedi & Rasheedunnisa Begum. (2017) Poly ADP-ribose polymerase-1: Beyond transcription and towards differentiation. Seminars in Cell & Developmental Biology 63, pages 167-179.
Crossref
Rebecca Gupte, Ziying Liu & W. Lee Kraus. (2017) PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes. Genes & Development 31:2, pages 101-126.
Crossref
Xin Luo, Keun Woo Ryu, Dae-Seok Kim, Tulip Nandu, Carlos J. Medina, Rebecca Gupte, Bryan A. Gibson, Raymond E. Soccio, Yonghao Yu, Rana K. Gupta & W. Lee Kraus. (2017) PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. Molecular Cell 65:2, pages 260-271.
Crossref
Jing Lu, Renwei Zhang, Huiqi Hong, Zuolong Yang, Duanping Sun, Shuya Sun, Xiaolei Guo, Jiantao Ye, Zhuoming Li & Peiqing Liu. (2016) The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:12, pages 3027-3039.
Crossref
Manasi S. ShahMichael Brownlee. (2016) Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circulation Research 118:11, pages 1808-1829.
Crossref
C Wang, C Qu, Y Alippe, S L Bonar, R Civitelli, Y Abu-Amer, M O Hottiger & G Mbalaviele. (2016) Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation. Cell Death & Disease 7:3, pages e2153-e2153.
Crossref
Purna KrishnamurthyMark H. Kaplan. (2016) STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation. Immune Network 16:4, pages 201.
Crossref
F. Macian. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 573 579 .
Sangeetha Hareendran, Banumathi Ramakrishna & Giridhara R. Jayandharan. (2016) Synergistic inhibition of PARP-1 and NF-κB signaling downregulates immune response against recombinant AAV2 vectors during hepatic gene therapy. European Journal of Immunology 46:1, pages 154-166.
Crossref
Purvi Mehrotra, Purna Krishnamurthy, Jie Sun, Shreevrat Goenka & Mark H. Kaplan. (2015) Poly-ADP-ribosyl polymerase-14 promotes T helper 17 and follicular T helper development. Immunology 146:4, pages 537-546.
Crossref
María Isabel Rodríguez, Jara Majuelos-Melguizo, Juan Manuel Martí Martín-Consuegra, Mariano Ruiz de Almodóvar, Abelardo López-Rivas & Francisco Javier Oliver. (2015) Deciphering the Insights of Poly(ADP-Ribosylation) in Tumor Progression. Medicinal Research Reviews 35:4, pages 678-697.
Crossref
Jiawei Shou, Jing Jing, Jiansheng Xie, Liangkun You, Zhao Jing, Junlin Yao, Weidong Han & Hongming Pan. (2015) Nuclear factor of activated T cells in cancer development and treatment. Cancer Letters 361:2, pages 174-184.
Crossref
Keun Woo Ryu, Dae-Seok Kim & W. Lee Kraus. (2015) New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases. Chemical Reviews 115:6, pages 2453-2481.
Crossref
Sheikh Fayaz Ahmad, Khairy M.A. Zoheir, Mushtaq Ahmad Ansari, Hesham M. Korashy, Saleh A. Bakheet, Abdelkader E. Ashour, Othman A. Al-Shabanah, Mohammed M. Al-harbi & Sabry M. Attia. (2015) The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice. Molecular Immunology 63:2, pages 394-405.
Crossref
Jiang-Jiang Qin, Subhasree Nag, Wei Wang, Jianwei Zhou, Wei-Dong Zhang, Hui Wang & Ruiwen Zhang. (2014) NFAT as cancer target: Mission possible?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846:2, pages 297-311.
Crossref
Niraj Lodhi, Andrew V. Kossenkov & Alexei V. Tulin. (2014) Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark. Nucleic Acids Research 42:11, pages 7028-7038.
Crossref
Suowen Xu, Peter Bai, Peter J. Little & Peiqing Liu. (2014) Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications. Medicinal Research Reviews 34:3, pages 644-675.
Crossref
Carolin Daniel, Katharina Gerlach, Martin Väth, Markus F. Neurath & Benno Weigmann. (2014) Nuclear factor of activated T cells-A transcription factor family as critical regulator in lung and colon cancer. International Journal of Cancer 134:8, pages 1767-1775.
Crossref
Jolyane MelocheAude PfliegerMylène VaillancourtRoxane PaulinFrançois PotusSotirios ZervopoulosColin GraydonAudrey CourboulinSandra Breuils-BonnetÈve TremblayChristian CoutureEvangelos D. MichelakisSteeve ProvencherSébastien Bonnet. (2014) Role for DNA Damage Signaling in Pulmonary Arterial Hypertension. Circulation 129:7, pages 786-797.
Crossref
Bor-Tsang Wu, Wei-Yong Lin, I-Ching Chou, Hsin-Ping Liu, Cheng-Chun Lee, Yuhsin Tsai, Jia-Ye Lee & Fuu-Jen Tsai. (2013) Association of poly(ADP-ribose) polymerase-1 polymorphism with Tourette syndrome. Neurological Sciences 34:11, pages 1911-1916.
Crossref
Maria Manuela Rosado, Elisabetta Bennici, Flavia Novelli & Claudio Pioli. (2013) Beyond DNA repair, the immunological role of PARP-1 and its siblings. Immunology 139:4, pages 428-437.
Crossref
M. Sambucci, F. Laudisi, F. Novelli, E. Bennici, M. M. Rosado & C. Pioli. (2013) Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation. The Scientific World Journal 2013, pages 1-8.
Crossref
Péter Bai & László Virág. (2012) Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes. FEBS Letters 586:21, pages 3771-3777.
Crossref
Ruoning Wang & Douglas R Green. (2012) Metabolic checkpoints in activated T cells. Nature Immunology 13:10, pages 907-915.
Crossref
Teddy T. C. Yang & Chi-Wing Chow. 2012. Transcriptional Regulation. Transcriptional Regulation 75 84 .
Young Dong Yoo, Cindy T. Huang, Xiaoqing Zhang, Timothy M. Lavaute & Su-Chun Zhang. (2011) Fibroblast Growth Factor Regulates Human Neuroectoderm Specification Through ERK1/2-PARP-1 Pathway. Stem Cells 29:12, pages 1975-1982.
Crossref
É. Szabó, I. Kovács, T. Grune, A. Haczku & L. Virág. (2011) PARP-1: a new player in the asthma field?. Allergy 66:7, pages 811-814.
Crossref
Opeyemi A. Olabisi & Chi-Wing Chow. 2011. Poly(ADP-ribose) Polymerase. Poly(ADP-ribose) Polymerase 47 55 .
Ganta Vijay Chaitanya, Jonathan S Alexander & Phanithi Prakash Babu. (2010) PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Communication and Signaling 8:1.
Crossref
Jianfeng Chen, Yong Sun, Xia Mao, Qizhan Liu, Hui Wu & Yabing Chen. (2010) RANKL Up-regulates Brain-type Creatine Kinase via Poly(ADP-ribose) Polymerase-1 during Osteoclastogenesis. Journal of Biological Chemistry 285:47, pages 36315-36321.
Crossref
Alexander König, Martin E. Fernandez-Zapico & Volker Ellenrieder. (2010) Primers on Molecular Pathways —The NFAT Transcription Pathway in Pancreatic Cancer. Pancreatology 10:4, pages 416-422.
Crossref
Martin R. Müller & Anjana Rao. (2010) NFAT, immunity and cancer: a transcription factor comes of age. Nature Reviews Immunology 10:9, pages 645-656.
Crossref
Matthias Altmeyer, Manja Barthel, Matthias Eberhard, Hubert Rehrauer, Wolf-Dietrich Hardt & Michael O. Hottiger. (2010) Absence of Poly(ADP-Ribose) Polymerase 1 Delays the Onset of Salmonella enterica Serovar Typhimurium-Induced Gut Inflammation . Infection and Immunity 78:8, pages 3420-3431.
Crossref
Francesca Nasta, Federica Laudisi, Manolo Sambucci, Maria M. Rosado & Claudio Pioli. (2010) Increased Foxp3+ Regulatory T Cells in Poly(ADP-Ribose) Polymerase-1 Deficiency. The Journal of Immunology 184:7, pages 3470-3477.
Crossref
Rut Valdor & Fernando Macian. (2010) Mechanisms of self-inactivation in anergic T cells. Inmunología 29:1, pages 20-33.
Crossref
Heather L. Schultheisz, Blair R. Szymczyna & James R. Williamson. (2009) Enzymatic Synthesis and Structural Characterization of 13 C, 15 N-Poly(ADP-ribose) . Journal of the American Chemical Society 131:40, pages 14571-14578.
Crossref
Ian Baine, Brian T. Abe & Fernando Macian. (2009) Regulation of T-cell tolerance by calcium/NFAT signaling. Immunological Reviews 231:1, pages 225-240.
Crossref
Furong Gao, Sung Won Kwon, Yingming Zhao & Ying Jin. (2009) PARP1 Poly(ADP-ribosyl)ates Sox2 to Control Sox2 Protein Levels and FGF4 Expression during Embryonic Stem Cell Differentiation. Journal of Biological Chemistry 284:33, pages 22263-22273.
Crossref
Jun-ichi Sakamaki, Hiroaki Daitoku, Kenji Yoshimochi, Masanao Miwa & Akiyoshi Fukamizu. (2009) Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1. Biochemical and Biophysical Research Communications 382:3, pages 497-502.
Crossref
Dan Huang, Yan Wang, Chongzhe Yang, Yuhua Liao & Kai Huang. (2009) Angiotensin II promotes poly(ADP-ribosyl)ation of c-Jun/c-Fos in cardiac fibroblasts. Journal of Molecular and Cellular Cardiology 46:1, pages 25-32.
Crossref
M Carbone, M N Rossi, M Cavaldesi, A Notari, P Amati & R Maione. (2008) Poly(ADP-ribosyl)ation is implicated in the G0–G1 transition of resting cells. Oncogene 27:47, pages 6083-6092.
Crossref
. (2008) Current World Literature. Current Opinion in Lipidology 19:5, pages 525-535.
Crossref
Lisa M Nilsson, Jenny Nilsson-Öhman, Anna V Zetterqvist & Maria F Gomez. (2008) Nuclear factor of activated T-cells transcription factors in the vasculature: the good guys or the bad guys?. Current Opinion in Lipidology 19:5, pages 483-490.
Crossref
W Lee Kraus. (2008) Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Current Opinion in Cell Biology 20:3, pages 294-302.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.