73
Views
69
CrossRef citations to date
0
Altmetric
Article

Protein Tyrosine Kinase 6 Negatively Regulates Growth and Promotes Enterocyte Differentiation in the Small Intestine

, , , , , & show all
Pages 4949-4957 | Received 28 Sep 2005, Accepted 08 Apr 2006, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Fumina Ohsaka & Kei Sonoyama. (2018) Murine intestinal organoids resemble intestinal epithelium in their microRNA profiles. Bioscience, Biotechnology, and Biochemistry 82:9, pages 1560-1567.
Read now
Patrick M. Brauer, Yu Zheng, Lin Wang & Angela Tyner. (2010) Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells. Cell Cycle 9:20, pages 4190-4199.
Read now
Yu Zheng, Maoyu Peng, Zebin Wang, John M. Asara & Angela L. Tyner. (2010) Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor. Molecular and Cellular Biology 30:17, pages 4280-4292.
Read now

Articles from other publishers (66)

Raghuveera Kumar Goel, Nayoung Kim & Kiven Erique Lukong. (2023) Seeking a better understanding of the non-receptor tyrosine kinase, SRMS. Heliyon 9:6, pages e16421.
Crossref
Xi Huang, Youci Zhou, Yunwei Sun & Qijun Wang. (2022) Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism. Progress in Lipid Research 87, pages 101178.
Crossref
Chaoqun Liu, Zhihua Pan, Qian Chen, Zetao Chen, Weiwei Liu, Ling Wu, Muhong Jiang, Wandie Lin, Yujie Zhang, Weihao Lin, Rui Zhou & Liang Zhao. (2021) Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
H. Yesid Estupiñán, Anna Berglöf, Rula Zain & C. I. Edvard Smith. (2021) Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects. Frontiers in Cell and Developmental Biology 9.
Crossref
Xiang Xiao, Dongwang Zheng, Fei Liang, Shibo Ying, Peibei Sun, Jianmin Yu & Ya Ni. 2021. Molecular Mechanisms in Spermatogenesis. Molecular Mechanisms in Spermatogenesis 1 20 .
Milica B. Gilic & Angela L. Tyner. (2020) Targeting protein tyrosine kinase 6 in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:2, pages 188432.
Crossref
Luping Qiu, Kymberly Levine, Ketan S. Gajiwala, Ciarán N. Cronin, Asako Nagata, Eric Johnson, Michelle Kraus, John Tatlock, Robert Kania, Timothy Foley & Shaoxian Sun. (2018) Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers. PLOS ONE 13:6, pages e0198374.
Crossref
Rik GH Lindeboom, Lisa van Voorthuijsen, Koen C Oost, Maria J Rodríguez‐Colman, Maria V Luna‐Velez, Cristina Furlan, Floriane Baraille, Pascal WTC Jansen, Agnès Ribeiro, Boudewijn MT Burgering, Hugo J Snippert & Michiel Vermeulen. (2018) Integrative multi‐omics analysis of intestinal organoid differentiation. Molecular Systems Biology 14:6.
Crossref
Darren J. Wozniak, Andre Kajdacsy-Balla, Virgilia Macias, Susan Ball-Kell, Morgan L. Zenner, Wenjun Bie & Angela L. Tyner. (2017) PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer. Nature Communications 8:1.
Crossref
Xiao-Jing Wang, Ying Xiong, Ze-Biao Ma, Jian-Chuan Xia & Yan-Fang Li. (2016) The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer. Chinese Journal of Cancer 35:1.
Crossref
Ippei Kikuchi, Atsushi Takahashi-Kanemitsu, Natsuki Sakiyama, Chao Tang, Pei-Jung Tang, Saori Noda, Kazuki Nakao, Hidetoshi Kassai, Toshiro Sato, Atsu Aiba & Masanori Hatakeyama. (2016) Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways. Nature Communications 7:1.
Crossref
Priya S. Mathur, Jessica J. Gierut, Grace Guzman, Hui Xie, Rosa M. Xicola, Xavier Llor, Michael I. Chastkofsky, Ansu O. Perekatt & Angela L. Tyner. (2016) Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Molecular Cancer Research 14:6, pages 563-573.
Crossref
Raghuveera Kumar Goel & Kiven Erique Lukong. (2016) Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology. Cancer and Metastasis Reviews 35:2, pages 179-199.
Crossref
Ricci J. Haines, Richard S. Beard, Rebecca A. Eitner, Liwei Chen & Mack H. Wu. (2016) TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells. PLOS ONE 11:4, pages e0154351.
Crossref
Michael I. Chastkofsky, Wenjun Bie, Susan M. Ball-Kell, Yu-Ying He & Angela L. Tyner. (2015) Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin. Journal of Investigative Dermatology 135:10, pages 2492-2501.
Crossref
M Peng, S M Ball-Kell & A L Tyner. (2015) Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse. Cell Death & Disease 6:8, pages e1848-e1848.
Crossref
Yoshiaki Mizuguchi, Susan Specht, Kumiko Isse, Eizaburo Sasatomi, John G. Lunz3rd3rd, Toshihiro Takizawa & Anthony J. Demetris. (2015) Breast tumor kinase/protein tyrosine kinase 6 (Brk/PTK6) activity in normal and neoplastic biliary epithelia. Journal of Hepatology 63:2, pages 399-407.
Crossref
Raghuveera Kumar Goel & Kiven Erique Lukong. (2015) Tracing the footprints of the breast cancer oncogene BRK — Past till present. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1856:1, pages 39-54.
Crossref
Noah F. Shroyer, Kristin Bell & Yuan-Hung Lo. 2015. Intestinal Tumorigenesis. Intestinal Tumorigenesis 55 99 .
Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Lorella Vecchio, Jean Marc Muller, Mauro Krampera & Kiven Erique Lukong. (2014) Signaling pathways in breast cancer: Therapeutic targeting of the microenvironment. Cellular Signalling 26:12, pages 2843-2856.
Crossref
You-Fang Chen, Gang Ma, Xun Cao, Zhi-Liang Huang, Mu-Sheng Zeng & Zhe-Sheng Wen. (2014) Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma. Medical Oncology 31:12.
Crossref
PETER MAKOVICKY, EVA TUMOVA, ZDENEK VOLEK, PAVOL MAKOVICKY & PAVEL VODICKA. (2014) Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model. Experimental and Therapeutic Medicine 8:5, pages 1623-1627.
Crossref
Maoyu Peng, Rajyasree Emmadi, Zebin Wang, Elizabeth L. Wiley, Peter H. Gann, Seema A. Khan, Nilanjana Banerji, William McDonald, Szilard Asztalos, Thao N.D. Pham, Debra A. Tonetti & Angela L. Tyner. (2014) PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors. Oncotarget 5:15, pages 6038-6048.
Crossref
Jiezhong Chen, Aymen Elfiky, Mei Han, Chen Chen & M. Wasif Saif. (2014) The Role of Src in Colon Cancer and Its Therapeutic Implications. Clinical Colorectal Cancer 13:1, pages 5-13.
Crossref
Sayem Miah, Raghuveera Kumar Goel, Chenlu Dai, Natasha Kalra, Erika Beaton-Brown, Edward T. Bagu, Keith Bonham & Kiven E. Lukong. (2014) BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration. PLoS ONE 9:2, pages e87684.
Crossref
L Jin & R J Craven. (2013) The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor. Oncogene 33:3, pages 326-335.
Crossref
Haroon A Hussain. (2014) Evolution of breast cancer therapeutics: Breast tumour kinase’s role in breast cancer and hope for breast tumour kinase targeted therapy. World Journal of Clinical Oncology 5:3, pages 299.
Crossref
Bodo Speckmann, Hans-Jürgen Bidmon, Andrea Borchardt, Helmut Sies & Holger Steinbrenner. (2014) Intestinal selenoprotein P in epithelial cells and in plasma cells. Archives of Biochemistry and Biophysics 541, pages 30-36.
Crossref
M Peng, S M Ball-Kell, R R Franks, H Xie & A L Tyner. (2013) Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models. Oncogenesis 2:12, pages e81-e81.
Crossref
Li-na Liu, Pei-yu Huang, Zhi-rui Lin, Li-juan Hu, Jian-zhong Liang, Man-zhi Li, Lin-quan Tang, Mu-sheng Zeng, Qian Zhong & Bo-hang Zeng. (2013) Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis. Journal of Translational Medicine 11:1.
Crossref
Yu Zheng, Zebin Wang, Wenjun Bie, Patrick M. Brauer, Bethany E. Perez White, Jing Li, Veronique Nogueira, Pradip Raychaudhuri, Nissim Hay, Debra A. Tonetti, Virgilia Macias, André Kajdacsy-Balla & Angela L. Tyner. (2013) PTK6 Activation at the Membrane Regulates Epithelial–Mesenchymal Transition in Prostate Cancer. Cancer Research 73:17, pages 5426-5437.
Crossref
Raghuveera K. Goel, Sayem Miah, Kristin Black, Natasha Kalra, Chenlu Dai & Kiven E. Lukong. (2013) The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. FEBS Journal 280:18, pages 4539-4559.
Crossref
Gaofeng Fan, Guang Lin, Robert Lucito & Nicholas K. Tonks. (2013) Protein-tyrosine Phosphatase 1B Antagonized Signaling by Insulin-like Growth Factor-1 Receptor and Kinase BRK/PTK6 in Ovarian Cancer Cells*. Journal of Biological Chemistry 288:34, pages 24923-24934.
Crossref
Natalie Ludyga, Natasa Anastasov, Michael Rosemann, Jana Seiler, Nadine Lohmann, Herbert Braselmann, Karin Mengele, Manfred Schmitt, Heinz Höfler & Michaela Aubele. (2013) Effects of Simultaneous Knockdown of HER2 and PTK6 on Malignancy and Tumor Progression in Human Breast Cancer Cells. Molecular Cancer Research 11:4, pages 381-392.
Crossref
Yu Zheng & Angela L. Tyner. (2013) Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer. European Journal of Clinical Investigation 43:4, pages 397-404.
Crossref
Jessica J. Gierut, Priya S. Mathur, Wenjun Bie, Jin Han & Angela L. Tyner. (2012) Targeting Protein Tyrosine Kinase 6 Enhances Apoptosis of Colon Cancer Cells following DNA Damage. Molecular Cancer Therapeutics 11:11, pages 2311-2320.
Crossref
Stephanie Ma, Jessie Y.J. Bao, Pak Shing Kwan, Yuen Piu Chan, Carol M. Tong, Li Fu, Na Zhang, Amy H.Y. Tong, Yan–Ru Qin, Sai Wah Tsao, Kwok Wah Chan, Si Lok & Xin–Yuan Guan. (2012) Identification of PTK6, via RNA Sequencing Analysis, as a Suppressor of Esophageal Squamous Cell Carcinoma. Gastroenterology 143:3, pages 675-686.e12.
Crossref
Yiwei Gao, Velasco Cimica & Nancy C. Reich. (2012) Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3. Journal of Biological Chemistry 287:25, pages 20904-20912.
Crossref
Karolin K. Abdul-Aziz & Muobarak J. Tuorkey. (2012) Targeting tumor necrosis factor alpha (TNF-α) in diabetic rats could approve avenues for an efficient strategy for diabetic therapy. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 6:2, pages 77-84.
Crossref
S. Sridhara. (2012) Ecdysone receptor and ultraspiracle proteins are tyrosine phosphorylated during adult development of silkmoths. Insect Biochemistry and Molecular Biology 42:2, pages 91-101.
Crossref
Marie-Pier Tetreault & Jonathan P. Katz. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 97 113 .
Taeko K. Noah, Bridgitte Donahue & Noah F. Shroyer. (2011) Intestinal development and differentiation. Experimental Cell Research 317:19, pages 2702-2710.
Crossref
Jessica Gierut, Yu Zheng, Wenjun Bie, Robert E. Carroll, Susan Ball-Kell, Andrea Haegebarth & Angela L. Tyner. (2011) Disruption of the Mouse Protein Tyrosine Kinase 6 Gene Prevents STAT3 Activation and Confers Resistance to Azoxymethane. Gastroenterology 141:4, pages 1371-1380.e2.
Crossref
Patrick M. Brauer, Yu Zheng, Mark D. Evans, Carmen Dominguez-Brauer, Donna M. Peehl & Angela L. Tyner. (2011) The Alternative Splice Variant of Protein Tyrosine Kinase 6 Negatively Regulates Growth and Enhances PTK6-Mediated Inhibition of β-Catenin. PLoS ONE 6:3, pages e14789.
Crossref
Edward Chan & Anjaruwee S. Nimnual. (2010) Deregulation of the cell cycle by breast tumor kinase (Brk). International Journal of Cancer 127:11, pages 2723-2731.
Crossref
Nancy E Castro & Carol A Lange. (2010) Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells. Breast Cancer Research 12:4.
Crossref
Patrick M. Brauer & Angela L. Tyner. (2010) Building a better understanding of the intracellular tyrosine kinase PTK6 — BRK by BRK. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1806:1, pages 66-73.
Crossref
Hiroyasu Sakai, Yasuhiro Yamada, Masahito Shimizu, Kuniaki Saito, Hisataka Moriwaki & Akira Hara. (2010) Genetic ablation of Tnfα demonstrates no detectable suppressive effect on inflammation-related mouse colon tumorigenesis. Chemico-Biological Interactions 184:3, pages 423-430.
Crossref
Helena L. Palka-Hamblin, Jessica J. Gierut, Wenjun Bie, Patrick M. Brauer, Yu Zheng, John M. Asara & Angela L. Tyner. (2010) Identification of β-catenin as a target of the intracellular tyrosine kinase PTK6. Journal of Cell Science 123:2, pages 236-245.
Crossref
Eun-Jung LimDae-Weon ParkJin-Gu LeeChu-Hee LeeYoe-Sik BaeYoung-Chul HwangJae-Weon JeongByung-Rho ChinSuk-Hwan Baek. (2010) Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression. Experimental and Molecular Medicine 42:10, pages 712.
Crossref
Andrea Haegebarth, Ansu O. Perekatt, Wenjun Bie, Jessica J. Gierut & Angela L. Tyner. (2009) Induction of Protein Tyrosine Kinase 6 in Mouse Intestinal Crypt Epithelial Cells Promotes DNA Damage–Induced Apoptosis. Gastroenterology 137:3, pages 945-954.
Crossref
Kiven E. Lukong, Marc-Étienne Huot & Stéphane Richard. (2009) BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. Cellular Signalling 21:9, pages 1415-1422.
Crossref
Laurens G. van der FlierHans Clevers. (2009) Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium. Annual Review of Physiology 71:1, pages 241-260.
Crossref
Jun Guo, Shannon Longshore, Rajalakshmi Nair & Brad W. Warner. (2009) Retinoblastoma Protein (pRb), but Not p107 or p130, Is Required for Maintenance of Enterocyte Quiescence and Differentiation in Small Intestine. Journal of Biological Chemistry 284:1, pages 134-140.
Crossref
Mei-Lun Wang, Sue A. Keilbaugh, Tanesha Cash-Mason, Xi C. He, Linheng Li & Gary D. Wu. (2008) Immune-mediated signaling in intestinal goblet cells via PI3-kinase- and AKT-dependent pathways. American Journal of Physiology-Gastrointestinal and Liver Physiology 295:5, pages G1122-G1130.
Crossref
Michele A. Battle, Benjamin J. Bondow, Moriah A. Iverson, Scott J. Adams, Ronald J. Jandacek, Patrick Tso & Stephen A. Duncan. (2008) GATA4 Is Essential for Jejunal Function in Mice. Gastroenterology 135:5, pages 1676-1686.e1.
Crossref
M Aubele, A K Walch, N Ludyga, H Braselmann, M J Atkinson, B Luber, G Auer, S Tapio, T Cooke & J M S Bartlett. (2008) Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients. British Journal of Cancer 99:7, pages 1089-1095.
Crossref
Robert H Whitehead, Pamela S Robinson, Janice A Williams, Wenjun Bie, Angela L Tyner & Jeffrey L Franklin. (2008) Conditionally immortalized colonic epithelial cell line from a Ptk 6 null mouse that polarizes and differentiates in vitro . Journal of Gastroenterology and Hepatology 23:7pt1, pages 1119-1124.
Crossref
S. D'Aniello, M. Irimia, I. Maeso, J. Pascual-Anaya, S. Jimenez-Delgado, S. Bertrand & J. Garcia-Fernandez. (2008) Gene Expansion and Retention Leads to a Diverse Tyrosine Kinase Superfamily in Amphioxus. Molecular Biology and Evolution 25:9, pages 1841-1854.
Crossref
Maja Klapper, Mike Böhme, Inke Nitz & Frank Döring. (2008) Transcriptional regulation of the fatty acid binding protein 2 (FABP2) gene by the hepatic nuclear factor 1 alpha (HNF-1α). Gene 416:1-2, pages 48-52.
Crossref
Kiven E. Lukong & Stéphane Richard. (2008) Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. Cellular Signalling 20:2, pages 432-442.
Crossref
Christopher Brynczka, Paul Labhart & B Alex Merrick. (2007) NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation. BMC Genomics 8:1.
Crossref
Frank A. Simmen, Rijin Xiao, Michael C. Velarde, Rachel D. Nicholson, Margaret T. Bowman, Yoshiaki Fujii-Kuriyama, S. Paul Oh & Rosalia C. M. Simmen. (2007) Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Krüppel-like factor 9. American Journal of Physiology-Gastrointestinal and Liver Physiology 292:6, pages G1757-G1769.
Crossref
Julie Hanson Ostrander, Andrea R. Daniel, Kristopher Lofgren, Celina G. Kleer & Carol A. Lange. (2007) Breast Tumor Kinase (Protein Tyrosine Kinase 6) Regulates Heregulin-Induced Activation of ERK5 and p38 MAP Kinases in Breast Cancer Cells. Cancer Research 67:9, pages 4199-4209.
Crossref
Maja Klapper, Mike Böhme, Inke Nitz & Frank Döring. (2007) The human intestinal fatty acid binding protein (hFABP2) gene is regulated by HNF-4α. Biochemical and Biophysical Research Communications 356:1, pages 147-152.
Crossref
Deborah C Rubin. (2007) Intestinal morphogenesis. Current Opinion in Gastroenterology 23:2, pages 111-114.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.