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Molecular and Cellular Biology Volume 28, 2008 - Issue 9
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Article

RalGDS Couples Growth Factor Signaling to Akt Activation

Yansheng HaoSackler School of Graduate Biomedical Sciences and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts02111
,
Richard WongSackler School of Graduate Biomedical Sciences and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts02111
&
Larry A. FeigSackler School of Graduate Biomedical Sciences and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts02111Correspondence[email protected]
Pages 2851-2859 | Received 24 Oct 2007, Accepted 10 Feb 2008, Published online: 27 Mar 2023

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Ruth Nussinov, Chung-Jung Tsai, Serena Muratcioglu, Hyunbum Jang, Attila Gursoy & Ozlem Keskin. (2015) Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation. Expert Review of Proteomics 12:6, pages 669-682.
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Andrew Pitoniak, Colin A. Chavel, Jacky Chow, Jeremy Smith, Diawoye Camara, Sheelarani Karunanithi, Boyang Li, Kennith H. Wolfe & Paul J. Cullen. (2015) Cdc42p-Interacting Protein Bem4p Regulates the Filamentous-Growth Mitogen-Activated Protein Kinase Pathway. Molecular and Cellular Biology 35:2, pages 417-436.
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Caroline Morel, Claire L. Standen, Dae Young Jung, Susan Gray, Helena Ong, Richard A. Flavell, Jason K. Kim & Roger J. Davis. (2010) Requirement of JIP1-Mediated c-Jun N-Terminal Kinase Activation for Obesity-Induced Insulin Resistance. Molecular and Cellular Biology 30:19, pages 4616-4625.
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Zhen Wang, Yunhe Zhou, Dongsong Nie, Yan Tan, Shuai Zhao, Guoxiang Wang & Tuanlao Wang. (2022) RILP inhibits proliferation, migration, and invasion of PC3 prostate cancer cells. Acta Histochemica 124:7, pages 151938.
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Alessia D’Aloia, Edoardo Arrigoni, Barbara Costa, Giovanna Berruti, Enzo Martegani, Elena Sacco & Michela Ceriani. (2021) RalGPS2 Interacts with Akt and PDK1 Promoting Tunneling Nanotubes Formation in Bladder Cancer and Kidney Cells Microenvironment. Cancers 13:24, pages 6330.
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Fan Bao, Peiqi Hao, Su An, Yang Yang, Ying Liu, Qian Hao, Mubashir Ejaz, Xiao-Xi Guo & Tian-Rui Xu. (2021) Akt scaffold proteins: the key to controlling specificity of Akt signaling. American Journal of Physiology-Cell Physiology 321:3, pages C429-C442.
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Lisa H. Apken & Andrea Oeckinghaus. 2021. Signal Transduction in Cancer and Immunity. Signal Transduction in Cancer and Immunity 21 105 .
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Tam Duong, Neal R. Rasmussen & David J. Reiner. (2020) Insulated Switches: Dual-Function Protein RalGEFRGL-1 Promotes Developmental Fidelity. International Journal of Molecular Sciences 21:20, pages 7610.
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Hanna Shin, Christian Braendle, Kimberly B. Monahan, Rebecca E. W. Kaplan, Tanya P. Zand, Francisca Sefakor Mote, Eldon C. Peters & David J. Reiner. (2019) Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals. PLOS Genetics 15:5, pages e1008056.
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Ruiling Liu, Tingting Fan, Wenwen Geng, Youhai H. Chen, Qingguo Ruan & Cui Zhang. (2017) Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway. PLOS ONE 12:1, pages e0170666.
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Adriana O. Santos, Maria Carla Parrini & Jacques Camonis. (2016) RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases. PLOS ONE 11:5, pages e0154840.
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Z Wang, Y Zhou, X Hu, W Chen, X Lin, L Sun, X Xu, W Hong & T Wang. (2015) RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS. Cell Death & Disease 6:10, pages e1923-e1923.
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R. Shirakawa & H. Horiuchi. (2015) Ral GTPases: crucial mediators of exocytosis and tumourigenesis. Journal of Biochemistry 157:5, pages 285-299.
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Mahasin A. Osman. 2015. The Cytoskeleton in Health and Disease. The Cytoskeleton in Health and Disease 11 62 .
Leanna R. Gentry, Timothy D. Martin, David J. Reiner & Channing J. Der. (2014) Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:12, pages 2976-2988.
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Justin H. Hwang, Tao Jiang, Shreya Kulkarni, Nathalie Faure & Brian S. Schaffhausen. (2013) Protein Phosphatase 2A Isoforms Utilizing Aβ Scaffolds Regulate Differentiation through Control of Akt Protein. Journal of Biological Chemistry 288:44, pages 32064-32073.
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Rebecca L. Scotland, Leah Allen, Leah J. Hennings, Ginell R. Post & Steven R. Post. (2013) The Ral Exchange Factor Rgl2 Promotes Cardiomyocyte Survival and Inhibits Cardiac Fibrosis. PLoS ONE 8:9, pages e73599.
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Maaike C.W. van den Berg, Inkie J.A. van Gogh, Alida M.M. Smits, Miranda van Triest, Tobias B. Dansen, Marieke Visscher, Paulien E. Polderman, Marjolein J. Vliem, Holger Rehmann & Boudewijn M.T. Burgering. (2013) The Small GTPase RALA Controls c-Jun N-terminal Kinase-mediated FOXO Activation by Regulation of a JIP1 Scaffold Complex. Journal of Biological Chemistry 288:30, pages 21729-21741.
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Lin LuYa Nan WangWei Hua SunZhu Hui LiuQi ZhangLi Jin PuKe YangLing Jie WangZhen Bin ZhuHua MengPing YangRun DuQiu Jing ChenLi Shun WangHong YuWei Feng Shen. (2013) Two-Dimensional Fluorescence In-Gel Electrophoresis of Coronary Restenosis Tissues in Minipigs. Arteriosclerosis, Thrombosis, and Vascular Biology 33:3, pages 572-580.
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Jonathan M. Cooper, Brian O. Bodemann & Michael A. White. 2013. Inhibitors of the Ras superfamily G-proteins, Part B. Inhibitors of the Ras superfamily G-proteins, Part B 137 156 .
K. Hochstenbach, D.M. van Leeuwen, R.W. Gottschalk, H. Gmuender, S.B. Stølevik, U.C. Nygaard, M. Løvik, B. Granum, E. Namork, H. van Loveren & J.H.M. van Delft. (2012) Transcriptomic fingerprints in human peripheral blood mononuclear cells indicative of genotoxic and non-genotoxic carcinogenic exposure. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746:2, pages 124-134.
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Derek S Johnson & Youhai H Chen. (2012) Ras family of small GTPases in immunity and inflammation. Current Opinion in Pharmacology 12:4, pages 458-463.
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Yael Gus-Brautbar, Derek Johnson, Li Zhang, Honghong Sun, Peng Wang, Shirley Zhang, Lining Zhang & Youhai H. Chen. (2012) The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras. Molecular Cell 45:5, pages 610-618.
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Gabriela Bedó, Angel Pascual & Ana Aranda. (2010) Early Thyroid Hormone-induced Gene Expression Changes in N2a-β Neuroblastoma Cells. Journal of Molecular Neuroscience 45:2, pages 76-86.
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Maaike C.W. van den BergBoudewijn M.T. Burgering. (2011) Integrating Opposing Signals Toward Forkhead Box O. Antioxidants & Redox Signaling 14:4, pages 607-621.
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Juyong Yoon, Kyoung-Hwa Koo & Kang-Yell Choi. (2011) MEK1/2 Inhibitors AS703026 and AZD6244 May Be Potential Therapies for KRAS Mutated Colorectal Cancer That Is Resistant to EGFR Monoclonal Antibody Therapy . Cancer Research 71:2, pages 445-453.
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Dominico Vigil, Jacqueline Cherfils, Kent L. Rossman & Channing J. Der. (2010) Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?. Nature Reviews Cancer 10:12, pages 842-857.
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Elisa Ferro & Lorenza Trabalzini. (2010) RalGDS family members couple Ras to Ral signalling and that's not all. Cellular Signalling 22:12, pages 1804-1810.
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Dominico Vigil, Timothy D. Martin, Falina Williams, Jen Jen Yeh, Sharon L. Campbell & Channing J. Der. (2010) Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms. Journal of Biological Chemistry 285:45, pages 34729-34740.
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A G Sowalsky, A Alt-Holland, Y Shamis, J A Garlick & L A Feig. (2009) RalA suppresses early stages of Ras-induced squamous cell carcinoma progression. Oncogene 29:1, pages 45-55.
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Nathan T. Ihle, Robert LemosJr.Jr., Peter Wipf, Adly Yacoub, Clint Mitchell, Doris Siwak, Gordon B. Mills, Paul Dent, D. Lynn Kirkpatrick & Garth Powis. (2009) Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance. Cancer Research 69:1, pages 143-150.
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E. Nigel WardleE. Nigel Wardle. 2009. Guide to Signal Pathways in Immune Cells. Guide to Signal Pathways in Immune Cells 129 151 .
Tomohiko Maehama, Masahiko Tanaka, Hiroshi Nishina, Makoto Murakami, Yasunori Kanaho & Kentaro Hanada. (2008) RalA Functions as an Indispensable Signal Mediator for the Nutrient-sensing System. Journal of Biological Chemistry 283:50, pages 35053-35059.
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T F Franke. (2008) PI3K/Akt: getting it right matters. Oncogene 27:50, pages 6473-6488.
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