38
Views
67
CrossRef citations to date
0
Altmetric
Article

A Glycine-Arginine Domain in Control of the Human MRE11 DNA Repair Protein

, , , , &
Pages 3058-3069 | Received 09 Nov 2007, Accepted 09 Feb 2008, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Zhenbao Yu, Taiping Chen, Josée Hébert, En Li & Stéphane Richard. (2009) A Mouse PRMT1 Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation. Molecular and Cellular Biology 29:11, pages 2982-2996.
Read now

Articles from other publishers (66)

Lauren E. Bunke, Clairine I. S. Larsen, Jessica N. Pita-Aquino, Isabella K. Jones & Kinjal Majumder. (2023) The DNA Damage Sensor MRE11 Regulates Efficient Replication of the Autonomous Parvovirus Minute Virus of Mice. Journal of Virology.
Crossref
Barbora Otahalova, Zuzana Volkova, Jana Soukupova, Petra Kleiblova, Marketa Janatova, Michal Vocka, Libor Macurek & Zdenek Kleibl. (2023) Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex. International Journal of Molecular Sciences 24:6, pages 5612.
Crossref
Yifan Zhao, Bo Jiang, Zhouyang Gu, Tianle Chen, Wei Yu, Shiyin Liu, Xing Liu, Dongyin Chen, Fei Li & Weilin Chen. (2023) Discovery of cysteine-targeting covalent histone methyltransferase inhibitors. European Journal of Medicinal Chemistry 246, pages 115028.
Crossref
Mashiat N. Chowdhury & Hong Jin. (2022) The RGG motif proteins: Interactions, functions, and regulations . WIREs RNA 14:1.
Crossref
Peng Zhu, Xuheng Yan, Xiewu Jiang, Hui Li, Rongjian Chen, Sheng Wang & Chaozheng Li. (2022) The MRE11 opposes white spot syndrome virus infection through the IRF and Dorsal mediated antiviral pathways in shrimp. Fish & Shellfish Immunology 126, pages 347-356.
Crossref
Hao Wu, Yichao Zhang, Shuo Liu, Dongwu Liu, Ao Li, Hongkuan Deng, Xiuzhen Zhang, Weiwei Wu, Baohua Liu & Qiuxiang Pang. (2022) Protein Arginine Methyltransferase 1 and its Dynamic Regulation Associated with Cellular Processes and Diseases. Protein & Peptide Letters 29:3, pages 218-230.
Crossref
照宏 朱. (2022) Research Progress of Protein Arginine Methyltransferase 1 Inhibitors in the Treatment of Antitumor. Pharmacy Information 11:02, pages 102-112.
Crossref
Telmo Díez Pérez, Adam Quintana, Jacqueline A. De Lora, Andrew P. Shreve, Gabriel P. López & Nick J. Carroll. (2021) DNA Binding by an Intrinsically Disordered Elastin-like Polypeptide for Assembly of Phase Separated Nucleoprotein Coacervates. Industrial & Engineering Chemistry Research 60:48, pages 17408-17416.
Crossref
Charlène Thiebaut, Louisane Eve, Coralie Poulard & Muriel Le Romancer. (2021) Structure, Activity, and Function of PRMT1. Life 11:11, pages 1147.
Crossref
Ruiqing Lu, Han Zhang, Yi-Nan Jiang, Zhao-Qi Wang, Litao Sun & Zhong-Wei Zhou. (2021) Post-Translational Modification of MRE11: Its Implication in DDR and Diseases. Genes 12:8, pages 1158.
Crossref
Juri Na, Joseph A. Newman, Chee Kin Then, Junetha Syed, Iolanda Vendrell, Ignacio Torrecilla, Sophie Ellermann, Kristijan Ramadan, Roman Fischer & Anne E. Kiltie. (2021) SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. Cell Death & Disease 12:2.
Crossref
Rashmi Panigrahi & J. N. Mark Glover. (2021) Structural insights into DNA double-strand break signaling. Biochemical Journal 478:1, pages 135-156.
Crossref
Sheetal Sharma, Roopesh Anand, Xuzhu Zhang, Sofia Francia, Flavia Michelini, Alessandro Galbiati, Hannah Williams, Daryl A. Ronato, Jean-Yves Masson, Eli Rothenberg, Petr Cejka & Fabrizio d’Adda di Fagagna. (2021) MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends. Cell Reports 34:1, pages 108565.
Crossref
Matthew T. McPherson, Ashton S. Holub, Aman Y. Husbands & Ruben C. Petreaca. (2020) Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells. Cancers 12:12, pages 3794.
Crossref
Samiur Rahman, Marella D. Canny, Tanner A. Buschmann & Michael P. Latham. (2020) A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex. Cells 9:7, pages 1678.
Crossref
Panagiotis Karakaidos, Dimitris Karagiannis & Theodoros Rampias. (2020) Resolving DNA Damage: Epigenetic Regulation of DNA Repair. Molecules 25:11, pages 2496.
Crossref
Valeria Spadotto, Roberto Giambruno, Enrico Massignani, Marija Mihailovich, Marianna Maniaci, Francesca Patuzzo, Francesco Ghini, Francesco Nicassio & Tiziana Bonaldi. (2020) PRMT1-mediated methylation of the microprocessor-associated proteins regulates microRNA biogenesis. Nucleic Acids Research 48:1, pages 96-115.
Crossref
Yueru Sun, Thomas J. McCorvie, Luke A. Yates & Xiaodong Zhang. (2019) Structural basis of homologous recombination. Cellular and Molecular Life Sciences 77:1, pages 3-18.
Crossref
Marie-Christine Caron, Ajit K. Sharma, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel, Guy G. Poirier & Jean-Yves Masson. (2019) Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. Nature Communications 10:1.
Crossref
Luigi Alfano, Antonella Caporaso, Angela Altieri, Milena Dell’Aquila, Claudia Landi, Luca Bini, Francesca Pentimalli & Antonio Giordano. (2019) Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation. Nucleic Acids Research 47:8, pages 4068-4085.
Crossref
Yu-Jen Lee, Wen-Wei Chang, Chien-Ping Chang, Tsung-Yun Liu, Chun-Yi Chuang, Kun Qian, Y. George Zheng & Chuan Li. (2019) Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells. Scientific Reports 9:1.
Crossref
Anita E. Raposo & Sabine C. Piller. (2018) Protein arginine methylation: an emerging regulator of the cell cycle. Cell Division 13:1.
Crossref
Susanne Hellmuth, Cristina Gutiérrez‐Caballero, Elena Llano, Alberto M Pendás & Olaf Stemmann. (2018) Local activation of mammalian separase in interphase promotes double‐strand break repair and prevents oncogenic transformation. The EMBO Journal 37:22.
Crossref
P. Andrew Chong, Robert M. Vernon & Julie D. Forman-Kay. (2018) RGG/RG Motif Regions in RNA Binding and Phase Separation. Journal of Molecular Biology 430:23, pages 4650-4665.
Crossref
Qing Yuan, Ran Tian, Haiying Zhao, Lijuan Li & Xiaolin Bi. (2018) Multiple Arginine Residues Are Methylated in Drosophila Mre11 and Required for Survival Following Ionizing Radiation . G3 Genes|Genomes|Genetics 8:6, pages 2099-2106.
Crossref
Tamar B. Cáceres, Abhishek Thakur, Owen M. Price, Nicole Ippolito, Jun Li, Jun Qu, Orlando Acevedo & Joan M. Hevel. (2018) Phe71 in Type III Trypanosomal Protein Arginine Methyltransferase 7 (TbPRMT7) Restricts the Enzyme to Monomethylation. Biochemistry 57:8, pages 1349-1359.
Crossref
Feihong Chen, Gang Xu, Xiaodong Qin, Xiufeng Jin & Shaohua Gou. (2017) Hybrid of DNA-targeting Chlorambucil with Pt(IV) Species to Reverse Drug Resistance. Journal of Pharmacology and Experimental Therapeutics 363:2, pages 221-239.
Crossref
Joshi Niraj, Marie-Christine Caron, Karine Drapeau, Stéphanie Bérubé, Laure Guitton-Sert, Yan Coulombe, Anthony M. Couturier & Jean-Yves Masson. (2017) The identification of FANCD2 DNA binding domains reveals nuclear localization sequences. Nucleic Acids Research 45:14, pages 8341-8357.
Crossref
P von Morgen, K Burdova, T G Flower, N J O'Reilly, S J Boulton, S J Smerdon, L Macurek & Z Hořejší. (2017) MRE11 stability is regulated by CK2-dependent interaction with R2TP complex. Oncogene 36:34, pages 4943-4950.
Crossref
Vijay Menon & Lawrence F. Povirk. (2016) End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair. DNA Repair 43, pages 57-68.
Crossref
Weizheng Zhou, Wenxing Qin, Fan Qiao, Zhiyun Xu, Yang Yuan & Hezhong Chen. (2016) Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity. Tumor Biology 37:7, pages 9071-9076.
Crossref
Denis Velic, Anthony Couturier, Maria Ferreira, Amélie Rodrigue, Guy Poirier, Fabrice Fleury & Jean-Yves Masson. (2015) DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer. Biomolecules 5:4, pages 3204-3259.
Crossref
Gayathri Gurunathan, Zhenbao Yu, Yan Coulombe, Jean-Yves Masson & Stéphane Richard. (2015) Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage. Scientific Reports 5:1.
Crossref
A. Sandoval-Cabrera, A.L. Zarzosa-Álvarez, R.M. Martínez-Miguel & R.M. Bermúdez-Cruz. (2015) MR (Mre11-Rad50) complex in Giardia duodenalis: In vitro characterization and its response upon DNA damage. Biochimie 111, pages 45-57.
Crossref
Julien Lafrance-Vanasse, Gareth J. Williams & John A. Tainer. (2015) Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair. Progress in Biophysics and Molecular Biology 117:2-3, pages 182-193.
Crossref
Marie-Claude N. Laffitte, Marie-Michelle Genois, Angana Mukherjee, Danielle Légaré, Jean-Yves Masson & Marc Ouellette. (2014) Formation of Linear Amplicons with Inverted Duplications in Leishmania Requires the MRE11 Nuclease. PLoS Genetics 10:12, pages e1004805.
Crossref
Katrin Rein & Travis H. Stracker. (2014) The MRE11 complex: An important source of stress relief. Experimental Cell Research 329:1, pages 162-169.
Crossref
Yang Gao & Scott W. Nelson. (2014) Autoinhibition of Bacteriophage T4 Mre11 by Its C-terminal Domain. Journal of Biological Chemistry 289:38, pages 26505-26513.
Crossref
Francesca Damiola, Maroulio Pertesi, Javier Oliver, Florence Le Calvez-Kelm, Catherine Voegele, Erin L Young, Nivonirina Robinot, Nathalie Forey, Geoffroy Durand, Maxime P Vallée, Kayoko Tao, Terrell C Roane, Gareth J Williams, John L Hopper, Melissa C Southey, Irene L Andrulis, Esther M John, David E Goldgar, Fabienne Lesueur & Sean V Tavtigian. (2014) Rare key functional domain missense substitutions in MRE11A, RAD50, and NBNcontribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study. Breast Cancer Research 16:3.
Crossref
Madalena Barroso, Cristina Florindo, Hermann Kalwa, Zélia Silva, Anton A. Turanov, Bradley A. Carlson, Isabel Tavares de Almeida, Henk J. Blom, Vadim N. Gladyshev, Dolph L. Hatfield, Thomas Michel, Rita Castro, Joseph Loscalzo & Diane E. Handy. (2014) Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression. Journal of Biological Chemistry 289:22, pages 15350-15362.
Crossref
Woon Ki PaikSangduk KimIn Kyoung Lim. (2014) Protein Methylation and Interaction with the Antiproliferative Gene, BTG2 /TIS21/Pc3 . Yonsei Medical Journal 55:2, pages 292.
Crossref
Nitish Tayal, Preeti Choudhary, Shashi B. Pandit & Kuljeet Singh Sandhu. (2014) Evolutionarily conserved and conformationally constrained short peptides might serve as DNA recognition elements in intrinsically disordered regions. Molecular BioSystems 10:6, pages 1469.
Crossref
Joshua A. Regal, Todd A. Festerling, Jeffrey M. Buis & David O. Ferguson. (2013) Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms. Human Molecular Genetics 22:25, pages 5146-5159.
Crossref
Jana Krietsch, Michèle Rouleau, Émilie Pic, Chantal Ethier, Ted M. Dawson, Valina L. Dawson, Jean-Yves Masson, Guy G. Poirier & Jean-Philippe Gagné. (2013) Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Molecular Aspects of Medicine 34:6, pages 1066-1087.
Crossref
Yannick Auclair & Stéphane Richard. (2013) The role of arginine methylation in the DNA damage response. DNA Repair 12:7, pages 459-465.
Crossref
Palaniraja Thandapani, Timothy R. O’Connor, Timothy L. Bailey & Stéphane Richard. (2013) Defining the RGG/RG Motif. Molecular Cell 50:5, pages 613-623.
Crossref
Kyu-Sung Choi, Ji Yeon Kim, Seo-Kyung Lim, Yong Won Choi, Young Hwa Kim, So Young Kang, Tae Jun Park & In Kyoung Lim. (2012) TIS21/BTG2/PC3 accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2T68–p53S20 pathway. DNA Repair 11:12, pages 965-975.
Crossref
Juxian Wang, Limin Chen, Sarmistha Halder Sinha, Zhongjie Liang, Huifang Chai, Sakthivel Muniyan, Yu-Wei Chou, Chao Yang, Leilei Yan, You Feng, Keqin Kathy Li, Ming-Fong Lin, Hualiang Jiang, Yujun George Zheng & Cheng Luo. (2012) Pharmacophore-Based Virtual Screening and Biological Evaluation of Small Molecule Inhibitors for Protein Arginine Methylation. Journal of Medicinal Chemistry 55:18, pages 7978-7987.
Crossref
Zhenbao Yu, Gillian Vogel, Yan Coulombe, Danielle Dubeau, Elizabeth Spehalski, Josée Hébert, David O Ferguson, Jean Yves Masson & Stéphane Richard. (2011) The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation. Cell Research 22:2, pages 305-320.
Crossref
Wei He, Xiaoyan Ma, Xiao Yang, Yun Zhao, Junkang Qiu & Haiying Hang. (2011) A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage. Nucleic Acids Research 39:11, pages 4719-4727.
Crossref
Sophie E. Polo & Stephen P. Jackson. (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes & Development 25:5, pages 409-433.
Crossref
Zhigang Guo, Li Zheng, Hong Xu, Huifang Dai, Mian Zhou, Mary Rose Pascua, Qin M Chen & Binghui Shen. (2010) Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. Nature Chemical Biology 6:10, pages 766-773.
Crossref
Elisabeth-Maria Bissinger, Ralf Heinke, Wolfgang Sippl & Manfred Jung. (2010) Targeting epigenetic modifiers: Inhibitors of histone methyltransferases. MedChemComm 1:2, pages 114-124.
Crossref
Agnieszka Rupnik, Noel F. Lowndes & Muriel Grenon. (2009) MRN and the race to the break. Chromosoma 119:2, pages 115-135.
Crossref
Frédéric Dallaire, Paola Blanchette & Philip E. Branton. (2009) A Proteomic Approach To Identify Candidate Substrates of Human Adenovirus E4orf6-E1B55K and Other Viral Cullin-Based E3 Ubiquitin Ligases. Journal of Virology 83:23, pages 12172-12184.
Crossref
Thomas B. Nicholson, Taiping Chen & Stéphane Richard. (2009) The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. Pharmacological Research 60:6, pages 466-474.
Crossref
Jing Zhuang, Guochun Jiang, Henning Willers & Fen Xia. (2009) Exonuclease Function of Human Mre11 Promotes Deletional Nonhomologous End Joining. Journal of Biological Chemistry 284:44, pages 30565-30573.
Crossref
Céline Roques, Yan Coulombe, Mathieu Delannoy, Julien Vignard, Simona Grossi, Isabelle Brodeur, Amélie Rodrigue, Jean Gautier, Alicja Z Stasiak, Andrzej Stasiak, Angelos Constantinou & Jean-Yves Masson. (2009) MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. The EMBO Journal 28:16, pages 2400-2413.
Crossref
Manfred Jung. 2009. Epigenetic Targets in Drug Discovery. Epigenetic Targets in Drug Discovery 251 268 .
Orkide Ö. Koyuncu & Thomas Dobner. (2009) Arginine Methylation of Human Adenovirus Type 5 L4 100-Kilodalton Protein Is Required for Efficient Virus Production. Journal of Virology 83:10, pages 4778-4790.
Crossref
Young-Ho Lee & Michael R. Stallcup. (2009) Minireview: Protein Arginine Methylation of Nonhistone Proteins in Transcriptional Regulation. Molecular Endocrinology 23:4, pages 425-433.
Crossref
Ying Xie, Sui Ke, Nengtai Ouyang, Jinhan He, Wen Xie, Mark T. Bedford & Yanan Tian. (2009) Epigenetic Regulation of Transcriptional Activity of Pregnane X Receptor by Protein Arginine Methyltransferase 1. Journal of Biological Chemistry 284:14, pages 9199-9205.
Crossref
Ralf Heinke, Astrid SpannhoffRene Meier, Patrick TrojerIngo BauerManfred JungWolfgang Sippl. (2009) Virtual Screening and Biological Characterization of Novel Histone Arginine Methyltransferase PRMT1 Inhibitors. ChemMedChem 4:1, pages 69-77.
Crossref
Mark T. Bedford & Steven G. Clarke. (2009) Protein Arginine Methylation in Mammals: Who, What, and Why. Molecular Cell 33:1, pages 1-13.
Crossref
Astrid Spannhoff, Wolfgang Sippl & Manfred Jung. (2009) Cancer treatment of the future: Inhibitors of histone methyltransferases. The International Journal of Biochemistry & Cell Biology 41:1, pages 4-11.
Crossref
Peter Kuhn & Wei Xu. 2009. 299 342 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.