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Article

Transcription Regulation of the rRNA Gene by a Multifunctional Nucleolar Protein, B23/Nucleophosmin, through Its Histone Chaperone Activity

Kensaku Murano1 Department of Infection Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1Tennodai, Tsukuba305-8575
,
Mitsuru Okuwaki1 Department of Infection Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1Tennodai, Tsukuba305-8575;2 PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, 322-0012, Japan
,
Miharu Hisaoka1 Department of Infection Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1Tennodai, Tsukuba305-8575
&
Kyosuke Nagata1 Department of Infection Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1Tennodai, Tsukuba305-8575Correspondence[email protected]
Pages 3114-3126 | Received 20 Nov 2007, Accepted 03 Mar 2008, Published online: 27 Mar 2023

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
A. De Cola, M. Franceschini, A. Di Matteo, G. Colotti, R. Celani, E. Clemente, R. Ippoliti, A.M. Cimini, A.C. Dhez, B. Vallée, F. Raineri, I. Cascone, D. Destouches, V. De Laurenzi, J. Courty & L. Federici. (2018) N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy. Cancer Letters 412, pages 272-282.
Crossref
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Crossref
F Pozzo, T Bittolo, E Vendramini, R Bomben, P Bulian, F M Rossi, A Zucchetto, E Tissino, M Degan, G D’Arena, F Di Raimondo, F Zaja, G Pozzato, D Rossi, G Gaidano, G Del Poeta, V Gattei & M Dal Bo. (2017) NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components. Leukemia 31:11, pages 2407-2415.
Crossref
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Crossref
A Di Matteo, M Franceschini, A Paiardini, A Grottesi, S Chiarella, S Rocchio, C Di Natale, D Marasco, L Vitagliano, C Travaglini-Allocatelli & L Federici. (2017) Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ. Oncogenesis 6:9, pages e379-e379.
Crossref
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Crossref
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Crossref
Verline Justilien, Syed A. Ali, Lee Jamieson, Ning Yin, Adrienne D. Cox, Channing J. Der, Nicole R. Murray & Alan P. Fields. (2017) Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53 -Driven Lung Adenocarcinoma. Cancer Cell 31:2, pages 256-269.
Crossref
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Crossref
L. M. Ogawa & S. J. Baserga. (2017) Crosstalk between the nucleolus and the DNA damage response. Molecular BioSystems 13:3, pages 443-455.
Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Hong Zhou, Yapei Wang, Qiongying Lv, Juan Zhang, Qing Wang, Fei Gao, Haoli Hou, Hao Zhang, Wei Zhang & Lijia Li. (2016) Overexpression of Ribosomal RNA in the Development of Human Cervical Cancer Is Associated with rDNA Promoter Hypomethylation. PLOS ONE 11:10, pages e0163340.
Crossref
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Crossref
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Crossref
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Crossref
Timothy D. Matheson & Paul D. Kaufman. (2015) Grabbing the genome by the NADs. Chromosoma 125:3, pages 361-371.
Crossref
E. Smirnov, D. Cmarko, T. Mazel, M. Hornáček & I. Raška. (2016) Nucleolar DNA: the host and the guests. Histochemistry and Cell Biology 145:4, pages 359-372.
Crossref
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Crossref
Wenxue LiMyoung-Hwa LeeLisa HendersonRicha TyagiMuzna BachaniJoseph SteinerEmilie CampanacDax A. HoffmanGloria von GeldernKory JohnsonDragan MaricH. Douglas MorrisMargaret LentzKatherine PakAndrew MammenLyle OstrowJeffrey RothsteinAvindra Nath. (2015) Human endogenous retrovirus-K contributes to motor neuron disease. Science Translational Medicine 7:307.
Crossref
Concetta Di Natale, Pasqualina Liana Scognamiglio, Roberta Cascella, Cristina Cecchi, Anna Russo, Marilisa Leone, Amanda Penco, Annalisa Relini, Luca Federici, Adele Di Matteo, Fabrizio Chiti, Luigi Vitagliano & Daniela Marasco. (2015) Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions. The FASEB Journal 29:9, pages 3689-3701.
Crossref
Richa Ahuja, Neetu Rohit Kapoor & Vijay Kumar. (2015) The HBx oncoprotein of hepatitis B virus engages nucleophosmin to promote rDNA transcription and cellular proliferation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:8, pages 1783-1795.
Crossref
Jee‐Youn Kim, Young‐Eun Cho, Yong‐Min An, Sang‐Hoon Kim, Yong‐Gwan Lee, Jae‐Hoon Park & Sun Lee. (2015) GLTSCR 2 is an upstream negative regulator of nucleophosmin in cervical cancer . Journal of Cellular and Molecular Medicine 19:6, pages 1245-1252.
Crossref
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Crossref
Eui-Soon Park, Seunga Choi, Bongjin Shin, Jungeun Yu, Jiyeon Yu, Jung-Me Hwang, Hyeongseok Yun, Young-Ho Chung, Jong-Soon Choi, Yongwon Choi & Jaerang Rho. (2015) Tumor Necrosis Factor (TNF) Receptor-associated Factor (TRAF)-interacting Protein (TRIP) Negatively Regulates the TRAF2 Ubiquitin-dependent Pathway by Suppressing the TRAF2-Sphingosine 1-Phosphate (S1P) Interaction. Journal of Biological Chemistry 290:15, pages 9660-9673.
Crossref
Keun Woo Ryu, Dae-Seok Kim & W. Lee Kraus. (2015) New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases. Chemical Reviews 115:6, pages 2453-2481.
Crossref
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Crossref
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Crossref
Ramesh Balusu, Warren Fiskus & Kapil N. Bhalla. 2015. Targeted Therapy of Acute Myeloid Leukemia. Targeted Therapy of Acute Myeloid Leukemia 251 273 .
Karl Holmberg Olausson, Monica Nistér & Mikael S. Lindström. (2014) Loss of Nucleolar Histone Chaperone NPM1 Triggers Rearrangement of Heterochromatin and Synergizes with a Deficiency in DNA Methyltransferase DNMT3A to Drive Ribosomal DNA Transcription. Journal of Biological Chemistry 289:50, pages 34601-34619.
Crossref
Corey L. Smith, Timothy D. Matheson, Daniel J. Trombly, Xiaoming Sun, Eric Campeau, Xuemei Han, John R. YatesIIIIII & Paul D. Kaufman. (2014) A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli. Molecular Biology of the Cell 25:18, pages 2866-2881.
Crossref
Dai Hatakeyama, Masaki Shoji, Seiya Yamayoshi, Takenori Hirota, Monami Nagae, Shin Yanagisawa, Masahiro Nakano, Naho Ohmi, Takeshi Noda, Yoshihiro Kawaoka & Takashi Kuzuhara. (2014) A Novel Functional Site in the PB2 Subunit of Influenza A Virus Essential for Acetyl-CoA Interaction, RNA Polymerase Activity, and Viral Replication. Journal of Biological Chemistry 289:36, pages 24980-24994.
Crossref
Alessandro Arcovito, Sara Chiarella, Stefano Della Longa, Adele Di Matteo, Carlo Lo Sterzo, Giovanni Luca Scaglione & Luca Federici. (2014) Synergic Role of Nucleophosmin Three-helix Bundle and a Flanking Unstructured Tail in the Interaction with G-quadruplex DNA. Journal of Biological Chemistry 289:31, pages 21230-21241.
Crossref
Jayasha Shandilya, Parijat Senapati, Karthigeyan Dhanasekaran, Suma S. Bangalore, Manoj Kumar, A. Hari Kishore, Akshay Bhat, Gopinath S. Kodaganur & Tapas K. Kundu. (2014) Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression. FEBS Letters 588:14, pages 2198-2205.
Crossref
Mattia Poletto, Lisa Lirussi, David M. Wilson3rd3rd & Gianluca Tell. (2014) Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins. Molecular Biology of the Cell 25:10, pages 1641-1652.
Crossref
Chiou-Nan Shiue, Amir Nematollahi-Mahani & Anthony P.H. Wright. (2014) Myc-induced anchorage of the rDNA IGS region to nucleolar matrix modulates growth-stimulated changes in higher-order rDNA architecture. Nucleic Acids Research 42:9, pages 5505-5517.
Crossref
Denis Drygin, Sean E. O’Brien, Ross D. Hannan, Grant A. McArthur & Daniel D. Von Hoff. (2014) Targeting the nucleolus for cancer-specific activation of p53. Drug Discovery Today 19:3, pages 259-265.
Crossref
Kensaku Murano, Mitsuru Okuwaki, Fumitaka Momose, Michiko Kumakura, Shuhei Ueshima, Robert F. Newbold & Kyosuke Nagata. (2014) Reconstitution of human rRNA gene transcription in mouse cells by complete SL1 complex. Journal of Cell Science.
Crossref
M. Hisaoka, K. Nagata & M. Okuwaki. (2013) Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association. Nucleic Acids Research 42:2, pages 1180-1195.
Crossref
Nadine Hein, Katherine M. Hannan, Amee J. George, Elaine Sanij & Ross D. Hannan. (2013) The nucleolus: an emerging target for cancer therapy. Trends in Molecular Medicine 19:11, pages 643-654.
Crossref
Anne S. Calkins, J. Dirk Iglehart & Jean-Bernard Lazaro. (2013) DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1. Nucleic Acids Research 41:15, pages 7378-7386.
Crossref
Marie Morimoto & Cornelius Boerkoel. (2013) The Role of Nuclear Bodies in Gene Expression and Disease. Biology 2:3, pages 976-1033.
Crossref
Luca Federici & Brunangelo Falini. (2013) Nucleophosmin mutations in acute myeloid leukemia: A tale of protein unfolding and mislocalization. Protein Science 22:5, pages 545-556.
Crossref
Z Li & S R Hann. (2012) Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription. Oncogene 32:15, pages 1988-1994.
Crossref
Jan Padeken, María José Mendiburo, Sarantis Chlamydas, Hans-Jürgen Schwarz, Elisabeth Kremmer & Patrick Heun. (2013) The Nucleoplasmin Homolog NLP Mediates Centromere Clustering and Anchoring to the Nucleolus. Molecular Cell 50:2, pages 236-249.
Crossref
Sarah J. Goodfellow & Joost C. B. M. Zomerdijk. 2013. Epigenetics: Development and Disease. Epigenetics: Development and Disease 211 236 .
Bertrand Chin-Ming Tan, Chang-Ching Yang, Chia-Ling Hsieh, Yin-Hsiang Chou, Chang-Zheng Zhong, Benjamin Yat-Ming Yung & Hsuan Liu. (2012) Epigeneitc silencing of ribosomal RNA genes by Mybbp1a. Journal of Biomedical Science 19:1.
Crossref
Tomoya Fukawa, Masaya Ono, Taisuke Matsuo, Hisanori Uehara, Tsuneharu Miki, Yusuke Nakamura, Hiro-omi Kanayama & Toyomasa Katagiri. (2012) DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas. Cancer Research 72:22, pages 5867-5877.
Crossref
Mohammad Abdus Samad, Tetsuro Komatsu, Mitsuru Okuwaki & Kyosuke Nagata. (2012) B23/nucleophosmin is involved in regulation of adenovirus chromatin structure at late infection stages, but not in virus replication and transcription. Journal of General Virology 93:6, pages 1328-1338.
Crossref
Anthony J. Saporita, Hsiang-Chun Chang, Crystal L. Winkeler, Anthony J. Apicelli, Raleigh D. Kladney, Jianbo Wang, R. Reid Townsend, Loren S. Michel & Jason D. Weber. (2011) RNA Helicase DDX5 Is a p53-Independent Target of ARF That Participates in Ribosome Biogenesis. Cancer Research 71:21, pages 6708-6717.
Crossref
Leslie GueryNaïma BenikhlefThomas GautierCatherine PaulGaetan JegoErick DufourArnaud JacquelRadj CallyBénédicte ManouryTom Vanden BerghePeter VandenabeeleNathalie Droin & Eric Solary. (2011) Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood 118:17, pages 4694-4704.
Crossref
Ramesh BalusuWarren FiskusRekha RaoDaniel G. ChongSrilatha NalluriUma MudunuruHongwei MaLei ChenSreedhar VenkannagariKyungsoo HaSunil AbhyankarCasey WilliamsJoseph McGuirkHanna Jean Khoury, Celalettin Ustun & Kapil N. Bhalla. (2011) Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1. Blood 118:11, pages 3096-3106.
Crossref
E Colombo, M Alcalay & P G Pelicci. (2011) Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases. Oncogene 30:23, pages 2595-2609.
Crossref
Shrikanth S. Gadad, Parijat Senapati, Sajad Hussain Syed, Roshan Elizabeth Rajan, Jayasha Shandilya, Venkatesh Swaminathan, Snehajyoti Chatterjee, Emanuela Colombo, Stefan Dimitrov, Pier Giuseppe Pelicci, Udaykumar Ranga & Tapas K. Kundu. (2011) The Multifunctional Protein Nucleophosmin (NPM1) Is a Human Linker Histone H1 Chaperone. Biochemistry 50:14, pages 2780-2789.
Crossref
Tetsuro Komatsu, Hirohito Haruki & Kyosuke Nagata. (2011) Cellular and viral chromatin proteins are positive factors in the regulation of adenovirus gene expression. Nucleic Acids Research 39:3, pages 889-901.
Crossref
Mikael S. Lindström. (2011) NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling. Biochemistry Research International 2011, pages 1-16.
Crossref
Renate Voit & Ingrid Grummt. 2011. The Nucleolus. The Nucleolus 107 134 .
Raffaella Santoro. 2011. The Nucleolus. The Nucleolus 57 82 .
Shea Ping Yip, Parco M. Siu, Polly H. M. Leung, Yanxiang Zhao & Benjamin Y. M. Yung. 2011. The Nucleolus. The Nucleolus 213 252 .
Geunyeong Park, Zihua Gong, Junjie Chen & Ja-Eun Kim. (2010) Characterization of the DOT1L Network: Implications of Diverse Roles for DOT1L. The Protein Journal 29:3, pages 213-223.
Crossref
Denis DryginWilliam G. RiceIngrid Grummt. (2010) The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer. Annual Review of Pharmacology and Toxicology 50:1, pages 131-156.
Crossref
Jungeun Yu, Bongjin Shin, Eui-Soon Park, Sujeong Yang, Seunga Choi, Misun Kang & Jaerang Rho. (2010) Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation. Biochemical and Biophysical Research Communications 391:1, pages 322-328.
Crossref
Satoshi Kubota, Yoshiki Mukudai, Harumi Kawaki, Seiji Kondo, Takanori Eguchi, Kumi Sumiyoshi, Toshihiro Ohgawara, Tsuyoshi Shimo & Masaharu Takigawa. 2010. CCN Proteins in Health and Disease. CCN Proteins in Health and Disease 41 55 .
Jordanka Zlatanova & Paola Caiafa. (2009) CTCF and its protein partners: divide and rule?. Journal of Cell Science 122:9, pages 1275-1284.
Crossref
Yasser Perera, Hernán G. Farina, Jeovanis Gil, Arielis Rodriguez, Fernando Benavent, Lila Castellanos, Roberto E. Gómez, Boris E. Acevedo, Daniel F. Alonso & Silvio E. Perea. (2009) Anticancer peptide CIGB-300 binds to nucleophosmin/B23, impairs its CK2-mediated phosphorylation, and leads to apoptosis through its nucleolar disassembly activity. Molecular Cancer Therapeutics 8:5, pages 1189-1196.
Crossref
Paola Caiafa & Jordanka Zlatanova. (2009) CCCTC-binding factor meets poly(ADP-ribose) polymerase-1. Journal of Cellular Physiology 219:2, pages 265-270.
Crossref
Joanna L Birch, Bertrand C-M Tan, Kostya I Panov, Tatiana B Panova, Jens S Andersen, Tom A Owen-Hughes, Jackie Russell, Sheng-Chung Lee & Joost C B M Zomerdijk. (2009) FACT facilitates chromatin transcription by RNA polymerases I and III. The EMBO Journal 28:7, pages 854-865.
Crossref
Olha KhymenetsMontserat FitóMaría-Isabel CovasMagí FarréMaria-Antonia PujadasDaniel MuñozValentini KonstantinidouRafael de la Torre. (2009) Mononuclear Cell Transcriptome Response after Sustained Virgin Olive Oil Consumption in Humans: An Exploratory Nutrigenomics Study. OMICS: A Journal of Integrative Biology 13:1, pages 7-19.
Crossref
Takeya Morozumi, Tadasuke Naito, Pham Doan Lan, Emiko Nakajima, Tadayoshi Mitsuhashi, Satoshi Mikawa, Takeshi Hayashi, Takashi Awata, Hirohide Uenishi, Kyosuke Nagata, Tomomasa Watanabe & Noriyuki Hamasima. (2009) Molecular cloning and characterization of porcine Mx2 gene. Molecular Immunology 46:5, pages 858-865.
Crossref
Ammy Lin, Shan Wang, Tin Nguyen, Kathy Shire & Lori Frappier. (2008) The EBNA1 Protein of Epstein-Barr Virus Functionally Interacts with Brd4. Journal of Virology 82:24, pages 12009-12019.
Crossref
Joanna L. BirchJoost C.B.M. Zomerdijk. (2008) Structure and function of ribosomal RNA gene chromatin. Biochemical Society Transactions 36:4, pages 619-624.
Crossref

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