54
Views
48
CrossRef citations to date
0
Altmetric
Article

MED1 Phosphorylation Promotes Its Association with Mediator: Implications for Nuclear Receptor Signaling

, , &
Pages 3932-3942 | Received 11 Dec 2007, Accepted 31 Mar 2008, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Zachary C. Poss, Christopher C. Ebmeier & Dylan J. Taatjes. (2013) The Mediator complex and transcription regulation. Critical Reviews in Biochemistry and Molecular Biology 48:6, pages 575-608.
Read now
Natsumi Hasegawa, Akiko Sumitomo, Azusa Fujita, Nami Aritome, Shumpei Mizuta, Keiji Matsui, Ruri Ishino, Kana Inoue, Norinaga Urahama, Junko Nose, Toru Mukohara, Shingo Kamoshida, Robert G. Roeder & Mitsuhiro Ito. (2012) Mediator Subunits MED1 and MED24 Cooperatively Contribute to Pubertal Mammary Gland Development and Growth of Breast Carcinoma Cells. Molecular and Cellular Biology 32:8, pages 1483-1495.
Read now
Zeynep Madak-Erdogan, Mathieu Lupien, Fabio Stossi, Myles Brown & Benita S. Katzenellenbogen. (2011) Genomic Collaboration of Estrogen Receptor α and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs. Molecular and Cellular Biology 31:1, pages 226-236.
Read now
Madesh Belakavadi & Joseph D. Fondell. (2010) Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation. Molecular and Cellular Biology 30:10, pages 2437-2448.
Read now

Articles from other publishers (44)

Marie-Sophie Friedl, Lara Djakovic, Michael Kluge, Thomas Hennig, Adam W. Whisnant, Simone Backes, Lars Dölken & Caroline C. Friedel. (2022) HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform. PLOS ONE 17:10, pages e0276467.
Crossref
Zhong Chen, Zhenqing Ye, Raymond E Soccio, Tomoyoshi Nakadai, William Hankey, Yue Zhao, Furong Huang, Fuwen Yuan, Hongyan Wang, Zhifen Cui, Benjamin Sunkel, Dayong Wu, Richard K Dzeng, Jennifer M Thomas-Ahner, Tim H M Huang, Steven K Clinton, Jiaoti Huang, Mitchell A Lazar, Victor X Jin, Robert G Roeder & Qianben Wang. (2022) Phosphorylated MED1 links transcription recycling and cancer growth. Nucleic Acids Research 50:8, pages 4450-4463.
Crossref
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel & Sven Perner. (2022) CDK7 Predicts Worse Outcome in Head and Neck Squamous-Cell Cancer. Cancers 14:3, pages 492.
Crossref
Rayzel C. Fernandes, Damien A. Leach & Charlotte L. Bevan. 2022. Nuclear Receptors in Human Health and Disease. Nuclear Receptors in Human Health and Disease 277 293 .
Pan Liang, Linshen Mao, Yue Ma, Wei Ren & Sijin Yang. (2021) A systematic review on Zhilong Huoxue Tongyu capsule in treating cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms and clinical outcomes. Journal of Ethnopharmacology 277, pages 114234.
Crossref
Laia Richart, François-Clément Bidard & Raphaël Margueron. (2021) Enhancer rewiring in tumors: an opportunity for therapeutic intervention. Oncogene 40:20, pages 3475-3491.
Crossref
Irfan Asangani, Ian A. Blair, Gregory Van Duyne, Vincent J. Hilser, Vera Moiseenkova-Bell, Stephen Plymate, Cynthia Sprenger, A. Joshua Wand & Trevor M. Penning. (2021) Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer. Journal of Biological Chemistry 296, pages 100240.
Crossref
Matthew R. Femia, Rochelle M. Evans, Jibo Zhang, Xiaopeng Sun, Caroline J. Lebegue, Vincent R. Roggero & Lizabeth A. Allison. (2019) Mediator subunit MED1 modulates intranuclear dynamics of the thyroid hormone receptor. Journal of Cellular Biochemistry 121:4, pages 2909-2926.
Crossref
Joshua W. Russo, Mannan Nouri & Steven P. Balk. (2019) Androgen Receptor Interaction with Mediator Complex Is Enhanced in Castration-Resistant Prostate Cancer by CDK7 Phosphorylation of MED1. Cancer Discovery 9:11, pages 1490-1492.
Crossref
Reyaz ur Rasool, Ramakrishnan Natesan, Qu Deng, Shweta Aras, Priti Lal, Samuel Sander Effron, Erick Mitchell-Velasquez, Jessica M. Posimo, Shannon Carskadon, Sylvan C. Baca, Mark M. Pomerantz, Javed Siddiqui, Lauren E. Schwartz, Daniel J. Lee, Nallasivam Palanisamy, Goutham Narla, Robert B. Den, Matthew L. Freedman, Donita C. Brady & Irfan A. Asangani. (2019) CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation. Cancer Discovery 9:11, pages 1538-1555.
Crossref
Matthias Parrini, Katrin Meissl, Mojoyinola Joanna Ola, Therese Lederer, Ana Puga, Sebastian Wienerroither, Pavel Kovarik, Thomas Decker, Mathias Müller & Birgit Strobl. (2018) The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment. Frontiers in Immunology 9.
Crossref
Leonela Amoasii, Eric N. Olson & Rhonda Bassel-Duby. (2018) Control of Muscle Metabolism by the Mediator Complex. Cold Spring Harbor Perspectives in Medicine 8:2, pages a029843.
Crossref
T.J. Weber & W. Qian. 2018. Comprehensive Toxicology. Comprehensive Toxicology 264 285 .
Qing Chen, Ziyi Weng, Yunshu Lu, Yijun Jia, Longlong Ding, Fang Bai, Meixin Ge, Qing Lin & Kejin Wu. (2017) An Experimental Analysis of the Molecular Effects of Trastuzumab (Herceptin) and Fulvestrant (Falsodex), as Single Agents or in Combination, on Human HR+/HER2+ Breast Cancer Cell Lines and Mouse Tumor Xenografts. PLOS ONE 12:1, pages e0168960.
Crossref
Benjamin L. Allen & Dylan J. Taatjes. (2015) The Mediator complex: a central integrator of transcription. Nature Reviews Molecular Cell Biology 16:3, pages 155-166.
Crossref
Kedryn K. Baskin, Benjamin R. Winders & Eric N. Olson. (2015) Muscle as a “Mediator” of Systemic Metabolism. Cell Metabolism 21:2, pages 237-248.
Crossref
Katrina M. Waters, Brian S. Cummings, Harish Shankaran, Natalie E. Scholpa & Thomas J. Weber. (2014) ERK Oscillation-Dependent Gene Expression Patterns and Deregulation by Stress Response. Chemical Research in Toxicology 27:9, pages 1496-1503.
Crossref
Yuzhi Jia, Navin Viswakarma & Janardan K. Reddy. (2014) Med1 Subunit of the Mediator Complex in Nuclear Receptor-Regulated Energy Metabolism, Liver Regeneration, and Hepatocarcinogenesis. Gene Expression 16:2, pages 63-75.
Crossref
Bandish Kapadia, Navin Viswakarma, Kishore V. L. Parsa, Vasundhara Kain, Soma Behera, Sashidhara Kaimal Suraj, Phanithi Prakash Babu, Anand Kar, Sunanda Panda, Yi-jun Zhu, Yuzhi Jia, Bayar Thimmapaya, Janardan K. Reddy & Parimal Misra. (2013) ERK2-Mediated Phosphorylation of Transcriptional Coactivator Binding Protein PIMT/NCoA6IP at Ser298 Augments Hepatic Gluconeogenesis. PLoS ONE 8:12, pages e83787.
Crossref
Navin Viswakarma, Yuzhi Jia, Liang Bai, Qian Gao, Bingliang Lin, Xiaohong Zhang, Parimal Misra, Ajay Rana, Sanjay Jain, Frank J. Gonzalez, Yi-Jun Zhu, Bayar Thimmapaya & Janardan K. Reddy. (2013) The Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and Is Phosphorylated by AMP Kinase. Journal of Biological Chemistry 288:39, pages 27898-27911.
Crossref
Feng Jin, Shazia Irshad, Wei Yu, Madesh Belakavadi, Marina Chekmareva, Michael M. Ittmann, Cory Abate-Shen & Joseph D. Fondell. (2013) ERK and AKT Signaling Drive MED1 Overexpression in Prostate Cancer in Association with Elevated Proliferation and Tumorigenicity. Molecular Cancer Research 11:7, pages 736-747.
Crossref
Charles E. Foulds, Qin Feng, Chen Ding, Suzanna Bailey, Tamra L. Hunsaker, Anna Malovannaya, Ross A. Hamilton, Leah A. Gates, Zheng Zhang, Chunshu Li, Doug Chan, Amol Bajaj, Celetta G. Callaway, Dean P. Edwards, David M. Lonard, Sophia Y. Tsai, Ming-Jer Tsai, Jun Qin & Bert W. O’Malley. (2013) Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics. Molecular Cell 51:2, pages 185-199.
Crossref
Joseph D. Fondell. (2013) The Mediator complex in thyroid hormone receptor action. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:7, pages 3867-3875.
Crossref
T Hulf, T Sibbritt, E D Wiklund, K Patterson, J Z Song, C Stirzaker, W Qu, S Nair, L G Horvath, N J Armstrong, J G Kench, R L Sutherland & S J Clark. (2012) Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer. Oncogene 32:23, pages 2891-2899.
Crossref
Aileen M Klein, Elma Zaganjor & Melanie H Cobb. (2013) Chromatin-tethered MAPKs. Current Opinion in Cell Biology 25:2, pages 272-277.
Crossref
Shen-Hsi Yang, Andrew D. Sharrocks & Alan J. Whitmarsh. (2013) MAP kinase signalling cascades and transcriptional regulation. Gene 513:1, pages 1-13.
Crossref
Christian Miller, Ivan Matic, Kerstin C. Maier, Björn Schwalb, Susanne Roether, Katja Strässer, Achim Tresch, Matthias Mann & Patrick Cramer. (2012) Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions. Journal of Biological Chemistry 287:53, pages 44017-44026.
Crossref
Jiajun Cui, Katherine Germer, Tianying Wu, Jiang Wang, Jia Luo, Shao-chun Wang, Qianben Wang & Xiaoting Zhang. (2012) Cross-talk between HER2 and MED1 Regulates Tamoxifen Resistance of Human Breast Cancer Cells. Cancer Research 72:21, pages 5625-5634.
Crossref
Arumugam Nagalingam, Mourad Tighiouart, Lisa Ryden, Leena Joseph, Goran Landberg, Neeraj K. Saxena & Dipali Sharma. (2012) Med1 plays a critical role in the development of tamoxifen resistance. Carcinogenesis 33:4, pages 918-930.
Crossref
Claudio Napoli, Marcella Sessa, Teresa Infante & Amelia Casamassimi. (2012) Unraveling framework of the ancestral Mediator complex in human diseases. Biochimie 94:3, pages 579-587.
Crossref
Feng Jin, Frank Claessens & Joseph D. Fondell. (2012) Regulation of Androgen Receptor-dependent Transcription by Coactivator MED1 Is Mediated through a Newly Discovered Noncanonical Binding Motif. Journal of Biological Chemistry 287:2, pages 858-870.
Crossref
Chung-Jung TsaiRuth Nussinov. (2011) Gene-specific transcription activation via long-range allosteric shape-shifting. Biochemical Journal 439:1, pages 15-25.
Crossref
Wei Chen & Robert G. Roeder. (2011) Mediator-dependent nuclear receptor function. Seminars in Cell & Developmental Biology 22:7, pages 749-758.
Crossref
Jason M. Spaeth, Nam Hee Kim & Thomas G. Boyer. (2011) Mediator and human disease. Seminars in Cell & Developmental Biology 22:7, pages 776-787.
Crossref
Tilman Borggrefe & Xiaojing Yue. (2011) Interactions between subunits of the Mediator complex with gene-specific transcription factors. Seminars in Cell & Developmental Biology 22:7, pages 759-768.
Crossref
Zhong Chen, Chunpeng Zhang, Dayong Wu, Hongyan Chen, Anna Rorick, Xiaoting Zhang & Qianben Wang. (2011) Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. The EMBO Journal 30:12, pages 2405-2419.
Crossref
Dingxiao Zhang, Pingping Jiang, Qinqin Xu & Xiaoting Zhang. (2011) Arginine and Glutamate-rich 1 (ARGLU1) Interacts with Mediator Subunit 1 (MED1) and Is Required for Estrogen Receptor-mediated Gene Transcription and Breast Cancer Cell Growth. Journal of Biological Chemistry 286:20, pages 17746-17754.
Crossref
Warren ThomasBrian J. Harvey. (2011) Mechanisms Underlying Rapid Aldosterone Effects in the Kidney. Annual Review of Physiology 73:1, pages 335-357.
Crossref
Sohail Malik & Robert G. Roeder. (2010) The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nature Reviews Genetics 11:11, pages 761-772.
Crossref
Dylan J. Taatjes. (2010) The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends in Biochemical Sciences 35:6, pages 315-322.
Crossref
Navin Viswakarma, Yuzhi Jia, Liang Bai, Aurore Vluggens, Jayme Borensztajn, Jianming Xu & Janardan K. Reddy. (2010) Coactivators in PPAR-Regulated Gene Expression. PPAR Research 2010, pages 1-21.
Crossref
Sang Jun Han, David M. Lonard & Bert W. O’Malley. (2009) Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends in Endocrinology & Metabolism 20:1, pages 8-15.
Crossref
Inés Carrera & Jessica E Treisman. (2008) Message in a nucleus: signaling to the transcriptional machinery. Current Opinion in Genetics & Development 18:5, pages 397-403.
Crossref
Zeynep Madak-Erdogan, Karen J. Kieser, Sung Hoon Kim, Barry Komm, John A. Katzenellenbogen & Benita S. Katzenellenbogen. (2008) Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors. Molecular Endocrinology 22:9, pages 2116-2127.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.