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Molecular and Cellular Biology Volume 27, 2007 - Issue 9
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Article

The 3′ Untranslated Region Complex Involved in Stabilization of Human α-globin mRNA Assembles in the Nucleus and Serves an Independent Role as a Splice Enhancer

Xinjun Ji1 Departments of Genetics and Medicine
,
Jian Kong1 Departments of Genetics and Medicine
,
Russ P. Carstens2 Department of Medicine, Renal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104
&
Stephen A. Liebhaber1 Departments of Genetics and MedicineCorrespondence[email protected]
Pages 3290-3302 | Received 30 Nov 2005, Accepted 08 Feb 2007, Published online: 27 Mar 2023

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Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R. Ghanem, Andrew Kromer, Christopher Duncan-Lewis, Elizabeth Traxler, Mitchell J. Weiss, Yoseph Barash & Stephen A. Liebhaber. (2021) RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis. Molecular and Cellular Biology 41:9.
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Margarita I. Zarudnaya, Iryna M. Kolomiets, Andriy L. Potyahaylo & Dmytro M. Hovorun. (2019) Structural transitions in poly(A), poly(C), poly(U), and poly(G) and their possible biological roles. Journal of Biomolecular Structure and Dynamics 37:11, pages 2837-2866.
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Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Xinjun Ji, Matthew Gazzara, Nhu Nguyen, Gabrielle Aguilar, Massimo Martinelli, Yoseph Barash & Stephen A. Liebhaber. (2018) Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Molecular and Cellular Biology 38:16.
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Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Priya Chatterji, Elizabeth Traxler, Alfredo Penzo-Mendez, Mitchell J. Weiss, Ben Z. Stanger & Stephen A. Liebhaber. (2016) The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Molecular and Cellular Biology 36:2, pages 304-319.
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Xinjun Ji, Ji Wan, Melanie Vishnu, Yi Xing & Stephen A. Liebhaber. (2013) αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation. Molecular and Cellular Biology 33:13, pages 2560-2573.
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Articles from other publishers (21)

Massimo Martinelli, Gabrielle Aguilar, David S.M. Lee, Andrew Kromer, Nhu Nguyen, Benjamin J. Wilkins, Tatiana Akimova, Ulf H. Beier & Louis R. Ghanem. (2023) The poly(C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation. iScience 26:1, pages 105860.
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Simone A Beckham, Mehdi Y Matak, Matthew J Belousoff, Hariprasad Venugopal, Neelam Shah, Naveen Vankadari, Hans Elmlund, Joseph H C Nguyen, Bert L Semler, Matthew C J Wilce & Jacqueline A Wilce. (2020) Structure of the PCBP2/stem–loop IV complex underlying translation initiation mediated by the poliovirus type I IRES. Nucleic Acids Research 48:14, pages 8006-8021.
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Ya Liu, Xiao Zhang, Jiafei Lin, Yuxin Chen, Yongxia Qiao, Susu Guo, Yueyue Yang, Guoqing Zhu, Qiuhui Pan, Jiayi Wang & Fenyong Sun. (2019) CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. Cell Death & Disease 10:9.
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Xinjun Ji, Jesse Humenik & Stephen A. Liebhaber. (2019) A cytosine-rich splice regulatory determinant enforces functional processing of the human α-globin gene transcript. Blood 133:21, pages 2338-2347.
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Surender Singh, Suman Choudhary, Vijay Anand, Shalini Jaswal, Arvind K. Verma, Sudarshan Kumar, Jai K. Kaushik & Ashok K. Mohanty. (2019) New insights into the catalytic inactivity of mammary gland protein-40, a chitinase-like protein expressed during mammary gland involution. Molecular Biology Reports 46:2, pages 2243-2257.
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Xinjun Ji, Jesse Humenik, Daphne Yang & Stephen A Liebhaber. (2018) PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing. Nucleic Acids Research 46:4, pages 2030-2044.
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Sharif Moradi, Ali Sharifi-Zarchi, Amirhossein Ahmadi, Sepideh Mollamohammadi, Alexander Stubenvoll, Stefan Günther, Ghasem Hosseini Salekdeh, Sassan Asgari, Thomas Braun & Hossein Baharvand. (2017) Small RNA Sequencing Reveals Dlk1-Dio3 Locus-Embedded MicroRNAs as Major Drivers of Ground-State Pluripotency. Stem Cell Reports 9:6, pages 2081-2096.
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Xinjun Ji, Juw Won Park, Emad Bahrami-Samani, Lan Lin, Christopher Duncan-Lewis, Gordon Pherribo, Yi Xing & Stephen A. Liebhaber. (2016) αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome. Nucleic Acids Research 44:5, pages 2283-2297.
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Louis R. Ghanem, Priya Chatterji & Stephen A. Liebhaber. (2014) Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa. Gene Expression Patterns 14:2, pages 78-87.
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Thomas W. Bebee, Benjamin W. Cieply & Russ P. Carstens. 2014. Systems Biology of RNA Binding Proteins. Systems Biology of RNA Binding Proteins 267 302 .
Amanda Charlesworth, Hedda A. Meijer & Cornelia H. de Moor. (2013) Specificity factors in cytoplasmic polyadenylation. Wiley Interdisciplinary Reviews: RNA 4:4, pages 437-461.
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Mustapha Kandouz, Jing Zhao, Andrew Bier, Sergio Di Marco, Irene Oviedo-Landaverde, Imed-Eddine Gallouzi & Gerald Batist. (2013) Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells. PLoS ONE 8:3, pages e58500.
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Qishan Chen, Min Jin, Jianhua Zhu, Qingzhong Xiao & Li Zhang. (2013) Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation. BioMed Research International 2013, pages 1-12.
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Y. M. K. Yoga, D. A. K. Traore, M. Sidiqi, C. Szeto, N. R. Pendini, A. Barker, P. J. Leedman, J. A. Wilce & M. C. J. Wilce. (2012) Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides. Nucleic Acids Research 40:11, pages 5101-5114.
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Xinjun Ji, Jian Kong & Stephen A Liebhaber. (2011) An RNA-protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization. The EMBO Journal 30:13, pages 2622-2633.
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Alexa M. Dickson & Jeffrey Wilusz. (2011) Strategies for viral RNA stability: live long and prosper. Trends in Genetics 27:7, pages 286-293.
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Melanie R. Vishnu, Marina Sumaroka, Peter S. Klein & Stephen A. Liebhaber. (2011) The poly(rC)-binding protein αCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation . RNA 17:5, pages 944-956.
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Donald E. Riley & John N. Krieger. (2009) UTR dinucleotide simple sequence repeat evolution exhibits recurring patterns including regulatory sequence motif replacements. Gene 429:1-2, pages 80-86.
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K. Paukku, N. Kalkkinen, O. Silvennoinen, K. K. Kontula & J. Y. A. Lehtonen. (2008) p100 increases AT1R expression through interaction with AT1R 3'-UTR. Nucleic Acids Research 36:13, pages 4474-4487.
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Rodwell Mabaera, Michael R. Greene, Christine A. Richardson, Sarah J. Conine, Courtney D. Kozul & Christopher H. Lowrey. (2008) Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin. Blood 111:1, pages 411-420.
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Hee Kyu Lee, Ho Yoon Kwak, Jung Hur, In Ae Kim, Ji Sun Yang, Min Woo Park, Jaehoon Yu & Sunjoo Jeong. (2007) β-Catenin Regulates Multiple Steps of RNA Metabolism as Revealed by the RNA Aptamer in Colon Cancer Cells. Cancer Research 67:19, pages 9315-9321.
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