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Molecular and Cellular Biology Volume 31, 2011 - Issue 18
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Article

TSC-22 Promotes Transforming Growth Factor β-Mediated Cardiac Myofibroblast Differentiation by Antagonizing Smad7 Activity

Xiaohua Yan1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
,
Junyu Zhang1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
,
Lin Pan2 China-Japan Friendship Hospital, Institute of Clinical Research, Chaoyang District, Beijing100029, China
,
Peng Wang1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
,
Hua Xue1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
,
Long Zhang1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
,
Xia Gao1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
,
Xingang Zhao1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
,
Yuanheng Ning1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, China
&
Ye-Guang Chen1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing100084, ChinaCorrespondence[email protected]
 show all
Pages 3700-3709 | Received 05 Apr 2011, Accepted 08 Jul 2011, Published online: 20 Mar 2023

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Lan Xu. (2011) Averting a Roadblock in Transforming Growth Factor β Signaling. Molecular and Cellular Biology 31:18, pages 3684-3686.
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Charles Colin Thomas Hindmarch, Lian Tian, Ping Yu Xiong, Francois Potus, Rachel Emily Teresa Bentley, Ruaa Al-Qazazi, Kurt W. Prins & Stephen L. Archer. (2022) An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats. Frontiers in Physiology 13.
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Yang Sun & Zi-jian Li. (2021) The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-β type I receptor degradation. Acta Pharmacologica Sinica 43:3, pages 634-644.
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Zhuowang Ge, Chengye Yin, Yingze Li, Ding Tian, Yin Xiang, Qianhui Li, Yong Tang & Yachen Zhang. (2022) Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter region. Journal of Translational Medicine 20:1.
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Sabreena Aashaq, Asiya Batool, Shabir Ahmad Mir, Mushtaq Ahmad Beigh, Khurshid Iqbal Andrabi & Zaffar Amin Shah. (2021) TGF‐β signaling: A recap of SMAD‐independent and SMAD‐dependent pathways. Journal of Cellular Physiology 237:1, pages 59-85.
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Somayeh Saadat, Mahdi Noureddini, Maryam Mahjoubin-Tehran, Sina Nazemi, Layla Shojaie, Michael Aschner, Behnaz Maleki, Mohammad Abbasi-kolli, Hasan Rajabi Moghadam, Behrang Alani & Hamed Mirzaei. (2021) Pivotal Role of TGF-β/Smad Signaling in Cardiac Fibrosis: Non-coding RNAs as Effectual Players. Frontiers in Cardiovascular Medicine 7.
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Federica Maria Conedera, Ana Maria Quintela Pousa, David Mikal Presby, Nadia Mercader, Volker Enzmann & Markus Tschopp. (2020) Diverse Signaling by TGFβ Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis. Cellular and Molecular Neurobiology 41:1, pages 43-62.
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Lin Fu, Chun-Ping Cui, Xueli Zhang & Lingqiang Zhang. (2020) The functions and regulation of Smurfs in cancers. Seminars in Cancer Biology 67, pages 102-116.
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Kegui Zhang, Meiping Zhang, Zhijun Luo, Zhili Wen & Xiaohua Yan. (2020) The dichotomous role of TGF-β in controlling liver cancer cell survival and proliferation. Journal of Genetics and Genomics 47:9, pages 497-512.
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Kalliopi Tzavlaki & Aristidis Moustakas. (2020) TGF-β Signaling. Biomolecules 10:3, pages 487.
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Sophie T. PhuongDung Tran, Christopher J. Hipolito, Hiroyuki Suzuki, Rudy Xie, Huynh Dam Kim Tuyen, Peter ten Dijke, Naohiro Terasaka, Yuki Goto, Hiroaki Suga & Mitsuyasu Kato. (2019) Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1. Biochemical and Biophysical Research Communications 516:2, pages 445-450.
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Xiaomeng Zhang, Huaning Xie, Pan Chang, Huishou Zhao, Yunlong Xia, Ling Zhang, Xiong Guo, Chong Huang, Feng Yan, Lang Hu, Chen Lin, Yueyang Li, Zhenyu Xiong, Xiong Wang, Guohua Li, Longxiang Deng, Shan Wang & Ling Tao. (2019) Glycoprotein M6B Interacts with TβRI to Activate TGF-β-Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation. Stem Cells 37:2, pages 190-201.
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Xiaohua Yan, Jingyi Wu, Quanlong Jiang, Hao Cheng, Jing-Dong J Han & Ye-Guang Chen. (2018) CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis. Journal of Molecular Cell Biology 10:1, pages 48-59.
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Keiji Miyazawa & Kohei Miyazono. (2017) Regulation of TGF-β Family Signaling by Inhibitory Smads. Cold Spring Harbor Perspectives in Biology 9:3, pages a022095.
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Feng Wang, Jun Wang, Xuan Yang, Danjie Chen & Liuxing Wang. (2016) MiR-424-5p participates in esophageal squamous cell carcinoma invasion and metastasis via SMAD7 pathway mediated EMT. Diagnostic Pathology 11:1.
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Beatriz Roson-Burgo, Fermin Sanchez-Guijo, Consuelo Del Cañizo & Javier De Las Rivas. (2016) Insights into the human mesenchymal stromal/stem cell identity through integrative transcriptomic profiling. BMC Genomics 17:1.
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Nan Li, Yong Yang, Kangmin He, Fayun Zhang, Libo Zhao, Wei Zhou, Jinghe Yuan, Wei Liang & Xiaohong Fang. (2016) Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane. Scientific Reports 6:1.
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Akiko Hata & Ye-Guang Chen. (2016) TGF-β Signaling from Receptors to Smads. Cold Spring Harbor Perspectives in Biology 8:9, pages a022061.
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Carl-Henrik Heldin & Aristidis Moustakas. (2016) Signaling Receptors for TGF-β Family Members. Cold Spring Harbor Perspectives in Biology 8:8, pages a022053.
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Xiaohua Yan, Hongwei Liao, Minzhang Cheng, Xiaojing Shi, Xia Lin, Xin-Hua Feng & Ye-Guang Chen. (2016) Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling. Journal of Biological Chemistry 291:1, pages 382-392.
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Raúl Vivar, Claudio Humeres, Claudia Muñoz, Pía Boza, Samir Bolivar, Felipe Tapia, Sergio Lavandero, Mario Chiong & Guillermo Diaz-Araya. (2016) FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:1, pages 128-138.
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Xiaohua Yan & Ye-Guang Chen. 2016. TGF-β Signaling. TGF-β Signaling 49 61 .
Annina Kelloniemi, Jani Aro, Juha Näpänkangas, Elina Koivisto, Erja Mustonen, Heikki Ruskoaho & Jaana Rysä. (2015) TSC-22 up-regulates collagen 3a1 gene expression in the rat heart. BMC Cardiovascular Disorders 15:1.
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Aurélie Pépin, Armelle Biola-Vidamment, Perle Latré de Laté, Marie-Alix Espinasse, Véronique Godot & Marc Pallardy. (2015) Les protéines de la famille TSC-22D. médecine/sciences 31:1, pages 75-83.
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Bing Zhao & Ye-Guang Chen. (2014) Regulation of TGF- β Signal Transduction . Scientifica 2014, pages 1-9.
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XiaoHua Yan, Jun Pan, WanWan Xiong, MinZhang Cheng, YingYuan Sun, SuPing Zhang & YeGuang Chen. (2013) Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus. Science China Life Sciences 57:1, pages 128-136.
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Yu Cao & Lingqiang Zhang. (2012) A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks. Cellular and Molecular Life Sciences 70:13, pages 2305-2317.
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Fei Huang & Ye-Guang Chen. (2012) Regulation of TGF-β receptor activity. Cell & Bioscience 2:1, pages 9.
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