Citations (59)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Katsura Asano. (2014) Why is start codon selection so precise in eukaryotes?. Translation 2:1.
Read now
Read now
Hiroyuki Hiraishi, Byung-Sik Shin, Tsuyoshi Udagawa, Naoki Nemoto, Wasimul Chowdhury, Jymie Graham, Christian Cox, Megan Reid, Susan J. Brown & Katsura Asano. (2013) Interaction between 25S rRNA A Loop and Eukaryotic Translation Initiation Factor 5B Promotes Subunit Joining and Ensures Stringent AUG Selection. Molecular and Cellular Biology 33:18, pages 3540-3548.
Read now
Read now
Daine Barth-Baus, C. Ramana Bhasker, Wendy Zoll & William C. Merrick. (2013) Influence of translation factor activities on start site selection in six different mRNAs. Translation 1:1.
Read now
Read now
Articles from other publishers (56)
Jonathan Bohlen, Mykola Roiuk, Marilena Neff & Aurelio A Teleman. (2023) PRRC2 proteins impact translation initiation by promoting leaky scanning. Nucleic Acids Research 51:7, pages 3391-3409.
Crossref
Crossref
Pilar Martín-Marcos, Álvaro Gil-Hernández & Mercedes Tamame. (2022) Wide mutational analysis to ascertain the functional roles of eL33 in ribosome biogenesis and translation initiation. Current Genetics 68:5-6, pages 619-644.
Crossref
Crossref
Jue Zhang, Shuai-Bo Pi, Nan Zhang, Jing Guo, Wei Zheng, Lizhi Leng, Ge Lin & Heng-Yu Fan. (2022) Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation. Nature Communications 13:1.
Crossref
Crossref
Urmila Sehrawat, Ora Haimov, Benjamin Weiss, Ana Tamarkin-Ben Harush, Shaked Ashkenazi, Alexander Plotnikov, Tzahi Noiman, Dena Leshkowitz, Gil Stelzer & Rivka Dikstein. (2022) Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation. Proceedings of the National Academy of Sciences 119:30.
Crossref
Crossref
Anup Kumar Ram, Monalisha Mallik, R. Rajendra Reddy, Amol Ratnakar Suryawanshi & Pankaj V. Alone. (2022) Altered proteome in translation initiation fidelity defective eIF5G31R mutant causes oxidative stress and DNA damage. Scientific Reports 12:1.
Crossref
Crossref
Ivaylo P. Ivanov, James A. Saba, Chen-Ming Fan, Ji Wang, Andrew E. Firth, Chune Cao, Rachel Green & Thomas E. Dever. (2022)
Evolutionarily conserved inhibitory uORFs sensitize
Hox
mRNA translation to start codon selection stringency
. Proceedings of the National Academy of Sciences 119:9.
Crossref
Crossref
Jinsheng Dong & Alan G Hinnebusch. (2022)
uS5/Rps2 residues at the 40S ribosome entry channel enhance initiation at suboptimal start codons
in vivo
. Genetics 220:1.
Crossref
Crossref
Jose L Llácer, Tanweer Hussain, Jinsheng Dong, Laura Villamayor, Yuliya Gordiyenko & Alan G Hinnebusch. (2021) Large-scale movement of eIF3 domains during translation initiation modulate start codon selection. Nucleic Acids Research 49:20, pages 11491-11511.
Crossref
Crossref
Aishwarya Rana, Nidhi Gupta & Anil Thakur. (2021) Post-transcriptional and translational control of the morphology and virulence in human fungal pathogens. Molecular Aspects of Medicine 81, pages 101017.
Crossref
Crossref
Anil Thakur, Swati Gaikwad, Anil K Vijjamarri & Alan G Hinnebusch. (2020) eIF2α interactions with mRNA control accurate start codon selection by the translation preinitiation complex. Nucleic Acids Research 48:18, pages 10280-10296.
Crossref
Crossref
Maria S. Benitez-Cantos, Martina M. Yordanova, Patrick B.F. O'Connor, Alexander V. Zhdanov, Sergey I. Kovalchuk, Dmitri B. Papkovsky, Dmitry E. Andreev & Pavel V. Baranov. (2020) Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context. Genome Research 30:7, pages 974-984.
Crossref
Crossref
Fujun Zhou, Hongen Zhang, Shardul D. Kulkarni, Jon R. Lorsch & Alan G. Hinnebusch. (2020) eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide. RNA 26:4, pages 419-438.
Crossref
Crossref
Edward W J Wallace, Corinne Maufrais, Jade Sales-Lee, Laura R Tuck, Luciana de Oliveira, Frank Feuerbach, Frédérique Moyrand, Prashanthi Natarajan, Hiten D Madhani & Guilhem Janbon. (2020) Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom. Nucleic Acids Research 48:5, pages 2312-2331.
Crossref
Crossref
Helena Firczuk, James Teahan, Pedro Mendes & John E.G. McCarthy. (2019) Multisite rate control analysis identifies ribosomal scanning as the sole high‐capacity/low‐flux‐control step in mRNA translation. The FEBS Journal 287:5, pages 925-940.
Crossref
Crossref
Ivan B. Lomakin, Swastik De, Jimin Wang, Aditi N. Borkar & Thomas A. Steitz. (2020) Crystal structure of the C-terminal domain of DENR. Computational and Structural Biotechnology Journal 18, pages 696-704.
Crossref
Crossref
Greco Hernández, Vincent G. Osnaya & Xochitl Pérez-Martínez. (2019) Conservation and Variability of the AUG Initiation Codon Context in Eukaryotes. Trends in Biochemical Sciences 44:12, pages 1009-1021.
Crossref
Crossref
Charles Antony A, Anup Kumar Ram, Kalloly Dutta & Pankaj V. Alone. (2019) Ribosomal mutation in helix 32 of 18S rRNA alters fidelity of eukaryotic translation start site selection. FEBS Letters 593:8, pages 852-867.
Crossref
Crossref
Anil Thakur, Laura Marler & Alan G Hinnebusch. (2019) A network of eIF2β interactions with eIF1 and Met-tRNAi promotes accurate start codon selection by the translation preinitiation complex. Nucleic Acids Research 47:5, pages 2574-2593.
Crossref
Crossref
William C. Merrick & Graham D. Pavitt. (2018) Protein Synthesis Initiation in Eukaryotic Cells. Cold Spring Harbor Perspectives in Biology 10:12, pages a033092.
Crossref
Crossref
Jose Luis Llácer, Tanweer Hussain, Adesh K Saini, Jagpreet Singh Nanda, Sukhvir Kaur, Yuliya Gordiyenko, Rakesh Kumar, Alan G Hinnebusch, Jon R Lorsch & V Ramakrishnan. (2018) Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. eLife 7.
Crossref
Crossref
Kai Ying Lin, Nabanita Nag, Tatyana V. Pestova & Assen Marintchev. (2018) Human eIF5 and eIF1A Compete for Binding to eIF5B. Biochemistry 57:40, pages 5910-5920.
Crossref
Crossref
David J. Young, Desislava S. Makeeva, Fan Zhang, Aleksandra S. Anisimova, Elena A. Stolboushkina, Fardin Ghobakhlou, Ivan N. Shatsky, Sergey E. Dmitriev, Alan G. Hinnebusch & Nicholas R. Guydosh. (2018) Tma64/eIF2D, Tma20/MCT-1, and Tma22/DENR Recycle Post-termination 40S Subunits In Vivo. Molecular Cell 71:5, pages 761-774.e5.
Crossref
Crossref
Nikolay E. Shirokikh & Thomas Preiss. (2018) Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions. WIREs RNA 9:4.
Crossref
Crossref
Anil Thakur & Alan G. Hinnebusch. (2018)
eIF1 Loop 2 interactions with Met-tRNA
i
control the accuracy of start codon selection by the scanning preinitiation complex
. Proceedings of the National Academy of Sciences 115:18.
Crossref
Crossref
Gary Loughran, Andrew E. Firth, John F. Atkins & Ivaylo P. Ivanov. (2018) Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection. PLOS ONE 13:2, pages e0192648.
Crossref
Crossref
Pilar Martin-Marcos, Fujun Zhou, Charm Karunasiri, Fan Zhang, Jinsheng Dong, Jagpreet Nanda, Shardul D Kulkarni, Neelam Dabas Sen, Mercedes Tamame, Michael Zeschnigk, Jon R Lorsch & Alan G Hinnebusch. (2017) eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast. eLife 6.
Crossref
Crossref
Leiming Tang, Jacob Morris, Ji Wan, Chelsea Moore, Yoshihiko Fujita, Sarah Gillaspie, Eric Aube, Jagpreet Nanda, Maud Marques, Maika Jangal, Abbey Anderson, Christian Cox, Hiroyuki Hiraishi, Leiming Dong, Hirohide Saito, Chingakham Ranjit Singh, Michael Witcher, Ivan Topisirovic, Shu-Bing Qian & Katsura Asano. (2017) Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide. Nucleic Acids Research 45:20, pages 11941-11953.
Crossref
Crossref
Michael G. Kearse & Jeremy E. Wilusz. (2017) Non-AUG translation: a new start for protein synthesis in eukaryotes. Genes & Development 31:17, pages 1717-1731.
Crossref
Crossref
Alan G. Hinnebusch. (2017) Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation. Trends in Biochemical Sciences 42:8, pages 589-611.
Crossref
Crossref
Ivaylo P. Ivanov, Jiajie Wei, Stephen Z. Caster, Kristina M. Smith, Audrey M. Michel, Ying Zhang, Andrew E. Firth, Michael Freitag, Jay C. Dunlap, Deborah Bell-Pedersen, John F. Atkins & Matthew S. Sachs. (2017) Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity. mBio 8:3.
Crossref
Crossref
Jinsheng DongColin Echeverría Aitken, Anil ThakurByung-Sik ShinJon R. Lorsch & Alan G. Hinnebusch. (2017) Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons. Proceedings of the National Academy of Sciences 114:11.
Crossref
Crossref
Jyothsna Visweswaraiah & Alan G Hinnebusch. (2017) Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo. eLife 6.
Crossref
Crossref
Zane A Jaafar, Akihiro Oguro, Yoshikazu Nakamura & Jeffrey S Kieft. (2016) Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling. eLife 5.
Crossref
Crossref
Nabanita Nag, Kai Ying Lin, Katherine A. Edmonds, Jielin Yu, Devika Nadkarni, Boriana Marintcheva & Assen Marintchev. (2016) eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling. Nucleic Acids Research, pages gkw552.
Crossref
Crossref
Thomas E Dever, Terri Goss Kinzy & Graham D Pavitt. (2016)
Mechanism and Regulation of Protein Synthesis in
Saccharomyces cerevisiae
. Genetics 203:1, pages 65-107.
Crossref
Crossref
Ioanna Tzani, Ivaylo P. Ivanov, Dmitri E. Andreev, Ruslan I. Dmitriev, Kellie A. Dean, Pavel V. Baranov, John F. Atkins & Gary Loughran. (2016)
Systematic analysis of the
PTEN
5′ leader identifies a major AUU initiated proteoform
. Open Biology 6:5, pages 150203.
Crossref
Crossref
Jian-Wei Zhou, Yuan Li, Li-Xia Yue, Cheng-Lin Luo, Yao Chen & Jian-Ying Zhang. (2015) Autoantibody response to Sui1 and its tissue-specific expression in hepatocellular carcinoma. Tumor Biology 37:2, pages 2547-2553.
Crossref
Crossref
Jose L. Llácer, Tanweer Hussain, Laura Marler, Colin Echeverría Aitken, Anil Thakur, Jon R. Lorsch, Alan G. Hinnebusch & V. Ramakrishnan. (2015) Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Molecular Cell 59:3, pages 399-412.
Crossref
Crossref
Jyothsna Visweswaraiah, Yvette Pittman, Thomas E Dever & Alan G Hinnebusch. (2015) The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo. eLife 4.
Crossref
Crossref
Klaske A.M.H. Thiadens & Marieke von Lindern. (2015) Selective mRNA translation in erythropoiesis. Biochemical Society Transactions 43:3, pages 343-347.
Crossref
Crossref
Hadar Sinvani, Ora Haimov, Yuri Svitkin, Nahum Sonenberg, Ana Tamarkin-Ben-Harush, Benoit Viollet & Rivka Dikstein. (2015) Translational Tolerance of Mitochondrial Genes to Metabolic Energy Stress Involves TISU and eIF1-eIF4GI Cooperation in Start Codon Selection. Cell Metabolism 21:3, pages 479-492.
Crossref
Crossref
Nikolaos TsotakosPatricia SilveyraZhenwu LinNeal Thomas, Mudit VaidJoanna Floros. (2015) Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. American Journal of Physiology-Lung Cellular and Molecular Physiology 308:1, pages L58-L75.
Crossref
Crossref
Adesh K Saini, Jagpreet S Nanda, Pilar Martin-Marcos, Jinsheng Dong, Fan Zhang, Monika Bhardwaj, Jon R Lorsch & Alan G Hinnebusch. (2014) Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex. Nucleic Acids Research 42:15, pages 9623-9640.
Crossref
Crossref
Alan G. Hinnebusch. (2014) The Scanning Mechanism of Eukaryotic Translation Initiation. Annual Review of Biochemistry 83:1, pages 779-812.
Crossref
Crossref
Pilar Martin-Marcos, Jagpreet S. Nanda, Rafael E. Luna, Fan Zhang, Adesh K. Saini, Vera A. Cherkasova, Gerhard Wagner, Jon R. Lorsch & Alan G. Hinnebusch. (2014) Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy. RNA 20:2, pages 150-167.
Crossref
Crossref
Rafael E. Luna, Haribabu Arthanari, Hiroyuki Hiraishi, Barak Akabayov, Leiming Tang, Christian Cox, Michelle A. Markus, Lunet E. Luna, Yuka Ikeda, Ryosuke Watanabe, Edward Bedoya, Cathy Yu, Shums Alikhan, Gerhard Wagner & Katsura Asano. (2013) The Interaction between Eukaryotic Initiation Factor 1A and eIF5 Retains eIF1 within Scanning Preinitiation Complexes. Biochemistry 52:52, pages 9510-9518.
Crossref
Crossref
Pilar Martin-Marcos, Jagpreet Nanda, Rafael E. Luna, Gerhard Wagner, Jon R. Lorsch & Alan G. Hinnebusch. (2013) β-Hairpin Loop of Eukaryotic Initiation Factor 1 (eIF1) Mediates 40 S Ribosome Binding to Regulate Initiator tRNAMet Recruitment and Accuracy of AUG Selection in Vivo. Journal of Biological Chemistry 288:38, pages 27546-27562.
Crossref
Crossref
Assen Marintchev. (2013) Roles of helicases in translation initiation: A mechanistic view. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:8, pages 799-809.
Crossref
Crossref
Jordi Querol-Audi, Chaomin Sun, Jacob M. Vogan, M. Duane Smith, Yu Gu, Jamie H.D. Cate & Eva Nogales. (2013) Architecture of Human Translation Initiation Factor 3. Structure 21:6, pages 920-928.
Crossref
Crossref
Jiajie Wei, Ying Zhang, Ivaylo P. Ivanov & Matthew S. Sachs. (2013) The Stringency of Start Codon Selection in the Filamentous Fungus Neurospora crassa. Journal of Biological Chemistry 288:13, pages 9549-9562.
Crossref
Crossref
Jagpreet S. Nanda, Adesh K. Saini, Antonio M. Muñoz, Alan G. Hinnebusch & Jon R. Lorsch. (2013) Coordinated Movements of Eukaryotic Translation Initiation Factors eIF1, eIF1A, and eIF5 Trigger Phosphate Release from eIF2 in Response to Start Codon Recognition by the Ribosomal Preinitiation Complex*. Journal of Biological Chemistry 288:8, pages 5316-5329.
Crossref
Crossref
Felix Voigts-Hoffmann, Sebastian Klinge & Nenad Ban. (2012) Structural insights into eukaryotic ribosomes and the initiation of translation. Current Opinion in Structural Biology 22:6, pages 768-777.
Crossref
Crossref
Sooncheol Lee, Botao LiuSoohyun LeeSheng-Xiong Huang, Ben Shen & Shu-Bing Qian. (2012) Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proceedings of the National Academy of Sciences 109:37.
Crossref
Crossref
Colin Echeverría Aitken & Jon R Lorsch. (2012) A mechanistic overview of translation initiation in eukaryotes. Nature Structural & Molecular Biology 19:6, pages 568-576.
Crossref
Crossref
Rafael E. Luna, Haribabu Arthanari, Hiroyuki Hiraishi, Jagpreet Nanda, Pilar Martin-Marcos, Michelle A. Markus, Barak Akabayov, Alexander G. Milbradt, Lunet E. Luna, Hee-Chan Seo, Sven G. Hyberts, Amr Fahmy, Mikhail Reibarkh, David Miles, Patrick R. Hagner, Elizabeth M. O'Day, Tingfang Yi, Assen Marintchev, Alan G. Hinnebusch, Jon R. Lorsch, Katsura Asano & Gerhard Wagner. (2012) The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β. Cell Reports 1:6, pages 689-702.
Crossref
Crossref
Gary Loughran, Matthew S. Sachs, John F. Atkins & Ivaylo P. Ivanov. (2012) Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5. Nucleic Acids Research 40:7, pages 2898-2906.
Crossref
Crossref