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Molecular and Cellular Biology Volume 32, 2012 - Issue 4
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Article

TCERG1 Regulates Alternative Splicing of the Bcl-x Gene by Modulating the Rate of RNA Polymerase II Transcription

Marta Montesa Department of Molecular Biology, Instituto de Parasitología y Biomedicina López Neyra, IPBLN-CSIC, Granada, Spain
,
Alexandre Cloutierb Department of Microbiology and Infectious Diseases, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Québec, Canada
,
Noemí Sánchez-Hernándeza Department of Molecular Biology, Instituto de Parasitología y Biomedicina López Neyra, IPBLN-CSIC, Granada, Spain
,
Laetitia Michelleb Department of Microbiology and Infectious Diseases, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Québec, Canada
,
Bruno Lemieuxb Department of Microbiology and Infectious Diseases, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Québec, Canada
,
Marco Blanchettec Stowers Institute for Medical Research, Kansas City, Missouri, USA
,
Cristina Hernández-Munaind Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra, IPBLN-CSIC, Granada, Spain
,
Benoit Chabotb Department of Microbiology and Infectious Diseases, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Québec, Canada
&
Carlos Suñéa Department of Molecular Biology, Instituto de Parasitología y Biomedicina López Neyra, IPBLN-CSIC, Granada, SpainCorrespondence[email protected]
 show all
Pages 751-762 | Received 08 Sep 2011, Accepted 30 Nov 2011, Published online: 20 Mar 2023

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Kuo-Ming Lee & Woan-Yuh Tarn. (2013) Coupling pre-mRNA processing to transcription on the RNA factory assembly line. RNA Biology 10:3, pages 380-390.
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Pan Yang, Huaifeng Liu, Yan Li, Qunwei Gao, Xin Chen, Junyan Chang, Yangyang Li, Shuran Chen, Rui Dong, Huazhang Wu, Changqing Liu & Gaofeng Liu. (2022) Overexpression of TCERG1 as a prognostic marker in hepatocellular carcinoma: A TCGA data-based analysis. Frontiers in Genetics 13.
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Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin, Xuetian Zhang, Yupei Wang, Xiaodong Xie, Qiang Li, Cuixia Di & Hong Zhang. (2021) Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation. Journal of Experimental & Clinical Cancer Research 40:1.
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María del Mar Noblejas-López, Cristina Nieto-Jiménez, Eva M. Galán-Moya, David Tebar-García, Juan Carlos Montero, Atanasio Pandiella, Miguel Burgos & Alberto Ocaña. (2021) MZ1 co-operates with trastuzumab in HER2 positive breast cancer. Journal of Experimental & Clinical Cancer Research 40:1.
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Sonia Borao, José Ayté & Stefan Hümmer. (2021) Evolution of the Early Spliceosomal Complex—From Constitutive to Regulated Splicing. International Journal of Molecular Sciences 22:22, pages 12444.
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Brittany Lynn Angarola & Olga Anczuków. (2021) Splicing alterations in healthy aging and disease. WIREs RNA 12:4.
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Tam T. Quach, Harrison J. Stratton, Rajesh Khanna, Pappachan E. Kolattukudy, Jérome Honnorat, Kathrin Meyer & Anne-Marie Duchemin. (2020) Intellectual disability: dendritic anomalies and emerging genetic perspectives. Acta Neuropathologica 141:2, pages 139-158.
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Cole Townsend, Majety N. Leelaram, Dmitry E. Agafonov, Olexandr Dybkov, Cindy L. WillKarl Bertram, Henning UrlaubBerthold Kastner, Holger Stark & Reinhard Lührmann. (2020) Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 370:6523.
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Marc Suñé-Pou, María J. Limeres, Cristina Moreno-Castro, Cristina Hernández-Munain, Josep M. Suñé-Negre, María L. Cuestas & Carlos Suñé. (2020) Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease. Frontiers in Genetics 11.
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Megan Stevens & Sebastian Oltean. (2019) Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing. Frontiers in Genetics 10.
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Chloe F. A. Warren, Michelle W. Wong-Brown & Nikola A. Bowden. (2019) BCL-2 family isoforms in apoptosis and cancer. Cell Death & Disease 10:3.
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Cristina Moreno-Castro, Silvia Prieto-Sánchez, Noemí Sánchez-Hernández, Cristina Hernández-Munain & Carlos Suñé. (2019) Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly. Journal of Cell Science.
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Marine Pons, Silvia Prieto, Laetitia Miguel, Thierry Frebourg, Dominique Campion, Carles Suñé & Magalie Lecourtois. (2018) Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila. Acta Neuropathologica Communications 6:1.
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Alexandre Cloutier, Lulzim Shkreta, Johanne Toutant, Mathieu Durand, Philippe Thibault & Benoit Chabot. (2018) hnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the alternative splicing response to oxaliplatin-mediated DNA damage. Scientific Reports 8:1.
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Juan Pablo Muñoz-Cobo, Noemí Sánchez-Hernández, Sara Gutiérrez, Younes El Yousfi, Marta Montes, Carme Gallego, Cristina Hernández-Munain & Carlos Suñé. (2016) Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes Associated with Cellular Morphology and Cytoskeleton Dynamics and Is Required for Neurite Outgrowth in Neuroblastoma Cells and Primary Neuronal Cultures. Molecular Neurobiology 54:10, pages 7808-7823.
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Noemí Sánchez-Hernández, Silvia Prieto-Sánchez, Cristina Moreno-Castro, Juan Pablo Muñoz-Cobo, Younes El Yousfi, Sofía Boyero-Corral, Marc Suñé-Pou, Cristina Hernández-Munain & Carlos Suñé. (2017) Targeting proteins to RNA transcription and processing sites within the nucleus. The International Journal of Biochemistry & Cell Biology 91, pages 194-202.
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Zodwa Dlamini, Fortunate Mokoena & Rodney Hull. (2017) Abnormalities in alternative splicing in diabetes: therapeutic targets. Journal of Molecular Endocrinology 59:2, pages R93-R107.
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Anna Fàbregas, Silvia Prieto-Sánchez, Marc Suñé-Pou, Sofía Boyero-Corral, Josep Ramón Ticó, Encarna García-Montoya, Pilar Pérez-Lozano, Montserrat Miñarro, Josep Mª Suñé-Negre, Cristina Hernández-Munain & Carlos Suñé. (2017) Improved formulation of cationic solid lipid nanoparticles displays cellular uptake and biological activity of nucleic acids. International Journal of Pharmaceutics 516:1-2, pages 39-44.
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Jonàs Juan-Mateu, Olatz Villate & Décio L Eizirik. (2016) MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research. European Journal of Endocrinology 174:5, pages R225-R238.
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Noemí Sánchez-Hernández, Stéphanie Boireau, Ute Schmidt, Juan Pablo Muñoz-Cobo, Cristina Hernández-Munain, Edouard Bertrand & Carlos Suñé. (2016) The in vivo dynamics of TCERG1, a factor that couples transcriptional elongation with splicing. RNA 22:4, pages 571-582.
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Francis Raj Gandhi Amrit, Elizabeth Marie Steenkiste, Ramesh Ratnappan, Shaw-Wen Chen, T. Brooke McClendon, Dennis Kostka, Judith Yanowitz, Carissa Perez Olsen & Arjumand Ghazi. (2016) DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans. PLOS Genetics 12:2, pages e1005788.
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Soraya Becerra, Eduardo Andrés‐León, Silvia Prieto‐Sánchez, Cristina Hernández‐Munain & Carlos Suñé. (2015) Prp40 and early events in splice site definition. WIREs RNA 7:1, pages 17-32.
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Nicolás Nieto Moreno, Luciana E. Giono, Adrián E. Cambindo Botto, Manuel J. Muñoz & Alberto R. Kornblihtt. (2015) Chromatin, DNA structure and alternative splicing. FEBS Letters 589:22, pages 3370-3378.
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Marta Montes, Mayte Coiras, Soraya Becerra, Cristina Moreno-Castro, Elena Mateos, Jara Majuelos, F. Javier Oliver, Cristina Hernández-Munain, José Alcamí & Carlos Suñé. (2015) Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing. PLOS ONE 10:10, pages e0139812.
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Shiran NaftelbergIgnacio E. SchorGil AstAlberto R. Kornblihtt. (2015) Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure. Annual Review of Biochemistry 84:1, pages 165-198.
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Benoit Chabot. (2015) My road to alternative splicing control: from simple paths to loops and interconnections. Biochemistry and Cell Biology 93:3, pages 171-179.
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Ramesh Ratnappan, Francis R. G. Amrit, Shaw-Wen Chen, Hasreet Gill, Kyle Holden, Jordan Ward, Keith R. Yamamoto, Carissa P. Olsen & Arjumand Ghazi. (2014) Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans. PLoS Genetics 10:12, pages e1004829.
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Pamela Bielli, Matteo Bordi, Valentina Di Biasio & Claudio Sette. (2014) Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection. Nucleic Acids Research 42:19, pages 12070-12081.
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Anna Fàbregas, Noemí Sánchez-Hernández, Josep Ramon Ticó, Encarna García-Montoya, Pilar Pérez-Lozano, Josep M. Suñé-Negre, Cristina Hernández-Munain, Carlos Suñé & Montserrat Miñarro. (2014) A new optimized formulation of cationic solid lipid nanoparticles intended for gene delivery: Development, characterization and DNA binding efficiency of TCERG1 expression plasmid. International Journal of Pharmaceutics 473:1-2, pages 270-279.
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Carlos DeOcesano-Pereira, Murilo S. Amaral, Kleber S. Parreira, Ana C. Ayupe, Jacqueline F. Jacysyn, Gustavo P. Amarante-Mendes, Eduardo M. Reis & Sergio Verjovski-Almeida. (2014) RETRACTED: Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis . Nucleic Acids Research 42:13, pages 8343-8355.
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Mayte Coiras, Marta Montes, Immaculada Montanuy, María Rosa López-Huertas, Elena Mateos, Caroline Le Sommer, Mariano A Garcia-Blanco, Cristina Hernández-Munain, José Alcamí & Carlos Suñé. (2013) Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication. Retrovirology 10:1.
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Célia Jeronimo, Alain R. Bataille & François Robert. (2013) The Writers, Readers, and Functions of the RNA Polymerase II C-Terminal Domain Code. Chemical Reviews 113:11, pages 8491-8522.
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Alberto R. Kornblihtt, Ignacio E. Schor, Mariano Alló, Gwendal Dujardin, Ezequiel Petrillo & Manuel J. Muñoz. (2013) Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nature Reviews Molecular Cell Biology 14:3, pages 153-165.
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Natalia N. Singh, Joonbae Seo, Sarah J. Rahn & Ravindra N. Singh. (2012) A Multi-Exon-Skipping Detection Assay Reveals Surprising Diversity of Splice Isoforms of Spinal Muscular Atrophy Genes. PLoS ONE 7:11, pages e49595.
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Claudia B. Zraly & Andrew K. Dingwall. (2012) The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit. Nucleic Acids Research 40:13, pages 5975-5987.
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Marta Montes, Soraya Becerra, Miguel Sánchez-Álvarez & Carlos Suñé. (2012) Functional coupling of transcription and splicing. Gene 501:2, pages 104-117.
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Noemí Sánchez-Hernández, Lidia Ruiz, Miguel Sánchez-Álvarez, Marta Montes, Maria J. Macias, Cristina Hernández-Munain & Carlos Suñé. (2012) The FF4 and FF5 Domains of Transcription Elongation Regulator 1 (TCERG1) Target Proteins to the Periphery of Speckles. Journal of Biological Chemistry 287:21, pages 17789-17800.
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